Novigan indications for use. Novigan - indications for use and important features of taking the medicine

Description of the dosage form

Release form, composition and packaging

Film-coated tablets white, round, biconvex, with "NOVIGAN" embossed.

Excipients: microcrystalline cellulose, corn starch, glycerol, colloidal anhydrous silicon, purified talc, magnesium stearate, hypromellose, macrogol 6000, titanium dioxide, polysorbate 80, sorbic acid, dimethicone.

10 pieces. - blisters (2) - cardboard boxes.
10 pieces. - blisters (10) - cardboard boxes.
10 pieces. - blisters (20) - cardboard boxes.

Clinical and pharmacological group

Spasmoanalgesic

pharmachologic effect

A combination drug that includes NSAIDs (ibuprofen), a myotropic antispasmodic (pitofenone hydrochloride), an anticholinergic blocker of central and peripheral action (fenpiverinium bromide).

Novigan ® has analgesic, antispasmodic and anti-inflammatory effects.

Ibuprofen is a derivative of phenylpropionic acid. It has analgesic, anti-inflammatory and antipyretic effects. The main mechanism of action is inhibition of the synthesis of prostaglandins - modulators of pain sensitivity, thermoregulation and inflammation in the central nervous system and peripheral tissues. In women with primary dysmenorrhea, it reduces the elevated level of prostaglandins in the myometrium and thereby reduces intrauterine pressure and heart rate.

Pitophenone hydrochloride has a direct myotropic effect on the smooth muscles of internal organs and causes its relaxation.

Phenpiverinium bromide - due to its anticholinergic effect, it has an additional relaxing effect on smooth muscles.

The combination of the three components of the drug leads to a mutual enhancement of their pharmacological action.

Pharmacokinetics

When taken orally, the components of Novigan ® are well absorbed from the gastrointestinal tract. Cmax in blood plasma is achieved in approximately 1-2 hours. The main component of the drug, ibuprofen, is 99% bound to plasma proteins, accumulates in the synovial fluid, metabolized in the liver and is excreted 90% in the urine in the form of metabolites and conjugates. A small part of imbuprofen is excreted in bile. T1/2 from blood plasma is 2 hours.

Indications for use of the drug

- mild or moderate pain syndrome due to spasms of the smooth muscles of internal organs: renal and biliary colic, biliary dyskinesia, intestinal colic, algodismenorrhea and other spastic conditions of the smooth muscles of internal organs;

- headache, incl. migraine, toothache;

- for short-term symptomatic treatment (no more than 5 days) for joint pain, neuralgia, myalgia, tendinitis, bursitis, radiculitis;

— if necessary, to reduce elevated body temperature during colds and infectious and inflammatory diseases.

Dosage regimen

The drug is prescribed orally, 1-2 tablets. up to 4 times/day. The maximum daily dose is 6 tablets.

At algodismenorrhea- 1 tablet every 4 hours.

It is advisable to take Novigan ® either 1 hour before a meal or 3 hours after a meal. The maximum duration of treatment without consulting a doctor is 5 days.

To avoid irritating the stomach, take the drug immediately after meals or drink it with milk.

Side effect

From the digestive system: nausea, vomiting, NSAID gastropathy (decreased appetite, pain and discomfort in the epigastric region, abdominal pain), irritation, dry oral mucosa or pain in the mouth, ulceration of the gum mucosa, aphthous stomatitis, pancreatitis, constipation, diarrhea, flatulence, digestive disorders ; possible - erosive and ulcerative lesions of the gastrointestinal tract, bleeding from the gastrointestinal tract, impaired liver function.

From the central nervous system and peripheral nervous system: headache, dizziness, drowsiness, anxiety, nervousness and irritability, psychomotor agitation, confusion, hallucinations.

From the senses: hearing impairment, ringing in the ears, reversible toxic amblyopia, blurred vision or double vision, dryness and irritation of the eyes, swelling of the conjunctiva and eyelids (allergic origin), scotoma.

From the respiratory system: dyspnea.

From the cardiovascular system: heart failure, tachycardia, increased blood pressure.

From the urinary system: edema syndrome, impaired renal function, acute renal failure, interstitial nephritis, proteinuria, polyuria, cystitis, red staining of urine.

Allergic reactions: skin rash (usually erythematous or urticarial), skin itching, urticaria (including on the conjunctiva and mucous membranes of the nasopharynx), angioedema, Quincke's edema, aseptic meningitis (more often in patients with autoimmune diseases), bronchospastic syndrome, anaphylactoid reactions, anaphylactic shock, fever, erythema multiforme, toxic epidermal necrolysis (Lyell's syndrome), eosinophilia, allergic rhinitis.

From the hematopoietic organs: aplastic anemia, hemolytic anemia, thrombocytopenic purpura, agranulocytosis, leukopenia.

Anticholinergic effects: dry mouth, decreased sweating, accommodation paresis, tachycardia, urinary retention.

Contraindications to the use of the drug

- erosive and ulcerative lesions of the gastrointestinal tract in the acute phase;

- "aspirin" bronchial asthma;

- severe liver dysfunction;

- severe renal dysfunction;

- diseases of the optic nerve;

- angle-closure glaucoma;

- acute intermittent porphyria;

- deficiency of glucose-6-phosphate dehydrogenase;

- tachyarrhythmias;

- prostatic hyperplasia;

- acute intestinal obstruction, megacolon;

- pregnancy;

- lactation period (breastfeeding);

- children under 16 years of age;

- hypersensitivity to the components of the drug;

- hypersensitivity to other NSAIDs.

WITH caution The drug should be used in patients with impaired liver and kidney function, with chronic heart failure, with a history of gastric and duodenal ulcers, ulcerative colitis, with a tendency to bronchospasm, and blood clotting disorders.

Use of the drug during pregnancy and lactation

The drug is contraindicated during pregnancy and lactation (breastfeeding).

Use for liver dysfunction

Use is contraindicated in cases of severe liver dysfunction.

Use for renal impairment

Use is contraindicated in cases of severe renal impairment.

special instructions

Novigan ® is intended for episodic or short-term treatment (up to 5 days).

With long-term (more than a week) use of the drug, monitoring of the peripheral blood picture and the functional state of the liver is necessary.

Taking the drug may mask the symptoms of acute diseases of the abdominal organs that require emergency medical care.

Overdose

Symptoms: nausea, vomiting, stomach pain, visual disturbances.

Treatment: gastric lavage, adsorbents, symptomatic treatment.

Drug interactions

Inducers of microsomal oxidation (ethanol, barbiturates, rifampicin, tricyclic antidepressants) increase the production of hydroxylated active metabolites, increasing the risk of severe toxic liver damage.

Microsomal oxidation inhibitors reduce the risk of hepatotoxicity. The drug reduces the natriuretic and diuretic activity of furosemide and hypothiazide. Reduces the effectiveness of uricosuric drugs, enhances the effect of antiplatelet agents, fibrinolytics (increasing the risk of hemorrhagic complications).

When interacting with mineralocorticoids, glucocorticoids, colchicine, estrogen, ethanol, the drug can enhance the ulcerogenic effect with an increased risk of bleeding.

Enhances the effect of oral hypoglycemic agents and insulin.

Antacids and cholestyramine reduce the absorption of ibuprofen.

The drug increases the plasma concentrations of digoxin, phenytoin, methotrexate, and lithium.

Caffeine enhances the analgesic effect of ibuprofen. When administered simultaneously with acetylsalicylic acid, ibuprofen inhibits the antiplatelet effect of small doses of acetylsalicylic acid.

When prescribed simultaneously with thrombolytic agents (alteplase, streptokinase, urokinase), the risk of bleeding increases. Cefamandole, cefoperazone, cefotetan, valproic acid increase the incidence of hypoprothrombinemia. Cyclosporine and gold preparations enhance the effect of ibuprofen on prostaglandin synthesis in the kidneys, which is manifested by increased nephrotoxicity.

Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of developing its hepatotoxic effects.

Drugs that block tubular secretion reduce excretion and increase plasma concentrations of ibuprofen.

When using ibuprofen simultaneously with potassium-sparing diuretics, there is a risk of developing hyperkalemia, and with other NSAIDs, the risk of developing adverse reactions from the gastrointestinal tract increases.

Conditions for dispensing from pharmacies

The drug is available with a prescription.

Storage conditions and periods

The drug should be stored out of reach of children, in a dry place, protected from light at temperatures up to 25°C. Shelf life - 5 years.

It is known that it is dangerous to relieve painful sensations without finding out their exact cause. At the same time, there are situations when the pain is difficult to endure, and you have to self-medicate. The main thing in such cases is to find out more information about the medicine. Let's look at what the analgesic Novigan is and the indications for use of this drug.

Novigan - composition

The drug Nogvigan is produced by an Indian pharmaceutical company in tablet form. These are round tablets with a film coating on top. In their composition they contain three active ingredients at once, acting differently and thereby ensuring maximum effectiveness for pain of a different nature. The composition of the Novigan tablet according to the active ingredients is as follows:

ibuprofen;
pitofenone hydrochloride;
fenpiverinium bromide.

As auxiliary components that are used in the manufacture of the drug shell and added to the active substances to ensure the chemical and mechanical stability of the drug, its better susceptibility by the body, etc., Novigan contains:

starch;
cellulose;
talc;
silica;
titanium dioxide;
glycerol;
magnesium stearate;
polysorbate 80;
macrogol 6000;
hypromellose;
Dimethicone

Novigan - action

Novigan tablets are quickly absorbed and exhibit their therapeutic effect one to two hours after administration. After 24 hours, the drug is completely eliminated from the body, mainly through the urinary system. Novigan works, the indications for use of which include different types of pain, due to the properties of each of the active substances separately and due to their interaction, which enhances the overall effect. Let's look at what these components are and how they affect pain:

Ibuprofen (400 mg)– a non-steroidal anti-inflammatory substance, a derivative of phenylpropionic acid. By suppressing the biosynthesis of prostaglandins (hormone-like substances that at the biochemical level cause pain), pain is reduced, as well as inflammation, swelling, and elevated body temperature.
Pitophenone hydrochloride (5 mg)– a compound that has a direct effect on spasmodic smooth muscle tissue of internal organs, eliminating spasm. Muscle tension, which provokes compression of blood vessels and nerve fibers, often causes intense pain, which recedes when relaxation occurs.
Phenpiverinium bromide (0.1 mg)– this component belongs to the group of m-anticholinergic drugs that “turn off” the receptors of internal organs that respond to the neurotransmitter acetylcholine. Due to this, a decrease in smooth muscle tone and pain relief are achieved.

What does Novigan help with?

Novigan, the indications for use of which are listed in the attached instructions, is recommended for pain of moderate and low intensity, but for debilitating, unbearable pain syndrome it will not show the desired effect. Let's look at Novigan's indications:

pain associated with spasm of the smooth muscles of internal organs - kidneys, liver, gallbladder and bile ducts, etc.;
spastic pain syndrome with dysmenorrhea;
headaches of various origins, including;
pain in the joints, lower back, nerves, skeletal muscles (as short-term pain relief therapy).

The above symptoms are the main ones for prescribing this anesthetic and in most cases are successfully eliminated by taking a standard dosage. As directed by the attending physician, Novigan can also be used in some other pathological situations associated with painful sensations not mentioned in the instruction leaflet.

How to take Novigan?

The drug Novigan, the use of which must occur in accordance with certain rules, is an intensely active drug. It is recommended to take it an hour before a meal or three hours after it, which will ensure the highest effectiveness. At the same time, in order to avoid potential negative effects on the walls of the stomach, it is permissible to take these tablets immediately after eating. A reduction in the risk of irritation to the mucous membranes of the digestive tract is also achieved by drinking the drug with milk rather than water.

The standard dosage of Novigan is 1 tablet three times a day with an interval of at least 4-6 hours between doses. The duration of use of the drug should be as short as possible and not exceed five days for self-treatment. Longer use of these tablets is permissible only under the supervision of specialists and with the performance of certain tests.

Novigan for toothache

Pain caused by damage to dental tissues or gums causes great discomfort, so it must be stopped in a timely manner. This is an acceptable solution in cases where it is not possible to immediately see a dentist. The drug Novigan helps effectively, but the analgesic effect is due to one component - ibuprofen.

The other two active components of the drug, which act on spasmodic muscle tissue, do not help in this case. Therefore, it is more rational to take other one-component tablets with ibuprofen for toothache, but if there is nothing else at hand, it is better to use Novigan. In this case, it is recommended to combine the analgesic with the use of a local antiseptic for the oral cavity.

Novigan for headaches

The drug Novigan, the main indications for use of which include headaches of various origins, is very effective and quickly relieves painful sensations. This is achieved through a combination of tablet components that act in different directions on several mechanisms of pain. The drug Novigan is recommended mainly for tension headaches associated with stress, anxiety, or overstrain of the neck and head muscles caused by prolonged stay in an uncomfortable position. Copes with moderate migraine syndrome.

Novigan for menstrual pain

Painful sensations in the lower abdomen during menstruation plague many women, often accompanied by bloating and intestinal upset, headaches, and nausea. It is worth understanding that these symptoms may indicate pathological disorders of the reproductive system that require examination and treatment. Because in this case, the source of pain is the spasming uterus; Novigan helps a lot with menstruation. To further help yourself with this, you should lie down with a warm heating pad on your stomach, which helps relieve the spasm.

Novigan - side effects

Due to the presence of several active components in the composition of the medication in question, Novigan has a significant number of side effects. We list the main complaints that may be presented when pain is eliminated with these tablets:

lowering blood pressure;
tachycardia;
pain in the stomach;
stool disorder;
dry mouth;
dry skin;
visual disturbances;
dizziness;
drowsiness;
irritability;
weakness;
convulsions;
allergic manifestations.

Novigan - contraindications

Like any other medications, Novigan tablets have limited use. Let's consider in what cases using them to relieve pain is undesirable and dangerous:

ulcers and erosions of the walls of the gastrointestinal tract;
acute inflammatory bowel diseases;
intestinal obstruction;
a history of allergic reactions in response to taking non-steroidal anti-inflammatory drugs;
severe liver or kidney disease;
disorders of blood clotting and hematopoiesis;
granulocytopenia;
tachyarrhythmia;
optic nerve diseases;
severe dehydration;
heart failure;
severe somatic diseases;
concomitant use of certain medications (anticoagulants, glucocorticosteroids, antiplatelet agents, etc.);
arterial hypertension;
pregnancy;
age up to 16 years, etc.

Is it possible to drink Novigan during pregnancy?

The instructions for use indicate that Novigan is prohibited from being prescribed during pregnancy, and this applies to all periods of gestation. Taking this drug can negatively affect not only the condition of a pregnant woman, but also jeopardizes the normal development of the unborn child. In addition, pain cannot be relieved with this remedy during breastfeeding.

Novigan and alcohol - compatibility

As with most systemic medications, Novigan and alcohol should not be used together. Therefore, during the treatment period it is recommended to refrain from drinking even small doses of low-alcohol drinks. It is worth remembering that some medications may contain alcohol, so their use simultaneously with Novigan is dangerous.

We will describe such a complex drug as Novigan, its instructions for use and tell you what it helps with. After all, there are often situations when it is necessary to stop painful sensations of various origins. But not all pills that are available at the pharmacy should be taken thoughtlessly.

Only after reading the instructions, or even better, after consulting a doctor, can you use painkillers. Some people experience side effects, and in some situations it is completely contraindicated to take most medications, even those sold in pharmacies without a prescription. Individual characteristics of the body, allergic predisposition and chronic diseases significantly affect the availability of medications in your home medicine cabinet.

Composition and release form

The drug Novigan contains a complex of active substances. This:

Ibuprofen, which has anti-inflammatory, analgesic and antipyretic effects, in an amount of 400 mg;
Pitophenone hydrochloride, which affects the smooth muscles of all organs, eliminating its spasms, 5 mg;
Phenpiverinium bromide, which additionally provides a relaxing and calming effect, in a volume of 100 mcg.

Due to these components, Novigan simultaneously acts as an analgesic in many situations, an antispasmodic, and is also able to reduce high temperatures during inflammatory processes in the body.

Inhibits the synthesis of prostaglandins and blocks pain signals entering the central nervous system. And together, all these components can quickly help a person feel better and eliminate the unpleasant symptoms of the disease.

Novigan is available in the form of film-coated tablets. There are 10 pieces packed in one blister.

Indications and contraindications

Doctors prescribe this drug in all cases where it can affect a painful syndrome and if it is necessary to normalize body temperature. What Novigan helps with:

Headaches and migraines.
Gynecological problems, especially cases of dysmenorrhea and menstrual syndrome.
Myalgia, neuralgia, sciatica, as well as in the treatment of other neurological disorders.
Eliminates joint discomfort.
Toothache of various origins.
For intestinal, gastric, liver diseases, biliary dyskinesia and other problems when pain occurs due to spasms of smooth muscles.

The duration of taking the drug should not exceed five days and the dosage prescribed by the doctor must be followed. And in some cases, it is completely forbidden to use this remedy, as it can cause various negative consequences. Contraindications are:

cases of intestinal obstruction, gastrointestinal diseases, especially in acute conditions, with internal bleeding, ulcers, gastritis and other damage to the mucous membrane of the stomach, duodenum, etc.;
Particular care should be taken when taking the drug if there are problems with the liver or kidneys;
diseases of the heart, blood, blood vessels, this complex of substances can increase or decrease blood pressure and disrupt hematopoietic processes;
for glaucoma and diseases of the optic nerve;
prostatic hyperplasia;
in old age;
in cases of diabetes;
if any allergic reactions to anti-inflammatory non-steroidal drugs in the form of urticaria, bronchial asthma, polyps of the nasal mucosa, rhinosinusitis, etc. have previously been observed.
during pregnancy and during breastfeeding;
simultaneously with alcohol or even smoking;
after long-term use of other non-steroidal anti-inflammatory drugs or medications such as anticoagulants, SSRIs, antiplatelet agents, oral corticosteroids, etc.

Instructions for use of Novigan

According to the basic recommendation, these tablets are taken an hour before meals or 2-3 hours after. But, if irritation of the gastric mucosa occurs, then it is permissible to consume them immediately after meals or at least wash them down with a glass of milk. Most often, one tablet is prescribed three times a day. In some cases, doctors prescribe two or three times a day, then the maximum daily dose should not exceed six.

They should be taken no longer than five days. In cases where long-term treatment is required, you should be constantly monitored by a doctor and monitor the condition of the liver, kidneys and blood using tests.

How long does it take for the product to start working? Depending on individual characteristics and sensitivity to the components of the drug, Novigan can eliminate pain symptoms within 15-20 minutes after taking it orally. But sometimes it takes up to an hour.

Side effects

When Novigan is used correctly and taken in recommended doses, adverse reactions occur extremely rarely. Nevertheless, you need to be aware of the possibility of their occurrence. So, after consuming the drug or overdosing it, the following reactions of the body may occur:

hepatitis will worsen;
shortness of breath or bronchospasms will appear;
aphthous stomatitis, gastropathy, ulcers of the gastric or intestinal mucosa, pancreatitis and other gastrointestinal problems;
attacks of tachycardia, increased blood pressure or cases of heart failure;
the occurrence of migraines and headaches, the appearance of nervousness, dizziness, irritability, insomnia and other mental disorders;
exacerbation of kidney and liver diseases;
anemia, thrombocytopenia, agranulocytosis, or even thrombocytopenic purpura;
problems with hearing, vision, ringing in the ears, accommodation paresis;
allergic reactions of various types.

At the first negative manifestations, you should stop taking the drug and consult a doctor for help. In acute cases of overdose or allergy, you need to call an ambulance.

Price

The cost of the drug in Moscow pharmacies ranges from 80-110 rubles per pack of 10 tablets. In Kyiv, Novigan will cost 150 hryvnia for the same amount of medicine.

To know exactly how much this product costs, you need to check with pharmacies in your city, since these prices are approximate.

Video: 7 steps to relieve toothache.

The Indian drug Novigan (ibuprofen + pitofenone hydrochloride + fenpiverinium bromide) is a combined analgesic and antispasmodic drug used for pain syndromes of various etiologies, incl. - for headaches. One of the main tasks of doctors for chronic headaches and pain syndromes of other localization is to choose the optimal drug in a given situation, which, at the same time as being highly effective, would also have a favorable safety profile for single and long-term use. Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs to treat pain-related conditions. Recently, the arsenal of NSAIDs has been significantly updated. Combination drugs have appeared on pharmacy shelves, containing, in addition to NSAIDs, two or even three more pharmacologically friendly components. One of the most promising NSAID-containing painkillers is the drug Novigan. It contains the NSAID ibuprofen, the peripheral papaverine-like antispasmodic pitofenone hydrochloride and the mixed (central and peripheral) anticholinergic action fenpiverinium bromide. All active ingredients of Novigan are endowed with different mechanisms of action and enhance the analgesic and antispasmodic effects of each other. Ibuprofen, like other NSAIDs, inhibits the synthesis of prostaglandins, mediators of pain and inflammation. Its anti-inflammatory effect is also realized by stabilizing the cell membrane and specific proteins, suppressing the processes of leukocyte adhesion and phagocytosis, and inhibiting the production of free radicals. The analgesic effect of ibuprofen is stronger than that of propoxyphene and acetylsalicylic acid. In patients with primary dysmenorrhea (menstrual pain in the absence of organic pathology of the genital organs), ibuprofen, by reducing the concentration of prostaglandins in the uterus, reduces intrauterine pressure and its excess tone. In addition, ibuprofen inhibits the formation of thromboxane, which promotes platelet aggregation (sticking together).

Pitophenone hydrochloride, being a papaverine-like substance, acts on the smooth muscle “framework” of the genital organs, promoting muscle relaxation. Fenpiverinium acts in conjunction with pitofenone hydrochloride, relaxing smooth muscles due to the blockade of m-cholinergic receptors. Novigan is quickly absorbed in the digestive tract. The maximum concentrations of active substances in the blood plasma are observed at 2 hours of the drug’s presence in the body. Novigan is excreted just as quickly (its half-life does not exceed 2 hours). If Novigan is taken after a meal, the rate and extent of its absorption is significantly reduced, but this has little effect on the bioavailability of the drug. Novigan is excreted in urine (more than 90%), and the remainder in bile. The drug should be taken 1 hour before or 3 hours after meals, and the second option should be considered more successful, because in this case, the irritating effect of ibuprofen on the gastric mucosa is neutralized. According to general recommendations, Novigan is taken 1 tablet up to 3 times a day, with 3 tablets being the maximum allowable dose. Novigan should not be taken for more than 5 days. A long-term medication course using Novigan is possible only under medical supervision, including monitoring of the blood picture and liver and kidney functions. To reduce the risk of negative side reactions from the gastrointestinal tract, Novigan should be taken in the minimum effective dosage. If symptoms of gastropathy appear, the patient should be referred for esophagogastroduodenoscopy and blood and stool tests. During treatment, alcohol consumption should be completely avoided. Concomitant use of Novigan with other NSAIDs increases the risk of side effects from the gastrointestinal tract. Caffeine potentiates the analgesic effect of the drug. When Novigan is used in recommended doses, it does not enter into clinically significant interactions with commonly used drugs.

Pharmacology

The combined drug has analgesic, anti-inflammatory and antispasmodic effects. Suppresses the synthesis of prostaglandins. The drug contains the NSAID ibuprofen, the myotropic antispasmodic drug pitofenone hydrochloride and the m-anticholinergic drug of central and peripheral action fenpiverinium bromide.

Ibuprofen is a derivative of phenylpropionic acid. It has analgesic, anti-inflammatory and antipyretic effects. The main mechanism of action is inhibition of the synthesis of prostaglandins - modulators of pain sensitivity, thermoregulation and inflammation in the central nervous system and peripheral tissues. In women with primary dysmenorrhea, it reduces the increased level of prostaglandins in the myometrium and thereby reduces intrauterine pressure and the frequency of uterine contractions.

Pitophenone hydrochloride has a direct myotropic effect on the smooth muscles of internal organs and causes its relaxation.

Phenpiverinium bromide, due to its anticholinergic effect, has an additional relaxing effect on smooth muscles.

The combination of the three components of the drug leads to a mutual enhancement of their pharmacological action.

Pharmacokinetics

Suction and distribution

Metabolism and excretion

Ibuprofen is metabolized in the liver and is excreted 90% in the urine in the form of metabolites and conjugates. A small portion of ibuprofen is excreted in bile. T1/2 from blood plasma is 2 hours.

Release form

White film-coated tablets, round, biconvex, embossed "NOVIGAN" on one side; Cross-sectional appearance: white to almost white.

Excipients: microcrystalline cellulose - 55 mg, corn starch - 76 mg, glycerol - 2.9 mg, colloidal silicon dioxide - 5 mg, talc - 12 mg, magnesium stearate - 4 mg.

Shell composition: hypromellose 6 cps - 5.686 mg, macrogol 6000 - 1.124 mg, talc - 1.957 mg, titanium dioxide - 1.059 mg, polysorbate 80 - 0.058 mg, sorbic acid - 0.058 mg, dimethicone - 0.058 mg.

10 pieces. - blisters (1) - cardboard packs.
10 pieces. - blisters (2) - cardboard packs.

Dosage

Orally, 1 hour before or 3 hours after meals. To avoid irritating the stomach, you can take the drug immediately after meals or wash it down with milk.

In the absence of special instructions from a doctor, Novigan ® is recommended to be taken for spastic pain, 1 tablet. up to 3 times/day. The maximum daily dose is 3 tablets. Do not exceed the indicated dose!

The course of treatment with Novigan ®, without consulting a doctor, should not exceed 5 days. Longer use is possible under the supervision of a physician with monitoring of peripheral blood parameters and the functional state of the liver.

Overdose

Symptoms: abdominal pain, nausea, vomiting, lethargy, drowsiness, depression, headache, tinnitus, metabolic acidosis, coma, acute renal failure, decreased blood pressure, bradycardia, tachycardia, atrial fibrillation, respiratory arrest.

Treatment: gastric lavage (only within an hour after administration), activated charcoal, alkaline drinking, forced diuresis, symptomatic therapy (correction of acid-base status, blood pressure). There is no specific antidote.

Interaction

At therapeutic doses, Novigan ® does not interact significantly with commonly used drugs.

Inducers of microsomal oxidation enzymes in the liver (phenytoin, ethanol, barbiturates, flumecinol, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, increasing the risk of developing severe intoxications.

Microsomal oxidation inhibitors reduce the risk of hepatotoxicity.

The drug reduces the hypotensive activity of vasodilators and the natriuretic effect of furosemide and hydrochlorothiazide.

Reduces the effectiveness of uricosuric drugs.

Strengthens the effect of indirect anticoagulants, antiplatelet agents, fibrinolytics (which increases the risk of bleeding).

Increases the side effects of mineralocorticoids, glucocorticoids (increases the risk of gastrointestinal bleeding), estrogens, ethanol.

Enhances the hypoglycemic effect of sulfonylurea derivatives.

Antacids and cholestyramine reduce the absorption of ibuprofen.

The drug increases the concentration of digoxin, lithium preparations, methotrexate in the blood.

Enhances the effect of m-anticholinergic blockers, histamine H1 receptor blockers, butyrophenones, phenothiazines, amantadine and quinidine.

Concomitant administration of other NSAIDs increases the incidence of side effects.

Caffeine enhances the analgesic effect.

When administered simultaneously, it reduces the anti-inflammatory and antiplatelet effect of acetylsalicylic acid (it is possible to increase the incidence of acute coronary insufficiency in patients receiving small doses of acetylsalicylic acid as an antiplatelet agent after starting to take Novigan ®).

Cefamandole, cefoperazone, cefotetan, valproic acid, plicamycin increase the incidence of hypoprothrombinemia when administered simultaneously.

Myelotoxic drugs increase the manifestations of hematotoxicity of the drug.

Cyclosporine and gold preparations enhance the effect of ibuprofen on the synthesis of prostaglandins in the kidneys, which is manifested by increased nephrotoxicity.

Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of developing its hepatotoxic effects.

Drugs that block tubular secretion reduce excretion and increase plasma concentrations of ibuprofen.

Side effects

From the digestive system: NSAID gastropathy (abdominal pain, nausea, vomiting, heartburn, loss of appetite, diarrhea, flatulence, constipation, ulceration of the gastrointestinal mucosa, which, in some cases, are complicated by perforation and bleeding; irritation or dryness of the oral mucosa , pain in the mouth, ulceration of the gum mucosa, aphthous stomatitis), pancreatitis, hepatitis.

From the respiratory system: shortness of breath, bronchospasm.

From the central nervous system and peripheral nervous system: headache, dizziness, insomnia, anxiety, nervousness and irritability, psychomotor agitation, drowsiness, depression, confusion, hallucinations, aseptic meningitis (more often in patients with autoimmune diseases).

From the organ of hearing: hearing loss, hearing loss, ringing in the ears.

From the organ of vision: visual impairment (toxic damage to the optic nerve, blurred visual perception, scotoma, dryness and irritation of the eyes, swelling of the conjunctiva and eyelids (allergic origin), accommodation paresis).

From the cardiovascular system: heart failure, tachycardia, increased blood pressure.

From the urinary system: acute renal failure, allergic nephritis, nephrotic syndrome (edema), oliguria, anuria, polyuria, proteinuria, cystitis, red staining of urine.

Allergic reactions: skin rash (usually erythematous or urticaria), skin itching, angioedema, anaphylactoid reactions, anaphylactic shock, bronchospasm or dyspnea, fever, erythema multiforme exudative (including Stevens-Johnson syndrome), toxic epidermal necrolysis (syndrome) Lyell), eosinophilia, allergic rhinitis.

From the hematopoietic organs: anemia (including hemolytic, aplastic), thrombocytopenia and thrombocytopenic purpura, agranulocytosis, leukopenia.

Other: increased or decreased sweating.

From the laboratory parameters: bleeding time (may increase), serum glucose concentration (may decrease), creatinine clearance (may decrease), hematocrit or hemoglobin (may decrease), serum creatinine concentration (may increase), liver transaminase activity (may increase ).

Indications

mild or moderate pain syndrome due to spasms of smooth muscles of internal organs: renal and biliary colic, biliary dyskinesia, intestinal colic;
dysmenorrhea;
headache, incl. migraine character;
short-term symptomatic treatment for joint pain, neuralgia, sciatica, myalgia.

Contraindications

erosive and ulcerative changes in the mucous membrane of the stomach or duodenum, active gastrointestinal bleeding;
inflammatory bowel diseases in the acute phase, incl. ulcerative colitis;
anamnestic data on an attack of bronchial obstruction, rhinitis, urticaria, after taking acetylsalicylic acid or other NSAIDs (complete or incomplete acetylsalicylic acid intolerance syndrome - rhinosinusitis, urticaria, polyps of the nasal mucosa, bronchial asthma);
liver failure or active liver disease;
renal failure (creatinine clearance less than 30 ml/min), progressive kidney disease;
confirmed hyperkalemia;
hemophilia and other bleeding disorders (including hypocoagulation), hemorrhagic diathesis;
period after coronary artery bypass surgery;
acute intermittent porphyria;
granulocytopenia;
hematopoietic disorders;
deficiency of glucose-6-phosphate dehydrogenase;
tachyarrhythmias;
angle-closure glaucoma;
optic nerve diseases;
prostatic hyperplasia;
intestinal obstruction;
pregnancy;
lactation period (breastfeeding);
age up to 16 years;
hypersensitivity to any component of the drug.

Carefully:

elderly age;
congestive heart failure;
cerebrovascular diseases;
arterial hypertension;
dyslipidemia/hyperlipidemia;
diabetes;
peripheral arterial disease;
nephrotic syndrome;
CC less than 30-60 ml/min;
hyperbilirubinemia;
peptic ulcer of the stomach and duodenum (history);
presence of Helicobacter pylori infection;
gastritis, enteritis, colitis;
long-term use of NSAIDs;
blood diseases of unknown etiology (leukopenia, anemia);
smoking;
frequent drinking of alcohol (alcoholism);
severe somatic diseases;
concomitant therapy with the following drugs: anticoagulants (for example, warfarin), antiplatelet agents (for example, acetylsalicylic acid, clopidogrel), oral corticosteroids (for example, prednisolone), selective serotonin reuptake inhibitors (for example, citalopram, fluoxetine, paroxetine, sertraline).

Features of application

Use during pregnancy and breastfeeding

The drug is contraindicated during pregnancy and lactation (breastfeeding).

Use for liver dysfunction

Contraindicated for use in liver failure or active liver disease

Use for renal impairment

Use is contraindicated in renal failure (creatinine clearance less than 30 ml/min) and progressive kidney disease. With caution - in case of nephrotic syndrome, CC less than 30-60 ml/min.

Use in children

Contraindicated in children under 16 years of age

special instructions

With long-term use, monitoring of the peripheral blood picture and the functional state of the liver and kidneys is necessary.

To reduce the risk of developing adverse events from the gastrointestinal tract, the minimum effective dose should be used. When symptoms of gastropathy appear, careful monitoring is indicated, including esophagogastroduodenoscopy, a blood test to determine hemoglobin and hematocrit, and a stool test for occult blood.

If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study.

During the treatment period you should refrain from drinking alcohol.

Impact on the ability to drive vehicles and operate machinery

During the treatment period, the patient should refrain from engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Novigan is suitable for relieving pain and spasms. The drug has an effect on the smooth muscles of organs, promotes their relaxation.

The effectiveness of the drug is due to the fact that it is a combination of three antispasmodic and analgesic substances. They combine harmoniously with each other, leaving no chance for pain.

In this article we will look at why doctors prescribe Novigan, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS of people who have already used Novigan can be read in the comments.

Composition and release form

The drug Novigan is available in the dosage form of tablets, film-coated, enteric-coated. They have a round shape, biconvex surface and white color.

They contain several active ingredients with varying concentrations of each of them in one tablet:

Ibuprofen – 400 mg;
Pitophenone hydrochloride – 5 mg;
Phenpiverinium bromide – 0.1 mg.

Clinical and pharmacological group: spasmoanalgesic.

What does Novigan help with?

The drug Novigan has certain indications for use associated with pain of various types. It helps in such cases:

Headaches, as well as during migraines.
For dysmenorrhea, that is, severe pain during menstruation in women.
For short-term pain in joints and other body systems. And also neuralgia, myalgia.
Pain that is accompanied by spasms: with renal and intestinal colic, also biliary dyskinesia and other similar problems.

Novigan is a combination drug that has antispasmodic, anti-inflammatory and analgesic effects.

pharmachologic effect

The drug has an analgesic, antispasmodic (relieves spasms), and anti-inflammatory effect. These processes occur due to the inclusion of ibuprofen, pitofenone hydrochloride, and fenpiverinium bromide in the composition of the drug.

Ibuprofen is a non-steroidal anti-inflammatory drug that relieves pain and fever.
Pitophenone hydrochloride - has a direct effect on the smooth muscle cells of hollow organs, thereby reducing smooth muscle tone and spasm.
Phenpiverinium bromide - affects cholinergic receptors, blocks them, which leads to additional relaxation of smooth muscles.

The above three substances in combination enhance each other's effects.

Instructions for use

Novigan should be taken orally 2 hours before or 3 hours after meals. In case of irritation from the gastrointestinal tract, the tablets can be washed down with milk or taken immediately after meals.

The average recommended therapeutic dose for the drug is 1 tablet 2-3 times a day. The maximum daily dose should not exceed 3 tablets per day.
The course of treatment should not exceed 5 days; the need for further use of Novigan tablets is determined by the doctor.

Long-term use of the drug requires periodic monitoring of laboratory parameters of the functional state of red bone marrow, peripheral blood, liver and kidneys.

Contraindications

The drug should not be used in the following cases:

“Aspirin” asthma;
Collaptoid states;
Periods of pregnancy and lactation;
Intestinal obstruction, erosive and ulcerative lesions of the gastrointestinal tract in the acute phase;
Hypersensitivity or individual intolerance to Novigan or its components.

Use with caution:

Blood clotting disorders;
Erosive and ulcerative lesions of the gastrointestinal tract in the medical history;
Simultaneous use with oral anticoagulants;
Severe heart and/or renal failure.

Side effects

The drug "Novigan", instructions for use and reviews indicate this, can cause negative reactions in the body. After taking the medication, the following may develop:

allergy;
accommodation;
proteinuria;
kidney dysfunction;
paresis;
oliguria;
urinary retention;
tachycardia;
staining of urine;
nephritis;
anuria;
dry mouth.

When using an increased dose of the drug, inhibition of reaction, drowsiness, acidosis, and tinnitus occur. Patients experience nausea, vomiting, abdominal pain and headache. There may be a decrease in blood pressure and disturbances in the rhythm of the heart. The severe consequences of an overdose include coma, respiratory arrest, and liver disease.

Analogs

Structural analogues of the active substance: Novospaz.

Prices

The average price of NOVIGAN, tablets in pharmacies (Moscow) is 110 rubles.

Conditions for dispensing from pharmacies

The drug is approved for use as a means of OTC.