Amosin indications for use. Review: use of the antibiotic Amosin for the treatment of children

Instructions for use:

Amosin is an antibacterial drug.

Pharmacological action of Amosin

The active ingredient of Amosin is amoxicillin, which has bactericidal activity, suppressing streptococci, staphylococci, Shigella, Salmonella, Klebsiella, Escherichia coli, the causative agent of meningitis, sepsis.

Release form

Amosin is produced in granules, powder, suspension, solution for administering the drug intramuscularly, intravenously.

Indications for use of Amosin

The antibiotic Amosin is prescribed for bacterial infections: pneumonia, sinusitis, bronchitis, tonsillitis, pharyngitis, acute otitis media, pyelitis, urethritis, pyelonephritis, cystitis, endometritis, gonorrhea, cervicitis, cholangitis, impetigo, peritonitis, cholecystitis, secondary infected dermatosis, listeriosis, borreliosis , listeriosis, sepsis, meningitis, endocartitis, salmonellosis, dysentery.

How to use Amosin according to instructions

According to the indicated indications, Amosin is taken orally, after or before meals. The tablet is swallowed whole, it can be divided or chewed, diluted in water (20 ml or 100 ml).

According to the instructions, children over 10 years of age and adults are prescribed to take Amosin 3 times a day, 0.5 g. If the infection is severe, take 0.75-1 g of antibiotic, also three times a day.

Children are usually given the antibiotic Amosin in the form of a suspension: at the age of 5-10 years - 0.25 g; 2-5l – 0.125g, up to 2 years – 20 mg/kg three times a day. If the infection in a child is severe, he is given 60 mg/kg three times a day.

For newborns and premature babies, the same dosage of the drug is indicated, but the interval between doses should be longer. Treatment lasts 5-12 days.

Amosin is prescribed for acute uncomplicated gonorrhea in a dosage of 3g; women are usually prescribed this dosage in double volume.

For infectious acute diseases of the gastrointestinal tract (typhoid, paratyphoid), bile ducts, and gynecological infections, Amosin is prescribed to adults three times a day, 1.5-2 g, or four times a day, 1-1.5 g.

Adults with leptospirosis Amoxin take 0.5-0.75 g four times a day for 6-12 days; for salmonellosis - 1.5-2g three times a day for 2-4 weeks.

For minor surgical interventions to prevent endocarditis, adults take Amosin according to instructions an hour before surgery - 3-4 g. According to indications, the antibiotic is taken again after 8-9 hours.

Side effects

The use of Amosin can cause: skin flushing, rhinitis, urticaria, fever, conjunctivitis, eosinophilia, exfoliative dermatitis, dysbacteriosis, nausea, diarrhea, taste disturbances, stomatitis, glossitis, mild increase in the activity of liver enzymes, arthralgia, anxiety, ataxia, insomnia, dizziness , peripheral neuropathy, depression, neutropenia, anemia, thrombocytopenic purpura, behavior changes.

An overdose of Amosin causes diarrhea, nausea, vomiting, and water-electrolyte imbalance. For treatment, you should rinse the stomach, take activated charcoal, a saline laxative, and perform hemodialysis.

Contraindications to the use of Amosin

The antibiotic Amosin should not be taken for gastrointestinal diseases, incl. history, infectious mononucleosis, hypersensitivity, renal failure, during lactation, pregnancy.

According to the instructions, Amosin cannot be combined with aminoglycosides; its absorption and speed of action are negatively affected by antacids, laxatives, and glucosamine.

The antibiotic, in turn, increases the effectiveness of indirect anticoagulants and reduces the effectiveness of oral contraceptives containing estrogen. The concentration of amoxicillin is increased by nonsteroidal drugs, diuretics, oxyphenbutazone, phenylbutazone, and allopurinol.

Amosin - modern, popular antibiotic. It fights bacterial infections and is effective against streptococcus, salmonella, listeria, anthrax, and Helicobacter pylori. The medicine belongs to the group of semi-synthetic penicillins. His can be given to children from birth.

Amosin is a broad-spectrum antibiotic.

Action

The main active ingredient of the drug is amoxicillin.

It prevents the synthesis of substances that make up the cell membranes of pathogenic microorganisms. This leads to the death of bacteria. The active components of Amosin penetrate the body and begin to act within 15 minutes after administration.

Release form, prices and manufacturers

The medication is available in different forms, so it can be used to treat children of any age.

Capsules- white gelatin (250 mg, 20 pieces per package) - 60 rub.
Pills- hemicilin+5dric white color with active ingredient content 250 mg or 500 mg. Price 250 mg (blister of 10 pieces) - 25 rubles; 500 mg (blister of 10 pieces) - 60 rub.

Tablets are used only for the treatment of children over 5 years of age.

Powder for preparing suspension- yellowish with a specific odor is available in dosages: 125 mg, 250 mg, 500 mg (10 sachets each) - 40, 55, 85 rubles. respectively.

Amosin is a domestically produced drug, produced by the pharmaceutical company Sintez AKO OJSC. The medicine is sold without a prescription.

Indications for use

The medicine is prescribed for infections caused by pathogenic microorganisms if they are sensitive to the antibiotic. Amosin is used for:

pathologies of the respiratory system;
ENT diseases;
diseases of the urinary organs;

Urinary tract infection is one of the most common diseases in children.

skin infections;
endocarditis;
endometritis;
enterocolitis, peritonitis;
meningitis;
listeriosis;
dysentery and other diseases.

The drug is absorbed from the digestive organs and spreads throughout the body through the blood.

The medicine is effective for eight hours after administration.

Directions for use and dosage

It is most convenient for children to give Amosin in the form of a suspension. To prepare it, you need to pour the contents of the sachet into a glass of boiled chilled water (if the active ingredient content is 125 mg, then the powder is diluted in 2.5 ml of liquid, 250 mg - 5 ml and 500 mg - 10 ml, respectively), stir.

The dosage is determined by the attending physician and depends on the severity and nature of the disease.

The dosage of the drug is determined individually in each specific case. The instructions recommend the following regimen for taking Amosin suspension:

Children over 10 years old- three times a day, 500 mg.
Patients aged 5 to 10 years - 250 mg three times a day.
From 2 to 5 years- 125 mg three times a day.
Dose for babies under 2 years old It is calculated as follows: 20 mg for every kilogram of the child’s weight. This dose is divided into three doses per day.

Children over 5 years of age can be given the drug in the form of tablets, capsules or suspension.

Capsules must be swallowed without chewing, before or after meals.

For a newborn and a child under 5 years old - only in the form of liquid.

Exact adherence to the dosage will avoid unpleasant side effects.

Side effects

Amosin is a strong antibiotic, and sometimes it causes adverse reactions. In such cases, it is replaced with softer analogues.

The drug may cause side effects from:

Gastrointestinal organs - indigestion, nausea;

The drug may cause abdominal pain and nausea.

CNS - overexcitation, sleep disturbance, anxiety, tearfulness;
respiratory organs - shortness of breath;
allergies - itching, rash, nasal congestion,.

In some cases, in children, as a result of taking the drug, the liver slightly increased in size. Rarely, but side effects from the cardiovascular system (tachycardia) may still occur.

If your baby experiences any reactions after taking Amosin, inform your doctor.

Usually, during and after antibiotic therapy, parents give their children drugs that help restore normal intestinal microflora. We talk about how to restore a child’s body after taking antibiotics.

Contraindications

The use of Amosin for the treatment of children is not always possible. The drug has a number of contraindications. Please read the instructions first or consult your doctor. The medicine should not be given to children with:

diseases of the gastrointestinal tract;
problems with the liver and kidneys;
mononucleosis of infectious origin;
bronchial asthma.

The medicine is contraindicated for patients with bronchial asthma.

The drug in the form of tablets and capsules is contraindicated in children under the age of five years. in such cases, only Amosin suspension can be given.

Overdose

There are known cases of overdose, but there is no specific antidote (a drug that binds and removes the components of a drug from the body) to Amosin. Patients may experience symptoms such as nausea, diarrhea,...

In such cases, you should immediately call an ambulance. In case of an overdose of an antibiotic, the child’s stomach is washed out and laxatives and enterosorbent drugs are prescribed.

Amosin's analogs

There are analogues of the drug Amosin on sale; they are also prescribed to children for infectious diseases. Below is a brief overview of the most popular of these medications. The active ingredient of these drugs is also amoxicillin:

(manufacturer Astellas Pharma, the Netherlands), - release form - tablets (average price - 300 rubles for 20 tablets of 250 mg); prescribed for infections of the respiratory tract, genitourinary organs, and skin. Children under one year of age are given the drug in doses not exceeding 60 mg per kilogram of body weight per day.

Amosin's analogue is Flemoxin Solutab.

(manufacturer Lek, Slovenia) - sold in the form of tablets (230 rubles for 14 pieces) and powder for preparing a suspension (120 rubles). The drug is given to children from birth. Patients under three months of age are prescribed 30 mg per kilogram of body weight per day.
(manufactured by GlaxoSmithKline Export, UK) - available in the form of powder for the preparation of suspension (average price - 145 rubles per bottle) and tablets (260 rubles for 20 pcs.); a modern antibiotic, often prescribed to children by doctors of various specialties.

Other well-known analogues in composition and mechanism of action include Danemox, Amokson.

In this article you can read the instructions for use of the drug Amosin. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of the antibiotic Amosin in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Amosin in the presence of existing structural analogues. Use for the treatment of sore throat, pneumonia, sinusitis and other infectious diseases in adults, children, as well as during pregnancy and lactation. Composition and interaction of the drug with alcohol.

Amosin- a broad-spectrum antibiotic from the group of semisynthetic penicillins. Acts bactericidal. Inhibits transpeptidase, disrupts the synthesis of peptidoglycan (supporting polymer of the cell wall) during division and growth, and causes lysis of bacteria. Acid resistant.

Active against aerobic gram-positive bacteria: Staphylococcus spp. (staphylococcus) (except penicillinase-producing strains), Streptococcus spp. (streptococcus); aerobic gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Bacillus anthracis, Listeria monocytogenes (Listeria), Helicobacter pylori (Helicobacter), Klebsiella spp. (klebsiella).

Microorganisms that produce penicillinase are resistant to amoxicillin.

The action develops 15-30 minutes after administration and lasts 8 hours.

Compound

Amoxicillin (in trihydrate form) + excipients.

Pharmacokinetics

After oral administration, Amosin is quickly and almost completely (93%) absorbed from the gastrointestinal tract. Eating does not affect the absorption of the drug and is not destroyed in the acidic environment of the stomach. Found in high concentrations in plasma, sputum, bronchial secretions (distribution in purulent bronchial secretions is poor), pleural and peritoneal fluid, urine, contents of skin blisters, lung tissue, intestinal mucosa, female genital organs, prostate gland, middle ear fluid, bone , adipose tissue, gall bladder (with normal liver function), fetal tissue. When the dose is doubled, the concentration also doubles. The concentration in bile exceeds the concentration in plasma by 2-4 times. In the amniotic fluid and umbilical cord vessels, the concentration of amoxicillin is 25-30% of the plasma level in a pregnant woman. It penetrates the blood-brain barrier (BBB) poorly; in case of inflammation of the meninges (meningitis), the concentration in the cerebrospinal fluid is about 20%. Plasma protein binding - 17%. A small amount is excreted in breast milk. Amoxicillin is partially metabolized to form inactive metabolites. Amoxicillin is excreted 50-70% unchanged in the urine by tubular excretion (80%) and glomerular filtration (20%), with bile - 10-20%.

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

respiratory infections (including bronchitis, pneumonia);
infections of the ENT organs (including sinusitis, pharyngitis, tonsillitis, acute otitis media);
infections of the genitourinary system (including pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea);
gynecological infections (including endometritis, cervicitis);
infections of the gastrointestinal tract (including peritonitis, enterocolitis, typhoid fever, cholangitis, cholecystitis);
infections of the skin and soft tissues (including erysipelas, impetigo, secondary infected dermatoses);
leptospirosis;
listeriosis;
Lyme disease (borreliosis);
dysentery;
salmonellosis, salmonella carriage;
meningitis;
endocarditis (prevention);
sepsis.

Release forms

Capsules 250 mg.

Tablets 250 mg and 500 mg.

Powder for the preparation of suspension for oral administration 125 mg, 250 mg and 500 mg.

Instructions for use and dosage

The drug is taken orally, before or after meals. The dosage regimen is set individually, taking into account the severity of the disease, the sensitivity of the pathogen to the drug, and the age of the patient.

Adults and children over 10 years old (with a body weight of more than 40 kg) are prescribed 500 mg 3 times a day, in case of severe disease - 0.75-1 g 3 times a day.

Children aged 5 to 10 years are prescribed 250 mg 3 times a day, from 2 to 5 years old - 125 mg 3 times a day, for children under 2 years old - 20 mg/kg per day in 3 divided doses. The course of treatment is 5-12 days.

For children under 5 years of age, the drug is prescribed in the form of a suspension (the ideal pediatric form of the drug).

For the treatment of acute uncomplicated gonorrhea, the drug is prescribed in a dose of 3 g once; When treating women, repeated administration of the indicated dose is recommended.

For acute infectious diseases of the gastrointestinal tract (paratyphoid fever, typhoid fever) and biliary tract, for gynecological infectious diseases, adults are prescribed 1.5-2 g 3 times a day or 1-1.5 g 4 times a day.

For leptospirosis, adults are prescribed 500-750 mg 4 times a day for 6-12 days.

For salmonella-carrying adults - 1.5-2 g 3 times a day for 2-4 weeks.

To prevent endocarditis during minor surgical interventions, adults are prescribed a dose of 3-4 g 1 hour before the procedure. If necessary, a repeat dose is prescribed after 8-9 hours. In children, the dose is halved.

Rules for preparing a suspension from a single-dose package

Boiled and cooled water is poured into a clean glass in the amount indicated in the table, then the contents of one package are poured out and mixed until a homogeneous suspension is obtained.

The dose in the package is 125 mg - the required amount of water is 2.5 ml;
dose in a package 250 mg - required amount of water 5 ml;
dose in a package 500 mg - required amount of water 10 ml.

After use, rinse the glass with water, dry and store in a dry, clean place.

Side effect

hives;
skin hyperemia;
erythema;
angioedema;
rhinitis;
conjunctivitis;
fever;
joint pain;
eosinophilia;
exfoliative dermatitis;
exudative erythema multiforme;
Stevens-Johnson syndrome;
reactions similar to serum sickness;
anaphylactic shock;
dysbacteriosis;
change in taste;
vomiting, nausea;
diarrhea;
stomatitis;
glossitis;
pseudomembranous enterocolitis;
excitation;
anxiety;
insomnia;
confusion;
behavior change;
depression;
peripheral neuropathy;
headache;
dizziness;
convulsive reactions;
interstitial nephritis;
leukopenia, neutropenia, thrombocytopenic purpura, anemia;
labored breathing;
tachycardia;
vaginal candidiasis;
superinfection (especially in patients with chronic diseases or reduced body resistance).

Contraindications

allergic diathesis;
bronchial asthma, hay fever;
Infectious mononucleosis;
lymphocytic leukemia;
liver failure;
history of gastrointestinal diseases (especially colitis associated with the use of antibiotics);
lactation period (breastfeeding);
hypersensitivity to the components of the drug;
hypersensitivity to other penicillins, cephalosporins, carbapenems;
children under 3 years of age (for tablets and capsules).

Use during pregnancy and breastfeeding

The use of the drug during pregnancy is possible only in cases where the expected benefit of therapy for the mother outweighs the potential risk to the fetus.

Use during lactation is contraindicated. If use is necessary during lactation, breastfeeding should be stopped.

Use in children

Contraindicated in children under 3 years of age (for tablets and capsules). For children under 5 years of age, the drug is prescribed in the form of a suspension.

special instructions

When carrying out a course of treatment with Amosin, it is necessary to monitor the state of the function of the hematopoietic organs, liver and kidneys.

Superinfection may develop due to the growth of microflora insensitive to amoxicillin, which requires a corresponding change in antibacterial therapy.

When treating patients with bacteremia, a bacteriolysis reaction (Jarisch-Herxheimer reaction) rarely develops.

In patients who are hypersensitive to penicillins, cross-allergic reactions with cephalosporin antibiotics are possible.

When treating mild diarrhea while using Amosin, you should avoid prescribing antidiarrheal drugs that reduce intestinal motility; You can use kaolin- or attapulgite-containing antidiarrheal agents. In case of severe diarrhea, it is necessary to carry out differential diagnosis and prescribe appropriate therapy.

Treatment should be continued for another 48-72 hours after the disappearance of clinical signs of the disease.

When using estrogen-containing oral contraceptives and amoxicillin simultaneously, additional methods of contraception should be used, if possible.

Drug interactions

Antacids, glucosamine, laxatives, food, antibiotics of the aminoglycoside group, when used simultaneously, slow down and reduce the absorption of Amosin; ascorbic acid - increases its absorption.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) exhibit synergism with amoxicillin; bacteriostatic drugs (macrolides, chloramphenicol, lincosamines, tetracyclines, sulfonamides) - antagonism.

Amoxicillin, when used simultaneously, increases the effectiveness of indirect anticoagulants (by suppressing intestinal microflora, reducing the synthesis of vitamin K and the prothrombin index); reduces the effectiveness of estrogen-containing oral contraceptives, ethinyl estradiol (the risk of intermenstrual bleeding), as well as drugs, during the metabolism of which para-aminobenzoic acid is formed.

The combined use of Amosin with alcohol is prohibited (the hepatotoxic effect of ethanol is enhanced).

Diuretics, allopurinol, oxyphenbutazone, phenylbutazone, nonsteroidal anti-inflammatory drugs (NSAIDs) and drugs that block tubular secretion, when used simultaneously with Amosin, reduce tubular secretion and increase the concentration of amoxicillin.

When Amosin is used simultaneously with allopurinol, the risk of developing a skin rash increases.

Amoxicillin, when used simultaneously, reduces the clearance and increases the toxicity of methotrexate.

Amoxicillin, when used simultaneously, enhances the absorption of digoxin.

Analogues of the drug Amosin

Structural analogues of the active substance:

Amoxisar;
Amoxicillin;
Amoxicillin trihydrate;
Gonoform;
Grunamox;
Danemox;
Ospamox;
Flemoxin Solutab;
Hiconcil;
Ecobol.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.

Name:

Amosin

Pharmacological
action:

Broad-spectrum antibiotic group of semisynthetic penicillins.
Acts bactericidal.
Inhibits transpeptidase, disrupts the synthesis of peptidoglycan (supporting polymer of the cell wall) during division and growth, and causes lysis of bacteria.
Acid resistant.
Active against aerobic gram-positive bacteria: Staphylococcus spp. (except for penicillinase-producing strains), Streptococcus spp.; aerobic gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Bacillus anthracis, Listeria monocytogenes, Helicobacter pylori, Klebsiella spp.
Microorganisms that produce penicillinase are resistant to amoxicillin.
The action develops 15-30 minutes after administration and lasts 8 hours.

Pharmacokinetics
Suction
After oral administration, amoxicillin is quickly and almost completely (93%) absorbed from the gastrointestinal tract. Eating does not affect the absorption of the drug and is not destroyed in the acidic environment of the stomach. Cmax of the active substance in plasma is observed after 1-2 hours. When taken orally at a dose of 125 mg and 250 mg, Cmax in blood plasma is 1.5-3 mcg/ml and 3.5-5 mcg/ml, respectively.
Distribution
Has a large Vd: found in high concentrations in plasma, sputum, bronchial secretions (distribution in purulent bronchial secretions is weak), pleural and peritoneal fluid, urine, contents of skin blisters, lung tissue, intestinal mucosa, female genital organs, prostate gland, fluid middle ear, bone, adipose tissue, gall bladder (with normal liver function), fetal tissue.
When the dose is doubled, the concentration also doubles.
The concentration in bile exceeds the concentration in plasma by 2-4 times.
In the amniotic fluid and umbilical cord vessels, the concentration of amoxicillin is 25-30% of the plasma level in a pregnant woman. It penetrates poorly through the BBB; in case of inflammation of the meninges (meningitis), the concentration in the cerebrospinal fluid is about 20%.
Plasma protein binding - 17%.
A small amount is excreted in breast milk.

Metabolism
Amoxicillin is partially metabolized to form inactive metabolites.
Removal
T1/2 of amoxicillin is 1-1.5 hours.
Amoxicillin is excreted 50-70% unchanged in the urine by tubular excretion (80%) and glomerular filtration (20%), with bile - 10-20%.
Pharmacokinetics in special clinical situations
In premature infants, newborns and children under 6 months, T1/2 is 3-4 hours.
If renal function is impaired (creatinine clearance ≤ 15 ml/min), T1/2 of amoxicillin increases to 8.5 hours.
Amoxicillin is removed by hemodialysis.

Indications for
application:

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:
- respiratory infections (including bronchitis, pneumonia);
- infections of the ENT organs (including sinusitis, pharyngitis, tonsillitis, acute otitis media);
- infections of the genitourinary system (including pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea);
- gynecological infections (including endometritis, cervicitis);
- infections of the gastrointestinal tract (including peritonitis, enterocolitis, typhoid fever, cholangitis, cholecystitis);
- infections of the skin and soft tissues (including erysipelas, impetigo, secondary infected dermatoses);
- leptospirosis;
- listeriosis;
- Lyme disease (borreliosis);
- dysentery;
- salmonellosis, salmonella carriage;
- meningitis;
- endocarditis (prevention);
- sepsis.

Mode of application:

Amosin capsules and tablets
The drug is intended for oral use.
Capsules are taken before or after meals. Do not crush or chew Amosin capsules before taking.
Amosin tablets are taken regardless of meals.
Amosin tablets can be divided and crushed.
It is recommended to take Amosin at regular intervals.
The duration of therapy and dose of amoxicillin is determined by the doctor. As a rule, adults and children over 10 years of age (with a body weight of more than 40 kg) are prescribed 500 mg of amoxicillin three times a day.
In severe cases of the disease, the dose of amoxicillin is increased to 750-1000 mg three times a day. Children from 5 to 10 years old are usually prescribed 250 mg of amoxicillin three times a day. The average duration of therapy is from 5 to 12 days (as a rule, therapy is continued for 2-3 days after the disappearance of clinical manifestations of the disease).

Women may be advised to take amoxicillin again at the same single dose.
For acute diseases of the gastrointestinal tract and gynecological diseases of bacterial etiology, adults are usually prescribed 1500-2000 mg of amoxicillin three times a day or 1000-1500 mg of amoxicillin four times a day.
For leptospirosis, adults are usually prescribed 500-750 mg of amoxicillin four times a day.
The duration of the course of taking Amosin is 6-12 days. In case of salmonella carriage, adults are usually prescribed 1500-2000 mg of amoxicillin three times a day.
The duration of the course of taking Amosin is 2-4 weeks.
In order to prevent endocarditis during minor surgical interventions, adults are usually prescribed 3000-4000 mg of amoxicillin 60 minutes before the start of surgery.

At high risks, it is recommended to re-take amoxicillin 8-9 hours after taking the first dose.
For children, it is recommended to prescribe 50% of the adult dose for prevention.
For patients with impaired renal function (with creatinine clearance of 15-40 ml/min), it is recommended to change the frequency of taking Amosin while maintaining a single dose.
As a rule, the recommended dose is taken at intervals of 12 hours.
In patients with impaired renal function (with creatinine clearance less than 10 ml/min), the standard dose should be reduced by 15-50%.
The maximum recommended daily dose of amoxicillin for patients with anuria is 2000 mg.
With prolonged use of the drug Amosin, the function of the hematopoietic system, kidneys and liver should be monitored.

Powder for the preparation of oral suspension Amosin
The drug is intended for the preparation of a suspension taken orally.
The prepared suspension is taken before or after meals.
To prepare a suspension from powder packaged in disposable bags, pour chilled boiled water into a glass, add the contents of the bag and stir until an equilibrium suspension is obtained. The amount of water is measured depending on the dose of amoxicillin in the package (to obtain a suspension containing 250 mg of amoxicillin in 5 ml of suspension).
For a dose of amoxicillin in a sachet of 125 mg, take 2.5 ml of drinking water, for a dose of 250 mg - 5 ml of drinking water, for a dose of 500 mg - 10 ml of drinking water.
The drug should be taken immediately after preparing the suspension.
After taking the drug, the glass should be rinsed in running water and dried.
To prepare a suspension from powder packaged in jars or bottles, measure 62 ml of chilled boiled water and add in parts to the bottle or jar.

While adding water, shake the jar or bottle to form an equilibrium suspension.
The finished suspension contains 50 mg of amoxicillin per 1 ml.
Before each use of the suspension, shake the bottle.
Dosing of the suspension is carried out using a measuring spoon included in the kit.
The duration of use and dose of the drug Amosin is determined by the doctor. Adults and children weighing more than 40 kg (over 10 years old) are usually prescribed 500 mg of amoxicillin three times a day.
In severe cases of the disease, the dose is increased to 750-1000 mg of amoxicillin three times a day. Children aged 5 to 10 years are usually prescribed 250 mg of amoxicillin three times a day.
Children aged 2 to 5 years are usually prescribed 125 mg of amoxicillin three times a day.
Children under 2 years of age are usually prescribed 20 mg of amoxicillin per 1 kg of body weight three times a day.
The average duration of therapy is from 5 to 12 days (as a rule, the drug is continued for 2-3 days after the disappearance of clinical manifestations of the disease).

Specific treatment regimens for Amosin. In the acute form of uncomplicated gonorrhea, adults are usually prescribed a single dose of 3000 mg of amoxicillin.
Women may be prescribed to take the recommended dose of amoxicillin again.
For acute infectious diseases of the biliary tract and gastrointestinal tract, as well as gynecological diseases, adults are usually prescribed 1500-2000 mg of amoxicillin three times a day or 1000-1500 mg of amoxicillin four times a day.
For leptospirosis, adults are usually prescribed 500-750 mg of amoxicillin four times a day.
The duration of taking Amosin is from 6 to 12 days.
In case of salmonella carriage, adults are usually prescribed 1500-2000 mg of amoxicillin three times a day.
The duration of taking Amosin is 2-4 weeks.

To prevent endocarditis during minor surgical operations, adults are usually prescribed 3000-4000 mg of amoxicillin 60 minutes before surgery.
If there is a high risk of developing endocarditis, amoxicillin is prescribed again 8-9 hours after taking the first dose.
For children, it is recommended to reduce prophylactic doses of amoxicillin by half.
If renal function is impaired and creatinine clearance is from 15 to 40 ml/min, it is recommended to increase the interval between doses of amoxicillin to 12 hours (in this case, the single dose of Amosin is not changed).
If renal function is impaired and creatinine clearance is less than 10 ml/min, the dose of amoxicillin should be reduced by 15-50%.
The maximum recommended daily dose for anuria is 2000 mg of amoxicillin.
With prolonged use of amoxicillin, it is recommended to monitor the function of the hematopoietic system, liver and kidneys.

Side effects:

When taking the drug Amosin, the following undesirable effects due to amoxicillin may develop:
-from the hepatobiliary system and gastrointestinal tract: dysbacteriosis, impaired taste, vomiting, diarrhea, nausea, glossitis, stomatitis, increased activity of liver enzymes, pseudomembranous colitis;
- from the blood system: eosinophilia, neutropenia, leukopenia, anemia, thrombocytopenic purpura;
- from the nervous system: anxiety, agitation, sleep-wake disturbance, ataxia, confusion, depressive states, behavior changes. In addition, headache, peripheral neuropathy, dizziness and convulsions may develop;
- allergic reactions: urticaria, hyperemia and itching of the skin, erythema, allergic rhinitis and conjunctivitis, hyperthermia, exudative erythema multiforme, exfoliative dermatitis, Quincke's edema, reactions similar to serum sickness, anaphylactic shock;
- other: arthralgia, difficulty breathing, interstitial nephritis, tachycardia, candidal vaginitis, superinfection.
When prescribing the drug to patients with sepsis, the development of the Jarisch-Herxheimer reaction (bacteriolysis reaction) is possible.
If diarrhea develops while taking amoxicillin as symptomatic therapy, drugs that reduce intestinal motility should not be prescribed; the use of kaolin- or attapulgite-containing antidiarrheals is allowed.
If unwanted effects develop, you should consult a doctor.

Contraindications:

Allergic diathesis;
- bronchial asthma, hay fever;
- Infectious mononucleosis;
- lymphocytic leukemia;
- liver failure;
- history of gastrointestinal diseases (especially colitis associated with the use of antibiotics);
- lactation period (breastfeeding);
- hypersensitivity to the components of the drug;
- hypersensitivity to other penicillins, cephalosporins, carbapenems;
- children under 3 years of age (for tablets and capsules).
Carefully the drug should be prescribed during pregnancy, renal failure, and also if there is a history of bleeding.

When carrying out a course of treatment with Amosin, it is necessary to monitor the state of the function of the hematopoietic organs, liver and kidneys.
Superinfection may develop due to the growth of microflora insensitive to amoxicillin, which requires a corresponding change in antibacterial therapy.
When treating patients with bacteremia, a bacteriolysis reaction (Jarisch-Herxheimer reaction) rarely develops.
In patients who are hypersensitive to penicillins, cross-allergic reactions with cephalosporin antibiotics are possible.
For the treatment of mild diarrhea while using Amosin, you should avoid prescribing antidiarrheal drugs that reduce intestinal motility; You can use kaolin- or attapulgite-containing antidiarrheal agents.
For severe diarrhea it is necessary to carry out differential diagnosis and prescribe appropriate therapy.
Treatment should be continued for another 48-72 hours after the disappearance of clinical signs of the disease.
When using estrogen-containing oral contraceptives and amoxicillin simultaneously, additional methods of contraception should be used, if possible.

Interaction
other medicinal
by other means:

There is a decrease in the absorption of amoxicillin when combined with glucosamine, laxatives, antacids, aminoglycosides and food.
Ascorbic acid, when used simultaneously, enhances the absorption of amoxicillin.
Bactericidal antibiotics, when used simultaneously with the drug Amosin, potentiate the effect of amoxicillin, while bacteriostatic antibiotics reduce the severity of the antimicrobial effect of amoxicillin.
Amoxicillin, by suppressing intestinal microflora, reduces the production of vitamin K and reduces prothrombin index, thus increasing the effectiveness of indirect coagulants taken simultaneously with the drug Amosin.

Amoxicillin, when used in combination, reduces the effectiveness of estrogen-containing drugs (including combined oral contraceptives), as well as drugs that form para-aminobenzoic acid during metabolism.
When taking Amosin, women who use combined oral contraceptives are recommended to use additional contraceptives (for example, barrier).
When used simultaneously with amoxicillin there is an increase in the toxicity of methotrexate, as well as increased absorption of digoxin.

Plasma concentrations of amoxicillin increase when combined with non-steroidal anti-inflammatory drugs, allopurinol, oxyphenbutazone, diuretics and phenylbutazone, as well as other drugs that block tubular secretion.
When using the drug Amosin in combination with allopurinol the risk of developing skin allergic reactions increases.

Pregnancy:

The use of the drug during pregnancy is possible only in cases where the expected benefit of therapy for the mother outweighs the potential risk to the fetus.
Use during lactation is contraindicated.
If use is necessary during lactation, breastfeeding should be stopped.

Overdose:

Symptoms: when taking excessive doses of amoxicillin, patients may develop diarrhea, vomiting, nausea, pain in the epigastric region, as well as water and electrolyte imbalance.
Treatment: There is no specific antidote. When taking amoxicillin in doses significantly higher than recommended, the stomach should be lavaged and the patient should be prescribed enterosorbent agents.
If signs of overdose develop, symptomatic therapy is prescribed.
In addition, in case of an overdose of the drug Amosin, it is advisable to prescribe saline laxatives and carry out measures aimed at maintaining water and electrolyte balance.
In order to reduce plasma concentrations of amoxicillin, hemodialysis is allowed.

Release form:

Amosin capsules 10 pieces each in a blister pack made of aluminum foil and polymer materials, 1 or 2 blister packs are included in a cardboard box.

Powder for the preparation of oral suspension Amosin 125, 250 or 500 mg of the active component in sachets, 10, 20 or 40 sachets are included in a cardboard box, complete with or without a cup made of polymer materials.
Powder for the preparation of oral suspension Amosin 60g (5g amoxicillin) in cans or bottles made of polymer materials, 1 bottle is included in a cardboard box complete with a dosing device.

Amosin tablets 10 pieces each in blister packs made of polymer materials and aluminum foil, 1 or 2 blister packs are included in a cardboard pack.
Amosin tablets, 10 pieces in blister packs made of polymer materials and aluminum foil, 240 blister packs are included in a cardboard box (boxes for delivery to hospitals).

Storage conditions:

The drug should be stored out of the reach of children, in a dry place, protected from light.
Powder To prepare the suspension, it should be stored at a temperature of 15° to 25°C.
Tablets and capsules should be stored at a temperature not exceeding 25°C.
Shelf life - 2 years.

1 tablet Amosin 250 mg contains:

- excipients: potato starch, magnesium stearate, calcium stearate, magnesium hydrosilicate (talc), povidone (kollidon 90F).

1 capsule Amosin 250 mg contains:
- active ingredient: amoxicillin (in the form of trihydrate) - 250 mg;
- excipients: potato starch.

1 sachet of Amosin powder for the preparation of a suspension for oral administration 125 mg contains:
- active ingredient: amoxicillin (in trihydrate form) - 125 mg;
- excipients: polyvinylpyrrolidone (povidone), dextrose, disodium ethylenediaminetetraacetic acid (trilon B), sodium phosphate, sodium glutamate monohydrate, food flavoring, vanillin, sucrose.

Amosin is a modern, popular antibiotic. It fights bacterial infections and is effective against streptococcus, salmonella, listeria, anthrax, and Helicobacter pylori.

The medicine belongs to the group of semi-synthetic penicillins. Available in granules, powder, suspension, solution for administering the drug intramuscularly, intravenously.

In this article we will look at why doctors prescribe Amosin, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS of people who have already used Amosin can be read in the comments.

Composition and release form

The antibiotic Amosin is available in the form of powder, suspension, granules, solution, which requires intramuscular or intravenous administration.

The drug contains amoxicillin as an active substance.

Clinical and pharmacological group: broad-spectrum antibiotic of the penicillin group, destroyed by penicillinase.

Indications for use of Amosin

The antibiotic Amosin is prescribed for bacterial infections:

pneumonia, sinusitis, bronchitis, tonsillitis, pharyngitis, acute otitis media, pyelitis, urethritis, pyelonephritis, cystitis, endometritis, gonorrhea, cervicitis, cholangitis, impetigo, peritonitis, cholecystitis, secondary infected dermatosis, listeriosis, borreliosis, listeriosis, sepsis, meningitis, endocartitis, salmonellosis, dysentery.

pharmachologic effect

Amosin is an antimicrobial drug active against a wide range of gram-positive and gram-negative bacteria. Amosin contains amoxicillin, a semisynthetic antibiotic of the penicillin group. Amoxicillin has a pronounced bactericidal effect. The mechanism of action of the drug is associated with inhibition of the synthesis of peptidoglycan (a substance that is the basis of the bacterial membrane), which leads to disruption of the integrity of bacterial cell membranes and their death.

Instructions for use

According to the instructions for use, Amosin is taken orally before or after meals. The dosage regimen is set purely individually, taking into account the patient’s age and the severity of the infectious process.

Adults and children over 10 years of age (with body weight >40 kg) are prescribed 500 mg 3 times a day, for severe disease - 0.75-1 g 3 times a day.
Children aged 5 to 10 years are prescribed 250 mg 3 times / day, from 2 to 5 years - 125 mg 3 times / day, for children under 2 years - 20 mg / kg / day in 3 doses. The course of treatment is 5-12 days.
For children under 5 years of age, the drug is prescribed in the form of a suspension.

For acute uncomplicated gonorrhea, Amosin is taken in a single dose of 3000 mg.
For the treatment of acute infectious diseases of the gastrointestinal tract, biliary tract and organs of the female reproductive system, as well as salmonellosis, adults are recommended to take 1500-2000 mg 3 times a day or 1000-1500 mg of Amosin 4 times a day.

Contraindications

Contraindications to the use of Amosin are:

Bronchial asthma and hay fever;
Allergic diathesis;
Lymphocytic leukemia;
Liver failure;
Infectious mononucleosis;
Diseases of the gastrointestinal tract;
Breastfeeding period;
Hypersensitivity to amoxicillin and other penicillins, as well as carbapenems and cephalosporins;
Children under 3 years of age (for the dosage form in the form of capsules and tablets).

Amosin is prescribed with caution to pregnant women and patients with renal failure and a history of bleeding.

Side effects

Taking amoxicillin may cause side effects:

From the skin: urticaria, erythematous rashes, rhinitis, conjunctivitis, Quincke's edema, photosensitivity, anaphylactic shock, malignant exudative erythema, Lyell's syndrome (from ≥0.1% to<1%);
Cardiovascular problems: rapid heart rate, phlebitis, decreased blood pressure, prolonged QT interval
Diseases of the circulatory and lymphatic systems: leukopenia, thrombocytopenia, eosinophilia, neutropenia. In rare cases, hemolytic anemia, pancytopenia, thrombocytopenic purpura are possible
Digestive tract: nausea, stool disorders, changes in taste, glossitis, stomatitis, increased liver enzymes, dyspeptic disorders, hepatitis, pain in the epigastric region;
Respiratory system disorders: bronchospasms, dyspnea, inflammation in the lungs caused by an allergic reaction
Musculoskeletal system: myalgia, arthralgia, muscle weakness;
Problems of the peripheral system are caused by the appearance of headaches, migraines, drowsiness, increased nervousness and anxiety, dizziness, peripheral neuropathies, changes in behavior
Other: vaginal candidiasis, fever, difficulty breathing.

As a result of an overdose of the antibiotic Amosin, vomiting, nausea, diarrhea, and water-electrolyte imbalance may occur. In this case, it is recommended to perform hemodialysis, rinse the stomach, take a saline laxative, and activated charcoal.

Pregnancy and lactation

The use of the drug during pregnancy is possible only in cases where the expected benefit of therapy for the mother outweighs the potential risk to the fetus. Use during lactation is contraindicated. If use is necessary during lactation, breastfeeding should be stopped.

Price

The average price of AMOSIN, 250 mg tablets in pharmacies (Moscow) is 30 rubles. A package of 500 mg costs 60 rubles.

Amosin's analogs

Structural analogues of the active substance:

Amoxisar;
Amoxicillin;
Amoxicillin trihydrate;
Gonoform;
Grunamox;
Danemox;
Ospamox;
Flemoxin Solutab;
Hiconcil;
Ecobol.

Attention: the use of analogues must be agreed with the attending physician.