Pentalgin injections instructions for use. Pentalgin

Pentalgin injections instructions for use. Pentalgin - composition

Pentalgin

Compound

1 tablet of Pentalgin-IC contains:
Metamizole sodium – 300 mg;
Paracetamol – 200 mg;
Caffeine – 20 mg;
Phenobarbital – 10 mg;
Codeine phosphate – 9.5 mg (in terms of codeine – 7 mg);
Excipients.

1 tablet of the drug Pentalgin-ICN contains:
Metamizole sodium – 300 mg;
Paracetamol – 300 mg;
Caffeine – 50 mg;
Phenobarbital – 10 mg;
Codeine phosphate – 8 mg;
Excipients.

1 tablet of the drug Pentalgin-FS contains:
Metamizole sodium – 300 mg;
Paracetamol – 300 mg;
Caffeine – 50 mg;
Phenobarbital – 10 mg;
Codeine phosphate – 8 mg;
Excipients.

pharmachologic effect

Pentalgin is a combined analgesic, antipyretic and anti-inflammatory drug. The drug contains 5 active components, the pharmacological properties of which determine the pharmacological properties of the drug Pentalgin:
Paracetamol and metamizole sodium are non-selective non-steroidal anti-inflammatory drugs that have pronounced antipyretic and analgesic effects; metamizole sodium also has a pronounced anti-inflammatory effect. The mechanism of action of these substances is based on their ability to inhibit the synthesis of prostaglandins by inhibiting the enzyme cyclooxygenase.
Phenobarbital – has pronounced antispasmodic, muscle relaxant and sedative activity, helps enhance the therapeutic effects of non-steroidal anti-inflammatory drugs.
Codeine is a drug from the group of narcotic analgesics that reduces the excitability of the cough center and has an analgesic effect. In therapeutic doses it does not cause depression of the respiratory center and does not affect the secretory activity of the bronchi. With frequent use of codeine, as well as taking large doses, drug dependence may develop. Helps enhance the effect of sedatives and non-steroidal anti-inflammatory drugs.
Caffeine - stimulates the central nervous system, prevents the development of collapse, enhances the therapeutic effects of paracetamol and metamizole sodium.

After oral administration, the active components of the drug are well absorbed in the gastrointestinal tract.
Metamizole sodium is biotransformed in the intestinal walls; the unchanged substance is not found in the bloodstream. The degree of association of the active metabolite of metamizole with plasma proteins reaches 50-60%. Metabolized in the liver, excreted primarily by the kidneys in the form of pharmacologically active and inactive metabolites.
Paracetamol has a high degree of binding to plasma proteins. Paracetamol and caffeine are metabolized in the liver and excreted primarily by the kidneys in the form of metabolites. The half-life of paracetamol ranges from 1 to 4 hours.
Phenobarbital is metabolized in the liver and is an inducer of microsomal liver enzymes. It is excreted primarily by the kidneys in the form of metabolites; the half-life is about 3-4 days.
Codeine penetrates well through the blood-brain barrier and accumulates in the body; codeine accumulation is predominantly observed in adipose tissue, lungs, liver and kidneys. Codeine is hydrolyzed by tissue esterases, followed by conjugation with glucuronic acid in the liver. Codeine metabolites have analgesic activity. It is excreted mainly by the kidneys in the form of metabolites, some of it is excreted in bile.

Indications for use

The drug is used to treat patients with acute pain syndrome of various localizations, including:
Arthralgia, myalgia, neuralgia, headache and toothache of various etiologies.
Algodismenorrhea.
Migraine and migraine-like headaches.
In addition, the drug can be used as symptomatic therapy in patients with influenza and ARVI to relieve fever, inflammation and muscle pain.

Mode of application

The drug is taken orally, it is recommended to swallow the tablet whole, without chewing or crushing, with the required amount of water. An interval of at least 4 hours should be observed between doses of the drug. The duration of the course of treatment and the dose of the drug are determined by the attending physician individually for each patient.
Adults and adolescents over 12 years of age with acute, short-term pain syndrome are usually prescribed 1 tablet of the drug once.
Adults and adolescents over the age of 12 years with long-term pain syndrome, which is accompanied by various diseases of the musculoskeletal system and nervous system, are usually prescribed 1 tablet of the drug 1-3 times a day. The maximum duration of treatment is 5 days, unless the attending physician prescribes otherwise.
Adults and adolescents over 12 years of age are usually prescribed 1 tablet of the drug 1-3 times a day as an antipyretic agent. The maximum duration of treatment is 3 days, unless the attending physician prescribes otherwise.

The maximum daily dose of the drug is 4 tablets.
With prolonged use of the drug, drug dependence may develop.
If it is necessary to use the drug for more than 7 days in a row, it is necessary to monitor liver function and the morphological composition of the blood.

Side effects

When using the drug, patients experienced the following side effects:
From the gastrointestinal tract: nausea, vomiting, dry mouth, pain in the epigastric region, loss of appetite, digestive disorders, stool disorders (possible development of both constipation and diarrhea). In addition, there may be an increase in the activity of liver enzymes, which, as a rule, is not accompanied by jaundice.
From the central and peripheral nervous system: increased fatigue, disturbance of sleep and wakefulness, impaired coordination of movements, anxiety, headache, irritability, tremors of the extremities.
From the cardiovascular system and hematopoietic system: increased blood pressure, heart rhythm disturbances, extrasystole, anemia, including hemolytic, sulfhemoglobinemia, methemoglobinemia.
From the senses: blurred vision, increased intraocular pressure, tinnitus.

Allergic reactions: skin rash, itching, urticaria, Lyell's syndrome, Stevens-Johnson syndrome, bronchospasm, Quincke's edema.
Others: impaired liver and/or kidney function, acute renal failure, renal colic, interstitial nephritis, excessive sweating, asthenia, shortness of breath, decreased blood sugar. With prolonged use of the drug and sudden cessation of its use, withdrawal syndrome may develop.
It should be taken into account that the use of the drug may affect the results of doping control in athletes.
The use of the drug in some cases complicates the diagnosis in patients with acute abdominal pain.
If side effects develop, you must stop taking the drug and contact your doctor.

Contraindications

Increased individual sensitivity to the components of the drug.
Severe liver and/or kidney diseases.
Erosive and ulcerative lesions of the stomach and duodenum.
Disorders of the hematopoietic system, including thrombocytopenia, leukopenia, anemia.
Diseases of the cardiovascular system, including acute myocardial infarction, arrhythmia, arterial hypertension.
The period of pregnancy and lactation, as well as children under 12 years of age.

The drug is contraindicated in patients who have recently suffered a traumatic brain injury, as well as with increased intracranial pressure of various etiologies.
The drug should not be prescribed to patients with glaucoma, glucose-6-phosphate dehydrogenase deficiency and a tendency to bronchospasm. In addition, the drug is not prescribed for conditions that are accompanied by respiratory depression.
The drug should be prescribed with caution to patients suffering from bronchial asthma, diabetes mellitus, impaired liver and/or kidney function, and elderly patients.
Caution should be exercised when prescribing the drug to patients whose work involves operating potentially dangerous machinery and driving a car.

Pregnancy

The drug is contraindicated for use during pregnancy.
If it is necessary to use the drug during lactation, the issue of interrupting breastfeeding should be resolved.

Drug interactions

When the drug is used in combination with anti-inflammatory non-steroidal drugs and aminophenazone, an increase in the toxic effect of both drugs is observed.
When the drug is used in combination with coumarin anticoagulants, an increase in their therapeutic effect is observed.
Paracetamol reduces the effectiveness of drugs that are intensively metabolized in the liver.
When the drug is used in combination with rifampicin, a decrease in the therapeutic effects of paracetamol is observed.
Cimetidine, when used simultaneously, reduces the toxicity of paracetamol and enhances its pharmacological effects.
When the drug is used in combination with oral contraceptives, tricyclic antidepressants and allopurinol, an increase in the toxic effect of metamizole sodium is observed.
When used in combination, inducers of microsomal liver enzymes reduce the effectiveness of metamizole sodium.
Metamizole sodium, when used simultaneously, reduces the level of cyclosporine in the blood.

When used in combination, codeine enhances the effects of drugs that depress the central nervous system.
There is a mutual enhancement of effects when using monoamine oxidase inhibitors, tricyclic antidepressants and codeine.
Caffeine, when used in combination, reduces the effectiveness of drugs that depress the central nervous system and enhances the pharmacological effect of non-steroidal anti-inflammatory drugs.
Phenobarbital accelerates the biotransformation of quinidine, doxycycline, estrogens and carbamazepine.
When the drug is used in combination with drugs that depress the central nervous system, an increase in the effect of phenobarbital is observed.
Valproic acid and sodium valproate, when used simultaneously, help reduce the metabolism of phenobarbital.
The combined use of the drug with ethanol is contraindicated.

Overdose

When using excessive doses of the drug, patients experience the development of nausea, vomiting, heart rhythm disturbances, allergic reactions, feelings of weakness, hypotension, pallor of the skin, pain in the epigastric region and hepatonecrosis. With a further increase in dose, depression of the respiratory center and central nervous system is possible.
In case of overdose, gastric lavage, enterosorbents and symptomatic therapy are indicated. In case of poisoning with paracetamol, it is possible to administer N-acetylcysteine and take oral methionine.

Release form

Pentalgin-IC tablets, 10 pieces in a blister, 1 blister in a cardboard package.
Pentalgin-ICN tablets, 12 pieces in a blister, 1 blister in a cardboard package.
Pentalgin-FS tablets, 10 pieces in a blister, 1 blister in a cardboard package. Attention!
Description of the drug " Pentalgin"on this page is a simplified and expanded version of the official instructions for use. Before purchasing or using the drug, you should consult your doctor and read the instructions approved by the manufacturer.
Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.

Pentalgin is a modern and very effective antispasmodic analgesic. It helps relieve pain of various origins, reduce fever during colds and reduce the severity of inflammation.

Active ingredients and dosage form

The combined drug Pentalgin is produced in the form of tablets for oral administration. They contain nonsteroidal anti-inflammatory components (and naproxen), a myotropic antispasmodic (drotaverine hydrochloride), a histamine and muscarinic receptor blocker (pheniramine maleate), as well as caffeine, which has psychostimulating and adaptogenic properties.

Light green tablets are supplied in blisters of 4, 6, 10 and 12 pieces.

Pentalgin: what do pills help with?

Pentalgin has analgesic, antispasmodic, anti-inflammatory and antipyretic properties.

Paracetamol blocks the enzyme cyclooxygenase in the central nervous system, and affects the centers of thermoregulation and pain, which determines its analgesic and antipyretic effect.

The NSAID naproxen reduces the activity of cyclooxygenase, thereby reducing the release of inflammatory mediators - prostaglandins.

Drotaverine helps relieve spasms of smooth muscle elements by suppressing the activity of the phosphodiesterase-4 enzyme.

Pheniramine has a mild sedative effect, reduces spasms and blocks specific histamine receptors. Under its influence, inflammatory exudation decreases.

Caffeine tones and dilates blood vessels and increases the bioavailability of other components.

A single dose for pain relief is 1 tablet, and the frequency of administration is 1-3 times a day.. Permissible daily dose – 4 tablets. However, you should not use this drug for more than 5 days in a row. As an antipyretic (antipyretic) for colds, Pentalgin is taken for up to 3 days. If there is a need to continue treatment, you should consult your doctor.

Indications

Pentalgin is indicated for pain (including spastic origin) and fever due to colds.

Contraindications

Pentalgin should not be taken by patients with the so-called. the “aspirin triad,” which includes salicylate intolerance and recurrent polyposis of the nose and nasal sinuses.

Other contraindications include:

individual hypersensitivity to active or auxiliary ingredients of drugs;
in the organs of the digestive system;
erosions and ulcers of the gastrointestinal tract (during exacerbation);
inhibition of hematopoiesis;
severe functional failure of the liver (including with and) and (or) kidneys;
carried out;
ventricular extrasystole;
spicy ;
high levels of potassium in the blood (hyperkalemia).

Pentalgin is not prescribed to children and adolescents under 18 years of age.

Pentalgin during pregnancy

Pentalgin is contraindicated for women during pregnancy and breastfeeding.. The active components of the drug are able to bypass the hematoplacental barrier and are found in breast milk. If treatment is necessary during lactation, the question of temporarily transferring the baby to artificial feeding or replacing the drug with a safer one is raised.

Side effects

When a hypersensitivity reaction develops, skin rashes () may appear and swelling may develop.

Possible side effects of Pentalgin:

If at least one of the listed symptoms develops, treatment with the drug should be stopped and the doctor should be informed about side effects.

Overdose

In case of an overdose, the liver can be seriously damaged (even hepatonecrosis, i.e., tissue death, cannot be ruled out). Signs appear 12-48 hours after taking a large dose of Pentalgin. Encephalopathy progresses against its background.

If the dose is significantly exceeded, the patient’s heart rhythm and kidney function are disrupted, and the pancreas is affected.

Coma and death are possible.

In case of Pentalgin poisoning, you should call an ambulance, urgently perform a gastric lavage and give it to the victim.

An effective antidote for paracetamol is Acetylcysteine, but the use of this drug makes sense only within 8 hours after poisoning.

If bleeding occurs in the gastrointestinal tract, the patient is advised to take antacids and additional gastric lavage with a cooled isotonic solution. To stop epileptic seizures, an injection of Diazepam (iv) is given. Against the background of an overdose, respiratory function may be depressed, so additional oxygenation (the victim is given an oxygen cushion) and mechanical ventilation may be required. Saline solutions are administered intravenously to normalize water and electrolyte balance.

Interaction with other medications

It is important to exclude the parallel use of Pentalgin with Rifampicin and drugs from the tricyclic and tricyclic groups, since they increase the risk of toxic liver damage. For the same reason, reception was excluded ethanol(including alcohol-based pharmaceutical tinctures).

Paracetamol present in the combined drug potentiates the effect indirect anticoagulants, worsening blood clotting. Diflunisal increases the hepatotoxic effect of paracetamol by increasing its serum concentration by one and a half times.

Another active ingredient, naproxen, reduces the effectiveness of the diuretic. Furosemide and increases the toxicity of antibacterial agents from the sulfonamide group. It also slows down the excretion of lithium.

The antispasmodic component drotaverine reduces the effectiveness of the remedy for - Levodopa.

Pheniramine has a depressant effect on the central nervous system in combination with sleeping pills and.

The biotransformation of caffeine in the body slows down when taken birth control pills, fluoroquinolones Norfloxacin and Ciprofloxacin, as well as Medicines for treatment Disulfiram. Caffeine metabolism accelerates when taken in parallel anticonvulsants and antiepileptic drugs(in particular Primidone) and barbiturates.

Reception psychostimulants(including drinks containing caffeine) leads to excessive stimulation of the central nervous system (overexcitation and increased reflexes or, conversely, inhibition).

You should not take Pentalgin and others at the same time non-steroidal anti-inflammatory drugs(especially those containing paracetamol).

Additionally

Particular caution should be observed when prescribing Pentalgin to persons with the following pathologies:

Patients suffering from these diseases are strongly recommended to consult with their doctor before starting treatment.

If symptomatic treatment continues for more than 5-7 days, monitoring of liver function tests is required. A peripheral blood test (PBC) is also required.

Alcohol intake should be avoided during treatment!

Patients taking Pentalgin should be careful when driving. It is advisable to temporarily refrain from working with potentially dangerous mechanisms, since the ability to concentrate may be reduced.

Pentalgin is a combined medicinal product that has anti-inflammatory, analgesic, antispasmodic, and antipyretic effects. Such a wide range is explained by the fact that the composition includes several active ingredients at once. The instructions for use will tell you in detail what Pentalgin helps with and how to use it correctly.

In accordance with the description, the product is available in tablets; the duration of action of the drug on the body is from four to six hours.

Composition, action

The drug contains five components: paracetamol, metamizole sodium, phenobarbital, codeine, caffeine. Paracetamol and metamizole sodium have an analgesic effect and exhibit an anti-inflammatory effect. Phenobarbital enhances the therapeutic effect of non-steroidal anti-inflammatory drugs. Codeine reduces arousal and has a characteristic analgesic effect. Caffeine dilates blood vessels in the brain, increases productivity, relieves lethargy, and improves well-being.

Pentalgin N contains naproxen instead of paracetamol.

Indications

Pentalgin will help with muscle and joint pain.

The indications for use of the drug note that this remedy helps with:

joint pain;
muscles;
sciatica;
headache, toothache;
migraine attacks;
pain syndrome after injuries, surgical operations;
during menstruation.

The medicine is also used for colds, to reduce high body temperature, inflammatory manifestations, and muscle pain.

Contraindications

Pentalgin is contraindicated in the following conditions:

exacerbation of peptic ulcer of the stomach and duodenum;
liver disease, kidney disease, heart disease;
disorders of the circulatory system;
hypersensitivity to the components of the drug.

The medicine should not be taken by patients with high blood pressure who have suffered head injuries. The drug is prescribed with caution to patients suffering from exacerbation of liver disease, kidney disease, diabetes, asthma, alcohol dependence, and patients with glaucoma.

Important! The use of the medicine by elderly patients is possible after consultation with a medical professional and only as prescribed.

Doses and rules of administration

Pentalgin should be taken without exceeding the prescribed dose.

Pentalgin tablet includes 325 mg of paracetamol, 100 mg of naproxen, 50 mg of caffeine, 40 mg of drotaverine, 10 mg of pheniramine maleate. The tablets are swallowed whole, do not bite or crush, and are washed down with water. The time interval between doses should be at least four hours.

The duration of taking the medicine and the dose are prescribed by the doctor to the patient personally. You are allowed to take no more than four tablets per day. Adult patients and children over 12 years of age are recommended to take one tablet 1 - 3 times a day.

When using this drug as an antipyretic, the duration of use is no more than three days, as an analgesic - five days; if there is a need to increase the duration of taking the medicine, you should consult with your doctor.

Important! Taking Pentalgin should not be combined with alcohol; you should refrain from work that requires increased attention and instant response to the situation. If side effects occur, it is advisable to stop taking the pills and contact your doctor for advice.

Overdose

In case of drug overdose the following is observed:

nausea;
vomit;
lack of appetite;
pain in the intestines;
stomach bleeding;
pale skin;
cardiopalmus;
clouding of mind;
elevated temperature;
possible headache;
convulsions;
frequent urination;
hysterical attacks;
epilepsy.

Liver dysfunction may appear between 12 and 48 hours after an overdose. In case of severe poisoning of the body with the drug, the development of liver failure, coma, and possible death are possible. If an overdose occurs, you need to rinse your stomach, take activated carbon tablets, and be sure to contact a medical facility for medical assistance.

Side effects

The product may cause negative reactions in the body.

When using Pentalgin, patients experienced side effects of the drug. Indicators of side effects of the drug on the body are:

disorders of the gastrointestinal tract;
nervous, immune, respiratory systems;
sense organs;
allergy.

Pentalgin during pregnancy

Women should not take this medication during pregnancy. If the mother takes the drug while breastfeeding, the baby is transferred to formula milk.

Analogs

Analogues are Pentalfen, Pentamialgin (contain narcotic substances, dispensed in pharmacies by prescription), Plivalgin, Sedal M, Sedalgin plus, Santotitralgin, Citramon, Spazmalgon, . Cheap analogues are Andipal, Spazgan, Caffetin, Drotaverine, Paracetamol, they help with moderate pain. If Pentalgin is changed to another medicine, it is necessary to consult a doctor, only he will be able to suggest similar substitutes for the drug.

Price

In pharmacies, the drug is sold in cardboard packaging, which contains from four to twenty-four pieces. The price of tablets varies from 56 to 165 rubles and is available without a prescription. The Pentalgin N package contains ten tablets, the cost is from 169 rubles to 220 rubles, sold only with a prescription.

In this article you can read the instructions for use of the drug Pentalgin. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Pentalgin in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Pentalgin in the presence of existing structural analogues. Use for the treatment of headache, toothache and other pain and fever in adults, children, as well as during pregnancy and lactation. The composition of the drug and conditions for over-the-counter and prescription release, depending on the presence of components prohibited for general sale.

Pentalgin is a combined drug that has an analgesic, anti-inflammatory, antispasmodic, and antipyretic effect.

Paracetamol is an analgesic-antipyretic, has an antipyretic and analgesic effect due to the blockade of COX in the central nervous system and its effect on the centers of pain and thermoregulation.

Naproxen is a non-steroidal anti-inflammatory drug that has anti-inflammatory, analgesic and antipyretic effects associated with non-selective suppression of COX activity, which regulates the synthesis of prostaglandins.

Caffeine is a psychostimulant that causes dilation of the blood vessels of skeletal muscles, heart, and kidneys; increases mental and physical performance, helps eliminate fatigue and drowsiness; increases the permeability of histohematic barriers and increases the bioavailability of non-narcotic analgesics, thereby enhancing the therapeutic effect. It has a tonic effect on the blood vessels of the brain.

Drotaverine - has a myotropic antispasmodic effect due to inhibition of PDE 4, acts on the smooth muscles of the gastrointestinal tract, biliary tract, genitourinary system, and blood vessels.

Pheniramine is a histamine H1 receptor blocker. It has an antispasmodic and mild sedative effect, reduces exudation, and also enhances the analgesic effect of paracetamol and naproxen.

Codeine has an analgesic effect due to the stimulation of opioid receptors in various parts of the central nervous system, leading to stimulation of the antinociceptive system and a change in the emotional perception of pain.

Phenobarbital is a barbiturate that increases the analgesic effectiveness of metamizole sodium and paracetamol.

Phenobarbital and codeine increase the analgesic effect of metamizole sodium and naproxen.

Paracetamol + Naproxen + Caffeine + Drotaverine hydrochloride + Pheniramine maleate + excipients (green tablets, do not contain codeine and are sold without a prescription).

Metamizole sodium + Naproxen + Caffeine + Phenobarbital + Codeine (in phosphate form) + excipients (Pentalgin N).

Paracetamol + Metamizole sodium + Caffeine + Phenobarbital + Codeine phosphate + excipients (Pentalgin ICN).

Paracetamol + Propyphenazone + Caffeine + Codeine phosphate + Phenobarbital + excipients (Pentalgin Plus).

The components of the drug are well absorbed from the gastrointestinal tract.

In the intestinal wall it is hydrolyzed to form the active metabolite, 4-methyl-amino-antipyrine, which in turn is metabolized to 4-formyl-amino-antipyrine and other metabolites. The binding of the active metabolite to proteins is 50-60%. Metabolites are excreted by the kidneys and excreted in breast milk.

Bioavailability is 95%. Binds to blood proteins. It is excreted in the urine mainly in the form of a metabolite (dimethylnaproxen), in small quantities - in bile.

Well absorbed in the intestines. It is excreted mainly by the kidneys in the form of metabolites, about 10% - unchanged.

Slightly binds to plasma proteins. It undergoes biotransformation in the liver (10% goes into morphine by demethylation). Excreted by the kidneys (5-15% unchanged).

Penetrates well through the placental barrier. Biotransformed in the liver. The main metabolite has no pharmacological activity. Excreted by the kidneys, incl. 20-25% - unchanged.

pain syndrome of various origins, including pain in the joints, muscles, radiculitis, algodismenorrhea, neuralgia, toothache, headache (including those caused by cerebral vasospasm);
pain syndrome associated with spasm of smooth muscles, incl. for chronic cholecystitis, cholelithiasis, postcholecystectomy syndrome, renal colic;
post-traumatic and postoperative pain syndrome, incl. accompanied by inflammation;
colds accompanied by fever (as symptomatic therapy).

Tablets (green, OTC).

Tablets (N, ICN, Plus).

Instructions for use and dosage

The drug is prescribed 1 tablet 1-3 times a day. The maximum daily dose is 4 tablets.

The drug should not be taken for more than 5 days as an analgesic and for more than 3 days as an antipyretic without a doctor’s prescription.

Do not exceed the indicated doses of the drug.

skin rash;
hives;
angioedema;
thrombocytopenia, leukopenia, agranulocytosis, anemia;
excitation;
anxiety;
strengthening reflexes;
tremor;
headache;
sleep disorders;
dizziness;
decreased concentration;
heartbeat;
arrhythmias;
increased blood pressure;
erosive and ulcerative lesions of the gastrointestinal tract;
nausea, vomiting;
epigastric discomfort;
stomach ache;
constipation;
renal dysfunction;
hearing loss;
noise in ears;
increased intraocular pressure in patients with angle-closure glaucoma;
dermatitis;
increased breathing.

erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase);
complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (including a history);
severe liver failure;
severe renal failure;
anemia, leukopenia;
condition after coronary artery bypass surgery;
severe organic diseases of the cardiovascular system (including acute myocardial infarction);
paroxysmal tachycardia;
frequent ventricular extrasystole;
severe arterial hypertension;
alcohol intoxication;
glaucoma;
hyperkalemia;
deficiency of glucose-6-phosphate dehydrogenase;
pregnancy;
lactation period (breastfeeding);
children and adolescents up to 18 years of age;
hypersensitivity to the components of the drug.

Use during pregnancy and breastfeeding

The use of the drug is contraindicated during pregnancy and lactation (breastfeeding).

Use in elderly patients

The drug should be used with caution in elderly patients.

The simultaneous use of Pentalgin with other drugs containing paracetamol and/or NSAIDs, as well as with drugs to relieve symptoms of colds, flu and nasal congestion should be avoided.

When using the drug Pentalgin for more than 5-7 days, peripheral blood counts and the functional state of the liver should be monitored.

Paracetamol distorts the results of laboratory tests of glucose and uric acid in blood plasma.

If it is necessary to determine 17-ketosteroids, Pentalgin should be discontinued 48 hours before the study. Please note that naproxen increases bleeding time.

The effect of caffeine on the central nervous system depends on the type of nervous system and can manifest itself as both excitation and inhibition of higher nervous activity.

During the treatment period, the patient should avoid drinking alcohol.

Impact on the ability to drive vehicles and operate machinery

In some cases, a decrease in concentration and speed of psychomotor reactions is possible, therefore, during the treatment period, the patient should be careful when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

When taking the drug Pentalgin simultaneously with barbiturates, tricyclic antidepressants, rifampicin, ethanol (alcohol), the risk of hepatotoxicity increases (these combinations should be avoided).

Paracetamol enhances the effect of indirect anticoagulants and reduces the effectiveness of uricosuric drugs.

Long-term use of barbiturates reduces the effectiveness of paracetamol.

When used simultaneously with paracetamol and ethanol (alcohol), the risk of acute pancreatitis increases.

Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxic action of paracetamol.

Diflunisal increases the plasma concentration of paracetamol by 50%, which increases the risk of hepatotoxicity.

Naproxen can cause a decrease in the diuretic effect of furosemide, an increase in the effect of indirect anticoagulants, increases the toxicity of sulfonamides and methotrexate, reduces the excretion of lithium and increases its concentration in the blood plasma.

With the combined use of caffeine and barbiturates, primidone, anticonvulsants (hydantoin derivatives, especially phenytoin), it is possible to increase metabolism and increase the clearance of caffeine; while taking caffeine and cimetidine, oral contraceptives, disulfiram, ciprofloxacin, norfloxacin - a decrease in the metabolism of caffeine in the liver (slowing its excretion and increasing its concentration in the blood).

Concomitant use of caffeinated beverages and other CNS stimulants may result in excessive CNS stimulation.

When used concomitantly, drotaverine may weaken the antiparkinsonian effect of levodopa.

With simultaneous use of pheniramine with tranquilizers, hypnotics, MAO inhibitors, ethanol (alcohol), the depressant effect on the central nervous system may be enhanced.

Analogues of the drug Pentalgin

Structural analogues of the active substance:

What does Pentalgin help with?

Pentalgin is an effective combination drug that helps to quickly eliminate moderate or severe pain caused by various diseases.

This analgesic (pain reliever) also has a good antispasmodic, antipyretic and anti-inflammatory effect, which can significantly reduce the inflammatory process in the body.

The main components of the medicinal substances of Pentalgin are Drotaverine (relieves spasms of the smooth muscles of the body), Caffeine (normalizes the tone of blood vessels), Naproxen (has an analgesic effect), as well as Paracetamol (antipyretic and analgesic properties).

The drug allows you to quickly eliminate moderate or quite severe pain of various types.

Main indications for use of Pentalgin:

pain syndrome due to radiculitis, neuralgia, arthritis, cholelithiasis, renal colic, etc.;
severe toothache or headache;
neuralgia;
chronic cholecystitis;
injuries (stale, bruise, sprain, dislocation, fracture);
muscle and joint pain;
febrile syndrome;
postoperative period;
algodismenorrhea;
migraine;
period of menstruation;
colds, which are accompanied by an increase in body temperature.

Remember: before using Pentalgin, it is advisable to consult with a general practitioner to prevent the possible development of an allergic reaction to this drug.

The drug is available in the form of tablets or soluble capsules for internal use.

How to drink Pentalgin?

The daily dose of Pentalgin for adults is 1 t. 2-3 r. per day, depending on the severity and nature of the pain. The maximum dose of the drug should not exceed more than 4 tablets per day to prevent a possible overdose of the drug.

It is not recommended to take Pentalgin on an ongoing basis for more than 3-5 days, as this may negatively affect the general condition of the patient. The minimum interval between taking the drug should be at least 5-7 hours.

For children, this analgesic can be taken from the age of 14, no more than 1 t per day. While taking Pentalgin, the abuse of any alcoholic beverages is strictly contraindicated!

Attention: the drug should be used only for short-term pain relief, and Pentalgin is not recommended for long-term use without first consulting a physician.

Contraindications to the use of Pentalgin

acute renal or liver failure;
peptic ulcer of the stomach and duodenum;
increased sensitivity of the body to the main components of the drug;
age up to 14 years;
paroxysmal tachycardia;
glaucoma;
arterial hypertension (high blood pressure);
diabetes mellitus (take Pentalgin with extreme caution);
gastrointestinal bleeding;
severe liver and kidney diseases;
bronchial asthma;
traumatic brain injury.

Side effects of Pentalgin

digestive system disorders (diarrhea, constipation);
skin itching;
nausea;
allergic rash on the body;
headache;
vomiting (occurs most often with a drug overdose);
hearing loss;
arrhythmia;
noise in the ears and head;
insomnia;
tachycardia (rapid heartbeat);
dermatitis;
anxiety and irritability.

If any of the above side effects develop, you must completely stop further use of the drug, and also be sure to consult a doctor!

In this article, we discussed what Pentalgin helps with, as well as how it should be taken correctly.

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Remember, self-medication is dangerous to your health! Consult your doctor

Pentalgin: instructions for use, composition, analogues

Pentalgin is a modern and very effective antispasmodic analgesic. It helps relieve pain of various origins, reduce fever during colds and reduce the severity of inflammation.

Active ingredients and dosage form

The combined drug Pentalgin is produced in the form of tablets for oral administration. They contain non-steroidal anti-inflammatory components (paracetamol and naproxen), a myotropic antispasmodic (drotaverine hydrochloride), a histamine and muscarinic receptor blocker (pheniramine maleate) as well as caffeine, which has psychostimulating and adaptogenic properties.

Light green tablets are supplied in blisters of 4, 6, 10 and 12 pieces.

Pentalgin: what do pills help with?

Pentalgin has analgesic, antispasmodic, anti-inflammatory and antipyretic properties.

Paracetamol blocks the enzyme cyclooxygenase in the central nervous system, and affects the centers of thermoregulation and pain, which determines its analgesic and antipyretic effect.

The NSAID naproxen reduces the activity of cyclooxygenase, thereby reducing the release of inflammatory mediators - prostaglandins.

Drotaverine helps relieve spasms of smooth muscle elements by suppressing the activity of the phosphodiesterase-4 enzyme.

Pheniramine has a mild sedative effect, reduces spasms and blocks specific histamine receptors. Under its influence, inflammatory exudation decreases.

Caffeine tones and dilates blood vessels and increases the bioavailability of other components.

A single dose for pain relief is 1 tablet, and the frequency of administration is 1-3 times a day. The permissible daily dose is 4 tablets. As an analgesic, this drug should not be used for more than 5 days in a row. As an antipyretic (antipyretic) for colds, Pentalgin is taken for up to 3 days. If there is a need to continue treatment, you should consult your doctor.

Indications

Pentalgin is indicated for pain (including spastic origin) and fever due to colds.

Contraindications

Pentalgin should not be taken by patients with the so-called. “aspirin triad”, which includes salicylate intolerance, bronchial asthma and recurrent polyposis of the nose and nasal sinuses.

Other contraindications include:

Pentalgin is not prescribed to children and adolescents under 18 years of age.

Pentalgin during pregnancy

Pentalgin is contraindicated for women during pregnancy and breastfeeding. The active components of the drug are able to bypass the hematoplacental barrier and are found in breast milk. If treatment is necessary during lactation, the question of temporarily transferring the baby to artificial feeding or replacing the drug with a safer one is raised.

Side effects

With the development of a hypersensitivity reaction, skin rashes (urticaria) may appear and Quincke's edema may develop.

Possible side effects of Pentalgin:

inhibition of hematopoiesis (manifested by anemia, thrombocytopenia and leukopenia);
arterial hypertension (high blood pressure);
heart rhythm disturbances;
heartbeat;
tachycardia;
psycho-emotional arousal;
unmotivated feeling of anxiety;
hyperreflexia;
shiver;
dizziness;
headache;
insomnia;
impaired ability to concentrate;
dyspeptic disorders;
damage to the mucous membranes of the digestive organs (erosions and ulcers);
decreased functional activity of the liver and (or) kidneys;
pain in the abdominal area;
noise in ears;
decreased acuity of auditory perception;
rapid breathing;
skin inflammatory reactions (dermatitis).

If at least one of the listed symptoms develops, treatment with the drug should be stopped and the doctor should be informed about side effects.

Overdose

In case of an overdose, the liver can be seriously damaged (even hepatonecrosis, i.e., tissue death, cannot be ruled out). Signs of liver failure appear hours after taking a large dose of Pentalgin. Encephalopathy progresses against its background.

If the dose is significantly exceeded, the patient’s heart rhythm and kidney function are disrupted, and the pancreas is affected.

Coma and death are possible.

In case of Pentalgin poisoning, you should call an ambulance, urgently perform gastric lavage and give the victim enterosorbents.

An effective antidote for paracetamol is Acetylcysteine, but the use of this drug makes sense only within 8 hours after poisoning.

Interaction with other medications

It is important to exclude the parallel use of Pentalgin with Rifampicin and drugs from the groups of tricyclic antidepressants and barbiturates, since they increase the risk of toxic liver damage. For the same reason, reception was excluded ethanol(including alcohol-based pharmaceutical tinctures).

The antispasmodic component drotaverine reduces the effectiveness of the drug for Parkinson's disease - Levodopa.

Pheniramine has a depressant effect on the central nervous system in combination with sleeping pills and tranquilizers.

The biotransformation of caffeine in the body slows down when taken birth control pills, fluoroquinolone antibiotics Norfloxacin and Ciprofloxacin, as well as Medicines for the treatment of alcoholism Disulfiram. Caffeine metabolism accelerates when taken in parallel anticonvulsants and antiepileptic drugs(in particular Primidone) and barbiturates.

Reception psychostimulants(including drinks containing caffeine) leads to excessive stimulation of the central nervous system (overexcitation and increased reflexes or, conversely, inhibition).

You should not take Pentalgin and others at the same time non-steroidal anti-inflammatory drugs(especially those containing paracetamol).

Additionally

Particular caution should be observed when prescribing Pentalgin to persons with the following pathologies:

cerebral vascular lesions;
hepatitis (viral and alcoholic);
epilepsy;
angle-closure glaucoma;
peripheral arterial disease;
benign hyperbilirubinemia.

Patients suffering from these diseases are strongly recommended to consult with their doctor before starting treatment.

If symptomatic treatment continues for more than 5-7 days, monitoring of liver function tests is required. A peripheral blood test (PBC) is also required.

Alcohol intake should be avoided during treatment!

Patients taking Pentalgin should be careful when driving. It is advisable to temporarily refrain from working with potentially dangerous mechanisms, since the ability to concentrate may be reduced.

Caution when taking Pentalgin should be observed in elderly and senile patients.

Conditions for storage and release from pharmacies

A doctor's prescription is not required to purchase Pentalgin.

Tablets should be kept in places protected from sunlight at a temperature of no more than +25°C.

Keep away from children!

The shelf life of the drug is 2 years from the date of release (marked on the packaging). Do not use after the expiration date!

Analogues of Pentalgin

Analogs of the drug Pentalgin are:

Plisov Vladimir, doctor, medical observer

The information is provided for informational purposes only. Do not self-medicate. At the first sign of disease, consult a doctor. There are contraindications, a doctor's consultation is required. The site may contain content prohibited for viewing by persons under 18 years of age.

Pentalgin - instructions for use, what it helps with, composition and contraindications

There are currently many new drugs available. Some of them are dispensed by pharmacies without a doctor's prescription, others - strictly by prescription. It is useful for people to know what Pentalgin tablets are - instructions for use, how the medicine works, in what cases it helps, whether it can be given to children, what warnings there are.

What is Pentalgin

The release form of the drug is in the form of tablets. In the photo, Pentalgin tablets are capsules coated with a green, embossed shell. The cut of the tablets is green, sometimes with white splashes. Pentalgin is packaged in blister packs of 2, 4, 12 tablets. External packaging – cardboard box. You can buy Pentalgin in a pharmacy without a doctor's prescription. The shelf life of the tablets is two years from the date of manufacture; the medicine must be stored in a dry, unlit place.

What does Pentalgin help with?

The drug has a combined pharmacological effect: analgesic; antipyretic (lowers temperature, relieves inflammation); antispasmodic effect. Pentalgin helps eliminate pain of various natures:

in joints, muscles;
toothache, headache;
with spasm of the smooth muscles of internal organs;
postoperative, caused by inflammation;
symptomatic in febrile states during a cold.

For toothache

A good result is achieved when Pentalgin is used for toothache. Thanks to its combined pharmacological action, the drug simultaneously relieves pain and fights the inflammatory process of pulpitis. The effect is achieved half an hour after taking the medicine, but if the medicine does not help, the dose should not be increased. It is necessary to see a dentist for treatment of inflammation.

For headaches

The drug is an analgesic. Doctors recommend using Pentalgin for headaches. For migraines, the drug has the ability to dilate blood vessels, which helps improve blood supply to the brain and the patient’s well-being. The effect of pain relief is increased by blocking pain receptors with the drug, which is why Pentalgin has received positive reviews in the fight against headaches.

During menstruation

The occurrence of pain in the lower abdomen during algodismenorrhea (menstruation) is associated with excessive synthesis of prostaglandins: they cause contraction of the uterus and spasm of the pelvic vessels. Due to stagnation of blood, tissues do not receive enough oxygen, and this causes stimulation of pain receptors. Pentalgin for pain during menstruation relieves pain by regulating the synthesis of prostaglandins, reducing the frequency of uterine muscle contractions and by blocking pain receptors.

From temperature

The use of Pentalgin for colds is effective. It helps eliminate all symptoms of flu and sore throat: normalize temperature, fight inflammation in the body and relieve pain during feverish conditions. The combined effect of the drug is the reason that doctors often prescribe Pentalgin for fever.

Instructions for use of Pentalgin

The medicine is produced by the manufacturer with annotation on its use. Instructions for use of the drug Pentalgin contain:

description of pharmacological properties;
information about the active and auxiliary substances that are part of the drug;
a list of patient conditions when the drug can be used;
a warning about side effects that may occur when using the drug;
contraindications for use.

Compound

The combined effect of Pentalgin is due to the properties of five active substances. The composition of Pentalgin tablets depends on the type of drug. The manufacturer produces the drug with four names: this allows you to select the appropriate drug for a person’s individual sensitivity to analgesics. Pentalgin of all four varieties necessarily includes paracetamol.

It begins to relieve pain, affecting the centers of thermoregulation and pain, and relieves spasms. Together with the analgesic, it has an anti-inflammatory and antipyretic effect. In combination with paracetamol, the manufacturer uses other active substances. Pentalgin additionally contains four substances, the names of which are indicated in the instructions. The active elements of the drug together with paracetamol may be:

Naproxen. This non-steroidal substance regulates the synthesis of prostaglandins, which are responsible for muscle contraction. It relieves spasm, inflammation, and lowers temperature.
Caffeine. It has the ability to dilate blood vessels, increases brain activity, relieves signs of fatigue, drowsiness, and increases the effect of other painkillers.
Drotaverine hydrochloride. Relieves spasm of smooth muscles of the genitourinary system, gastrointestinal tract, biliary tract, blood vessels.
Pheniramine maleate. It blocks the synthesis of histamine, has a sedative effect, and fights inflammatory processes. The substance relieves spasms, increases the effect of paracetamol and naproxen.
Propyphenazone.
Codeine. It is a narcotic element. Affects opioid receptors and changes the perception of pain. Reduces the degree of excitation of the center responsible for coughing, enhances the effect of anti-inflammatory and sedative substances. Long-term use may cause drug dependence.
Phenobarbital. Refers to barbiturates, increases the analgesic effect of paracetamol and metamizole.
Metamizole sodium. A non-steroidal drug that has an analgesic effect.

Indications for use

The instructions for the medicine contain recommendations on when the tablets can be taken. Indications for use of Pentalgin are as follows:

for pain in muscles and bones caused by arthralgia, myalgia, neuralgia, algodismenorrhea, migraine, ankylosing spondylitis, radiculitis, rheumatoid arthritis, spina bifida;
for pain caused by spasm, for diseases: chronic cholecystitis, cholelithiasis, renal colic;
after surgery, if pain and inflammation occur;
with chills, high temperature, inflammation during colds.

Dosage

How to take Pentalgin? The instructions contain the maximum dosage limits for the drug. The dosage of Pentalgin is one tablet half an hour before or after a meal with plenty of water, the daily norm is three tablets, in special cases four. It is necessary to maintain an interval of four hours between doses of the medicine. When using the drug to normalize the temperature, the course of treatment is three days; for pain relief, it is not recommended to use tablets for longer than five days. The duration of treatment and the number of appointments are determined by the doctor.

Side effects

The instructions warn that there is a risk of a reaction to the use of the drug from internal organs and systems. Side effects of Pentalgin may be as follows:

allergic manifestations in the form of skin itching, rash, urticaria;
changes in blood composition, anemia;
increased heart rate, arrhythmia, increased blood pressure;
dizziness, increased agitation, anxiety, sleep disturbance, decreased attention;
pain in the stomach, diarrhea, nausea, constipation, vomiting, loss of appetite;
decreased hearing, visual acuity, tinnitus;
disruption of the liver and kidneys.

Contraindications

People should not take the medicine on their own, because there are contraindications to the use of Pentalgin:

hypersensitivity, allergy to active substances;
pregnancy;
lactation period when breastfeeding a child;
children under 12 years of age;
gastrointestinal bleeding;
serious renal dysfunction, renal failure;
paroxysmal tachycardia;
hypertension;
diabetes;
inhibition of bone marrow hematopoiesis;
respiratory depression, asthma;
myocardial infarction.

It is not recommended to use tablets while taking other medications, because in combination with other active substances the toxicity of the drug may increase or the effect of the drug may decrease. It is forbidden to use Pentalgin and alcohol; you cannot take pills while driving, because they reduce attention. Pentalgin should be taken with caution by older people with viral hepatitis, alcoholic liver damage, and epilepsy.

Price for Pentalgin

How much does Pentalgin cost in a pharmacy? The cost of tablets in Moscow pharmacies depends on the active elements that are included in the medicine and packaging (the number of tablets in the package). The price of Pentalgin is presented in the table:

Packing of Pentalgin (pieces)

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Analogues of Pentalgin

The doctor may prescribe other tablets, an analogue of Pentalgin, if there are contraindications to the use of the medicine. The following tablets have an analgesic, antipyretic, and anti-inflammatory effect:

Video: drug Pentalgin

The information presented in the article is for informational purposes only. The materials in the article do not encourage self-treatment. Only a qualified doctor can make a diagnosis and make recommendations for treatment based on the individual characteristics of a particular patient.