Help on Tele2, tariffs, questions

Phthalazole is a broad-spectrum antibacterial agent. Belongs to the group of sulfonamide antibiotics.

Prevents the absorption of folic acid by bacterial cells, which is the main substance necessary for the formation of bacterial DNA and RNA. In addition to the antimicrobial effect, it has an anti-inflammatory effect, which develops by reducing the migration of leukocytes and the production of anti-inflammatory substances.

The medicine is used primarily for the treatment of infectious processes of the gastrointestinal tract and for preoperative preparation on the intestines.

Clinical and pharmacological group

Antibacterial agent, sulfanilamide derivative.

Terms of sale from pharmacies

Can buy without a doctor's prescription.

Price

How much does Fthalazol cost in pharmacies? The average price is 25 rubles.

Composition and release form

Phthalazole is available in the form of tablets for oral administration. The tablets are white, packed in blisters of 10 pieces in a cardboard box, the drug is accompanied by detailed instructions describing the characteristics.

• Each tablet of the drug Fthalazol contains the active ingredient - Phthalylsulfathiazole 500 mg, as well as a number of additional excipients.

The drug is effective against staphylococci, streptococci, gonococci, pneumococci, Pseudomonas aeruginosa and others.

Pharmacological effect

Phthalazole is a sulfonamide drug that has a pronounced bacteriostatic effect on the body. It is active against gram-positive and gram-negative microorganisms that provoke the development of intestinal infections.

After oral administration, the drug is practically not absorbed into the blood. It has its main therapeutic effect directly in the gastrointestinal tract. The mechanism of action of phthalylsulfothiazole is based on disruption of the synthesis of folic and dihydrofolic acids, which act as growth factors for microorganisms.

In addition to its antibacterial properties, Fthalazol has an anti-inflammatory effect, which is provided by its ability to reduce the number of migrating leukocytes and stimulate the production of GCS.

What does it help with?

Phthalazole can be used for various disorders of intestinal function that arose under the influence of disturbances in the quantitative composition and diet of food. That is, after a period of strict diet or recovery from fasting. Additionally, the drug reduces the phenomenon of increased levels of gas formation (flatulence).

Phthalazole is intended for the treatment of the following diseases:

• dysentery,
• colitis, enterocolitis, gastroenteritis,
• diarrhea of ​​various origins.

In addition, this drug has a good effect when used to prevent purulent complications during intestinal operations.

Phthalazole is indicated for patients without infectious lesions of the intestinal mucosa, if they are being prepared for surgery. The drug is also prescribed to children with advanced cases, which are provoked by taking broad-spectrum antibacterial pharmaceuticals. In this case, it relieves the symptoms of dysbiosis.

Contraindications

If the following contraindications are present, the drug should not be taken under any circumstances:

• intestinal obstruction;
• allergic reactions to certain components of the drug;
• blood clotting disorder;
• diseases of the thyroid gland (Graves disease);
• chronic kidney and liver diseases;
• hypersensitivity to the components of the drug.

Prescription during pregnancy and lactation

According to the instructions for use, it should not be taken during pregnancy and breastfeeding, or for very young children, as the drug is quite harmful. Phthalylsulfathiazole crosses the placenta and has a negative effect on the fetus. Also, during pregnancy there is a large load on the kidneys and the excretory system as a whole, and Phthalazol is quite toxic.

Dosage and method of administration

As indicated in the instructions for use, the dosage and duration of treatment should be prescribed by a specialist, depending on the degree of sensitivity of the intestinal microflora to sulfonamides.

According to the instructions for Fthalazol, the daily dose should not exceed 7 grams, and a single dose should not exceed 2 grams.

In acute cases of the disease, the following is prescribed:

• 1-2 days – 2 tablets, every 4 hours;
• 3-4 days – 2 tablets, every 6 hours;
• Day 5-6 – 2 tablets – every 8 hours.

Further treatment:

• 1-2 days - 2 tablets every 4 hours, at night - one (in total - 10);
• 3-4 days – 8 tablets per day, with an interval of 4 hours, except at night;
• Day 5 – 6 tablets, every 4 hours.

Instructions for use of Phthalazol for children

The duration of therapy for any diarrhea, regardless of its cause, is seven days. If the child’s diarrhea has stopped earlier, then the use of Phthalazol can be stopped 12 hours after the absence of loose stools. The dosage and frequency of taking Phthalazole is determined by the age of the child and the cause of diarrhea.

Children under 12 years of age with non-dysenteric diarrhea take Fthalazol according to the following regimen:

1. On the first day of the disease, Fthalazol is taken in an individual dosage, calculated by body weight, based on the ratio of 100 mg per 1 kg of weight. The calculated dosage of Phthalazole is divided into three doses per day. For example, a child weighs 10 kg, which means the daily dosage of Phthalazole for him is 100 * 10 = 1000 mg, which corresponds to two tablets. These two tablets must be divided by five, resulting in 0.4 (2/5). This means that the child needs to be given 0.4 (2/5) tablets every four hours with a break for night sleep;
2. On the second and subsequent days of the disease, it is necessary to take Fthalazol in a dosage of 250 - 500 mg (half - a whole tablet) per 1 kg of body weight per day. This means that the daily dosage of Phthalazol is also calculated depending on the child’s body weight. So, for a child weighing 10 kg, the daily dosage will be 250 * 10 – 500 * 10 = 2500 – 5000 mg, which corresponds to 5 – 10 tablets. This amount is divided into 3 – 4 doses, which are carried out during the day at regular intervals. That is, the child needs to be given 1 - 2 tablets 3 - 4 times a day. During night sleep, take a break from taking pills.

For acute dysentery, the dosage of Phthalazole depends on the age of the child:

• Children aged 0 - 3 years take Fthalazol half a tablet every 4 - 6 hours;
• Children aged 3 - 7 years take one tablet of Fthalazol (500 mg) every 4 - 6 hours;
• Children aged 7 - 12 years take 1 - 1.5 tablets (500 - 750 mg) every 4 - 6 hours.

Children over 12 years of age with any diarrhea take Phthalazol in adult dosages.

Adverse reactions

The use of the drug Fthalazol may cause the following side effects:

• From the blood system: agranulocytosis, leukopenia, hemolysis of erythrocytes, thrombocytopenia. With long-term use of the drug, anemia may occur due to a deficiency of pteroylglutaric and pantothenic acids produced by microbes.
• From the nervous system: depressed mood, headaches, dizziness.
• From the gastrointestinal tract: lesions of the oral cavity (gingivitis, stomatitis, glossitis), diarrhea, nausea, vomiting, gastritis, hepatitis, cholangitis, deficiency of B vitamins.
• From the cardiovascular system: cyanosis, myocarditis.
• From the urinary system: development of urolithiasis.
• From the respiratory system: eosinophilic pneumonia.
• Allergic reactions: skin rash (up to erythema nodosum and exudative erythema multiforme); in rare cases - swelling of the lips and face, Lyell's syndrome, periarteritis nodosa.

Overdose

An overdose of Phthalazole is possible and is manifested by the development of pancytopenia (a sharp decrease in the content of all cellular elements of the blood), nausea, vomiting and headache. In case of overdose, it is necessary to stop taking phthalazole. If necessary, symptomatic therapy is carried out.

special instructions

If necessary, Fthalazole is combined with sulfonamides or antibiotics that are well absorbed from the gastrointestinal tract.

Compatibility with other drugs

When using the drug, it is necessary to take into account interactions with other medications:

1. The drug reduces the effectiveness of oxacillin.
2. When used simultaneously with indirect anticoagulants, their effect is enhanced.
3. Para-aminosalicylic acid and barbiturates enhance the activity of sulfonamides.
4. In combination with thioacetazone and chloramphenicol, the risk of agranulocytosis increases.
5. In combination with nitrofurans, the risk of anemia and methemoglobinemia increases.
6. Phthalazole is chemically incompatible with acids and acid-reacting drugs, hexamethylenetetramine, and adrenaline solution.
7. In combination with drugs such as novocaine, anesthesin, dicaine, the antibacterial activity of sulfanilamide is inactivated by a competitive mechanism. The effect is enhanced by antibiotics and well-absorbed sulfonamides.

Description of the dosage form

Tablets from white to white with a slightly yellowish tint, flat-cylindrical with a chamfer and a score.

pharmachologic effect

Pharmacodynamics

Phthalazole, like other sulfonamide drugs, similar in structure to PABA, based on the principle of competitive relationships, prevents its inclusion in the synthesis of folic acid in the microbial cell. This leads to disruption of the formation of folic acid, which is involved in the synthesis of purine and pyrimidine bases, on which the growth and development of microorganisms depends. Phthalazole has the most pronounced bacteriostatic effect on vegetative forms of microbes. This effect develops gradually, because the microbial cell contains some reserves of PABA. In addition, the degree of affinity of phthalazole with dihydrofolic acid synthetase, the enzyme that limits the formation of folic acid, is much weaker compared to PABA. Therefore, phthalazole must be administered in sufficiently high doses to prevent the use of PABA microorganisms contained in tissues. Otherwise, resistant strains of pathogens may be formed that are not susceptible to further exposure to sulfonamide drugs.

In addition to being antibacterial, phthalazole, like other sulfonamide drugs, has an anti-inflammatory effect, which is associated with its ability to limit the migration of leukocytes, reduce the total number of migrating cellular elements and partially stimulate the production of GCS.

The spectrum of antimicrobial action of phthalazole, like other sulfonamides, is narrower than that of antibiotics. Sulfonamides have a bacteriostatic effect on Streptococcus, Pneumococcus, Staphylococcus, Meningococcus, Gonococcus, Escherichia coli, Pseudomonas aeruginosa, Shigella dysenteriae, Proteus vulgaris and a number of large viruses - the causative agents of trachoma and follicular conjunctivitis.

Pharmacokinetics

When taken orally, the drug is slowly adsorbed from the digestive tract - only 5% of the administered substance is found in the urine, resulting in a high concentration in the lumen of the colon, where, under the influence of microorganisms, the phthalazole molecule undergoes splitting into phthalic acid, amino group and norsulfazole. The latter has a bacteriostatic effect on pathogens of intestinal infections (bacillary dysentery, colitis, gastroenterocolitis). Acts primarily in the intestinal lumen.

Indications for the drug Fthalazol

dysentery (acute and chronic in the acute stage);

gastroenteritis;

prevention of purulent complications during surgical interventions on the intestines.

Contraindications

increased individual sensitivity to sulfonamide drugs;

diseases of the blood system;

diffuse toxic goiter;

chronic renal failure;

glomerulonephritis;

acute hepatitis;

intestinal obstruction.

Side effects

From the nervous system: headache, dizziness, depressed mood.

From the SSS side: myocarditis, cyanosis.

From the blood system: in rare cases - leukopenia, thrombocytopenia, agranulocytosis, hemolysis of erythrocytes. With long-term use, anemia may occur due to a deficiency of pantothenic and pteroylglutaric acids produced by microbial cells.

From the gastrointestinal tract: nausea, vomiting, diarrhea, lesions of the oral cavity (including stomatitis, gingivitis, glossitis), gastritis, cholangitis, hepatitis, deficiency of B vitamins (due to inhibition of intestinal microflora).

From the respiratory system: eosinophilic pneumonia.

From the urinary system: urolithiasis disease.

Allergic and toxic-allergic reactions: drug allergies, incl. skin manifestations of drug allergies in the form of various rashes, up to erythema nodosum and exudative erythema multiforme, in some cases - epidermal necrolysis (Lyell's syndrome). In some cases, allergic swelling of the lips and face and periarteritis nodosa occur.

Interaction

When using phthalazole together with other drugs, the following interactions may occur.

PAS and barbiturates: the activity of sulfonamides increases.

Thioacetazone, chloramphenicol: the possibility of developing agranulocytosis increases.

Nitrofurans: the risk of anemia and methemoglobinemia increases.

Indirect anticoagulants: the anticoagulant effect is enhanced.

Oxacillin: the activity of the antibiotic decreases.

The combined use of phthalazole with acids and acid-reacting drugs, hexamethylenetetramine, adrenaline solution is inappropriate, because they are chemically incompatible.

When phthalazole is used in combination with drugs containing PABA esters (novocaine, anesthesin, dicaine), the antibacterial activity of sulfonamide is inactivated by a competitive mechanism. The effect is enhanced by antibiotics and well-absorbed sulfonamides.

Directions for use and doses

Inside

For acute dysentery:

adults in the first 1-2 days - 1 g 6 times a day, in the 3-4th days - 1 g 4 times a day, in the 5-6th days - 1 g 3 times a day. The average course dose is 25-30 g. After 5-6 days, a second course of treatment is carried out: days 1-2 - 1 g 5 times a day (during the day - every 4 hours, at night - every 8 hours), 3- 4th day - 1 g 4 times a day (do not give at night), 5th day - 1 g 3 times a day. The total dose in the second cycle is 21 g, for mild cases - 18 g. Maximum doses for adults: single - 2 g, daily - 7 g;

children up to 3 years - 0.2 g/kg in 3 doses for 7 days, over 3 years - 0.4-0.75 g 4 times a day.

For other infections:

adults in the first 2-3 days, 1-2 g is prescribed every 4-6 hours, in the next 2-3 days - half doses;

children- 0.1 g/kg/day in equal doses every 4 hours with a night break, on the following days - 0.2-0.5 g every 6-8 hours.

Release form

Tablets, 0.5 g. 10 tablets each in contour cellless or contour cell packaging. 2 blister packs are placed in a cardboard pack.

Manufacturer

JSC "Dalkhimfarm"

680001, Khabarovsk, st. Tashkentskaya, 2.

Conditions for dispensing from pharmacies

On prescription.

Storage conditions for the drug Fthalazol

Keep out of the reach of children.

Shelf life of the drug Fthalazol

Do not use after the expiration date stated on the package.

Instructions for medical use

LS-000105 from 2015-10-12
Phthalazol - instructions for medical use - RU No. LSR-001247/10 dated 2013-08-13
Phthalazol - instructions for medical use - RU No. LSR-001247/10 dated 2012-09-11
Phthalazol - instructions for medical use - RU No. R N003869/01 dated 2018-08-13
Phthalazol - instructions for medical use - RU No. LS-002126 dated 2017-11-08
Phthalazol - instructions for medical use - RU No. LS-002126 dated 2006-10-20

Synonyms of nosological groups

For various disorders of the intestinal microflora, ranging from diarrhea to dysbiosis in children, Fthalazol comes to the rescue - a synthetic antimicrobial drug that has a wide spectrum of antimicrobial (bacteriostatic) action, especially in relation to the intestinal flora.

The drug has a detrimental effect on bacteria that cause infections in the digestive system. In addition, Fthalazol has an anti-inflammatory effect and also promotes the production of glucocorticosteroids - natural hormones that inhibit inflammatory processes in the body.

It is immediately worth noting that Fthalazol belongs to the group of sulfonamides, and not antibiotics. Despite the fact that the mechanism of action of such drugs is, in principle, similar (they are built into the structure of microorganisms and from the inside disrupt metabolic processes in their cells), Fthalazol is not an antibiotic drug.

pros of this medicine are as follows:

• Negative microflora, destroyed by the active substance, are removed from the gastrointestinal tract naturally along with feces during defecation. The remains of the medicine also come out with them;
• Only a tenth of the drug taken is absorbed into the body. It enters the liver through the blood and is excreted by the kidneys (with urine);
• Phthalazole does not accumulate in the body, is not addictive, and its effectiveness does not decrease even with repeated treatment of diarrhea.

Phthalazole is available in a single dosage form - tablets for oral administration.

The main active ingredient of Fthalazol is phthalylsulfathiazole (500 mg).

Sulfathiazole penetrates the pathogen cell through the cell wall, inhibits the metabolism of folic acid, which is necessary for most bacteria to synthesize nucleic acid components, namely purine and pyrimidine nitrogenous bases, which stops the synthesis of daughter DNA and makes reproduction impossible.

The active substance does not accumulate in tissues even with prolonged use of Phthalazol tablets, so there is no addiction or reduction in effectiveness when they are used repeatedly.

It is advisable to have this medicine in every home medicine cabinet. It helps quickly enough, stops diarrhea of ​​any origin, which allows you to reduce fluid loss in the human body and effectively prevent possible dehydration of the body.

Indications for use Fthalazol

According to the instructions for use, Phthalazol can be used for various disorders of intestinal function that arose under the influence of disturbances in the quantitative composition and diet of food. That is, after a period of strict diet or recovery from fasting. Additionally, the drug reduces the phenomenon of increased levels of gas formation (flatulence).

Phthalazole is intended for the treatment of the following diseases:

• dysentery,
• colitis, enterocolitis, gastroenteritis,
• diarrhea of ​​various origins.

In addition, this drug has a good effect when used to prevent purulent complications during intestinal operations.

Phthalazole is indicated for patients without infectious lesions of the intestinal mucosa, if they are being prepared for surgery. The drug is also prescribed to children with advanced cases of dysbiosis, which is provoked by taking broad-spectrum antibacterial pharmaceuticals. In this case, Fthalazol relieves the symptoms of dysbacteriosis.

Instructions for use Fthalazol, dosage

Since Fthalazole is from the sulfonamide group, like other medications or its analogues, they are drunk before meals, half an hour to an hour. Doctors recommend consuming 2-3 liters of free liquid per day during the course.

According to the instructions, Fthalazol should not be taken more than 2 g per dose and more than 7 g per day.

Adults – 1-2 g every 4-6 hours for 5-7 days. Higher doses for adults orally: single dose – 2 g, daily dose – 7 g. Children under 3 years of age – 200 mg/kg/day in 3 doses for 7 days. Children over 3 years old - 400-750 mg (depending on age) 4 times a day.

A single dose of Phthalazol for children aged 3 to 7 years is 0.4 - 0.5 g, and for children aged 8 to 14 years - 0.5 - 0.75 g. The course of treatment in children should not exceed 7 days.

In case of further relapse (re-development of the disease), it is recommended to repeat the course of taking Fthalazole again according to the following scheme: 1-2 days: 1 t. every 4-5 hours (approximately 5-6 t. per day); Day 3-4: 1 t. 3-4 r. per day; Day 5-6: 1 t. 2-3 r. for a day.

The treatment regimen, features of administration and the exact dosage of Phthalazole depend on the disease, the presence of chronic pathologies in the patient and age.

Features of application

Simultaneously with Phthalazol, it is advisable to prescribe B vitamins, since due to the inhibition of the growth of E. coli, the synthesis of vitamins of this group decreases.

The medication does not have a negative effect on the psychomotor functions of the human body, and therefore, during therapy with Phthalazole, driving vehicles and working with potentially dangerous mechanisms are allowed.

Before starting to take the medicine, you should make sure that there are no symptoms of intoxication and dehydration, expressed in dizziness, weakness, elevated body temperature, nausea, and severe vomiting. If one of the above symptoms is present, it is contraindicated to take Phthalazol and you should urgently seek medical help.

The consumption of alcoholic beverages is contraindicated, which in combination with the active compound Phthalazole phthalylsulfathiazole can lead to serious poisoning.

The disease, the nature of its course, the age of the patient, his condition - these are the factors that influence the indication for the prescription of tablets, the dosage and frequency. But, no matter what the doctor prescribes Fthalazol tablets or its analogue, he must check the sensitivity of the microflora that provoked the disease.

Side effects and contraindications Fthalazol

• pain in the intestinal area (lower abdomen);
• dysbacteriosis;
• increased gas formation;
• decreased or complete lack of appetite;
• development of intestinal candidiasis;
• nausea;
• difficulty in defecation;
• vomit.

Allergic reactions often occur - skin rashes, flushing of the skin, sneezing, lacrimation. In this case, you should immediately stop taking the drug and consult a doctor to replace it with a more suitable drug.

Overdose

An overdose of Phthalazol most often results in headache or migraine pain, fluctuations in the emotional background, nausea, vomiting, diarrhea, damage to the oral cavity (stomatitis, gingivitis, glossitis), as well as gastritis, cholangitis, cholecystitis and hepatitis; Most often, signs of urolithiasis occur, sometimes to the point of complete blockage of urination.

In case of overdose, for the purpose of partial rehabilitation, medications containing folic acid (vitamin B9) are used.

Symptomatic treatment should also be used.

Contraindications:

• Hepatitis;
• Kidney failure;
• Infancy up to two years of age;
• Hypersensitivity to the components of the drug;
• Blood diseases;
• Intestinal obstruction;
• Toxic goiter;
• Glomerulonephritis.

The use of the drug during pregnancy and lactation is possible only when the expected benefit to the mother outweighs the potential risk to the child.

Children under two months of age can take phthalazole only in case of congenital toxoplasmosis.

Analogues of Fthalazol, list

1. Bactrim;
2. Berlocid;
3. Biseptol;
4. Brifeseptol;
5. Dvaseptol;
6. Co-trimoxazole;
7. Neonutrin;
8. Pentasa;
9. Prednisolone;
10. Retinol;
11. Salosinal;
12. Salofalk;
13. Triamcinolone;
14. Urbazon;
15. Fortecortin;
16. Fortecortin Mono;
17. Metosulfabol;
18. Oriprim;
19. Sinersul;
20. Sulotrim;
21. Sulgin;
22. Phtazin;
23. Furazolidone.

Important - instructions for use of Fthalazol, price and reviews do not apply to analogues and cannot be used as a guide to the use of drugs of similar composition or action. All therapeutic prescriptions must be made by a doctor. When replacing Fthalazol with an analogue, it is important to consult a specialist; you may need to change the course of therapy, dosage, etc. Do not self-medicate!

Ten years ago, this drug was the only one against diarrhea. But today there are several of its analogues, although some continue to prefer Phthalazole. Maybe because of its reasonable price, because all modern drugs today are expensive and not every person can buy them.

For various disorders of the intestinal microflora, experts suggest using the drug “Fthalazol” during therapy. What does this medicine help with? How to take it correctly? This information is presented below.

Short description

This drug is available exclusively in tablet form.

Some experts argue that a blister with such pills should be present in every home medicine cabinet in case of sudden poisoning.

So, what exactly are Fthalazol tablets? What does this remedy help with? We give a comprehensive answer: this is an effective medicine that helps very well with a variety of microbial lesions of the intestinal mucosa.

Compound

The drug "Fthalazol": indications for use

The drug is highly effective in the treatment of the following diseases:

• gastroenteritis;
• colitis;
• dysentery (acute and chronic forms);
• any imbalance of intestinal microflora;
• salmonellosis;
• infectious diseases.

When preparing a patient for surgery on the intestinal tract, he is most often prescribed the drug Fthalazol.

What else does the above remedy help with:

• food poisoning;
• dysbacteriosis in children.

But not in all cases you can use Fthalazol tablets. The indications for use listed above are not taken into account if the patient experiences the following symptoms:

• severe vomiting;
• weakness;
• dizziness;
• decreased skin turgor;
• repeated loose stools (more than eight times a day).

Experts note that in such a situation, the patient should seek medical help, and in no case take Phthalazol tablets on their own without a doctor’s prescription. The use of the medicine in question can be harmful to the patient’s health, since dehydration and disruption of the electrolyte balance of the blood occurs in the body.

Contraindications

The instructions prohibit the use of the drug "Fthalazol" for the treatment of imbalances in intestinal microflora and other concomitant diseases if the patient has the following problems:

• blood diseases;
• acute hepatitis;
• Graves' disease.

For young patients under two years of age, the drug Fthalazol is contraindicated. Indications are also not taken into account if the patient has hypersensitivity to the components of the above drug.

In addition, the instructions prohibit the use of this drug for the treatment of intestinal disorders caused by fungal infections of the mucous membrane. Otherwise, the patient’s well-being may worsen, because the drug has no damaging effect on bacteria, it only inhibits their growth.

The drug "Fthalazol" should be used with extreme caution in patients suffering from nephritis and nephrosis.

Side effects

As a result of taking the above medication, in some cases the patient may experience the following side effects from the gastrointestinal tract:

• pain in the intestinal area;
• dysbacteriosis;
• decreased appetite;
• development of intestinal candidiasis;
• nausea;
• difficulty in defecation;
• vomit.

Sometimes patients experience symptoms of allergic reactions, such as watery eyes, skin rashes, and regular sneezing. In such cases, the patient should stop taking the pills and consult their doctor.

Mode of application

When observing symptoms of dysentery, the patient is prescribed a course of therapy according to the following scheme:

• the first two days he needs to take 1 g of medication six times a day;
• on the third and fourth days the patient should take 1 g of the drug four times;
• on the fifth and sixth days he is prescribed no more than 1 g of medication three times.

Then patients should undergo a second course of treatment according to the appropriate regimen:

• in the first two days he should take 1 g of the medicine six times a day (at night, it is taken every eight hours, so the final dose of the drug during this period is about 5 g daily);
• over the next two days, the patient needs to take 1 g of the product every four hours (do not take it at night).

During the entire course of therapy, the patient must take at least 21 g of the above drug.

If the disease is in a particularly mild form, then the minimum dosage can be reduced to eighteen grams. Any changes to the dosage regimen must be agreed with a specialist.

How to give Phthalazol tablets to children? Young patients who have not yet reached the age of three are allowed to take the drug at the rate of 0.2 g per kilogram of body weight. This dose is then divided into three parts and given to children every eight hours (that is, about three times a day).

If a small patient is more than three years old, he is prescribed medicine in an amount of 0.4 - 0.75 g per kilogram of body weight. This dose is then divided into four parts. The drug is given to the child every six hours, that is, no more than four times a day.

Other disorders of the intestinal microflora are treated with other dosages of the drug:

• adult patients can take 1 g of medication 4 times in 24 hours in the first three days, in the next three days the above dosage is halved;
• For small patients, specialists prescribe the drug at the rate of 0.1 g per kilogram of body weight four times a day (this is on the first day), then the dosage is reduced by 50%, the drug is taken three times a day.

Patients who are pregnant are allowed to take the pills in question only under the strict supervision of a specialist. It should be noted that the active substance of the above medicine does not penetrate into breast milk, so if necessary, it can be taken without fear by nursing mothers.

Experts advise patients to take B vitamins (nicotinic acid, thiamine, riboflavin) during therapy. This will inhibit the growth of E. coli, which is responsible for the synthesis of the above vitamins.

Interaction with other drugs

The effectiveness of the above medicine is greatly enhanced by antibiotics. The same interaction is observed when combining the drug "Fthalazol" with sulfonamides.

In addition, experts note that the manifestation of hepatotoxicity of the above drug is enhanced by myelotoxic drugs.

The drug "Fthalazol" is an excellent assistant in the fight against intestinal infections of various etiologies.

For various disorders of the intestinal microflora, experts suggest using the drug “Fthalazol” during therapy. What does this medicine help with? How to take it correctly? This information is presented below.

Short description

This drug is available exclusively in tablet form.

Some experts argue that a blister with such pills should be present in every home medicine cabinet in case of sudden poisoning.

So, what exactly are Fthalazol tablets? What does this remedy help with? We give a comprehensive answer: this is an effective medicine that helps very well with a variety of microbial lesions of the intestinal mucosa.

Compound

The drug "Fthalazol": indications for use

The drug is highly effective in the treatment of the following diseases:

• gastroenteritis;
• colitis;
• dysentery (acute and chronic forms);
• any imbalance of intestinal microflora;
• salmonellosis;
• infectious diseases.

When preparing a patient for surgery on the intestinal tract, he is most often prescribed the drug Fthalazol.

What else does the above remedy help with:

• food poisoning;
• dysbacteriosis in children.

But not in all cases you can use Fthalazol tablets. The indications for use listed above are not taken into account if the patient experiences the following symptoms:

• severe vomiting;
• weakness;
• dizziness;
• decreased skin turgor;
• repeated loose stools (more than eight times a day).

Experts note that in such a situation, the patient should seek medical help, and in no case take Phthalazol tablets on their own without a doctor’s prescription. The use of the medicine in question can be harmful to the patient’s health, since dehydration and disruption of the electrolyte balance of the blood occurs in the body.

Contraindications

The instructions prohibit the use of the drug "Fthalazol" for the treatment of imbalances in intestinal microflora and other concomitant diseases if the patient has the following problems:

• blood diseases;
• acute hepatitis;
• Graves' disease.

For young patients under two years of age, the drug Fthalazol is contraindicated. Indications are also not taken into account if the patient has hypersensitivity to the components of the above drug.

In addition, the instructions prohibit the use of this drug for the treatment of intestinal disorders caused by fungal infections of the mucous membrane. Otherwise, the patient’s well-being may worsen, because the drug has no damaging effect on bacteria, it only inhibits their growth.

The drug "Fthalazol" should be used with extreme caution in patients suffering from nephritis and nephrosis.

Side effects

As a result of taking the above medication, in some cases the patient may experience the following side effects from the gastrointestinal tract:

• pain in the intestinal area;
• dysbacteriosis;
• decreased appetite;
• development of intestinal candidiasis;
• nausea;
• difficulty in defecation;
• vomit.

Sometimes patients experience symptoms of allergic reactions, such as watery eyes, skin rashes, and regular sneezing. In such cases, the patient should stop taking the pills and consult their doctor.

Mode of application

When observing symptoms of dysentery, the patient is prescribed a course of therapy according to the following scheme:

• the first two days he needs to take 1 g of medication six times a day;
• on the third and fourth days the patient should take 1 g of the drug four times;
• on the fifth and sixth days he is prescribed no more than 1 g of medication three times.

Then patients should undergo a second course of treatment according to the appropriate regimen:

• in the first two days he should take 1 g of the medicine six times a day (at night, it is taken every eight hours, so the final dose of the drug during this period is about 5 g daily);
• over the next two days, the patient needs to take 1 g of the product every four hours (do not take it at night).

During the entire course of therapy, the patient must take at least 21 g of the above drug.

If the disease is in a particularly mild form, then the minimum dosage can be reduced to eighteen grams. Any changes to the dosage regimen must be agreed with a specialist.

How to give Phthalazol tablets to children? Young patients who have not yet reached the age of three are allowed to take the drug at the rate of 0.2 g per kilogram of body weight. This dose is then divided into three parts and given to children every eight hours (that is, about three times a day).

If a small patient is more than three years old, he is prescribed medicine in an amount of 0.4 - 0.75 g per kilogram of body weight. This dose is then divided into four parts. The drug is given to the child every six hours, that is, no more than four times a day.

Other disorders of the intestinal microflora are treated with other dosages of the drug:

• adult patients can take 1 g of medication 4 times in 24 hours in the first three days, in the next three days the above dosage is halved;
• For small patients, specialists prescribe the drug at the rate of 0.1 g per kilogram of body weight four times a day (this is on the first day), then the dosage is reduced by 50%, the drug is taken three times a day.

Patients who are pregnant are allowed to take the pills in question only under the strict supervision of a specialist. It should be noted that the active substance of the above medicine does not penetrate into breast milk, so if necessary, it can be taken without fear by nursing mothers.

Experts advise patients to take B vitamins (nicotinic acid, thiamine, riboflavin) during therapy. This will inhibit the growth of E. coli, which is responsible for the synthesis of the above vitamins.

Interaction with other drugs

The effectiveness of the above medicine is greatly enhanced by antibiotics. The same interaction is observed when combining the drug "Fthalazol" with sulfonamides.

In addition, experts note that the manifestation of hepatotoxicity of the above drug is enhanced by myelotoxic drugs.

The drug "Fthalazol" is an excellent assistant in the fight against intestinal infections of various etiologies.