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This bactericidal agent belongs to the semi-synthetic penicillins. Effective against all kinds of microorganisms, including gram-negative ones (capable of resisting the action of antibiotics for a long time). The active substance, amoxicillin trihydrate, makes up 50% of the weight of the drug. In addition to it, the components are microcrystalline and dispersed cellulose, crospovidone, magnesium stearate, as well as flavoring additives.

Release form

The manufacturer produces Flemoxin in the form of white or light yellow tablets. Weighing 125, 250, 500 and 1000 mg, with engraving, respectively: 231, 232, 234, 236. The price in pharmacies depends on the size of the portions and ranges from 240 to 480 rubles. One package contains 20 tablets. Manufacturer: Japanese company Astellas. The medicine should be stored at a temperature of 15–25 °C.

Pharmacological action of the drug

Flemoxin prevents bacteria from creating cell membranes by blocking the main component of synthesis - peptidoglycan. This medication is quickly absorbed in the gastrointestinal tract. The convenience of its use is associated with the possibility of freely eating, even at the same time as the medicine, this will not affect the effect. Like any antibiotic, Flemoxin can only be used in accordance with a prescription prescribed by a doctor.

The effect of the medication begins soon after use, and reaches its maximum after an hour and a half. Taking 1000 mg of Flemoxin brings the concentration of the active substance in the blood to 8 mcg/l, in the gall bladder fluid - 25 mcg/l, in amniotic fluid during pregnancy - 2.5 mcg/l. These numbers increase in proportion to the dose.

A fifth of the active component interacts with blood proteins. The accumulation of the drug occurs in the internal membranes of hollow organs, bone tissue, fluid of the eye chambers, as well as in mucous secretions from the respiratory tract and lungs. The remainder of the substance continues to act in the body, creates additional protection against infection and speeds up recovery.

The therapeutic compound does not pass through the BBB (barrier between the circulatory system and the central nervous system). But with meningitis, it enters the cerebrospinal fluid in sufficient quantities.

The half-life of the drug in adults is from one to one and a half hours, in newborns and infants it is 3 times longer. 90% of the substance leaves the body within 8 hours, of which two thirds are excreted in the urine. Most of the metabolic products of amoxicillin have no effect on the body.

What does it help with?

Flemoxin successfully fights against various types of streptococci, tetanus and Haemophilus influenzae, Moraxella, Listeria, Helicobacter pylori. Can be used against fecal enterococcus, Proteus mirabilis, Salmonella (causing typhoid fever), Shigella Sonne, Vibrio cholerae. Does not affect microorganisms capable of synthesizing beta-lactamase. These include Pseudomonas aeruginosa, some Proteus, and Enterobacteriaceae.

List of indications:

• Bronchial, tracheal and pulmonary diseases. For example, flu, sinusitis, sinusitis.
• Inflammatory pathologies of the kidneys (pyelonephritis), bladder (cystitis), skin (furunculosis, streptoderma, erysipelas), bone tissue (osteomyelitis), and gastrointestinal tract.
• Some gynecological diseases (adnexitis).
• Together with other medications, it helps to cope with infectious mononucleosis, blood poisoning, and abscesses.
• Used after surgery to prevent complications.

How to take for adults

The individual dosage is influenced by factors such as the severity of the disease, the susceptibility of this type of microorganism to the drug, and the age of the patient. An adult takes 1000–4000 milligrams of medication per day in two servings.

The course of treatment for mild to moderate infections lasts no more than a week. This period increases to 10 days for streptococcal infection. If the disease has subsided, you can stop taking it only on the third day after the symptoms disappear.

How to take for children

Children's dosage is calculated based on body weight. For each kilogram, about 40 mg of the substance per day is required for moderate severity of the disease and up to 180 for complications. A child over 10 years old should be given two servings of 500 or 1000 milligrams. For younger children, doses of 250 mg are used, taken 3 times a day. Children 1–3 years old are given 125 milligrams three times a day.

Tablets are taken both before and after meals. The way they enter the body can be either swallowing whole, chewing with a glass of water, or preparing a syrup or suspension. The soluble form of Solutab is convenient for its pleasant taste (thanks to the lemon-tangerine filler) and rapid absorption.

Dosage regimen for angina

This disease is caused by staphylo- and streptococci, very resistant microorganisms. Only some antibiotics can effectively destroy them. A sore throat is accompanied by symptoms similar to a cold: high fever, sore throat, chills, weakness.

A study that reveals the sensitivity of pathogenic flora to medications requires time, which may not be available in the case of an acute form of the disease. Flemoxin would be a good solution, since it acts quickly, is universal and has mild side effects (compared to other bactericidal agents).

Children over 10 years of age and adults need to take about 1000-4000 milligrams of medication per two servings per day. It is better to dissolve the product in water; the child will readily drink this suspension with a pleasant smell. Inhalations will help as an additional way to relieve inflammation.

The course of treatment for mild to moderate infections lasts no more than a week. In cases where no improvement is observed within two days, the doctor should prescribe another antibiotic. After recovery, it is recommended to undergo probiotic therapy to restore the natural balance of microorganisms in the intestines.

Dosage regimen for sinusitis

This disease is an inflammation of the air-filled cavities connected to the nose. Symptoms: chills, fever, mucus and purulent discharge, pressure in the bridge of the nose, headache when bending or clenching the teeth. If left untreated, this disease can become chronic and cause vision problems, otitis, meningitis, periostitis, systemic inflammation of the body (sepsis).

The disease can be caused by bacteria, viruses, fungi, and allergic reactions. The presence of pus highly likely indicates a microbial source of infection. It is in the case of a bacterial infection that the antibiotic is extremely effective. If the disease is caused by fungi, its use is contraindicated, and it has no effect on viruses. The instructions for use advise taking 2000–3000 milligrams of the medicine in two servings. The allergic form of sinusitis, as well as sometimes the viral form, go away on their own.

Reception for cystitis

A common bladder disease can also be effectively treated with Flemoxin. In terms of the frequency of occurrence of the pathology, women and girls are in first place, children are in second; men are rarely infected with cystitis. Since inflammation of the bladder walls is caused by bacteria, antibiotic therapy becomes indispensable. It is recommended to take two tablets of Flemoxin Solutab 500 mg or 1000 mg per day.

Since cystitis can also be caused by bacteria that are insensitive to the product, it is necessary to do a urine test to identify the pathogen. In some cases, the sources of the disease are viruses, which means Flemoxin will not help. During pregnancy, not only the bladder, but also the kidneys become inflamed (pyelonephritis). In this case, there is a risk of miscarriage.

• Antispasmodics (No-shpa, Drotaverine). They make pain easier to bear.
• Antipyretics (Paracetamol). It is advisable to use only at temperatures above 38 °C.
• Complex action medications such as Urolesan and Canephron. They relieve inflammation, help against germs and relieve pain.

Also useful:

• Drink up to 3 liters of liquid during the day (pathogenic microbes are excreted along with urine).
• Follow a diet. Salt and hot spices cause irritation in the mucous membranes.
• Apply a heating pad to the lower abdomen.

Flemoxin Solutab and alcohol

Using the drug with alcoholic beverages is unacceptable, as this weakens the body's defense systems. Reduced immunity does not allow a person to normally resist the disease. As a result, the side effects indicated in the annotation appear much more intense. The digestive system becomes upset, attacks of severe nausea and vomiting appear, and sometimes appetite disappears. Added to this is the destructive effect on the liver and kidneys. Malignant tumors in the organs of the genitourinary system are possible.

Contraindications

• It should not be taken by people who are sensitive to medications based on penicillin and cephalosporin or to any of its components.
• It is not recommended to take during pregnancy and breastfeeding, except in situations where other methods do not help.

Side effects

Undesirable effects of treatment depend on the duration of taking the drug, the age of the patient and the individual characteristics of his body.

• Most often the digestive system reacts negatively to this drug. In such cases, an increase or decrease in appetite, diarrhea, nausea and vomiting are observed. These symptoms may indicate an overdose of the drug. Occasionally, acute diarrhea with blood occurs, this is a sign of hemorrhagic colitis.
• If the patient is prone to allergies, swelling and peeling of the hands and face, nettle fever, and a rash with itching are possible.
• Tremors of the limbs, dizziness, and possible fainting occur less frequently.
• In rare cases, cough, narrowing of the bronchi, and Quincke's edema are observed.
• If the patient has mononucleosis or a malignant lesion of the lymphatic tissue, a skin rash appears in most cases. This phenomenon occurs regardless of the patient's sensitivity to penicillin. In case of such a reaction, there is no need to stop taking the drug.
• There is also the possibility of superinfection.
• Resisting the effects of penicillins, microorganisms develop cross-resistance to cephalosporins.
• When treating cystitis, inflammatory processes in the kidneys of a non-infectious nature are possible.

Interaction with other substances

• Bactericidal medications like Rifampicin enhance the effect of the drug.
• The drugs Probenecid, Phenylbutazone and Xifenbutazone reduce the half-life rate of amoxicillin, and accordingly its concentration in the blood increases.
• Flemoxin sometimes reduces the effectiveness of birth control pills when used simultaneously.
• If you use drugs with it that suppress the ability of bacteria to reproduce (tetracycline group, macrolides, Chloramphenicol), this may negatively affect its action.

Analogs

In addition to amoxyllicin, the active substance is clavulanic acid, which allows the product to effectively cope with bacteria that produce beta-lactamase. This occurs by slowing down the production of a protective enzyme by microorganisms. Available in the form of tablets, syrup, injection powder, dry substance for the preparation of drops and suspension.

Release form

Pills

Compound

1 tablet contains: amoxicillin trihydrate 291.4 mg, which corresponds to the content of amoxicillin 250 mg Excipients: lemon flavor - 2.8 mg, tangerine flavor - 2.3 mg, vanillin - 0.26 mg, crospovidone - 12.6 mg, magnesium stearate - 1.5 mg, saccharin - 3.3 mg, dispersible cellulose - 8.7 mg, microcrystalline cellulose - 12.6 mg.

Pharmacological effect

Broad-spectrum antibiotic; a combination drug of amoxicillin and clavulanic acid, a β-lactamase inhibitor. Amoxicillin is bactericidal and inhibits the synthesis of peptidoglycan in the bacterial cell wall. Active against gram-positive and gram-negative microorganisms (including strains producing many plasmid and some chromosomal β-lactamases). Clavulanic acid, which is part of the drug, inhibits type II, III, IV and V β-lactamases; it is not active against type I β-lactamases produced by Enterobacter spp., Pseudomonas aeruginosa, Serratia spp., Acinetobacter spp. Clavulanic acid has a high affinity for penicillinases, due to which it forms a stable complex with the enzyme, which prevents the enzymatic degradation of amoxicillin under the influence of β-lactamases and expands its spectrum of action. Flemoclav Solutab is active against aerobic gram-positive bacteria: Streptococcus spp., Staphylococcus spp. (except methicillin-resistant strains), Enterococcus spp., Corynebacterium spp., Bacillus anthracis, Listeria monocytogenes; anaerobic gram-positive bacteria: Clostridium spp. (except Clostridium difficile), Peptococcus spp., Peptostreptococcus spp.; aerobic gram -negative bacteria: Escherichia coli, Klebsiella spp., Proteus spp., Yersinia Enterocolitica, Salmonella spp., Haemophilus influenzae, haemophilus ducreyi, n, n, n. Eisseria Gonorrhoeae, Neisseria Meningitidis, Bordetella Pertussis, Moraxella Catarrhalis, Gardnerella vaginalis, Brucella spp. , Pasteurella multocida, Vibrio cholerae, Helicobacter pylori; anaerobic gram-negative bacteria: Bacteroides spp., including Bacteroides fragilis, Fusobacterium spp.

Pharmacokinetics

Amoxicillin: Absorption: After oral administration, it is quickly absorbed from the gastrointestinal tract. Absorption of amoxicillin after oral administration is 90-94%. Absolute bioavailability reaches 94%. Concomitant food intake does not affect absorption. Cmax in blood plasma is achieved 1-2 hours after administration. After taking a single dose of 500 mg/125 mg (amoxicillin/clavulanic acid), the average concentration of amoxicillin (after 8 hours) is 0.3 mg/l. After a single dose of 875 mg/125 mg (amoxicillin/clavulanic acid), the Cmax of amoxicillin in blood plasma is 12 mcg/ml. Distribution: After a single dose of 875 mg/125 mg (amoxicillin/clavulanic acid), the AUC of amoxicillin is 33 mcg x h/l. Serum protein binding is approximately 17-20%. Amoxicillin crosses the placental barrier and is excreted in small quantities into breast milk. Metabolism: A small part of amoxicillin is metabolized by hydrolysis of the beta-lactam ring to inactive metabolites (the main ones are penicillic and penamaldic acids). Excretion: Approximately 60-80% of amoxicillin is excreted through the kidneys during the first 6 hours after taking the drug. T1/2 is 0.9-1.2 hours. Pharmacokinetics in special clinical cases: In case of impaired renal function (creatinine clearance within 10-30 ml/min) T1/2 is 6 hours, and in the case of anuria it ranges between 10 and 15 hours. Excreted during hemodialysis. Clavulanic acid: Absorption: After oral administration, it is quickly absorbed from the gastrointestinal tract. Absolute bioavailability is approximately 60%. Concomitant food intake does not affect absorption. Cmax in blood plasma is achieved approximately 1-2 hours after administration. After taking a single dose of 500 mg/125 mg (amoxicillin/clavulanic acid), the average concentration of clavulanic acid reaches 0.08 mg/l (after 8 hours). After a single dose of 875 mg/125 mg (amoxicillin/clavulanic acid), the Cmax of clavulanic acid in blood plasma is 3 mcg/ml. Distribution: After a single dose of 875 mg/125 mg (amoxicillin/clavulanic acid), the AUC of clavulanic acid is 6 mcg x h/l. Serum protein binding is 22%. Clavulanic acid penetrates the placental barrier. There is no reliable data on excretion in breast milk. Metabolism: Clavulanic acid undergoes extensive metabolism through hydrolysis and subsequent decarboxylation. Excretion: Approximately 30-50% of clavulanic acid is excreted through the kidneys during the first 6 hours after taking the drug. T1/2 is approximately 1 hour. The total clearance for amoxicillin and clavulanic acid is 25 l/h. Pharmacokinetics in special clinical cases: In case of impaired renal function (creatinine clearance from 20 to 70 ml/min), T1/2 is 2.6 hours, and with anuria it ranges from 3-4 hours. It is eliminated by hemodialysis.

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug: Respiratory infections. Infections of the genitourinary system. Infections of the gastrointestinal tract. Infections of the skin and soft tissues.

Contraindications

Hypersensitivity to the components of the drug. Hypersensitivity to other beta-lactam antibiotics, incl. To other penicillins, cephalosporins, carbapenems. The drug should be used with caution in cases of polyvalent hypersensitivity to xenobiotics, infectious mononucleosis, lymphocytic leukemia, a history of gastrointestinal diseases (especially with colitis associated with the use of antibiotics), renal failure, during pregnancy and lactation, allergic reactions (including history).

Precautionary measures

From the hematopoietic system: rarely - thrombocytosis, hemolytic anemia; very rarely - leukopenia, granulocytopenia, thrombocytopenia, pancytopenia, anemia. These adverse reactions are reversible and disappear after discontinuation of therapy. From the coagulation system: very rarely - an increase in prothrombin time and bleeding time. These adverse reactions are reversible and disappear after discontinuation of therapy. From the nervous system: rarely - dizziness, headache, convulsions (in case of impaired renal function or drug overdose); very rarely - hyperactivity, restlessness, anxiety, insomnia, impaired consciousness, aggressive behavior. From the cardiovascular system: rarely - vasculitis. From the digestive system: often - abdominal pain, nausea (more often in case of overdose), vomiting, flatulence, diarrhea (generally, reactions from the digestive system are transient and rarely pronounced; their intensity can be reduced by taking the drug at the beginning of treatment food); pseudomembranous colitis (in case of severe and persistent diarrhea while taking the drug or within 5 weeks after completion of therapy), in most cases caused by Clostridium difficile; rarely - intestinal candidiasis, hemorrhagic colitis, discoloration of the surface layer of tooth enamel. From the liver: often - a slight increase in the activity of liver enzymes; rarely - hepatitis and cholestatic jaundice. Symptoms of liver dysfunction occur during treatment or immediately after stopping therapy, but in some cases they may appear several weeks after stopping the drug; more often observed in men and patients over 60 years of age; observed very rarely in children (less than 1/10,000). The risk of adverse reactions increases when using the drug for more than 14 days. Liver dysfunction is usually reversible, but can sometimes be severe and in very rare cases (less than 1/10,000) (only in patients with severe comorbidities or while taking potentially hepatotoxic drugs) can be fatal. From the genitourinary system: infrequently - itching, burning and vaginal discharge; rarely - interstitial nephritis.

Use during pregnancy and breastfeeding

When using Flemoclav Solutab during pregnancy, no negative effects on the fetus or newborn were noted. The use of the drug in the second and third trimesters of pregnancy is possible after a medical assessment of the risk/benefit. In the first trimester of pregnancy, the use of Flemoclav Solutab should be avoided (only for dispersible tablets 875 mg/125 mg). Dispersible tablets 125 mg/31.25 mg, 250 mg/62.5 mg, 500 mg/125 mg in the first trimester of pregnancy should be prescribed with caution. Amoxicillin and clavulanic acid penetrate the blood-placental barrier and are excreted in breast milk. It is possible to use the drug during breastfeeding. If a child develops sensitization, diarrhea or candidiasis of the mucous membranes, breastfeeding should be stopped.

Directions for use and doses

The drug is taken internally. The drug is prescribed before, during or after meals. The tablet can be swallowed whole, divided into pieces or chewed with a glass of water, and can also be diluted in water to form a syrup (20 ml) or suspension (100 ml), which has a pleasant fruity taste. The dosage regimen is set individually, taking into account the severity of the disease, the sensitivity of the pathogen to the drug, and the age of the patient. In the case of infectious and inflammatory diseases of mild to moderate severity, it is recommended to use the drug according to the following scheme: adults and children over 10 years of age are prescribed 500-750 mg 2 times / day or 375-500 mg 3 times / day; children aged 3 to 10 years are prescribed 375 mg 2 times / day or 250 mg 3 times / day; children aged 1 to 3 years are prescribed 250 mg 2 times a day or 125 mg 3 times a day. The daily dose of the drug for children (including children under 1 year old) is 30-60 mg/kg/day, divided into 2-3 doses. When treating severe infections, as well as for hard-to-reach foci of infection (for example, acute otitis media), a three-time dose is recommended. For chronic diseases, recurrent infections, severe infections, adults are prescribed 0.75-1 g 3 times a day; children - 60 mg/kg/day, divided into 3 doses. For acute uncomplicated gonorrhea, 3 g of the drug is prescribed in 1 dose in combination with 1 g of probenecid. For patients with impaired renal function with CC≤10 ml/min, the dose of the drug is reduced by 15-50%. In case of mild to moderate infections, the drug is taken for 5-7 days. However, for infections caused by Streptococcus pyogenes, the duration of treatment should be at least 10 days. The drug must be continued for 48 hours after the symptoms of the disease disappear.

Side effects

From the digestive system: rarely - changes in taste, nausea, vomiting, diarrhea, dysbacteriosis, stomatitis, glossitis. in some cases - a moderate increase in the activity of liver transaminases, cholestatic jaundice, hepatic cholestasis, acute cytolytic hepatitis, pseudomembranous and hemorrhagic colitis. From the urinary system, the development of interstitial nephritis, crystalluria. From the hematopoietic system, leukopenia, neutropenia, thrombocytopenic purpura, eosinophilia, thrombocytopenia, agranulocytosis, hemolytic anemia. From the nervous system, agitation, anxiety, insomnia, ataxia, confusion, behavior changes, depression, peripheral neuropathy, headache, dizziness, epileptic convulsions. Allergic reactions skin reactions, mainly in the form of specific maculopapular rashes, urticaria, skin flushing, erythematous rashes, rhinitis, conjunctivitis, erythema multiforme exudative (Stevens-Johnson syndrome), fever, arthralgia, eosinophilia, exfoliative dermatitis, reactions similar to serum sickness, toxic epidermal necrolysis, allergic vasculitis, acute generalized exanthematous pustulosis. in some cases - anaphylactic shock, angioedema. Other difficulty breathing, vaginal candidomycosis, superinfection (especially in patients with chronic diseases or reduced body resistance).

Overdose

Symptoms: nausea, vomiting, diarrhea with possible disturbances in water and electrolyte balance. Treatment: activated carbon and osmodiuretics are prescribed, it is necessary to maintain water and electrolyte balance, and symptomatic therapy is carried out. For convulsions, diazepam is prescribed. In case of severe renal failure, hemodialysis is performed.

Interaction with other drugs

When used concomitantly with some bacteriostatic drugs (for example, chloramphenicol, sulfonamides), antagonism with amoxicillin/clavulanic acid in vitro was observed. Amoxicillin/clavulanic acid should not be co-administered with disulfiram. The simultaneous use of drugs that inhibit the renal excretion of amoxicillin (probenecid, phenylbutazone, oxyphenbutazone and, to a lesser extent, acetylsalicylic acid, indomethacin and sulfinpyrazone) increases the concentration and longer presence of amoxicillin in the blood plasma and bile. The excretion of clavulanic acid is not impaired. When used simultaneously with Flemoklav Solutab, antacids, glucosamine, laxatives, aminoglycosides slow down and reduce the absorption of amoxicillin, ascorbic acid increases the absorption of amoxicillin. Concomitant use of Flemoclav Solutab with allopurinol may increase the risk of developing a skin rash. Aminopenicillins may decrease serum concentrations of sulfasalazine. Amoxicillin reduces the renal clearance of methotrexate, which may lead to an increased risk of toxicity. When taken concomitantly with amoxicillin, monitoring of the concentration of methotrexate in the blood serum is necessary. Concomitant use of amoxicillin/clavulanic acid and digoxin may lead to increased absorption of digoxin. With the simultaneous use of Flemoklav Solutab and indirect anticoagulants, the risk of bleeding may increase. In rare cases, while taking amoxicillin, a decrease in the effectiveness of oral contraceptives has been observed, so the patient should be advised to use non-hormonal methods of contraception.

special instructions

When taking Flemoclav Solutab, there is a possibility of cross-resistance and hypersensitivity with other penicillins or cephalosporins. If anaphylactic reactions develop, the drug should be stopped immediately and appropriate therapy administered: treatment of anaphylactic shock may require urgent administration of epinephrine (adrenaline), corticosteroids and elimination of respiratory failure. Superinfection (for example, candidiasis) may develop, especially in patients with chronic diseases and/or impaired immune system function. If superinfection occurs, the drug is discontinued and/or antibacterial therapy is adjusted accordingly. For patients with severe gastrointestinal disorders accompanied by vomiting and/or diarrhea, the administration of Flemoclav Solutab is not advisable until the above symptoms are eliminated, because Possible disruption of drug absorption from the gastrointestinal tract. The appearance of severe and persistent diarrhea may be associated with the development of pseudomembranous colitis, in which case the drug is discontinued and the necessary treatment is prescribed. In case of development of hemorrhagic colitis, immediate discontinuation of the drug and corrective therapy are also necessary. The use of drugs that weaken intestinal motility in these cases is contraindicated. If liver function is impaired, the drug should be prescribed with caution and under constant medical supervision. The drug should not be used for more than 14 days without assessing liver function. In a single study, prophylactic amoxicillin/clavulanate in women with premature rupture of membranes increased the risk of neonatal necrotizing enterocolitis. While taking the drug, an increase in prothrombin time may be observed. Therefore, Flemoklav Solutab should be prescribed with caution to patients receiving anticoagulant therapy (blood clotting parameters must be monitored). Due to the high concentration of amoxicillin in the urine, it can be deposited on the walls of the urinary catheter, so such patients require periodic catheter changes. Forced diuresis accelerates the elimination of amoxicillin and reduces its plasma concentration. During the period of use of Flemoklav Solutab, non-enzymatic methods for determining glucose in urine, as well as a test for urobilinogen, may give false positive results. During a course of treatment, it is necessary to monitor the functions of the hematopoietic organs, liver and kidneys. If seizures occur during therapy, the drug is discontinued. It should be noted that 1 dispersible tablet 875 mg/125 mg contains 25 mg of potassium.

"Flemoxin Solutab" is one of the drugs in the category of antibiotics, which is widely used in pediatric practice. The product dissolves well in any liquid - juices, drinking water, milk - and has a pleasant sweetish taste.

Composition of the product "Flemoxin Solutab"

The main component is amoxicillin.

Excipients are:

• dispersible cellulose;
• crospovidone;
• vanillin;
• flavorings (taste identical to tangerine and lemon);
• magnesium stearate;
• saccharin.

Indications for the use of Flemoxin Solutab in childhood

"Flemoxin Solutab" is used in the treatment of respiratory diseases, as well as pathologies of the ENT organs.

Additionally, the medicine can be prescribed during the treatment of bacterial infections affecting:

• surface of the skin and subcutaneous layer of tissue;
• the child's urinary system;

How to take Flemoxin Solutab

The instructions for children contain the following instructions. A child can take a tablet of the drug:

• swallow whole, simply with any liquid;
• Chew (the drug has a sweetish fruity taste) and drink with plenty of liquid.

If necessary, the tablet can be dissolved in water:

• If you need to get syrup, then take 20 ml of liquid per tablet.
• A suspension will be obtained if the tablet is diluted with 100 ml of water.

Regimen for taking the drug "Flemoxin Solutab" ( dosage depends on the number of completed years of the child):

• children over ten years of age: 500.0...750.0 mg twice a day with an interval of 12 hours or 375.0...500.0 mg three times a day (every 8 hours);
• from three to ten years: 375.0 mg every 12 hours or 250.0 mg every 8 hours;
• from one to three years: 250.0 mg twice a day or 125.0 mg three times a day.

The dosage depends on the following indicators:

• age;
• baby's weight;
• severity of the disease.

The daily dose is calculated based on the fact that there are 30.0...60.0 mg of the drug per kilogram of the child’s weight. The daily dose should be divided into several doses, most often no more than three.

The duration of the course of taking Flemoxin Solutab depends on the severity of the disease:

• for mild and moderate severity – 5…7 days;
• in severe/protracted form – at least 10 days.

Features of taking the drug

If the child has problems with the kidneys, the doctor reduces the daily dosage of the drug. This depends on the severity of the existing pathology and the dosage can ultimately be reduced by half (at the discretion of the specialist).

You can drink Flemoxin Solutab at any time, regardless of meals.

Dr. Komarovsky considers Flemoxin Solutab the safest children's antibiotic. The medication is practically non-toxic, and therefore, if necessary, can be used in children of the first year of life.

And to the question: “Can the drug be given to newborns?” Komarovsky gives a positive answer.

Side effects that accompany taking the drug

Since Flemoxin Solutab belongs to the group of penicillin antibiotics, the following side effects may be observed after taking the drug:

• the appearance of skin rashes like urticaria;
• development of angioedema.

Side effects may also develop from:

• Gastrointestinal tract. This may be an attack of nausea accompanied by vomiting, stool upset, or appetite disorders. Sometimes - an increase in the permissible amount of liver enzymes and the occurrence of hemorrhagic colitis.
• Genitourinary system. Very rarely, interstitial nephritis develops while taking the drug.
• Hematopoietic organs. A blood test may reveal a decrease in the number of platelets and neutrophils. In rare cases, hemolytic anemia is diagnosed.

Contraindications to the use of the drug in childhood

The drug should not be taken if the child has:

• individual intolerance to the component composition of the medication;
• drug allergy to drugs included in the penicillin and cephalosporin series.

In case of existing renal failure, as well as lymphocytic leukemia and mononucleosis, the medicine is prescribed with extreme caution.

Release form

The drug is offered in the form of dispersible - easily soluble in water - tablets of various dosages.

Analogues of Flemoxin Solutab

The main active component of the antibiotic is amoxicillin trihydrate. Analogues of the drug are many drugs, the basis of which is also amoxicillin trihydrate. This:

• "Amoxicillin";
• "Amoxicar";
• "Ospamox", etc.

The difference between Flemoxin Solutab and its analogues:

• release form;
• dispersible – quickly dissolving in water – structure of the drug.

Overdose and measures to eliminate it

Signs of an overdose will be:

• attacks of nausea ending in vomiting;
• intestinal disorder;
• disturbances of water and electrolyte balance.

Symptomatic therapy:

• gastric lavage is performed;
• requires the use of enterosorbents;
• Aqueous solutions of electrolytes are prescribed.

Storage of the drug and expiration date

Store the medicine at a temperature not exceeding +25. Shelf life - within five years from the date of issue.

Flemoxin solutab is a medicinal product, a broad-spectrum antibiotic.

The active component of the drug is amoxicillin, which has an antibacterial effect. Used for various inflammatory and infectious processes of the upper and lower respiratory tract, gastrointestinal tract, genitourinary system, soft tissues.

The duration of antibiotic therapy for mild and moderate infections is about 5-7 days, and in cases of infections caused by Streptococcus pyogenes - 10 days. The disappearance of clinical manifestations of the disease is by no means a signal for immediate discontinuation of the drug: it should be taken for another 2 days. If the use of Flemoxin is accompanied by severe diarrhea, then the presence of pseudomembranous colitis can be assumed. In such cases, the drug must be discontinued.

Clinical and pharmacological group

An antibiotic from the group of semisynthetic penicillins with a broad spectrum of action.

Terms of sale from pharmacies

Can buy according to a doctor's prescription.

Price

In Moscow pharmacies the average cost of the drug Flemoxin Solutab is:

• Flemoxin Solutab tablets 125 mg – 230-270 rub.
• Flemoxin Solutab tablets 250 mg – 300-330 rub.
• Flemoxin Solutab tablets 500 mg – 370-410 rub.
• Flemoxin Solutab tablets 1000 mg – 520-550 rub.

Composition and release form

Flemoxin Solutab dispersible tablets:

• 125, 250, 500 or 1000 mg package No. 20 (blisters of 5 pcs., 4 blisters per package);
• 125 mg package No. 14 (blisters of 7 pcs., 2 blisters per package).

The composition of dispersible (water-soluble) tablets includes amoxicillin in the form of amoxicillin trihydrate, microcrystalline and dispersible cellulose, vanillin, crospovidone, flavors (lemon and tangerine), magnesium stearate, saccharin.

The tablets are oval, white or white with a yellowish tint, with a dividing line on one side, and a digital designation (231, 232, 234 and 236) and the manufacturer’s logo on the other.

Pharmacological effect

Amoxicillin is a semisynthetic β-lactam antibiotic of the penicillin group with a wide spectrum of antimicrobial activity.

The bactericidal properties of the drug are due to the ability to suppress transpeptidase, disrupt the production of peptidoglycan (supporting protein of cell walls) during periods of division and growth, and provoke the lysis of microorganisms.

Shows activity against Gram (+) aerobes, including Staphylococcus spp. (with the exception of penicillinase-producing strains) and Streptococcus spp. (including Str.pneumoniae and faecalis); Gram (-) aerobes (gonococci, meningococci, Escherichia coli and Haemophilus influenzae, Proteus mirabilis; certain strains of Klebsiella, Shigella and Salmonella, as well as against H. pylori.

Ineffective against strains of Proteus P. rettgeri and vulgaris (they are indole-positive), serrations, pseudomonads, enterobacteria, Morganella morgani. Mycoplasma, rickettsia and viruses are resistant to amoxicillin.

A feature of the dosage form is that the tablets are easily dispersed in water to form a dispersion. Thanks to this, the drug is quickly and as completely as possible (more than 93% of the dose taken) absorbed from the digestive canal. Eating does not affect the absorption of the substance. TCmax - ranging from 60 to 120 minutes. When taking dispersible tablets, the plasma concentration of amoxicillin is higher than when taking insoluble forms of the drug. The active substance is resistant to acids.

Indications for use

Flemoxin Solutab tablets are intended for the treatment of diseases caused by microorganisms sensitive to Amoxicillin:

• infections of the musculoskeletal system, including osteomyelitis;
• infectious diseases of the skin and soft tissues - pyoderma, streptoderma, boils, carbuncles,;
• infectious diseases of the urinary tract and kidneys - interstitial nephritis;
• inflammatory diseases of the female genital organs - salpingitis, endocervicitis, septic complications after abortion or childbirth, endometritis;
• diseases of the respiratory system of an inflammatory-infectious nature - complicated, hospital-acquired pneumonia.

Contraindications

The use of Flemoxin Solutab is contraindicated in patients with individual intolerance to the components of the drug and other beta-lactam antibiotics, including other carbapenems, cephalosporins and penicillins.

Diseases/conditions for which the drug is prescribed with caution:

• Infectious mononucleosis;
• lymphocytic leukemia;
• history of gastrointestinal diseases (especially colitis associated with the use of antibacterial agents);
• renal failure;
• allergic reactions, including polyvalent hypersensitivity to xenobiotics (including a history);
• pregnancy;
• breastfeeding period.

Prescription during pregnancy and lactation

The use of Flemoxin Solutab during pregnancy and lactation is possible if the expected benefit of therapy for the mother outweighs the risk of side effects in the fetus and infant.

Amoxicillin is excreted in small quantities into breast milk, which can lead to the development of sensitization phenomena in an infant.

Dosage and method of administration

As indicated in the instructions for use, Flemoxin Solutab should be taken orally before, simultaneously or after meals.

Flemoxin Solutab can be swallowed whole, chewed or divided into pieces and washed down with a glass of water, or diluted in 20 or 100 ml of water to form a syrup or suspension that has a pleasant fruity taste.

The regimen for taking the drug is determined by the doctor on an individual basis. When determining it, it takes into account the severity of the condition, the age of the patient and the sensitivity of the infectious agent to the action of amoxicillin.

• children 1–3 years old: 2 times a day, 250 mg or 3 times a day, 125 mg;
• children 3–10 years old: 2 times a day, 375 mg or 3 times a day, 250 mg;
• children over 10 years of age and adults: 2 times a day, 500–750 mg or 3 times a day, 375–500 mg.

The dose of Flemoxin Solut for children (including those under 1 year of age) depends on weight and is 30–60 mg/kg per day, divided into 2–3 doses.

In cases of severe infections, as well as in the treatment of hard-to-reach foci of infection (for example, acute otitis media), the daily dose of Flemoxin Solutab is recommended to be divided into 3 doses.

In higher doses, the drug is used for recurrent infections, chronic diseases and severe infections: children - 60 mg/kg per day, divided into 3 doses, adults - 3 times a day, 750-1000 mg.

For acute uncomplicated gonorrhea, combination therapy is carried out: Flemoxin Solutab - 3000 mg and probenecid - 1000 mg (single dose).

For functional renal impairment (in patients with creatinine clearance ≤ 10 ml per minute), a dose reduction of 15–50% is indicated.

Course duration:

• moderate/mild infections: 5–7 days; longer use (at least 10 days) is indicated in cases of treatment of infections caused by Streptococcus pyogenes;
• severe infections, chronic diseases: duration is determined by the clinical picture; after the symptoms of the disease disappear, therapy is continued for another 48 hours.

Adverse reactions

Side effects appear as:

• nausea, changes in taste, diarrhea, vomiting, moderate increases in liver enzyme activity (sometimes), hemorrhagic and pseudomembranous colitis (extremely rare);
• interstitial nephritis (extremely rare);
• hemolytic anemia, neutropenia, agranulocytosis, thrombocytopenia.

When using the drug in the form of dispersible tablets, no adverse effects from the nervous system were observed.

The use of the drug may be accompanied by the development of hypersensitivity reactions, which are expressed in the form of a rash (mainly specific maculopapular), exudative erythema multiforme (rarely), angioedema and anaphylactic shock (in exceptional cases).

Overdose

Flemoxin solutab is prescribed in a certain dosage, but in case of overdose, gastric lavage is performed, activated charcoal, saline laxatives are given, and water and electrolyte balance is restored. Such events take place only in a hospital under the strict supervision of medical personnel.

special instructions

Use with caution in patients prone to allergic reactions.

During combination therapy with metronidazole, it is not recommended to drink alcohol.

Amoxicillin in combination with metronidazole is not recommended for use in patients under 18 years of age; should not be used for liver diseases.

Compatibility with other drugs

When using the drug, it is necessary to take into account interactions with other medications:

1. Amoxicillin may reduce the effectiveness of oral contraceptives.
2. Amoxicillin reduces the effect of drugs whose metabolism produces PABA.
3. Antacids, glucosamine, laxatives, aminoglycosides slow down and reduce, and ascorbic acid increases the absorption of amoxicillin.
4. Amoxicillin enhances the effect of indirect anticoagulants by suppressing intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index.
5. With the combined use of amoxicillin and clavulanic acid, the pharmacokinetics of both components does not change.
6. Probenecid, diuretics, allopurinol, phenylbutazone, NSAIDs reduce the tubular secretion of amoxicillin, which may be accompanied by an increase in its concentration in the blood plasma.
7. With the simultaneous use of amoxicillin with bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin), synergism appears; with bacteriostatic antibiotics (including macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) - antagonism.

Flemoxin Solutab is an antibacterial and bactericidal drug. Instructions for use for children and adults recommend taking tablets of 500, 1000, 125 and 250 mg for the treatment of infectious and inflammatory diseases caused by microorganisms sensitive to the action of amoxicillin: infections of the skin and soft tissues; infections of the digestive, respiratory and genitourinary systems. Reviews from patients and doctors confirm that this drug helps in the treatment of sore throat, sinusitis and other infections in adults and children.

Release form and composition

The dosage form of the antibiotic Flemoxin Solutab is dispersible tablets 125, 250, 500 or 1000 mg. Sold in blisters of 5 or 7 pcs.

Active ingredient: amoxicillin – 125, 250, 500 or 1000 mg (in the form of amoxicillin trihydrate).

pharmachologic effect

Flemoxin Solutab is a broad-spectrum semi-synthetic penicillin antibiotic. It is a 4-hydroxyl analogue of ampicillin. Has a bactericidal effect.

Active against aerobic gram-positive and gram-negative bacteria. microorganisms that produce penicillinase are resistant to amoxicillin, the active substance of the drug Flemoxin Solutab. Instructions for use for children and adults indicate that in combination with metronidazole, the antibiotic is active against Helicobacter pylori. Amoxicillin is believed to inhibit the development of Helicobacter pylori resistance to metronidazole.

Cross-resistance exists between amoxicillin and ampicillin. The spectrum of antibacterial action expands with the simultaneous use of amoxicillin and the beta-lactamase inhibitor clavulanic acid.

This combination increases the activity of Flemoxin Solutab against Bacteroides spp., Legionella spp., Nocardia spp., Pseudomonas (Burkholderia) pseudomallei. However, Pseudomonas aeruginosa, Serratia marcescens and many other gram-negative bacteria remain resistant.

What does Flemoxin Solutab help with?

Indications for use of the drug include infections:

• respiratory organs;
• soft tissues and skin;
• organs of the gastrointestinal tract;
• genitourinary system.

Instructions for use

Flemoxin Solutab is intended for oral use only. The tablets should be taken before, during or after meals. They can be swallowed whole, chewed with a glass of plain water, or divided into pieces. You can also dilute the tablet in water to form a suspension (100 ml) or syrup (20 ml), which has a pleasant fruity taste.

The dosage regimen of Flemoxin Solutaba is set individually for each patient. This takes into account the severity of the disease, the sensitivity of the pathogen to the drug, and the age of the patient.

For infectious-inflammatory pathologies of moderate and mild severity, it is advisable to use tablets according to the following scheme:

• children aged 1 to 3 years: 250 mg of the drug 2 times a day or 125 mg 3 times a day;
• children aged 3 to 10 years: 375 mg 2 times a day or 250 mg 3 times a day;
• Children over 10 years of age and adult patients are prescribed 500-750 mg of the drug 2 times a day or 375-500 mg 3 times a day.

The total daily dose of the drug for children (including children under 1 year of age) should be 30-60 mg/kg body weight per day, divided into 2-3 doses.

Instructions for the treatment of diseases

• When treating severe infectious diseases, as well as in hard-to-reach foci of infection (for example, acute otitis media), a three-time dose of the drug is necessary.
• For acute uncomplicated gonorrhea, the patient is prescribed 3 g of Flemoxin Solutaba in 1 dose (simultaneously with 1 g of probenecid).
• For patients with functional renal impairment with CC less than 10 ml/min, the dose of the drug is reduced by 15-50%.
• For chronic diseases, severe infections and recurrent infections, adult patients are prescribed 0.75-1 g 3 times a day, and children - 60 mg/kg body weight per day (divided into 3 doses).
• In case of infections of moderate and mild severity, Flemoxin Solutab is taken for 5-7 days. However, for infections caused by Streptococcus pyogenes, the duration of therapy should be at least 10 days.

Taking the pills must be continued for 48 hours after the signs of the disease disappear.

Contraindications

• pregnancy;
• lactation;
• hypersensitivity to amoxicillin;
• lymphocytic leukemia;
• breastfeeding period;
• renal failure;
• history of gastrointestinal pathology (especially colitis associated with the use of antibiotics);
• Infectious mononucleosis;
• polyvalent hypersensitivity to chemicals foreign to the body (xenobiotics).

Side effects

Children, pregnancy and breastfeeding

The use of Flemoxin Solutab during pregnancy and lactation is possible if the expected benefit of therapy for the mother outweighs the risk of side effects in the fetus and infant. Amoxicillin is excreted in small quantities into breast milk, which can lead to the development of sensitization phenomena in an infant.

It is used in children according to indications according to the dosage regimen (including infants and newborns).

special instructions

Due to the high likelihood of developing exanthema, which has a non-allergic etiology, in infectious mononucleosis and lymphocytic leukemia, Flemoxin Solutab is prescribed with caution.

For mild diarrhea that appears while taking the drug, antidiarrheal drugs that reduce intestinal motility should not be used. The presence of erythroderma in the medical history is not a contraindication for therapy.

Due to the growth of microflora insensitive to the action of Flemoxin Solutab, superinfection may develop (appropriate changes will be required in antibacterial therapy).

Drug interactions

Probenecid, phenylbutazone, oxyphenbutazone, diuretics, allopurinol, NSAIDs, and to a lesser extent, acetylsalicylic acid and sulfinpyrazone suppress the tubular secretion of penicillins, which leads to an increase in T1/2 and an increase in the concentration of amoxicillin in the blood plasma.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, vancomycin, rifampicin) exhibit synergism when taken simultaneously. Antagonism is possible when taken with some bacteriostatic drugs (for example, chloramphenicol, sulfonamides).

Analogues of the drug Flemoxin Solutab

Analogs in composition include:

1. Ospamox.
2. Amosin.
3. Amoxicillin-ratiopharm.
4. Danemox.
5. Grunamox.
6. Amoxicillin sodium sterile.
7. Gonoform.
8. Ecobol.
9. Amoxisar.
10. Amoxicillin DS.
11. Hiconcil.
12. Amoxicillin.
13. Amoxicillin trihydrate.
14. Amoxicillin Sandoz.

Vacation conditions and price

The average price of Flemoxin Solutab in Moscow is 307 rubles. In Kyiv you can buy an antibiotic for 119 hryvnia, in Kazakhstan - for 1266 tenge. In Minsk, pharmacies offer tablets for 7-9 bel. rubles Dispensed from pharmacies with a prescription.

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