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Tizalud is a drug from the group of centrally acting muscle relaxants, which is used to eliminate painful muscle spasms.

Release form, composition

Tizalud is available in the form of tablets for internal use. Tizanidine is used as the active component. The drug is available in 2 and 4 mg doses, 30 pcs. packaged.

pharmachologic effect

Under the influence of the drug Tizalud, there is a decrease in the increased tone of skeletal muscles and elimination of their spasm, as well as normalization of muscle resistance during passive motor activity. The tablets increase the strength of voluntary contractions. The muscle-relaxing effect of Tizalud is due to its ability to inhibit the spinal polysynaptic reflex. The drug has no effect on the transmission of excitations in the area of ​​neuromuscular synapses.

The use of Tizalud demonstrates effectiveness both in acute painful muscle spasms and in chronic spasticity of spinal and cerebral origin. The drug helps reduce cramps, reduce resistance to passive movements and increase the range of active movements.

Absorption of the active ingredient is rapid; maximum concentration is observed 60 minutes after taking the tablet. The average half-life is up to 4 hours.

Indications

Tizalud can be used as part of complex therapy for the following diseases and conditions:

• spasticity caused by multiple sclerosis;
• spasticity caused by spinal cord lesions;
• spasticity caused by brain lesions.

The drug is used to eliminate painful muscle spasms caused by:

• diseases affecting the spine: development of cervical and lumbar syndrome;
• surgical interventions, including herniated intervertebral discs and osteoarthritis of the hip joints.

Mode of application

Tizalud tablets are intended for internal use. The exact dosage and duration of use of the medicine is determined individually. It is allowed to gradually increase the dosage under supervision and on the recommendation of a doctor. In this case, it is necessary to observe an interval of 3 days to 1 week.

Contraindications

Tizalud is not used in cases of individual intolerance to the active or auxiliary components of the drug, as well as in cases of severe liver dysfunction, during pregnancy and breastfeeding. If it is necessary to use the drug during therapy for a nursing woman, it is necessary to consider the issue of cessation of lactation.

The use of the drug is contraindicated simultaneously with drugs based on ciprofloxacin and fluvoxamine.

Particular caution is required when using the drug during the treatment of patients with impaired liver and kidney function. It is also necessary to exercise special caution when using Tizalud during the treatment of patients in older age groups, since there is not sufficient clinical experience with the use of the drug in this category of people.

Adverse reactions

Tizalud may contribute to the development of unwanted side effects such as:

• nausea, hepatitis, dyspepsia, liver failure, increased activity of liver transaminases;
• increased fatigue, skin itching, urticaria, hyperkeratinemia;
• muscle weakness;
• drowsiness, weakness, hallucinations, hearing impairment, dizziness, sleep disturbances, dry mouth;
• bradycardia, decreased blood pressure, disturbances of consciousness.

If you abruptly stop using Tizalud after prolonged use, tachycardia may develop and blood pressure increases. In some cases, cerebrovascular accidents may occur.

In case of overdose, adverse reactions may occur in the form of nausea, vomiting, arterial hypotension, dizziness, miosis, anxiety, coma, and respiratory problems. As treatment, it is necessary to stop using the drug, rinse the stomach, and take activated charcoal repeatedly. In the future, you should consult a doctor to prescribe a drug for symptomatic treatment. There is no specific antidote; forced diuresis may be indicated.

Drug interactions

While using Tizalud, you should not drink alcohol, as this may enhance the sedative effect of the drug.

When Tizalud is used simultaneously with drugs from the group of diuretics and antihypertensive drugs, arterial hypertension or bradycardia may develop.

An increase in the sedative effect of Tizalud may be observed when used simultaneously with sedative drugs.

At the beginning of treatment with Tizalud, reactions may occur in the form of a feeling of drowsiness, so at this stage you should refrain from performing work that requires increased attention and driving.

One of the components of the drug is lactose, therefore it is recommended to refrain from using tablets for patients with a history of hereditary galactose intolerance, severe lactase deficiency and glucose malabsorption.

The drug is stored in a dark, dry place in compliance with the temperature regime: no more than 25 degrees.

Analogues, cost

The cost of the drug Tizalud for the period June 2017 was formed as follows:

• Tablets 2 mg, 30 pcs. – 140-145 rub.
• Tablets 4 mg, 30 pcs. – 200-210 rub.

Analogues of the drug Tizalud are: Tizanil, Sirdalud, Tizanidin-Teva. If you need to select a replacement, you must first consult with your doctor.

Reviews

“Tizalud was prescribed by a doctor as part of a complex treatment for osteochondrosis. Additionally, we used B vitamins, NSAID painkillers for internal and external use, and, of course, muscle relaxants like Tizalud will help with muscle spasms. If the pain was mild or moderate, I used the lowest effective dose recommended by the doctor. I tried to take the pill before going to bed, since the drug can cause drowsiness. Under the influence of the pill, all muscles gradually relax, and the body falls into sleep. Apart from drowsiness, there were no other side effects, and the medicine did not cause addiction either.”

Olga

“We came across Tizalud when a doctor prescribed the drug to treat pain in the spine. The tablets act quickly: they help cope with pain, and there were no side effects. The treatment itself took place in a hospital setting, under the constant supervision of doctors. You should not use such tablets on your own. The drug has contraindications; tablets are available in several dosages. Only a doctor can accurately select a treatment regimen and determine which additional medications should be used.”

Nina

« Tizalud works well to cope with various neurological diseases, pain accompanying osteochondrosis, and various painful spasms. The tablet is well tolerated and, what is important in my case, does not have an unpleasant taste. I simply could not take other drugs from the group of muscle relaxants because of the terrible taste - I know that such a reaction is very individual. During treatment, all sorts of side effects arose in the form of nausea, drowsiness, dizziness, and general weakness in the body. The drug is, of course, effective, but it is better to use such strong drugs only under the supervision of a doctor.”

Julia

“I was faced with the fact that even a stressful situation can cause severe back pain. No painkillers, even the strongest ones, brought the desired effect. The pain was so severe that I had no strength to bend down to put on my shoes. I used medications both internally and external creams, gels and ointments - no results. I went to the pharmacy, described the problem, and they advised me to try Tizalud. Of course, the drug did not work instantly, but there was noticeable relief immediately. Additionally, I used various anti-stress medications. I was able to get rid of back pain approximately 2 weeks after starting this treatment. I would like to note right away that it is better to take Tizalud at night, since the drug is strong and can cause drowsiness.”

Natalia

I have been faced with the problem of osteochondrosis for a long time, the last attack was so severe that I had to seek advice from a neurologist. The doctor listened to the complaints and prescribed Tizalud. I had never taken this drug before, but it turned out that it was a muscle relaxant that helped cope with pain. The doctor strongly recommended taking the drug once a day - before going to bed, and that’s what I do. The tablet is medium in size and easy to swallow. Sleep comes very quickly after taking it. My back pain went away and my sleep returned to normal. There were no side effects during use; many people noted severe weakness and drowsiness, but this can be easily prevented if you use the drug at night. I have seen reviews that the drug can cause withdrawal symptoms, but I have not observed such a side effect. The cost of the tablets is quite budgetary - at the time of purchase 200 rubles. for 30 pcs. 4 mg each. The drug turned out to be effective, but it should only be taken under the supervision of a doctor.

Tizalud is a centrally acting muscle relaxant drug.

Active substance

Tizanidine.

Release form and composition

Sold in tablet form. Produced in blister packs (10 tablets each), placed in cardboard boxes of 3 pcs.

Indications for use

• spastic state of skeletal muscles provoked by neurological pathologies (stroke, multiple sclerosis, degenerative diseases of the spinal cord, chronic myelopathy);
• painful spasm of skeletal muscles associated with damage to the spine (in particular, lumbar and cervical syndromes) or appearing after surgery (for hip osteoarthritis or herniated disc).

Contraindications

• severe liver dysfunction;
• hypersensitivity to the components of the drug;
• co-administration of fluvoxamine and ciprofloxacin.

Instructions for use of Tizalud (method and dosage)

• To stop painful spasms of skeletal muscles, a dose of 2-4 mg is prescribed 3 times a day. In severe cases, it is recommended to take an additional 2-4 mg of the drug at night.
• For spastic muscle conditions caused by neurological pathologies, the initial dose is 6 mg per day (divided into 3 doses). It is recommended to gradually increase the indicated dose by 2-4 mg per day every 3-7 days. The maximum therapeutic effect is usually achieved with a dose of 12-24 mg per day (divided into 3-4 doses). The dose should not be exceeded 36 mg per day.

Side effects

The use of Tizalud may cause the following adverse reactions:

• Central nervous system: sleep disturbances, drowsiness, dry mouth, weakness, hallucinations, dizziness, insomnia.
• Gastrointestinal tract: dyspepsia, dry mouth, acute liver failure, hepatitis, increased activity of liver enzymes, attacks of nausea.
• Cardiovascular system: in rare cases - loss of consciousness, decreased blood pressure, bradycardia and collapse.
• Musculoskeletal system: constant muscle weakness.
• Other: itching, fatigue, urticaria, hypercreatininemia, rash.

In case of abrupt withdrawal after a long course of treatment, there is a risk of increased blood pressure and the development of tachycardia. In rare cases, cerebrovascular accident may occur.

Overdose

Symptoms of Tizalud overdose:

• dizziness;
• nausea;
• breathing problems;
• significant decrease in blood pressure;
• drowsiness;
• coma;
• miosis;
• anxiety;
• vomit.

Treatment is symptomatic.

Analogues

Analogs by ATC code: Tizanidine, Sirdalud, Tizanil.

Do not decide to change the drug on your own; consult your doctor.

pharmachologic effect

Tizalud is a centrally acting muscle relaxant that reduces the increased tone of skeletal muscles and relieves their spasm; reduces muscle resistance during passive movements, increases the strength of voluntary contractions. The muscle-relaxing effect is due to inhibition of spinal polysynaptic reflexes, as well as stimulation of α2-adrenergic receptors. Tizanidine does not affect the transmission of excitation at neuromuscular synapses.

special instructions

Use with extreme caution in patients with functional disorders of the kidneys and liver.

At the beginning of therapy, if drowsiness occurs, it is necessary to avoid activities that require rapid psychomotor reactions and extreme concentration.

During pregnancy and breastfeeding

Contraindicated during pregnancy and lactation.

In childhood

Not prescribed to patients under 18 years of age.

In old age

Information is absent.

For impaired renal function

Take with caution in case of impaired renal function.

For liver dysfunction

Take with caution in case of liver dysfunction.

Drug interactions

• When taken simultaneously with antihypertensive drugs, severe arterial hypotension and bradycardia may develop.
• When taking ethanol simultaneously, the sedative effect increases.

Conditions for dispensing from pharmacies

Dispensed by prescription.

Storage conditions and periods

Store at a temperature not exceeding 25 °C. Keep away from children.

Shelf life – 3 years.

Price in pharmacies

The price of Tizalud for 1 package starts from 130 rubles.

Pharmacodynamics

Centrally acting muscle relaxant. The main point of application is in the spinal cord. By stimulating presynaptic alpha2-adrenergic receptors, it suppresses the release of excitatory amino acids from interneurons of the spinal cord, which leads to inhibition of polysynaptic transmission of excitation in the spinal cord. As a result, muscle tone decreases. In addition to muscle relaxant properties, it also has a central, moderately pronounced analgesic effect.

Effective against acute painful muscle spasms and chronic spasms of spinal and cerebral origin. Reduces spasticity and clonic convulsions, as a result of which resistance to passive movements decreases and the range of active movements increases.

Pharmacokinetics

Absorption - high; time to reach maximum plasma concentration (Cmax) - 1-2 hours. Bioavailability - 34%. Eating does not affect Coca Neti Ku Pharma. Volume of distribution - 2.6 l/kg. Communication with plasma proteins - 30%. In the dose range from 4 to 20 mg, pharmacokinetics are linear. Metabolized quickly and largely in the liver (95%) with the formation of inactive metabolites. The half-life (T1/2) is 2-4 hours. It is excreted mainly by the kidneys (70% of the dose in the form of metabolites, 2.7% unchanged). In patients with renal failure (creatinine clearance less than 25 ml/min), the maximum plasma concentration (Cmax) increases by 2 times, T1/2 - 14 hours, the area along the pharmacokinetic concentration-time curve (AUC) increases by 6 times.

2. indications for use

• painful muscle spasm associated with static and
  functional diseases of the spine (cervical and lumbar syndromes), as well as after surgical interventions (for example, for a herniated intervertebral disc or hip joint);
• spasticity of skeletal muscles in neurological diseases (for example, multiple sclerosis, chronic myelopagia, degenerative diseases of the spinal cord, consequences of cerebrovascular accidents, as well as cerebral palsy / patients over 18 years old /).

3. Method of application

Relief of painful muscle spasms: orally, 2-4 mg 3 times a day, in severe cases - an additional 2-4 mg at night.

Treatment of spasticity caused by neurological diseases: initial dose - 2 mg 3 times a day, then the dose is gradually increased by 2-4 mg at intervals of 3-7 days. The optimal daily dose is 12-24 mg in 3-4 doses; the maximum daily dose is 36 mg.

For patients with renal failure (with CC less than 25 ml/min), the recommended initial dose is 2 mg I once a day. The dose is increased gradually, slowly, taking into account tolerability and effectiveness. If
If you need to get a more pronounced effect, it is recommended to first increase the dose prescribed once a day, then increase the frequency of administration.

4. Side effects

From the nervous system: drowsiness, dizziness, hallucinations, insomnia, sleep disturbances.

From the cardiovascular system: bradycardia, decrease in blood pressure (in some cases pronounced, up to collapse and loss of consciousness).

From the digestive system: dry mouth, nausea, dyspepsia, increased activity of “liver” transaminases, liver failure.

From the musculoskeletal system: muscle weakness.

Others: increased fatigue, hypercreatininemia.

In case of abrupt withdrawal after prolonged treatment and/or taking high doses of the drug (as well as after simultaneous use with antihypertensive drugs): tachycardia, increased blood pressure, in some cases - acute cerebrovascular accident.

5. Contraindications

• severe liver dysfunction;
• simultaneous use with strong inhibitors of CYP1A2 isoenzymes (including fluvoxamine, ciprofloxacin);
• hypersensitivity to other components of the drug;
• rare hereditary lactose intolerance, severe lactase deficiency, glucose-galactose malabsorption (for this dosage form containing lactose);

The use of tizanidine in children (under 18 years of age) is not recommended, because experience with the drug in this category of patients is limited.

Carefully:

Renal failure, arterial hypotension, bradycardia, simultaneous use of oral contraceptives, age over 65 years

6. During pregnancy and lactation

Since there have been no controlled studies of tizanidine in pregnant women, it should not be used during pregnancy unless the expected benefit to the mother outweighs the possible risk to the fetus.

Tizanide is excreted in breast milk in small quantities. However, if it is necessary to use it during lactation, the issue of stopping breastfeeding should be decided.

7. Interaction with other drugs

Concomitant use of tizanidine with fluvoxamine or ciprofloxacin, inhibitors of cytochrome P450 isofermeite 1A2, leads to a 33-fold increase in AUC. The result of combined use may be a clinically significant and prolonged decrease in blood pressure, leading to drowsiness, weakness, and inhibited psychomotor reactions (in some cases, even collapse and loss of consciousness).

The simultaneous use of tizanidine with other inhibitors of the CYP1A2 isoenzyme - antiarrhythmic drugs (amiodarone, mexiletine, propafenone), cimetidine, fluoroquinolones (enoxacin, pefloxacin), rofecoxib, oral contraceptives, ticlopidine.

Antihypertensive drugs (MDs) increase the risk of a pronounced decrease in blood pressure and bradycardia.
Ethanol and sedative drugs can enhance the sedative effect, so simultaneous use with other sedatives and/or alcohol is not recommended.

8. Overdose

Symptoms: nausea, vomiting, marked decrease in blood pressure, dizziness, drowsiness, miosis, anxiety, respiratory failure, .

Treatment: gastric lavage, administration of activated carbon, forced diuresis, symptomatic therapy.

9. Release form

Tablets 2 or 4 mg - 30 pcs.

10. Storage conditions

At a temperature not higher than 25 °C.
Keep out of the reach of children.

Best before date

2 years.

11. Composition

1 tablet contains:

tizanidine hydrochloride - 2.288 mg and 4.576 mg in terms of tizanidine - 2.0 mg and 4.0 mg;

Excipients: Lactose anhydrous (lactopress)
117.012 mg and 234.024 mg, Microcrystalline cellulose 14.0 mg and 28.0 mg, Sodium carboxymethyl starch
(Primogel) 4.2 mg and 8.4 mg, Magnesium stearate 2.5 mg and 5.0 mg.

12. Conditions for dispensing from pharmacies

The drug is dispensed according to the prescription of the attending physician.

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* Instructions for medical use of the drug Tizalud are published in free translation. THERE ARE CONTRAINDICATIONS. BEFORE USE, YOU MUST CONSULT WITH A SPECIALIST

Tizalud tablets are a medicine designed to relieve muscle spasms.

The drug has a wide range of contraindications and many side effects, so it must be taken in strict accordance with the instructions developed by the manufacturer and as prescribed by doctors.

General characteristics of the drug

The drug Tizalud is produced by the Russian pharmaceutical company Veropharm. The drug is a white cylindrical tablet with beveled edges and a score on one of the surfaces. Each of them contains 2 or 4 mg of the active ingredient. The manufacturer packages tablets of 10 pcs. in blister packs made of PVC and aluminum foil.

In pharmacies, the medicine is sold in cardboard packs, each containing 3 blisters with medications and a leaflet with instructions for use.

Tizalud tablets can only be purchased with a doctor's prescription. The price of the drug depends on the concentration of the active substance and varies between 120−190 rubles per standard pack. The medicine must be stored in its original packaging at temperatures up to 25 °C. It is important to ensure that it is not exposed to moisture or direct sunlight. If the described conditions are met, the drug retains its pharmacological and organoleptic properties for 36 months. Unused tablets that have expired should be discarded.

Composition and pharmacological action

The main active ingredient in Tizalud is tizanidine hydrochloride. Once in the human body, this component stimulates the work of presynaptic α2-adrenergic receptors, inhibits the release of “excitatory” amino acids (glutamic, aspartic) and suppresses polysynaptic impulse transmission at the level of spinal cord interneurons. Due to this, tizanidine hydrochloride:

• eliminates muscle spasms;
• relieves clonic convulsions;
• reduces resistance to passive movements;
• increases the strength of voluntary muscle contractions;
• exhibits moderate analgesic properties.

The auxiliary components of the medicine are anhydrous lactose, microcrystalline cellulose, stearic acid and aerosil.

Indications for use

The active component of the drug acts as a centrally acting muscle relaxant, therefore the main indications for the use of Tizalud are:

• spasticity of skeletal muscles in multiple sclerosis, cerebral palsy, chronic myelopathy, degenerative processes in the tissues of the spinal cord and other neurological pathologies;
• pain syndrome and muscle spasms that accompany the development of functional and static diseases of the spinal column (lumbar and cervical regions).

In addition, the drug is used to relieve muscle cramps that occur after surgery for osteoarthritis of the hip joint and herniated disc.

Reception scheme

Tizalud is taken orally with a small amount of still water. The tablets are swallowed whole, without chewing or dissolving. For painful muscle spasms, patients are prescribed 2-4 mg of the drug three times a day. In severe cases, the daily dose of the drug is increased by 2 mg.

In cases where Tizalud is prescribed to relieve skeletal muscle spasticity, a more complex dosage regimen is used. In the first week, patients take 2 mg of the drug three times a day. Then the daily dose of the drug is increased by 2-4 mg with an interval of 72-96 hours. Most patients achieve optimal therapeutic effect when taking 12–24 mg of tizanidine hydrochloride per day.

Persons who have previously been diagnosed with renal failure are prescribed 2 mg of the drug per day. The initial dose is increased gradually, taking into account the tolerability of the drug and the effectiveness of therapy. First of all, increase the volume of the medicine, and only then - the frequency of administration.

For acute pain caused by muscle spasm, the drug is taken for 2-3 weeks. For chronic pain, the patient may require a longer course of therapy (from several months to a year). If necessary, the doctor can adjust the treatment regimen taking into account the dynamics of pain and muscle-tonic manifestations of the disease.

Taking more than 36 mg of tizanidine hydrochloride per day can cause dizziness, nausea, drowsiness, vomiting, increased anxiety, disturbances in the respiratory system, decreased blood pressure, constriction of the pupils and falling into a coma.

If one or more signs of overdose are detected, it is necessary to discontinue the medicine, rinse the stomach, take diuretics and activated charcoal. In addition, you should consult a doctor as soon as possible.

Side effects

Most patients easily tolerate treatment with Tizalud. Undesirable effects of the drug are rare. These include:

• drowsiness during the day or insomnia at night;
• general weakness, increased fatigue;
• significant reduction in blood pressure;
• dizziness;
• disturbance of sinus rhythm (bradycardia);
• nausea;
• hallucinations;
• muscle weakness;
• dry mouth, constant thirst;
• increased activity of liver transaminases;
• digestive disorders;
• acute inflammation of the liver.

The components present in Tizalud can provoke the development of allergic reactions in the form of urticaria, skin itching, rashes, swelling of facial tissues, etc.

Contraindications for use

Tizalud is not suitable for all patients who complain of muscle spasms. Most often, the reason for refusing to use this drug is individual intolerance to tizanidine hydrochloride and the auxiliary components of the drug. Contraindications to the use of tablets are:

• age under 18 years;
• simultaneous treatment with fluvoxamine;
• severe functional disruptions in the liver;
• pregnancy;
• breastfeeding period.

In patients taking Tizalud, the speed of psychomotor reactions and concentration of attention may decrease; therefore, the manufacturer recommends that persons undergoing therapy with this medication temporarily refrain from driving vehicles and other complex technical devices.

Drug analogues

On the modern pharmaceutical market you can find many analogues of the drug Tizalud in terms of the active ingredient and medicinal properties. These include:

• tablets Tizanil, Lioresal, Tolperisone, Mydocalm, Baclofen, Sirdalud, Tolperil-Zdorovye, Miolastan, Tizanidine and Baclosan;
• extended-release capsules Miorix;
• solutions for intramuscular administration Meloflex, Muscomed, Miaxil and Midostad Combi.

All centrally acting muscle relaxants included in this group have a lot of features in use, harmful effects, absolute and relative contraindications, so they can be used as an alternative to Tizalud tablets only with the consent of the attending physician.

The active substance of Tizaluda is tizanidine hydrochloride.

Pharmacological properties

Tizalud is a centrally acting muscle relaxant, is an agonist of a2-adrenergic receptors, mainly in spinal ascending neural networks. Suppresses polysynaptic spinal reflexes and has an antispastic effect with increased muscle tone, relieves spasms and clonic convulsions. The mechanism of action is associated with stimulation of presynaptic a2-adrenergic receptors, which promotes the release of amino acids that excite nerve endings that stimulate NMDA receptors, resulting in inhibition of the transmission of excitation in synapses (relieves spasms and muscle tone). It has an analgesic effect by reducing the release of excitatory neurotransmitters in the brain, reducing central sensitivity and activation of glycine. Rapidly and almost completely absorbed when taken orally. Maximum concentration in the blood after 1-2 hours.

Indications

• painful spasm of skeletal muscles caused by diseases of the spine (cervical and lumbar syndromes, radiculitis);
• postoperative pain associated with a herniated disc or osteoarthritis of the hip;
• spastic condition of skeletal muscles caused by neurological diseases (multiple sclerosis, chronic myelopathy, stroke, degenerative diseases of the spinal cord, cerebral palsy).

Release form

• tablets of 2 mg No. 30 in blisters;
• tablets of 4 mg No. 30 in blisters.

Directions for use and doses

The drug should be taken orally, regardless of food intake. The course of treatment, dose, is determined individually by the doctor, depending on the condition, dynamics of treatment and indications. The course can vary from 3 weeks to a year.

For painful spasms of skeletal muscles, 2-4 mg is prescribed 3 times a day. In severe cases, an additional 2-4 mg is prescribed at night.

In case of spastic condition of skeletal muscles, 2 mg is prescribed 3 times a day, gradually increasing the dose every day by 2-4 mg per day.

For patients with renal failure, the initial dose is 2 mg 1 time per day.

The maximum daily dose is 36 mg.

Children

Not applicable to children.

Use during pregnancy or breastfeeding

Use during pregnancy and breastfeeding is contraindicated. If you need to take the drug, you should stop breastfeeding.

Application Features

In case of abrupt withdrawal of the drug, tachycardia and pressure surges are possible. Tizalud contains lactose. It is not recommended for use in patients with galactose intolerance, severe lactase deficiency or glucose-galactose malabsorption syndrome. Use with caution in patients with impaired liver and kidney function.

Contraindications

• hypersensitivity to the components of the drug;
• simultaneous use of ciprofloxacin and fluvoxamine;
• bulbar palsy.

Side effects

The following side effects may occur during use:

• anaphylactic reactions, hypersensitivity reactions;
• hallucinations, confusion, visual impairment;
• asthenia, withdrawal syndrome;
• hypotension, hypertension, tachycardia, cerebrovascular accident;
• renal and liver failure;
• headache, dizziness, fainting, sleep disturbances;
• nausea, dry mouth, vomiting, diarrhea, abdominal pain.

Interaction with other drugs and other types of interactions

Concomitant use with antiarrhythmic drugs (amiodarone, mexiletine, propafenone), cimetidine, some fluoroquinolones (enoxacin, pefloxacin, norfloxacin), rofecoxib, oral contraceptives, ticlopidine is not recommended.

Use with caution with drugs that prolong the QT interval (for example, cisapride, amitriptyline, azithromycin).

With antihypertensive drugs, including diuretics, blood pressure control is necessary; bradycardia, hypotension, and collapse are possible.

Rifampicin reduces the concentration of tizalud in the blood; an increase in the dose of tizalud is recommended.

Alcohol intake is prohibited; it can lead to low blood pressure and lethargy.

The drug increases the sedative effect in combination with other sedatives, hypnotics and antihistamines.

The ability to influence the reaction rate when driving vehicles or other mechanisms

If drowsiness occurs, you should stop driving.

Overdose

When using high doses of the drug, the following symptoms may occur: anxiety, drowsiness, nausea, vomiting, bradycardia, hypotension, dizziness, respiratory distress, coma.

Treatment is drug withdrawal, gastric lavage, a course of enterosorbents. Further symptomatic treatment.