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Not only health depends on proper nutrition. It turns out that even healthy dishes can become poisonous if you add spices from medicine to them. Read and remember which combinations of food and medicine are dangerous for your body.

1. Lyme and cough medicine
You may have heard that you should not drink grapefruit juice while taking statins, drugs that lower cholesterol in the body. It's the same story with lime and pomelo. These fruits block the production of an enzyme that processes statins and other drugs, such as the cough medicine dextromethorphan. As a result, the drug accumulates in the blood, which can lead to unwanted side effects. When citrus fruits are combined with dextromethorphan, hallucinations and drowsiness may occur, and with statins, serious muscle damage can occur. The effect of these fruits lasts for just over a day, which means you should take them and your medications at least 24 hours apart.

2. Dairy products and antibiotics.
Some antibiotics, such as ciprofloxacin, combine in the stomach with calcium, iron and other minerals found in milk. This leads to the fact that the antibiotic is poorly absorbed and, accordingly, the effectiveness of its fight against infections is sharply reduced. When you buy a new medicine for asthma or colds, first ask whether the medicine is part of the group of so-called tetracyclines or fluoroquinols. If it does, try to avoid milk, yoghurt and cheese for 2 hours before and after taking your medication. And if you are also taking multivitamin or mineral complexes, check with your pharmacist at this time, as they may have a similar effect.

3. Smoked meats and antidepressants.
Read carefully what is written on the label of your “fun” pills. If they contain monoamine oxidase inhibitors (MAOIs), then taking them along with foods rich in the amino acid tyramine will lead to a dangerous spike in blood pressure. Unfortunately, the list of products containing this amino acid is not limited to barbecue and smoked salmon. It also includes red wine, sauerkraut, hot dogs, old cheeses and draft or homemade beer. However, do not panic ahead of time! Canned or bottled beer probably won't hurt you. Today, monoamine oxidase inhibitors are rapidly being replaced by new generation antidepressants that do not have similar side effects.

4. Apple juice and allergy medications.
Carefully! If you are taking medication for hay fever ahead of the hot summer days, then under no circumstances drink apple, orange or grapefruit juice with it without waiting 4 hours after taking the pills. These juices inhibit the peptide that transports the drug from the intestines into the blood. As a result, the effectiveness of the drug is reduced by 70 percent, which will make taking it almost pointless, and your runny nose and sneezing will become non-stop. Avoid these juices if you are taking Allegra for hay fever, the antibiotic ciprofloxacin, the thyroid medication Synthroid, or an allergy and asthma medication.

5. Cassia cinnamon and warfarin.
People who have been taking the blood-thinning drug warfarin for a long time know that vitamin K is very important while taking it. So you should never give up eating foods like broccoli or leafy greens. They contain a large amount of vitamin K, which plays a key role in blood clotting, and its decrease will have a bad effect on its density. But here another problem arises. Cassia cinnamon (cheap cinnamon from China, Vietnam and Indonesia, often sold as "Indonesian cinnamon") contains the substance coumarin, which, like the drug Warfarin, thins the blood. Taking both of these substances can cause serious liver damage. If you are taking warfarin, but cannot live without a cup of aromatic coffee with cinnamon, then switch to a high-quality, Ceylon variety of cinnamon.

6. Alcohol and paracetamol.
Your body uses the same enzyme to break down alcohol and paracetamol. Therefore, try to take a 6-hour break between using these substances. Remember that serious consequences will not appear immediately, but over time: So if you drink on a daily basis, it is better to stop taking Tylenol altogether. Their daily combination will lead to kidney and liver pathologies. For example, assistant to President George H. W. Bush Antonio Benedi drank 3-4 glasses of wine a day. In 1993, he caught a cold and took 10 paracetamol tablets over 4 days. This therapeutic dose was enough for him to end up in intensive care, and then for a liver transplant.

FOOD PLUS PILLS: WHEN IS IT LIFE DANGEROUS?

Some products form a life-threatening “explosive mixture” with medications, scientists say. For example, grapefruit juice makes drugs deadly. What other foods do not work well with medications and how to avoid dangerous combinations?

The champion for intractability with medications is grapefruit juice, says Konstantin Spakhov, Candidate of Medical Sciences, gastroenterologist.- Americans are required to test all new drugs for compatibility with it. After all, this refreshing drink, which is liked by so many, can sometimes lead to fatal outcomes.

Grapefruit juice causes heart drug overdose

The tragic story of a man who died from an overdose of Liprimar, a popular cholesterol-lowering drug, has become very famous in the medical world. But it was not the medicine that was to blame for this... Before this, the patient had been treated with the drug for many years and without problems. The problems began when the man became addicted to freshly squeezed grapefruit juice and drank 2-3 glasses of it daily. As a result, he died from severe kidney failure. The deceased's kidneys were clogged with a protein that is formed during the breakdown of muscle tissue - this is how a typical overdose of Liprimar and other similar cholesterol-lowering drugs occurs.

Grapefruit juice dramatically increases the absorption of many drugs from the intestines, and part of the drug that previously passed through the digestive tract in transit was absorbed - the drug accumulated, and in the end everything ended sadly. Grapefruit juice can cause an overdose of medications for heart disease and hypertension, antibiotics, hormones and many, many other drugs.

Milk weakens the effect of antibiotics

There are products that behave in the opposite way, preventing the absorption of medications and making their use either pointless or not very effective, continues Konstantin Spakhov. - A good doctor, when prescribing antibiotics, will always warn the patient that they cannot be combined with any dairy products. The calcium contained in them binds a significant part of the medicine, as a result it passes through the digestive tract without being absorbed.

Antibiotics are one of the most controversial drugs; many of them do not “like” not only dairy, but also sour foods - fruits, juices, soda, dry wine and any dishes made with vinegar. But antidepressants are even more controversial. They do not “digest” alcohol, especially red wine, dairy products, cheeses (primarily noble mold), beef, fish, sausages, etc. d. (see table). By treating depression with medications and taking these products, you risk a serious hypertensive crisis.

Many people are aware of the dangers of cocktails made from wine and drugs that act on the psyche. But few people know that combining booze with the usual painkiller paracetamol is much more dangerous. Moreover, many try to ease their hangover headaches. You can't do this. Many paid for this with their livers and went to another world. The most famous victim was 37-year-old Antonio Benedi, an aide to President George H. W. Bush. He was not an alcoholic, but had a daily habit of drinking 3-4 glasses of noble wine. Having fallen ill with a cold in 1993, he took 10 paracetamol tablets over 4 days. This is a therapeutic dose, but it was enough for his liver to “fall off.” They saved his life by performing an emergency liver transplant. But dozens of other patients did not have time.

The most dangerous combinations of foods and drugs

products	medicines
Milk and dairy products	They reduce the absorption of antibiotics such as tetracyclines (methacycline, doxycycline, etc.) and quinolones (ciprofloxacin, levofloxacin, lomefloxacin, etc.) They also act on iron supplements and the antifungal fluconazole. When combined with most antidepressants, they cause hypertensive crises.
Coffee (and sometimes tea and caffeinated sodas - colas)	They enhance the effect of theophylline (bronchial dilatation) and insulin, causing the effect of their overdose at normal doses. They weaken the effect of penicillin antibiotics and erythromycin. Interferes with the absorption of iron from drugs. Weaken the effects of haloperidol and other antipsychotics.
Sour fruits or juices, sodas, wine and syrups, marinades, dishes with vinegar	They weaken the effect of the most popular antibiotics of the penicillin series and erythromycin.
Milk, dairy products, cottage cheese, cheese, avocados, bananas, beans, wine, caviar, chocolate, coffee, fish, liver, raisins, red plums, salami, sausages, canned food, soy products, spinach, tomatoes, yeast extracts	When combined with many antidepressants and the most popular antiulcer drug cimetidine, they can cause severe hypertensive crises.

Broadcast from 03/20/2011

We don't even realize that when we take drugs, we can eat foods that block the action medications, and besides, they can harm us. Today we will tell you which combinations of foods and drugs threaten your health.
First cure- paracetamol. Many people use it to protect themselves from the flu. What should not be combined with paracetamol?

The most dangerous combination is alcohol.This is any alcoholic drink, even beer. Paracetamol is highly toxic; in doses above 10 grams it can kill the liver myself. This is explained by the fact that when paracetamol is absorbed, substances are formed that can destroy the liver. Enzyme, which is responsible for this is cytochrome 460. Alcohol leads to an increased effect of cytochrome. By combining alcohol with paracetamol, you increase the effect of the drug. This combination kills your liver.
If you drink paracetamol, you should forget about alcohol!

Drugs that lower cholesterol - statins. What is it contraindicated to combine statins with?
Statins should not be used with grapefruit and its juice. Grapefruit contains the substance - furocoumarin. Furocoumarins stop the action of drugs, as a result they settle in the body. If you take statins, avoid grapefruit and grapefruit juice for 2 hours before and after taking the drug.

Another medicine - diuretics, hypothiazide, for example. What should they not be used with?
Diuretic medications should not be combined with licorice or licorice. Liquorice is quite common in our lives. Licorice root is found in sweets, in sugar substitutes, in beer foaming agents, kvass and other non-alcoholic drinks. Also, many expectorant medications also contain liquorice.

This combination is dangerous because sodium is retained in the body, and with it a large volume of water, i.e. Diuretics don't help at all. Also, when sodium is retained, potassium deficiency occurs and the person develops hypokalemia. In the initial stage it is fatigue, all kinds of pain in the legs, and in the worst case it is myopathy, which is difficult to cure.

Myopathy- this is muscle damage, it can be heart muscle. If you are taking diuretic medications, then consuming licorice and products containing it is prohibited! This combination can cause fluid to be retained in the body, blood pressure will be increased, heart will be under threat, it may stop due to lack potassium.

Dangerous combination of foods and drugs

Dangerous combination of grapefruit juice and drugs.

What foods form a life-threatening mixture with drugs? What products are dangerous to combine antibiotics, antidepressants and paracetamol? When should you not drink juice? What medications does grapefruit juice combine with in a life-threatening manner?

The champion in intractability with medications is grapefruit juice.

The tragic story of a man who died from an overdose of Liprimar, a popular cholesterol-lowering drug, has become very famous in the medical world.

But it was not the medicine that was to blame. Previously, the patient had been treated with this drug for many years. The problems began when he became addicted to freshly squeezed grapefruit juice and drank 2-3 glasses of it daily. He eventually died from severe kidney failure.

Grapefruit juice dramatically increases the absorption of many drugs from the intestines, and part of the drug that previously passed through the digestive tract was not absorbed begins to be absorbed and accumulate.

Grapefruit juice can cause an overdose of heart and hypertension medications, antibiotics, hormones, and many other drugs.

Antibiotics

Antibiotics cannot be combined with any dairy products. The calcium contained in them binds a significant part of the medicine, as a result it passes through the digestive tract without being absorbed.

Many of the antibiotics do not “like” not only dairy, but also sour foods - fruits, juices, soda, dry wine and any dishes prepared with vinegar.

Antidepressants

Antidepressants do not “digest” alcohol, especially red wine, dairy products, cheeses, beef, fish, sausages, beans, chocolate, coffee, liver, tomatoes, caviar, canned food, soy, bananas. By treating depression with medications and taking these products, you risk a serious hypertensive crisis.

Paracetamol

Combining booze with paracetamol is very dangerous. You should absolutely not try to relieve a hangover headache with it. Many paid for this with their livers and went to another world.

In addition, many companies produce this medicine and modifications based on it under various names: efferalgan, fervex, coldrex, tera-flu, etc. Paracetamol is found in most painkillers and anti-flu medications. People think that these are different drugs, they make a mixture, and in the end they end up with an overdose of paracetamol. In Europe and America, it ranks first in the number of deaths.

When should you not drink juice?

Apple, plum, grapefruit and lemon juices You should not drink if you have a stomach ulcer or inflammatory processes in the intestines.

carrot juice Contraindicated for gastritis with high acidity, exacerbation of gastric ulcer, colitis, diarrhea.

Cherry juice irritates the kidneys, so it is not recommended to drink it during inflammatory processes.

For diabetes juice from melon, banana, peach, cherry plum, pear, carrots and other sweet fruits are consumed with caution and only after consulting a doctor.

Sour fruit juices not recommended for liver and gallbladder diseases.

Melon juice may cause hives, itchy skin in some people

Be attentive to yourself!

Paracetamol is one of the most common medications around the world. It has gained such popularity due to the combination of antipyretic, anti-inflammatory and analgesic effects. In some countries, instead of the more familiar name “paracetamol”, “acetaminophen” is used; both names are equal and mean the same substance.

The wide distribution of the drug among people and its over-the-counter availability make one think that this remedy can be taken for anything and as much as one wants. This is not entirely true, and therefore it is necessary to consider in more detail both the medicine itself and its side effects on the body.

Release form and composition

The main active ingredient of the drug is para-acetaminophenenol. The first sales of drugs with this substance began in 1953, when the drug was released.

At the moment, paracetamol has a huge number of different forms of release: from the usual familiar tablets to powders and soluble effervescent drinks. Every year more and more new trade names of drugs containing it are released. Around the world, paracetamol is considered the main medicine for colds; it is very difficult to find cold powders without paracetamol. However, side effects are often ignored by patients.

pharmachologic effect

The mechanism of action is based on the fact that the substance inhibits specific biologically active substances prostaglandins. Prostaglandins are formed during inflammation, causing pain and a local increase in temperature.

Unlike the first representative of non-steroidal anti-inflammatory drugs, acetylsalicylic acid, the side effects of paracetamol do not include irritation of the gastrointestinal mucosa, and therefore the risk of developing gastritis and stomach ulcers is much lower. This was the main reason for the popularity of the new remedy, including in children's practice.

Indications and contraindications for use

Since the antipyretic effect of the drug is most pronounced, its main indications are as follows:

• Symptomatic treatment of colds
• Pain syndrome, including migraines
• Myalgia
• Neuralgia
• Arthrosis

Important: paracetamol is a symptomatic drug, so treating the cause of the disease requires the use of other therapeutic methods.

It should be understood that paracetamol has contraindications just like any other members of the NSAID group. However, since the side effects are milder, it remains the drug of choice for many diseases. You should refuse to take it if you have a history of:

1. Individual intolerance
2. Inflammatory diseases of the gastrointestinal mucosa, as well as erosions and ulcerative lesions
3. Severe renal or liver failure
4. Age of the first month of life

In all these cases, taking the drug can be hazardous to health, and side effects in patients with contraindications can appear much more often and be much more pronounced.

Directions for use and doses

The method of application directly depends on what dosage form is used.

The average at which the therapeutic effect begins to occur is 10-15 mg per 1 kg of weight.

Paracetamol tablets and syrup are taken one or two hours after meals, washed down with plenty of liquid. This is necessary so that taking it on a full stomach does not slow down the absorption process and does not delay the onset of the effect.

In the form of suppositories, one suppository is administered rectally.

Important: do not use paracetamol for more than 5 days, as this may cause side effects. If the fever lasts longer than 5 days, you should immediately consult a doctor. Long-term use of paracetamol should be justified by a doctor, since the side effect increases with each subsequent day of use.

Use during pregnancy and breastfeeding

During pregnancy, a large number of medications are prohibited and this is no coincidence, since the side effects here can be extremely unpredictable.

Paracetamol is strictly prohibited for use in the third trimester of pregnancy, while in the 1st and 2nd trimesters, therapy with it is allowed as prescribed by a doctor. The possible harm and benefits for the mother should be weighed against each other.

The lactation period is not a contraindication, since less than 1% of paracetamol passes into breast milk and, as a result, it will not cause side effects in the child.

The main side effects of the drug are expressed in its negative effects on the kidneys. However, they most often appear with long-term (over 5-7 days) use.

Some researchers believe that taking paracetamol during pregnancy increases the risk of cryptorchidism, that is, testicular prolapse, in a male child. The drug is also considered one of the factors in the development of bronchial asthma in a child, the same applies to acetylsalicylic acid (aspirin).

In order to reduce the likelihood of any side effects, you should strictly follow the existing therapeutic regimen and take the drug only with the permission of your doctor.

special instructions

If the patient's appetite decreases, the dosage of the drug must also be reduced, since the side effects on the gastric mucosa may increase.

Some dosage forms include caffeine along with paracetamol. Caffeine is not only necessary to increase blood pressure in patients with hypotension, it also increases the effect of acetaminophen, since the combination greatly increases the bioavailability of acetaminophen. Especially such combination drugs can be useful in relieving hypotensive headaches.

The effectiveness of products with this active ingredient increases greatly if vitamin C (ascorbic acid) is present in the composition. Vitamin C slows the elimination of acetaminophen from the body, making the effects last slightly longer. Most often, compositions with ascorbic acid are found among cold powders. Also, due to slower elimination, the load on the liver is somewhat reduced.

Paracetamol is a medicine from the group of non-narcotic analgesics. Sold in tablets for adults - 500 mg (0.5 g). Has an analgesic and antipyretic effect. It is used as a symptomatic remedy for pain, fever, malaise in the case of colds and acute respiratory infections. The manufacturer can be domestic and foreign pharmaceutical companies.

Composition of the drug

pharmachologic effect

Paracetamol is a non-narcotic analgesic of central action from the anilide group. It has a pronounced antipyretic and moderate analgesic effect. The anti-inflammatory effect is so insignificant that it is not taken into account during therapy.

Pharmacodynamics

The drug blocks the enzyme cyclooxygenase (COX), which is involved in the synthesis of prostaglandins and other inflammatory mediators. Localization of action is the central parts of the nervous system, mainly the hypothalamus, where the thermoregulation center is located. As a result, the drug has a significant antipyretic effect - quickly and effectively reduces elevated body temperature. The analgesic effect is associated with inhibition of the transmission of pain impulses from the central regions to the periphery. The drug penetrates the BBB (blood-brain barrier) and into mother's milk.

Pharmacokinetics

Paracetamol is quickly and completely absorbed in the upper parts of the small intestine. Maximum plasma concentration occurs after 40-60 minutes. In the blood it binds to transport proteins in the blood, which deliver the active substance to the liver. Here the drug is metabolized to form glucuronides. It leaves the body in the urine mainly in the form of inactive metabolites. The half-life is from 1 to 4 hours in healthy people; in the elderly and patients with impaired liver or kidney function, this time is extended, which must be taken into account when prescribing treatment.

Indications and contraindications

The drug is used to relieve pain of various localizations: headache, muscle, dental, periodic in women, rheumatic, and neuralgia. The medicine effectively eliminates fever during colds, acute respiratory infections and acute respiratory viral infections.

Tablets are not recommended for intolerance to the components in the composition, blood disease with inhibition of one or more hematopoiesis, severe liver or kidney failure, Gilbert's syndrome (congenital hyperbilirubinemia), alcohol dependence. Paracetamol is not recommended in the early stages of pregnancy.

Methods of appointment

The maximum dosage of the drug is no more than 4 grams per day. Excessive doses can cause intoxication of the body and should be used only under medical supervision and laboratory control (complete blood count, blood biochemistry for liver and kidney parameters).

Adults and children over 12 years old, who are equivalent to the older age category, are prescribed 1-2 tablets 3-4 times a day. To obtain the maximum therapeutic effect, Paracetamol is taken between meals with a sufficient amount of liquid. Without medical supervision, the medicine can be taken for no more than 3-5 days.

Side effects

Adverse reactions to the drug rarely occur if the doctor's recommendations on daily dosages and duration of therapy are followed. In case of self-medication, side effects may appear, associated with a high risk of complications from various organs and systems.

Table - Adverse reactions to taking Paracetamol

Functional system of the body	Symptoms
Digestive tract	Epigastric discomfort, flatulence, nausea, rarely vomiting, loss of appetite, high concentration of liver enzymes in the blood
Blood-forming organs	Low levels of hemoglobin and red blood cells in the blood test (anemia)
Respiratory system	Difficulty breathing due to narrowing of the bronchial tract
Immunity	Itching of the skin, blisters (urticaria), swelling of the laryngeal mucosa with an attack of suffocation (Quincke's edema), anaphylactic reactions, life-threatening
Endocrine system	Decreased blood glucose levels, which manifests itself as deterioration in general condition and loss of consciousness

The occurrence of acute life-threatening conditions requires urgent medical intervention. In such cases, an ambulance should be called. In case of mild side effects, it is recommended to stop taking Paracetamol and consult a doctor.

Overdose

Exceeding daily doses leads to toxic damage to the liver and kidneys. An overdose develops when 10-15 grams (20-30 tablets) of Paracetamol are ingested per day. Clinical signs of poisoning increase within 12-24 hours after taking a large dosage of the drug. First, nausea and abdominal cramps appear, then repeated vomiting, pale skin color, irregularities in the heart area, clouding of consciousness, convulsions, and urinary retention. In severe cases, coma and death occur.

At the first signs of an overdose, you must call a medical team. If there are no symptoms of intoxication, but it is known that you are taking high doses of the drug, you should immediately consult a doctor. The sooner the body is detoxified, the lower the risk of developing irreversible processes in the liver and kidneys.

Treatment includes intravenous administration of the antidote Paracetamol - acetylcysteine. The drug is prescribed on the first day after taking the medication. The effectiveness of acetylcysteine ​​is higher within 8 hours from the onset of poisoning. As an alternative to the antidote, methionine is recommended for oral administration. Gastric lavage, sorbents and symptomatic drugs are prescribed depending on the clinical manifestations of intoxication.

Features of use for pregnant and nursing mothers

Paracetamol is contraindicated in the 1st trimester of pregnancy due to the high risk of toxic effects on the embryo. In the late period of gestation, the drug is used only in consultation with an obstetrician-gynecologist. No more than 1% of the active substance passes into breast milk, which allows feeding the baby during therapy under medical supervision.

Trade patent name: Paracetamol

International nonproprietary name:

paracetamol

Chemical name: para-acetaminophenol

Dosage form:

pills

Composition of the drug:
Active substance: paracetamol -200 mg,
Excipients: gelatin, potato starch, stearic acid, milk sugar (lactose).

Description: Tablets are white or white with a creamy tint, flat-cylindrical in shape, with a bevel and a score.

Pharmacotherapeutic group:

non-narcotic analgesic

ATS code: N02BE01

Pharmacological properties:

Paracetamol is an analgesic and antipyretic. Blocks the synthesis of prostaglandins in the central nervous system by inhibiting cyclooxygenase 1 and cyclooxygenase 2, affecting the centers of pain and thermoregulation. Does not exhibit anti-inflammatory effect. The lack of influence on the synthesis of prostaglandins in peripheral tissues determines the absence of a negative effect on water-salt metabolism (sodium and water retention) and the mucous membrane of the gastrointestinal tract.

Pharmacokinetics: paracetamol is quickly and almost completely absorbed from the gastrointestinal tract. Binds to plasma proteins by 15%. Paracetamol penetrates the blood-brain barrier. Less than 1% of the dose of paracetamol taken by a nursing mother passes into breast milk. The therapeutically effective concentration of paracetamol in plasma is achieved when administered at a dose of 10-15 mg/kg body weight. The half-life is 1-4 hours. Paracetamol is metabolized in the liver and excreted in the urine, mainly in the form of glucuronides and sulfonated conjugates, less than 5% is excreted unchanged in the urine.

Indications:
Used for rapid relief of headaches, including migraine pain, toothache, neuralgia, muscle and rheumatic pain, as well as algodismenorrhea, pain from injuries, burns; to reduce fever during colds and flu.

Contraindications:

• hypersensitivity to paracetamol or any other ingredient of the drug;
• severe liver or kidney dysfunction;
• children's age (up to 3 years)

Carefully:
Use with caution in cases of benign hyperbilirubinemia (including Gilbert's syndrome), viral hepatitis, alcoholic liver damage, glucose-6-phosphate dehydrogenase deficiency, alcoholism, pregnancy, lactation, and old age. The drug should not be taken simultaneously with other paracetamol-containing drugs.

Directions for use and dosage:

Adults, including the elderly and children over 12 years of age:
0.5-1 g, 1-2 hours after meals with plenty of liquid after 4-6 hours, maximum daily dose up to 4 g per day.
The interval between doses should be at least 4 hours. Do not take more than 8 tablets in 24 hours.
In patients with impaired liver or kidney function, with Gilbert's syndrome, in elderly patients, the daily dose should be reduced and the interval between doses should be increased.

Children:
Daily dose from 3 to 6 years (from 15 to 22 kg) - 1 g, up to 9 years (up to 30 kg) - 1.5 kg, up to 12 years (up to 40 kg) - 2 g. Frequency of administration - 4 times per day; the interval between each dose is at least 4 hours.
If symptoms persist, contact your doctor.

Do not exceed the indicated dose. If you take more than the recommended dose, seek medical attention, even if you feel well. An overdose of paracetamol can cause liver failure.

The drug is not recommended for use for more than five days as an analgesic and for more than three days as an antipyretic without a doctor’s prescription and supervision. Increasing the daily dose of the drug or the duration of treatment is possible only under the supervision of a physician.

Side effect:

At recommended doses, the drug is usually well tolerated. Paracetamol rarely causes side effects. Sometimes allergic reactions (skin rash, itching, urticaria, Quincke's edema), exudative erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), dizziness, nausea, epigastric pain may occur; anemia, thrombocytopenia, agranulocytosis; insomnia. With long-term use in large doses, the likelihood of dysfunction of the liver and kidneys, as well as the hematopoietic system, increases.

From the digestive system: nausea, epigastric pain, increased activity of liver enzymes, hepatonecrosis. From the endocrine system: hypoglycemia. If unusual symptoms occur, consult a doctor.

Overdose:

Signs of an overdose of paracetamol are nausea, vomiting, stomach pain, pale skin, anorexia. After a day or two, signs of liver damage are detected. In severe cases, liver failure and coma develop. A specific antidote for paracetamol poisoning is N-acetylcysteine.

Symptoms:
Pale skin, anorexia, nausea, vomiting; hepatonecrosis (the severity of necrosis directly depends on the degree of overdose). If you suspect an overdose, you should immediately seek medical help. The toxic effect of the drug in adults is possible after taking more than 10-15 g of paracetamol: increased activity of “liver” transaminases, increased prothrombin time (12-48 hours after administration); a detailed clinical picture of liver damage appears after 1-6 days. Rarely, liver dysfunction develops at lightning speed and can be complicated by renal failure (tubular necrosis).

Treatment:
The victim should undergo gastric lavage during the first 4 hours of poisoning, take adsorbents (activated carbon) and consult a doctor, administer SH-group donors and precursors for the synthesis of glutathione - methionine 8-9 hours after the overdose and N-acetylcysteine ​​- after 12 h. The need for additional therapeutic measures (further administration of methionine, intravenous administration of N-acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as on the time elapsed after its administration.

Special instructions:

Before taking, consult your doctor if:

• you have severe liver or kidney disease;
• You are taking anti-nausea and vomiting medications (metoclopramide, domperidone), as well as medications that lower blood cholesterol (cholestyramine);
• You are taking anticoagulants and need painkillers every day for a long time. Paracetamol in this case can be taken occasionally;

TO AVOID TOXIC DAMAGE TO THE LIVER, PARACETAMOL SHOULD NOT BE COMBINED WITH ALCOHOL BEVERAGES, AND SHOULD NOT BE TAKEN BY PERSONS PROMOTED TO CHRONIC ALCOHOL CONSUMPTION.

During long-term treatment, monitoring of the peripheral blood picture and the functional state of the liver is necessary.

Interaction: the drug, when taken for a long time, enhances the effect of indirect anticoagulants (warfarin and other coumarins), which increases the risk of bleeding. Inducers of microsomal oxidation enzymes in the liver (barbiturates, diphenin, carbamazepine, rifampicin, zidovudine, phenytoin, ethanol, flumecinol, phenylbutazone and tricyclic antidepressants) increase the risk of hepatotoxicity in overdoses.

Long-term use of barbiturates reduces the effectiveness of paracetamol.

Ethanol contributes to the development of acute pancreatitis.

Microsomal oxidation inhibitors (cimetidine) reduce the risk of hepatotoxicity. Concomitant use with other non-steroidal anti-inflammatory drugs increases the nephrotoxic effect.

Simultaneous long-term administration of paracetamol in high doses and salicylates increases the risk of developing kidney and bladder cancer. Diflunisal increases the plasma concentration of paracetamol by 50% - the risk of developing hepatotoxicity.

Myelotoxic drugs increase the manifestations of hematotoxicity of the drug. Metoclopramide and domperidone increase, and cholestyramine reduces the rate of absorption of paracetamol. The drug may reduce the activity of uricosuric drugs.

Release form:

Tablets 200 mg. 10 tablets per blister or cell-free packaging. 2 or 3 blister packs with instructions for use are placed in a cardboard pack. Contour cellless packages with an equal number of instructions for use are placed in cardboard boxes.

Storage conditions:

Store in a dry place, protected from light and out of reach of children, at a temperature not exceeding + 25 ° C.

Best before date:

3 years. Do not use after the expiration date stated on the package.

Conditions for dispensing from pharmacies:

Over the counter.

Manufacturer:

OJSC "Marbiopharm"
424006, Russia, Republic of Mari El, Yoshkar-Ola, st. K. Marx, 121

Paracetamol for colds is a fairly effective drug that helps eliminate fever and relieve pain. It is recommended for use by children and adults, but only in the dosages specified in the instructions.
In addition, when treating a cold with paracetamol, you must carefully study the list of contraindications and possible side effects that may develop during drug therapy.

A cold must be treated when the first signs of the disease appear, otherwise the patient may develop more severe health problems. Colds are especially dangerous for patients who suffer from chronic diseases, since such pathology can cause exacerbation. That is why it is especially important to diagnose and begin to treat a viral infection in a timely manner.
A cold is usually accompanied by the following symptoms:

• Nasal congestion;
• Weakness;
• Cough;
• Joint and muscle pain;
• Runny nose;
• General malaise;
• Apathy.

Note! These symptoms may also indicate that the patient has a more severe pathology, so you should not self-medicate.

At the first signs listed from the list, you need to consult a doctor who will identify the causative agent of the infection and prescribe proper treatment. For example, paracetamol for acute respiratory infections is prescribed in combination with other medications, since it has a very weak anti-inflammatory effect.

It should also be understood that taking paracetamol for colds and flu cannot eliminate all of the listed symptoms, but only relieves the fever and pain that most bother the patient.

Release form of the medicinal product

Up to eighteen years of age, the dosage is calculated based on body weight; at this age, the norm is fifteen milligrams per kilogram. The dosage for adults for colds and fever is four grams per day, with no more than one gram of the product used at a time.

It is important to start treatment with paracetamol when the first symptoms of a cold appear in adults and children. You should also observe an interval of four hours between doses; it is during this time that the active substance is completely eliminated from the body.

How to take paracetamol for acute viral respiratory infection? According to the instructions for acute respiratory infections, the drug is used in a standard dosage - 1-2 tablets at a time and no more than 4 grams per day. In this case, the tablet is taken an hour after a meal with plenty of water. The dosage is calculated according to the instructions depending on the amount of the active substance. Tablets are available in 200 and 500 mg. The duration of treatment is 3-4 days.

Is it possible for nursing mothers and women while pregnant to use paracetamol for colds? In the first case, it is necessary to take into account that the substance tends to accumulate in small quantities in breast milk, so a nursing mother should consult a doctor before treatment.

Pregnant women are generally contraindicated from taking any medications, however, if the therapeutic properties of the drug exceed the risk of harm to the mother and baby, then the drug can be used, but only with the permission of the attending physician.

Contraindications and side effects

In addition to the listed therapeutic properties, the medicine has a number of contraindications:

1. Impaired liver and kidney function.
2. Viral hepatitis.
3. Tuberculosis.
4. Intolerance to components.
5. Pathologies of the circulatory system.
6. Glucose deficiency.
7. Chronic alcoholism.

Side effects, provided dosages are observed and there are no contraindications, are observed quite rarely. As a rule, the analgesic is well tolerated by the body. Side effects include the following:

• Vomiting and nausea;
• Dizziness and loss of orientation in space;
• Allergy;
• Psychomotor agitation;
• Pain in the heart and stomach;
• Hemorrhage.

In rare cases, angioedema and coma may develop, even leading to death.

Interaction with other drugs

Many patients are interested in what is more effective for colds? Also, quite often people are interested in what is better for colds: ibuprofen or paracetamol? Before answering these questions, you need to understand the interaction of this medicine with other drugs and how to take paracetamol for a cold:

1. Caffeine - doubles the therapeutic effects of each other; as a result of this combination, the temperature drops faster and apathy disappears.
2. Aspirin has a similar medicinal effect, so you should not take paracetamol and aspirin together when you have a cold, such manipulations increase the load on the liver.
3. — unlike aspirin, the combination of paracetamol and analgin for colds effectively reduces temperature and eliminates pain.

special instructions

To avoid side effects when using an analgesic, the following rules should be followed:

• Follow the dosage indicated in the instructions.
• Do not use the product for more than three days with fever and five days with pain.
• Do not use to treat children without consulting a pediatrician.
• Maintain an interval between doses.
• Do not combine the analgesic with other medications that contain a similar active ingredient.

Should I take paracetamol if I don't have a fever?

Can paracetamol be used for a cold if there is no fever? Despite the fact that the analgesic, in addition to antipyretic effects, has a powerful analgesic effect, it is not advisable to use paracetamol for a cold without fever. This is explained by the fact that all painful sensations, except fever, disappear on their own within two days. Taking medication in this case only increases the load on the liver.