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Cortexin and Actovegin are nootropic drugs that are designed to normalize blood circulation, improve brain function and enhance emotional levels. When choosing a medicine, the doctor takes into account the characteristics of the patient’s body and the clinical picture of the disease.

Characteristics of Cortexin

This is a nootropic drug belonging to the group of protein bioregulators. The drug improves metabolic processes in brain structures. In addition, it has antioxidant, anticonvulsant, nootropic and cerebroprotective effects on the central nervous system.

In complex therapy, the drug is used for traumatic brain injuries, vegetative-vascular dystonia, epilepsy, encephalomyelitis, encephalitis, encephalopathies, neuroinfections, cerebrovascular accidents, cerebral palsy, delayed speech and psychomotor development in children, disorders of thinking, memory and learning ability.

The drug is produced in the form of a powder for the preparation of a solution intended for intramuscular injection. Lyophilisate is the active ingredient of the product. The effectiveness of Cortexin is due to the activity of its components, which enter the brain and have the following positive effects:

1. They slow down the process of lipid oxidation and prevent free radicals from negatively affecting brain cells. Increase cell survival during hypoxia.
2. They improve the learning process and memory, increase concentration and mental resistance to stressful and psycho-emotional situations.
3. Reduce the toxic effects of psychotropic substances, protect neurons from neurotoxic effects.
4. Suppress the activity of pathological foci in the brain.

Indications for use:

• cerebrovascular accident;
• vegetative-vascular dystonia;
• encephalitis;
• asthenia;
• cognitive impairment, resulting in impairment of memory, thinking and attention;
• perinatal damage to the central nervous system in children;
• epilepsy;
• problems with speech development;
• decreased ability to absorb new knowledge and learn.

The use of the drug has a positive effect on the development of the child and improves the condition in adults.

Contraindications include:

• individual intolerance to the components of the product;
• pregnancy;
• lactation period.

The drug must be injected for 10 days. The doctor selects the dose.

Most often, Cortexin is well tolerated, but sometimes allergic reactions may develop: itching, skin rash. This happens if the lyophilisate is diluted with novocaine. Its analogues are: Cerebrolysin, Ceraxon, Fezam.

Characteristics of Actovegin

This is a drug that is used to improve trophism and metabolism in tissues and stimulate the regeneration process. The main component is a deproteinized hemoderivative from the blood of calves. The medicine is produced in the form of tablets, ointments, gels, creams, and solutions for infusions.

Active substances improve tissue nutrition and utilization of glucose from the blood. Thanks to the drug, the cells of all tissues and organs acquire resistance to hypoxia, as a result of which, even with severe oxygen starvation, the cellular structures are minimally damaged. The medication enhances the production of energy molecules that are required for all vital processes occurring in the cells of various organs.

The main effect of the drug on the body is as follows:

• the synthesis of collagen fibers improves;
• the growth of blood vessels increases, which improves blood supply to tissues;
• the process of cell division is activated with their further entry into areas where restoration of tissue integrity is required;
• accelerates the healing of skin damage (burns, abrasions, cuts, incisions, wounds, etc.);
• tissue respiration processes are activated;
• the use of glucose by cells that are in a state of metabolic exhaustion or oxygen starvation is enhanced.

The medication helps improve energy exchange in the structures of the brain, supplies it with glucose, due to which all parts of the central nervous system normalize their work, and the severity of dementia decreases.

Actovegin injections are prescribed in the following cases:

• trophic damage;
• diabetic polyneuropathy;
• chemical, solar, thermal, radiation burns up to 3rd degree;
• encephalopathy;
• hemorrhagic stroke and its residual effects;
• ulcerative lesions of the skin;
• wounds of various origins that are difficult to treat;
• bedsores;
• angiopathy;
• traumatic brain injuries;
• ischemic stroke;
• radiation neuropathy;
• damage to the skin and mucous membranes caused by radiation damage.

Contraindications include:

• anuria, oliguria;
• pulmonary edema;
• fluid retention in the body;
• decompensated heart failure;
• excessive sensitivity to the components of the drug;
• age up to 18 years.

If the recommended dose is exceeded, no complications arise, because the components included in the composition are not capable of causing harm to the body. Sometimes, in case of individual intolerance to the drug, allergic and anaphylactic reactions may develop. The following side effects are also possible:

• joint pain;
• disruption of the gastrointestinal tract;
• headache;
• loss of consciousness;
• nausea, vomiting;
• general malaise;
• skin redness;
• rash;
• stagnation of fluid in the body;
• excessive sweating;
• labored breathing;
• hyperactivity.

Compound similarities

Both drugs have the same (animal) origin. Actovegin is obtained from the plasma of a young calf using the dialysis method with ultrafiltration. Pork and veal brain cortex is used to produce Cortexin.

Medicines have similar indications for use. In case of dangerous pathological processes, doctors may prescribe both medications to be injected at the same time.

What is the difference between Cortexin and Actovegin

Cortexin has the following differences from Actovegin:

• copes well alone with a disease such as dyscirculatory encephalopathy;
• helps newborns with brain injury;
• copes with chronic fatigue faster;
• prohibited during pregnancy and lactation;
• costs more.

Which is better - Cortexin or Actovegin?

It is impossible to answer exactly the question of which drug is more effective. Both drugs show high effectiveness in treating diseases. The doctor often prescribes taking medications together, because they have good compatibility. It all depends on the individual characteristics of the body and the course of the disease.

If Cortexin and Actovegin are compared before purchasing, it is necessary to compare their properties, composition, indications and contraindications. Both drugs help normalize blood circulation and prevent the development of hypoxia.

Manufacturer - Geropharm (Russia). The release form of the drug is a lyophilisate intended for the preparation of a solution for injection. The drug can only be administered intramuscularly. The active ingredient is the substance of the same name. Cortexin is a complex of polypeptide fractions that are highly soluble in water.

The lyophilisate contains glycine. This substance is used as a stabilizer. You can purchase the drug in packages containing 10 bottles (3 or 5 ml each). The concentration of the active ingredient is 5 and 10 mg. The indicated amount is contained in bottles of different volumes: 3 and 5 ml, respectively.

Cortexin belongs to the nootropic group of drugs. It is a neurometabolic stimulant that affects mental performance. It restores memory. Additionally, the drug stimulates cognitive functions. Thanks to the drug, the ability to learn is enhanced, and the brain’s resistance to the effects of negative factors, for example, oxygen deficiency or excessive stress, increases.

The active substance is obtained from the cerebral cortex of cattle. A drug based on it helps restore brain metabolism. The therapy has a pronounced effect on bioenergetic processes in nerve cells. The nootropic drug interacts with the neurotransmitter systems of the brain.

The active substance also exhibits neuroprotective properties, due to which the level of negative influence of a number of neurotoxic factors on neurons is reduced. Cortexin also exhibits antioxidant properties, due to which the process of lipid oxidation is disrupted. The resistance of neurons to the negative effects of a number of factors provoked by hypoxia increases.

During therapy, the function of neurons in the central nervous system and peripheral nervous system is restored. At the same time, there is an improvement in the functioning of the cerebral cortex. The imbalance of amino acids characterized by inhibitory and stimulating properties is eliminated. In addition, the regenerative function of the body is restored.

Indications for use of Cortexin:

• decreased intensity of blood supply to the brain;
• trauma, as well as complications that develop against this background;
• recovery after surgery;
• encephalopathy;
• impaired thinking, information perception, memory and other cognitive disorders;
• encephalitis, encephalomyelitis in any form (acute, chronic);
• epilepsy;
• vegetative-vascular dystonia;
• developmental disorders (psychomotor, speech) in children;
• asthenic disorders;
• cerebral palsy.

The safety and effectiveness of the drug during therapy during pregnancy have not been proven. This means you should refrain from taking Cortexin. The drug is contraindicated for breastfeeding women for the same reason. This product should not be used if a negative individual reaction to the components occurs.

In most cases, the drug does not cause side effects. However, there is a risk of developing hypersensitivity to the active component of the drug.

Properties of the drug Actovegin

Manufacturer - Takeda GmbH (Japan). The drug is available in the form of a solution and tablets. Actovegin concentrate containing deproteinized hemoderivative of calf blood is used as an active component. The solution is available in ampoules of 2, 5 and 10 ml. The concentration of the active substance differs, respectively: 80, 200, 400 mg. 1 tablet contains 200 mg of the active ingredient. The drug is produced in this form in packs of 50 pcs.

The drug belongs to the group of antihypoxic drugs. The mechanism of action is based on the restoration of glucose synthesis. Thanks to Actovegin, this substance is transported more actively, due to which metabolic processes in the body are normalized. During therapy, the membrane-stabilizing effect of the drug is manifested.

Thanks to the restoration of a number of processes (increased insulin-like activity, improved oxygen uptake, normalization of glucose transport), the drug can be used in the treatment of polyneuropathies that have developed against the background of diabetes mellitus. At the same time, sensitivity returns and mental state improves. Actovegin normalizes blood circulation in the affected areas, activates the regeneration process, and restores tissue trophism.

Indications for use:

• disruption of vascular function, which leads to degenerative changes in tissue structure, cerebral circulatory failure;
• pathological condition of peripheral vessels;
• polyneuropathy due to diabetes mellitus;
• trophic disorders of tissue structure.

The product has few contraindications. First of all, hypersensitivity to the deproteinized hemoderivative of calf blood is noted. The solution is contraindicated for insufficiency of cardiac function, pulmonary edema, fluid retention and various urinary disorders. The drug can be prescribed to pregnant women, as well as to patients during lactation. It is used in the treatment of newborns. The solution is administered intravenously, intra-arterially. The tablets are intended for oral use.

Allergic reactions sometimes develop during treatment. The compatibility of the drug with other drugs has not been studied. For this reason, you should refrain from simultaneous use with other types of medications. If intolerance to the active component occurs, the drug in question should be replaced with an analogue.

Comparison of Cortexin and Actovegin

Similarities

Both products are obtained from natural raw materials. They almost do not provoke side effects; during therapy, an individual negative reaction rarely develops. Available in the form of an injection solution.

What is the difference?

The mechanism of action of the drugs is different: Cortexin affects nerve cells, bioenergetic and metabolic processes, while Actovegin exhibits antihypoxic properties. The results of therapy vary somewhat. This means that drugs can be replaced with each other only in some cases.

The products also have other differences, for example, Actovegin is available not only in the form of a solution, but also in the form of tablets. The solution is recommended to be administered intravenously. Cortexin is used intramuscularly. The therapeutic dose of this medicine is less than in the case of Actovegin. In addition, Cortexin is not used during pregnancy and lactation.

Which is cheaper?

Actovegin in the form of a solution can be purchased for 1,520 rubles. (25 ampoules with a dosage of 40 mg). Cortexin price - 1300 rubles. (pack containing 10 ampoules with a dosage of 10 mg). Thus, the first of the products is cheaper, considering the amount of the drug contained in the packages.

Which is better: Cortexin or Actovegin?

For adults

Cortexin can be used as an independent treatment measure, while Actovegin is often prescribed as part of complex therapy. This means that the effect of the first drug is more pronounced.

Cortexin is a drug characterized by a nootropic, antioxidant and tissue-specific effect. The product improves brain metabolism. Highly effective for memory impairment and decreased learning ability.

Description

Cortexin is a nootropic drug that normalizes brain metabolism. The drug is characterized by a tissue-specific multifunctional effect on the brain. Cortexin enhances the efficiency of energy metabolism of brain cells. Intracellular protein synthesis improves.

This is a polypeptide product that contains the optimal amount of peptides.

The drug has a positive effect on changes in mental functions. After taking it, concentration and learning ability are improved, and the process of restoring brain functions is accelerated. Intellectual activity is stimulated.

Cortexin is not an antibiotic and the simultaneous use of different groups of medications is allowed. Available by prescription in pharmacies.

It is allowed to take the product during menstruation, but it is not prohibited to use the injection solution for HIV infection.

It is strictly forbidden to drink alcohol while being treated with medication. Can be consumed only two days before administration and 20 hours after. You need to be careful when using this remedy and driving a car. The medication has no effect on blood pressure.

Release form and composition

The medication is available as an injection solution. Produced in 5 and 10 mg. There are 10 pcs in one pack.

One bottle contains 10 mg of cortexin. An additional component is glycine.

Manufacturers

GEROPHARM (Russia).

Representative office: GEROPHARM GROUP OF COMPANIES (Russia).

Indications for use

Cortexin is prescribed for:

• complete cure of traumatic brain injuries;
• encephalopathy;
• changes in memory and thinking;
• asthenic pathologies;
• decreased learning ability;
• various forms of cerebral palsy;
• inhibition of psychomotor and speech development in children;
• epilepsy.

Important! Only a specialist can prescribe this drug after examining the patient.

Contraindications

Cortexin to improve brain function is not prescribed for:

• hypersensitivity to individual components in the composition;
• pregnancy and breastfeeding.

Side effects

Cortexin is usually very well received by people. In some cases, allergic reactions may occur. Redness may be observed at the injection site, which will subside after a certain period of time.

Benefits and harm to the body

Cortexin is very effective as part of complex therapy. After taking the product, children become more balanced and calm. There is a desire to learn. Memory improves.

Harm to the body is caused in the event of uncontrolled use of a drug to improve brain function.

Instructions for use and dosage (adults, elderly, during pregnancy and lactation, children)

Cortexin for memory is designed for injection into the muscle. Before manipulation, the product is diluted in 2 ml of a 0.5% solution of novocaine, liquid for injection or 0.9% sodium chloride solution.

Apply the composition every day once a day. For older age groups, inject 10 mg for 10 days. Children are injected at the rate of 0.5 mg/kg with a weight of up to 20 kg. With a weight of more than 20 kg, inject 10 mg for 10 days.

If necessary, the treatment can be repeated after 3-6 months.

For hemispheric ischemic stroke in severe current and early recovery periods, use a dose of 10 mg 2 times a day for 10 days. After 10 days, repeat the course of treatment again.

The use of Cortexin among the elderly causes an increase in motor activity, memory, and an improvement in the emotional and motivational sphere. Take in the same dosage as adults.

When carrying a baby and breastfeeding, it is strictly forbidden to use this remedy. If it is necessary to use the drug, temporarily stop lactation.

The bottle with the dissolved medicine must be disposed of immediately. It is prohibited to use it over time. Do not mix with other solutions.

Analogues, substitutes and generics

Substitutes for the drug are:

• Axotilin;
• Dendrix;
• Kwanil;
• Diphosphocin;
• Kemodin.

Only the doctor can replace the medication after examining the patient.

Comparison of drugs

There are many drugs whose action is aimed at restoring memory, eliminating panic attacks and treating neurological diseases. Comparisons of drugs are discussed below.

Cortexin or Ceraxon: which is better after a stroke

Both drugs act as nootropics, but their main component is different. Ceraxon is much more effective than Cortexin in eliminating cerebral edema. The analogue is more effective during the recovery period after a stroke. After taking Ceraxon, memory and attention are restored much faster. The drug can also be used in the acute period of the disease. Both medications have a fairly high price.

Cortexin or Encephabol: which is better for speech

Experts prescribe both means for children to develop speech. Effectiveness is noticed after taking Encephabol. Parents note the expansion of vocabulary and speed of learning.

Both drugs belong to a broad group of nootropic drugs. These medications stimulate metabolism in the tissues of the nervous system, providing nutrition and development of neurons (brain cells). This promotes the formation of new replacement neural connections, bypassing damaged cells.

Both are neuropeptides - protein molecules that are formed in the nervous system and have high biological activity. You can read more about the composition and mechanism of action of Cerebrolysin and Cortexin on our website in separate articles devoted to these drugs.

To answer the question of what is more effective than Cortexin or Cerebrolysin, you need to pay attention to the fact that many scientific sources say that Cerebrolysin is the only nootropic drug for which neurotrophic activity has been proven. It supports the viability of brain cells, activates their growth and development.

In turn, Cortexin is the only nootropic drug that stimulates mental functions and has a positive effect on the pathological electrical activity of the brain. This is proven by many psychological tests and EEG (electroencephalography) results. Thus, Cortexin is indicated for epilepsy, because has a moderate anticonvulsant effect.

What is the difference between Cerebrolysin and Cortexin?

There are no significant differences regarding the main active ingredient of these drugs. Both drugs are made from the brain structures of livestock and have a high degree of biological safety and sterility.

The country of manufacture of Cortexin is Russia, the manufacturer is the Geropharm group of companies. Cerebrolysin is produced by the Austrian company Ever Neuro Pharma with direct production in Germany. Both companies are reputable representatives of the pharmaceutical industry with a good reputation.

Cortexin contains Glycine, which is also a nootropic agent, as part of its additional substances. It belongs to the group of neuroamino acids. It has an “inhibiting” effect on neurons and improves signal transmission between brain cells. Helps improve mental performance and has a mild calming effect on the nervous system.

It is important that Cerebrolysin has a fairly extensive list of side effects, from simple redness at the injection site to a seizure. Although they are rare, it is imperative to take this feature into account, especially when prescribing to infants.

When using Cerebrolysin, some mothers complain of changes in the child's behavior. They say that children become disobedient and aggressive. This could presumably be due to the activating effect of the drug on the nervous system.

The instructions for use of Cortexin indicate that the only side effects noted are individual intolerance to the components of the drug.

What is more effective: Cortexin or Cerebrolysin?

As the experience of using both drugs shows, no significant clinical effects of these drugs have been noted. The effect of the medicine in each specific case is difficult to predict. It all depends on the extent and nature of the brain damage and previous therapy.

Based on the properties of the drugs, we can say that, for example, in a child with hypoxic brain damage, Cerebrolysin will have a greater effect. And in a child with convulsive readiness or epilepsy, it would be more advisable to use Cortexin. Therefore, the difference when taking one drug or another will be leveled depending on the effect on the nervous system that the doctor wants to achieve by prescribing these drugs.

Features of the use of drugs

Both drugs are available only in forms for parenteral administration. In this case, Cerebrolysin can be administered not only intramuscularly, but also intravenously.

Cortexin is available in vials with lyophilisate; before administration, it must be diluted in a solvent. Cerebrolysin is a ready-made solution and requires additional dilution only for intravenous use. The use of a ready-made solution is more convenient and safer in terms of the development of complications associated with the administration technique and microbial contamination of solutions.

Considering the positive effects of the drugs, the question arises: is it possible to use Cerebrolysin and Cortexin simultaneously? Theoretically, the drugs are compatible for use at the same time, but not in the same syringe.

But the use of drugs from the same group with a similar mechanism of action, especially in the form of injections, is inappropriate. And in some cases, the prescription of several drugs leads to polypharmacy, which is unacceptable in pediatric practice.

In the annotation to the drugs there is no indication of the potentiating effect when they are administered together, but the likelihood of adverse reactions increases.

An effective and acceptable option would be to inject Cerebrolysin after Cortexin if there are indications for a second course of treatment with nootropic drugs.

Having studied the question of how Cerebrolysin differs from Cortexin, you can understand which drug to choose to treat your baby. It is worth noting that the final decision on prescribing a particular medication remains with the attending physician. Only reasonable use of medications can bring the desired effect.

Valentina Ignasheva, pediatrician, especially for the site

Useful video

• Latin name: Cortexin
• ATX code: N06BX
• Active substance: Livestock cerebral cortex polypeptides
• Manufacturer: Geropharm LLC, Russia

Compound

Release form

The drug is available in the form of a sterile lyophilized powder for the preparation of a solution for intramuscular administration.

The cardboard packaging is completed with two blister packs, each containing 5 bottles of lyophilisate, and instructions for use.

In pharmacies you can buy Cortexin 10 mg No. 10 and Cortexin 5 mg No. 10.

Cortexin 10 mg is available in 22 mg doses in 5 ml bottles. The product is intended for the treatment of adult patients.

Cortexin 5 mg was created specifically for use in pediatrics. It is available in 11 g bottles with a capacity of 3 ml.

pharmachologic effect

Cortexin belongs to the group nootropic and gamkergic drugs , affecting mainly CNS . Against the background of its use, the following are noted:

• nootropic ;
• neuroprotective ;
• antioxidant ;
• tissue-specific effects.

Pharmacodynamics and pharmacokinetics

Cortexin is a bioregulator with a polypeptide structure, which is a complex of water-soluble neuropeptides . The molecular weight of these polypeptide fractions does not exceed 10 thousand daltons, which allows them to penetrate the physiological barrier separating central nervous And circulatory system .

The mechanism of action of the drug is realized through:

• activation of regulatory , neurons And brain neurotrophic factors ;
• normalization of the ratio amino acids , performing mediator functions of excitatory and inhibitory types of action, as well as important brain neurotransmitters And serotonin ;
• moderately expressed GABA-ergic effects;
• reducing the level of paroxysmal (attack-like) convulsive activity brain and the ability to normalize the indicators of its bioelectric activity;
• preventing the formation of oxidative degradation products lipids (free radicals).

The nootropic effect of Cortexin is accompanied by improvement higher brain functions , improving memory, increasing learning ability and stress resistance.

The neuroprotective effect is manifested in the ability of the product to increase tissue resistance brain to the damaging effects of various endogenous neurotoxic factors and reduce the toxic effects of neurotropic substances.

Antioxidant action manifested in the drug’s ability to influence oxidative stress (cell damage provoked by oxidative processes) and increase the survival rates of neurons under conditions of oxygen starvation.

The mechanism of this action is associated with the suppression of free radical processes and peroxide oxidation of cell membrane lipids , as well as with the correction of oxygen-dependent pathological conditions.

As a result: the destruction process slows down cell membranes , microcirculation improves, decreases permeability of vessel walls , the level of blood levels and triglycerides .

The tissue-specific effect of the drug is associated with an increase in intensity CNS neurons And PNS , stimulation of reparative processes in CNS , improvement of functional state cerebral cortex and general tone somatic and autonomic nervous system .

Pharmacokinetic characteristics cannot be determined, since the disintegration time of the L-series amino acids and neuropeptide fractions included in the active substance Cortexin is no more than 3 minutes.

This makes it impossible to establish the rate and extent of absorption of peptide residues, their distribution among various organs and tissues, as well as the rate and routes of their excretion from the body.

Indications for use of Cortexin: for which the medicine is prescribed to adults and children

Indications for use of the drug are:

• provoked bacteria or viruses infectious diseases of the nervous system ;
• conditions accompanied by a violation blood circulation in the brain ;
• TBI and its consequences;
• diffuse brain lesion syndrome different nature of origin;
• cerebral (suprasegmental) autonomic disorders .

In combination with other drugs, the drug is prescribed for treatment, as well as for the treatment acute and chronic inflammatory diseases of the brain and/or spinal cord of various etiologies.

For children, indications for the use of Cortexin are reduced learning ability, memory and thinking disorders, child retardation syndrome psychomotor and speech development (ZPRR), various forms cerebral palsy .

Contraindications

The drug is contraindicated in patients with hypersensitivity to cortexin and/or glycine.

Clinical studies to establish the effect of the drug on the body of a pregnant woman and the developing fetus have not been conducted. For this reason, the drug is not recommended for use at any time.

Since there are no data from clinical studies regarding the use of the drug during this period, if it is necessary to prescribe Cortexin, it is recommended to stop breastfeeding.

Side effects of the drug

Potentially possible side effects are those caused by individual sensitivity to the components included in the drug.

Cortexin injections, instructions for use (Method and dosage)

The drug is intended for injection into the muscle.

How to dilute Cortexin?

Before injection, the powder contained in the bottle should be diluted with one or two milliliters of a 0.5% solution (), saline solution (isotonic sodium chloride solution (0.9%)) or water for injection.

To prevent the formation of foam, they try to direct the needle towards the wall of the bottle.

How to inject a child with Cortexin?

Cortexin can be prescribed from the first days of life. In some situations, parents have to give their child injections themselves. And here questions arise about how to properly inject Cortexin and what is the best way to dilute the powder.

Before giving the injection, water for injection is drawn into the syringe, novocaine or saline solution , then pierce the lid of the bottle and pour the collected liquid into it.

The syringe should be removed (the needle remains in the cap) and the contents of the bottle should be thoroughly shaken until the powder is completely dissolved. After this, the syringe is reattached and the required amount of solution is drawn into it.

For an injection, it is better to take a new needle, since the needle with which the solvent for the lyophilisate was injected may already be fairly dull.

The medicine is administered slowly, as rapid administration can cause very severe pain.

For babies up to six months old, an intramuscular injection is given into the anterior surface of the thigh (so as not to accidentally damage the sciatic nerve).

For children, especially very young children, all injections are given with saline or water for injection. Injections with novocaine less painful than injections saline solution , however, dilute the drug novocaine is permitted only if there is firm confidence that this will not cause allergic reaction The child has ( novocaine capable of giving the strongest allergies And convulsions ).

Like others neurometabolic drugs , Cortexin is recommended to be injected before 12 noon, given its activating effect and ability to provoke psychomotor agitation .

Instructions for use of Cortexin for adults

Adult patients are given Cortexin injections once a day, daily for ten days, at a dose of 10 mg.

At massive ischemic stroke (MII) in the acute phase, as well as in the early recovery period, the indicated dose is recommended to be administered to the patient twice a day (morning and evening) for ten days. After ten days, the course should be repeated.

Instructions for use of Cortexin for children

In pediatric practice, the medicine is used to treat children from the first days of their life.

For patients whose weight does not exceed 20 kg, the drug is prescribed at a dose of 0.5 mg/kg body weight. For patients weighing more than 20 kg, a dose of 10 mg is indicated.

The duration of treatment is ten days. If necessary, after three to six months the patient may be prescribed a second course.

The drug extremely rarely causes side effects, has almost no contraindications and can be used to treat even newborn babies. Its main disadvantage is considered to be its release form: Cortexin is not available in tablets, and this partly complicates its use in children, if the latter require several courses.

Overdose

To date, there are no reports of side effects that have developed as a result of an overdose of Cortexin.

Interaction

The drug is incompatible with drugs that have a peptide structure.

Terms of sale

The drug belongs to the category of prescription drugs and should be dispensed from pharmacies only with a doctor's prescription.

Storage conditions

Cortexin should be stored in a dry place, protected from sunlight, at a temperature of 2 to 20°C.

Best before date

Suitable for use within 36 months from the date of manufacture.

special instructions

The drug is produced exclusively in the form of a lyophilisate; Cortexin is not produced in tablets.

The drug should not be mixed in the same syringe with any other medications.

Analogues of Cortexin

Cortexin analogues in tablets: Armadin And Armadin Lon G, Borizol , Rilutek , .

Analogues of Cortexin in ampoules: Armadin , Mexiprim , Neurotropin , Nikomex , Nucleo CMF Forte , Cytoflavin .

Cortexin or Cerebrolysiin - which is better?

Studies conducted on laboratory rats showed that Cortexin, when administered intraperitoneally and intraperitoneally, lateral ventricle of the brain have a similar effect.

A comparative analysis of the central effects of the drugs led to the conclusion that, despite all their similarities, Cortexin is more active.

At the same time, it provokes a much smaller number of adverse reactions and can be used from birth (whereas Cerebrolysin in pediatric practice it is used if there are justified indications).

According to some patients, injections Cerebrolysin less painful compared to Cortexin injections.

Cortexin for children

The instructions for use of Cortexin for children permit the use of this drug from the first days of a child’s life.

Doctors' reviews of Cortexin for children confirm the manufacturer's statements that the drug practically does not cause adverse reactions and does not have any teratogenic and carcinogenic effects and is well tolerated by patients.

Its use in neurology, neonatology and pediatrics can improve the child’s behavior and his general condition with various types of tones, normalize memory function and speech, and relieve headaches.

Reviews about Cortexin

Cortexin is a drug widely used in neurological practice. Reviews of Cortexin for adults, which can be found on numerous thematic forums, indicate the effectiveness of this drug for treating patients of all ages (both infants and the elderly).

Taking the drug allows you to speed up the recovery process after injuries and, and in older people it stimulates work brain , increases the ability to remember and concentrate, and also prevents a decrease in intellectual abilities.

Reviews of Cortexin for children allow us to conclude that the drug is most often prescribed to children who have certain deviations in neuropsychic development. In particular, the indications for use of the drug are cerebral palsy And brain damage that occurred in the prenatal period (close to the date of birth) or directly during childbirth.

Injections for children - and reviews of Cortexin confirm this - can achieve significant improvements: after a course of treatment with the drug, the child becomes calmer, he has an improvement in brain activity, an increased interest in learning, and improved memory and speech.

The use of the drug for infants (in particular, for newborns born ahead of schedule) allows you to notice obvious improvements in a fairly short time, which are manifested in the child’s calmer behavior or the emergence of new skills (for example, the ability to independently roll over from his back to his tummy and back).

Mothers whose children were prescribed Cortexin note that after the course of treatment the child literally “came to life before our eyes.” Many consider the advantages of the drug to be the absence of side effects and low toxicity of the drug. The disadvantages most often cited are the rather high price of the product and the pain of the injections.