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Afobazole is a modern drug from the group of anxiolytics (tranquilizers), developed by Russian pharmacologists. Afobazole, unlike other popular tranquilizers, has a milder effect, relieves anxiety well, has a sedative effect without depressing the nervous system. The drug does not cause drowsiness, does not reduce muscle tone and does not provoke drug dependence.

Afobazole helps the body resist stress factors and anxiety syndrome, facilitating a person’s adaptation in society. Human life in the modern world is accompanied by constant stress, which causes an unreasonable feeling of anxiety and psychological discomfort. Constant nervous tension that continues for a long time often leads to the development of a number of somatic diseases.

Trying to get rid of negative emotions, many resort to alcohol, cigarettes, or simply “eat up” stress. This behavior provokes the development of obesity, alcohol addiction, cardiovascular diseases and other serious health problems. A medical drug such as Afobazole is designed to prevent such consequences. It will cope with the state of pathological anxiety and help the nervous system resist stress loads.

Afobazole - the effect of the drug

Afobazole is a mild tranquilizer with a double effect. It has a stimulating effect and relieves anxiety and nervous tension, improving the patient's mental and physical condition. The action of the drug is aimed at eliminating somatic disorders and associated symptoms (respiratory, muscular, cardiovascular).

The use of a tranquilizer can reduce the frequency of autonomic disorders (dizziness, excessive sweating), and helps improve concentration and memory. Afobazole is widely used as part of complex treatment of the respiratory and gastrointestinal tract. With long-term use of the drug, drug dependence does not form and withdrawal syndrome does not appear.

The combination of a stimulating and anti-anxiety effect allows you to eliminate irritability, bad feelings, and feelings of anxiety. The drug helps relieve tension, relax, improve sleep and get rid of unreasonable fears. Afobazole is especially effective when used in patients with asthenic syndrome, suffering from increased vulnerability, uncertainty, emotional instability, and anxious suspiciousness.

Positive dynamics from taking the tranquilizer are observed on days 5-7 of use, the maximum positive effect is achieved after a month of treatment and persists for 2 weeks after discontinuation of the drug.

When taken orally, Afobazole is quickly absorbed from the gastrointestinal tract and binds well to plasma proteins, reaching its maximum concentration in a short time. It is eliminated from the body quite quickly, the half-life does not exceed 50 minutes; this feature of the drug significantly reduces the likelihood of an overdose.

Release form and price

Afobazole is produced in the form of white, flat-cylindrical tablets with a bevel. Each tablet contains 5 or 10 mg of the active component fabomotizol + excipients. The tablets are packaged in cellular contour blisters of 10 or 25 pieces, which are placed in cardboard packs. Another form of release is jars with a polymer lid containing 30, 50 or 100 tablets.

The average price for a package of Afobazole (60 pcs) in the pharmacy chain is from 280 to 350 rubles.

Indications for use

Afobazole is used to treat adult patients and is prescribed for the following conditions:

Afobazole is necessarily prescribed as part of complex therapy for chronic gastrointestinal diseases. With long-term dysfunction of the intestines, pancreas and liver, dysbacteriosis, the processes of absorption of nutrients necessary for a person are disrupted, which negatively affects the state of the nervous system, leading to the development of neuroses and depression. Patients experience mood swings, depression and other symptoms. Therefore, in addition to basic therapy aimed at restoring the function of the digestive organs, antidepressants must be included in the complex of treatment measures.

In addition, Afobazole is successfully used in the treatment of nicotine addiction. In many cases, attempts to quit smoking are unsuccessful, which is associated with increased emotional susceptibility to negative events. Most often, it happens that a person who quits smoking does not touch a cigarette for several days, but as soon as he gets nervous, the desire to inhale cigarette smoke becomes irresistible.

Afobazol can help such patients, since during the most difficult period of weaning off the daily dose of nicotine, it can significantly reduce exposure to stress factors, smooth out negative emotions and maintain peace of mind.

The therapeutic effect of Afobazole extends not only to this addiction. The drug is used to relieve hangover syndrome, it helps to cope with alcohol withdrawal and relieve depressive states that accompany alcohol withdrawal.

The particular effectiveness of the tranquilizer is noted in eliminating the symptoms of anxiety, depression and depression inherent in patients with diseases of the cardiovascular system and neurocirculatory dystonia. The drug is recommended for use in patients whose occupation is associated with constant stress or requires increased concentration (businessmen, students, drivers).

How to take Afobazol?

Instructions for use of Afobazole recommend taking the drug after meals. The tablets should be swallowed whole, without crushing or biting, and washed down with a small amount of liquid. The drug can be taken immediately in full dosage, rather than increasing it gradually, since the tranquilizer has a mild effect and the body does not need to get used to the medicine. You can stop taking it immediately, rather than reducing the dosage gradually. Since there is no addiction to Afobazole, there will be no negative consequences for the body. This feature of the drug makes it simple and accessible to use.

The standard regimen involves taking the drug 3 times a day. A single dose at a time is 10 mg. The maximum daily dose is 30 mg. If necessary, the doctor can increase the daily dose to 60 mg and extend the course of treatment to 3 months. The usual duration of therapy with Afobazole ranges from 2 weeks to 1 month. A second course of treatment can be prescribed after a break of 4 weeks.

If it is necessary to switch to other tranquilizers, it should be remembered that the therapeutic effect after discontinuation of Afobazole persists for 2 weeks, therefore, in order to avoid unwanted side reactions, it is recommended to take a new drug after this period. If Afobazole is prescribed after treatment with other tranquilizers, then the drug should be started 7 days after their discontinuation.

In case of an overdose of the drug, a sedative effect develops and increased drowsiness is noted. In such cases, as an emergency measure, the patient is prescribed caffeine and given symptomatic therapy.

Afobazole during pregnancy

The drug should not be prescribed during pregnancy and breastfeeding. If there is a need to take Afobazole during lactation, breastfeeding is stopped for a while, and the child is transferred to artificial formula.

Contraindications

Afobazole has few contraindications. It should not be taken for the following conditions:

1. Hypersensitivity to the components of the drug
2. Pregnancy
3. Lactation
4. Age up to 18 years
5. Lactase intolerance

Side effects

Afobazole is completely safe, its use is rarely accompanied by adverse reactions. In some cases, nausea, vomiting, and loose stools are observed. Patients with hypersensitivity may develop allergic reactions.

If adverse symptoms appear, you should stop taking the drug and consult a doctor to adjust the subsequent course of therapy.

Analogs

Afobazole has several analogues that are similar in therapeutic effect, but differ in composition. These are such popular drugs as:

• Tenoten
• Tranquilar
• Adaptol

The attending physician must decide whether to prescribe the drug or replace it with analogues. It is not recommended to replace Afobazol with analogues on your own, despite the fact that their therapeutic effect is largely identical, there are certain differences and indications for use. Let's consider this using the example of Tenoten and Grandaxin.

Tenoten is a homeopathic drug, its mechanism of action and composition are different from Afobazole, but it also has anti-anxiety and antidepressant effects, strengthens the central nervous system, improves memory and concentration. The drug can be used as a sedative and nootropic and prescribed not only to adults, but also to children. Despite the apparent advantages, most reviews indicate the rather high cost of the drug and insufficiently expressed effectiveness as disadvantages.

Grandaxin is used for the same indications as Afobazol; the drugs are practically in the same price category. The medication effectively relieves nervous tension and anxiety. At the same time, patients note that taking Grandaxin often provokes nausea, dizziness and lethargy, that is, it has many more adverse reactions.

Therefore, only an experienced specialist can choose a drug that will be effective in your case. The doctor will select the most optimal option, taking into account individual characteristics, possible contraindications and the severity of symptoms.

Afobazole, unlike other tranquilizers, is not able to enhance the narcotic effect of alcohol, so drinking alcohol during treatment with the drug will not cause negative consequences. However, drinking alcoholic beverages can significantly reduce the therapeutic effect of the drug or reduce the effect of its use to zero, since they have the opposite effect on the nervous system.

Afobazole activates its functions, and alcohol, on the contrary, causes inhibition. If the patient has cardiovascular disorders, drinking alcohol while taking Afobazole can significantly worsen the condition, and in case of neuroses, the effect of the drug will be suppressed.

Alcohol has a toxic effect on the brain, including disrupting the functions of the hypothalamus, which is responsible for the functioning of the endocrine system, so endocrine disturbances will become more pronounced and Afobazol will be unable to influence unfavorable symptoms.

At the same time, Afobazole is able to relieve a severe hangover, alleviate the psychological state and reduce mental manifestations associated with guilt and depression. A tranquilizer helps to cope with withdrawal symptoms in a short time and makes it easier to get out of this state. The auxiliary components of the drug help achieve this effect.

Thus, potato starch envelops the gastric mucosa, preventing the absorption of alcohol into the blood, microcrystalline cellulose and the substance povidone bind and remove from the body toxins formed as a result of the breakdown of alcohol. Lactose stimulates the nervous system, eliminating inhibition, magnesium stearate enhances the anti-anxiety effect of Afobazole.

Afobazole, by its type, belongs to selective non-benzodiazepine anxiolytics, and by its pharmacotherapeutic group, to tranquilizers. Unlike many other popular antidepressants, afobazole does not cause addiction, drowsiness, or muscle weakness. A distinctive advantage of the drug is also that it does not interfere with driving: attention and reaction do not decrease during the course of taking it.

The main difference from its analogues is the absence of the development of dependence and the occurrence of withdrawal syndrome when stopping the medication.

Used in the treatment of IBS

With long-term chronic diseases of the gastrointestinal tract, especially those accompanied by disruption of normal intestinal function, disorders of the human nervous system develop. Constant discomfort in the intestines: meterism, development of diarrhea syndrome, or, conversely, long-term

Afobazole packaging

Constipation depresses sick people. Conditions are created for the development of persistent neurosis and depression. At the same time, insufficiency of the pancreas and liver function, long-term intestinal dysbiosis, disrupt the processes of absorption by the digestive tract of substances necessary for the nervous system and brain, which contributes to the development of a person’s depressed state. The human psyche becomes uncontrollable, mood swings, panic attack syndrome, social phobia and other disorders occur. The consequence of chronic diseases of the digestive system, leading to impaired absorption of food, is the formation of irritable bowel syndrome (IBS). A prerequisite for complex treatment of irritable bowel syndrome, in addition to basic therapy aimed at restoring the functional state of the digestive organs (stomach, liver, pancreas, gallbladder, intestines), is the use of antidepressants such as afobazole. Such drugs help to break the cause-and-effect relationship, when a disturbance in the emotional state of a patient with IBS, a malfunction of his nervous system, themselves, in turn, lead to disruption of normal intestinal motility: the formation of diarrhea syndrome or constipation.

It will also be useful for other diseases of the digestive system that are of a psychosomatic nature, or, more simply put, that appear “on the basis of nervousness.” These are, first of all, disturbances in the functioning of the gallbladder, gastrointestinal tract and chronic gastritis and gastric ulcers.

Application

Afobazole is also used for:

• reducing anxiety;
• relieving a tense state (tearfulness, timidity, fear, insomnia);
• elimination of physical manifestations of an anxious state (cardiovascular, gastrointestinal disorders, dizziness, dry mouth).

Helps with hangover

The drug helps to cope with depression caused by hangover.

Helps quit smoking

In many cases, attempts to quit smoking are unsuccessful due to people's increased emotional sensitivity to negative or positive events in life. It happens that a person who quits smoking does not smoke for a day or another, but once you get really nervous, an irresistible desire to smoke arises. Afobazole may help such susceptible people. When quitting smoking, start a course of taking afobazole. During the period of weaning from nicotine addiction, it will significantly reduce exposure to stress and emotional sensitivity. For a more successful result in getting rid of nicotine addiction, it is necessary to limit the consumption of caffeine-containing drinks: black and green tea, coffee, energy drinks.

How to use?

The course of treatment is 3 weeks. The maximum therapeutic effect is achieved in the second week of taking the drug. A noticeable calming effect is observed somewhere on the second or third day of administration as the active substance accumulates in the body: morphodihydrochloride.

The price of a pack of afobazole is 220 rubles as of October 2011. One package contains 60 tablets in three blisters. The instructions for the drug recommend taking the drug three times a day, one tablet. The duration of the course is usually 2-4 weeks, but in some cases it is allowed to use it for up to 3 months and increase the daily dose to 60 mg, that is, up to 2 tablets at a time and three times a day (for example, to relieve hangover symptoms ).

Side effects

Despite the fact that the instructions for the drug indicate that there is no drowsiness effect, from my own experience I can say that it becomes somewhat more difficult to wake up in the morning.

Instructions

By clicking on the image below you can read the detailed official instructions for medical use of the drug Afobazole included in its packaging. To enlarge the image of the instructions, you must click again on the image that opens in the browser.

To normalize the state of the nervous system and achieve a comfortable emotional state, the most effective result from the use of afobazole is achieved when this drug is used in conjunction with the appropriate vitamin complexes. One of the requirements that vitamin complexes must meet is the content of the element magnesium. Based on my personal experience, I can recommend Panangin as the most effective and widely known such drug. It contains magnesium, which is necessary to strengthen the nervous system, as well as potassium to restore the cardiovascular system, which primarily suffers from nervous disorders.

Stressful situations await a person at every turn, and in order to put the nervous system in order, sometimes you have to resort to taking medications. Modern, popular sedatives include Afobazol. Feedback from doctors is that the drug is well tolerated by patients and does not cause addiction after long-term therapy. The dosage is calculated individually in each case by the attending physician.

"Afobazol": general information

Anti-anxiety drugs are the general name for a group of medications that affect the central nervous system. Based on their origin, they are divided into plant and synthetic.

The ranks of selective anxiolytics have been supplemented by the drug Afobazol. The instructions indicate that there are no side effects characteristic of the group of benzodeazipine tranquilizers in this drug. It has an anti-anxiety, activating effect and has a positive effect on the general condition. By taking the drug, you don’t have to worry about the body’s addiction, memory impairment, or the occurrence of “withdrawal syndrome” after completing the course of treatment.

"Afobazol" is a medicinal (psychotropic) product produced in Russia. The anxiolytic has a number of advantages compared to some antidepressants and benzodiazepine tranquilizers. The scientists who developed the drug claim that there are no negative consequences that usually accompany treatment with sedatives. "Afobazole", the composition of which does not cause an inhibitory, muscle relaxant effect, does not form drug dependence.

Clinical studies of Afobazole have confirmed its effectiveness. Both women and men aged 18 to 60 years with neurotic disorders took part in the trial. The first results of improving the emotional state and reducing anxiety were recorded already 3-10 days after starting to take the drug.

After 6 weeks of therapy, almost all patients experienced partial or complete remission. The product is recognized as absolutely safe for use in any field of medicine. Despite the free sale in pharmacies, before use you should consult a doctor to establish a diagnosis and prescribe a suitable treatment regimen.

Composition and release form

Today you can purchase a tablet form of the drug “Afobazol”. The composition of each tablet is 5 or 10 mg of the active substance fabomotizole hydrochloride (morpholinoethylthioethoxybenzimidazole). Additional components - potato starch, magnesium stearate, lactose monohydrate, povidone.

How does the drug work?

The selective axolytic in the composition of the product allows you to prevent changes in membrane-dependent receptors. This, in turn, helps reduce the level of irritability, discomfort, anxiety, and fear. Thanks to the drug, sleep is normalized, a surge of vital energy appears, and physical condition is restored.

Symptoms of somatic disorders associated with the respiratory, cardiovascular, sensory, and digestive systems eventually cease to appear and bother the patient. The result of therapy should be assessed in the 4th week of treatment, when the maximum effect of the drug "Afobazol" is achieved. Reviews from doctors indicate stabilization of blood pressure levels (stress often causes hypertension) after taking the drug. Symptoms of autonomic disorder (increased heart rate, tremors, shortness of breath, chest pain) are also reduced.

The effect of the drug lasts for 2 weeks after the end of administration. The patient ceases to feel constant fear and concern. Attacks of muscle twitching and dizziness are blocked, and attention is improved. Compared to benzodiazepines, the therapeutic effect is less pronounced.

When is Afobazol prescribed?

The use of a sedative is especially important for people suffering from a constant feeling of uncertainty, suspiciousness, and violent emotional manifestations in response to negative life situations. As part of complex therapy, it is prescribed to patients with bronchial asthma, hypertension, chronic insomnia, and oncological pathologies.

Taking Afobazole is mandatory for the following problems:

• neurasthenia and neuroses;
• systemic lupus erythematosus (autoimmune disease);
• cardiac ischemia;
• dermatological diseases (psoriasis, eczema, lichen);
• coding for alcohol addiction and smoking;
• premenstrual syndrome;
• irritable bowel syndrome;
• oncological pathologies;
• anxiety;
• cardiopsychoneurosis.

The drug can be used during periods of increased anxiety, for example before taking exams or when changing jobs. For each patient, an individual treatment regimen and dosage of the drug “Afobazol” are prescribed. Analogues of the drug contain other active ingredients, but have the most similar therapeutic effect. Only a specialist can select the optimal drug for therapy after first examining the patient.

How to take Afobazol?

The instructions for the medication are an important document that every patient should read before starting to use the drug. According to the annotation, the tablets are taken after meals. The optimal single dose is 10 mg. If necessary, the attending physician can adjust this value. Depending on the diagnosis, it varies both less and more. Drink a sedative 3 times a day at approximately the same interval of time. The maximum duration of use is 3 months, after which you need to take a break.

For a short course of treatment, you can purchase the drug in a cardboard package of 10 or 20 tablets. It is also available in cans of 50 and 100. This volume is best used if long-term therapy with Afobazol is necessary. The price starts from 280 rubles. and depends on the dosage of the active substance.

The results of using the product appear at different times. In some patients, an improvement in their emotional state is observed already on the third day of treatment, in others - a little later. The drug is well absorbed from the intestinal walls and is quickly eliminated from the body.

"Afobazol": contraindications

Despite the relative safety and non-toxicity of the components, the drug is still prohibited to be taken during pregnancy and lactation. Children under 18 years of age should not take it without a doctor's prescription. Persons who have an individual intolerance to the substances contained in it should avoid using the drug.

Some patients note the appearance of drowsiness after taking the sedative Afobazol. Reviews from doctors confirm the appearance of such symptoms only in the case of an independent increase in the recommended daily dose. If you follow the specialist's instructions, the drug helps improve concentration. Therefore, it is approved for use when it is necessary to control mechanisms.

Side effects

The development of an allergic reaction is possible if the body is intolerant to lactose, which is part of the drug "Afobazol". Overdose is rare and manifests itself in the form of significant sedation. Due to the fact that the drug is quickly eliminated from the body, this condition usually goes away on its own. Sometimes caffeine (sodium benzoate) may need to be given subcutaneously.

At the beginning of therapy, an undesirable reaction to Afobazole may occur. Side effects such as nausea and vomiting disappear after discontinuation of the drug. If symptoms persist, you should seek medical help.

Is the drug compatible with alcohol?

This question interests almost everyone who takes a sedative. The light tranquilizer Afobazol and alcohol are quite compatible. The components of the drug do not enhance the narcotic effect of ethanol, but rather, on the contrary, suppress it. Therefore, you may not feel intoxicated from a small amount of high-proof drinks. In turn, alcohol does not have the best effect on the healing process and will reduce its effectiveness.

It is not advisable to take the anxiolytic Afobazol and alcohol at the same time. The drug is often used in the treatment of withdrawal symptoms, when it is difficult for the patient to tolerate quitting alcohol or nicotine. This remedy makes it easier to endure this period. It also helps relieve hangover syndrome by “launching” the work of the central nervous system.

Interaction with other drugs

If several sedatives are used simultaneously for treatment, the effect is not always stronger. It makes no sense to take Afobazol with mild sedative medications based on medicinal herbs.

Most often, it is enough to take only Afobazol. Compatibility with other tranquilizers or nootropics will manifest itself in the form of a pronounced anti-anxiety effect. Drugs used to treat epilepsy will be more powerful.

What to replace it with?

Today, pharmaceutical companies offer a wide selection of sedative drugs of both natural and synthetic origin. If necessary, you can choose a substitute for the drug “Afobazol”. Analogues will have other active ingredients in their composition, but the therapeutic effect will be identical. Medications that can relieve anxiety and confusion syndromes include:

• "Diazepam";
• "Adaptol"
• "Phenazepam";
• "Elinium";
• "Amizil";
• "Atarax";
• "Tenoten";
• "Persen";
• "Mebix";
• "Phenibut";
• "Tranquesipam";
• "Neurofazol" (synonym for the drug "Afobazol").

Substitutes have a similar therapeutic effect, but they cannot be compared with the original remedy. The optimal remedy should be selected by the attending physician, taking into account the patient’s diagnosis and the presence of individual intolerance to the components. It is quite difficult to cope with the manifestation of neurosis on your own, because drugs can only remove the symptoms of the disease, but not solve the cause of the problem.

What do patients and doctors say?

Various life circumstances always hit the nerves and provoke panic attacks, depression, and fear of the future. Not everyone can cope with depression and hysterics. For help in such situations, you should contact a neurologist. Many specialists prefer to prescribe the “mild” tranquilizer “Afobazol” to their patients. The drug received mostly positive reviews from doctors, although some consider this to be a placebo effect, despite the huge number of people for whom the anxiolytic returned good health and a stable emotional state. Patients suffering from a constant feeling of anxiety and prone to worry say that the remedy really helps and suppresses unpleasant symptoms if the case is not advanced.

Most patients who have used the drug note a rapid therapeutic effect literally from the first day of use. Panic attacks, which are often accompanied by tachycardia and spasms in the chest and throat, stop. A calm state allows you to correctly assess the situation and find ways to resolve problems.

Negative reviews are quite rare and are mainly associated with side effects. Some patients did not feel any changes in their psychological state for the better after taking Afobazol. An overdose of an anxiolytic is practically excluded if you fully comply with the neurologist’s instructions and do not exceed the dosage.

Should I take Persen instead of Afobazole?

"Persen" is a plant-based sedative. It contains mint leaves, lemon balm, and medicinal valerian root extract. Natural origin has a positive effect on symptoms of anxiety, irritability, and promotes normal sleep without attacks of daytime sleepiness. When choosing “Afobazol” or “Persen” for treatment, it should be taken into account that the effect of the first is milder compared to a synthetic anxiolytic.

A plant-based sedative can be used in pediatrics under the strict supervision of a physician. "Persen" improves attention, calms and helps cope with insomnia. Can be prescribed in complex therapy for vegetative-vascular dystonia, withdrawal syndrome of potent medications. As a preventative measure, it is recommended during periods of constant stressful situations.

A specialist must choose between two sedatives. In milder cases, it is sometimes sufficient to take a herbal sedative. If the situation requires “serious” medications, the patient is prescribed Afobazol. Contraindications to the use of “Persen” are high blood pressure, pregnancy, children under 3 years of age and individual intolerance to the components.

"Afobazol" or "Adaptol"?

The sedative "Adaptol" belongs to the group of anxiolytics and has the same therapeutic effect as "Afobazol". Use is indicated for neuroses, emotional instability, stress of various etiologies. Helps reduce cravings for nicotine and improves tolerability of antipsychotics.

Clinical trials have confirmed the positive effect of the drug on mental activity. "Adaptol" also improves reaction speed when controlling various mechanisms and does not cause drowsiness during the day. The active ingredient of the drug is mebicar (one capsule contains 300 mg). Does not cause dependence or addiction.

The product is prohibited for use by children under 10 years of age, pregnant and lactating women. Side effects (dizziness, weakness) develop only when the recommended dose of Adaptol is significantly exceeded.

Many patients who first took Afobazol and then Adaptol noted that the sedative effect of the latter was weaker. Afobazole really has a pronounced anti-anxiety effect. He is able to cope with the symptoms of a panic attack, overcome feelings of fear and eliminate autonomic disorders (dry mouth, sudden dizziness). It makes sense to take the Latvian analogue only in mild cases, with minor neurological disorders.

Is it possible to replace Afobazol with Phenibut?

The drug "Phenibut" refers to nootropic medications derived from gamma-aminobutyric acid. Able to cope with tension, worry, anxiety. Promotes the activation of mental abilities and helps to concentrate. This occurs due to improved blood supply to brain tissue. The product is non-toxic and completely safe. It is eliminated from the body within 3 hours after administration. Despite some positive aspects of the drug, it is less well tolerated by patients and often causes undesirable consequences and addiction to the system, unlike Afobazole.

Price is of no small importance when choosing a drug, and Phenibut can easily be called an affordable medicine compared to the latest generation anxiolytic (cost is about 120 rubles). It is worth considering that during treatment with this sedative, it is prohibited to drink alcoholic beverages. Phenibut and ethanol have the same effect and inhibit the functioning of the central nervous system. Quite often, the drugs Afobazol and Phenibut are prescribed for the treatment of chronic alcoholism, when the patient suffers from memory impairment, loses interest in life, and experiences withdrawal symptoms.

Compared to Afobazol, the contraindications to the use of Phenibut are somewhat expanded. The drug, according to the instructions, is taken with caution for peptic ulcers and liver pathologies. Under strict medical supervision, a sedative is used in the treatment of children under 8 years of age. During pregnancy, the manufacturer advises against using the product, since there is no data on such studies. If there are symptoms of an overdose (drowsiness, vomiting, low blood pressure), it is necessary to urgently rinse the stomach.

Tranquilizers of different groups.

Composition Afobazol

The active substance is morphodihydrochloride.

Manufacturers

Valenta Pharmaceuticals (Russia), Pharmstandard-Leksredstva OJSC (Russia), Shchelkovo Vitamin Plant (Russia)

pharmachologic effect

Afobazole is a selective non-benzodiazepine anxiolytic.

Acting on sigma-1 receptors in nerve cells of the brain, Afobazole stabilizes GABA/benzodiazepine receptors and restores their sensitivity to endogenous inhibitory mediators.

It also increases the bioenergetic potential of nerve cells and protects them from damage (has a neuroprotective effect).

The effect of the drug is realized primarily as a combination of anxiolytic (anti-anxiety) and mild stimulating (activating) effects.

Afobazole reduces or eliminates feelings of anxiety (preoccupation, apprehension, apprehension, irritability), tension (fearfulness, tearfulness, restlessness, inability to relax, insomnia, fear), somatic manifestations of anxiety (muscular, sensory, cardiovascular, respiratory, gastrointestinal) intestinal symptoms), autonomic disorders (dry mouth, sweating, dizziness), cognitive disorders (difficulty concentrating, impaired memory).

The use of the drug is especially indicated in persons with predominantly asthenic personality traits in the form of anxious suspiciousness, uncertainty, increased vulnerability and emotional lability, and a tendency to emotional stress reactions.

The effect of the drug develops on days 5-7 of treatment.

The maximum effect is achieved by the end of 4 weeks of treatment and persists after the end of treatment for an average of 1-2 weeks.

Afobazole does not cause muscle weakness, drowsiness and does not have a negative effect on concentration and memory.

When using it, drug dependence does not form and “withdrawal” syndrome does not develop.

After oral administration, it is well and quickly absorbed from the gastrointestinal tract.

The maximum concentration of the drug in plasma is 0.130+0.073 mcg/ml; time to reach maximum concentration – 0.85+0.13 hours.

Metabolism:

• Afobazole undergoes a “first pass effect” through the liver,
• The main directions of metabolism are hydroxylation at the aromatic ring of the benzimidazole ring and oxidation at the morpholine fragment.

Afobazole is intensively distributed throughout well-vascularized organs; it is characterized by rapid transfer from the central pool (blood plasma) to the peripheral (highly vascularized organs and tissues).

The half-life of Afobazole when taken orally is 0.82+0.54 hours.

The short half-life is due to intensive biotransformation of the drug and rapid distribution from blood plasma to organs and tissues.

The drug is excreted primarily in the form of metabolites and partially unchanged in urine and feces.

Side effects Afobazole

Allergic reactions are possible.

Rarely - headache, which usually goes away on its own and does not require discontinuation of the drug.

Indications for use

Used in adults for anxiety conditions:

• generalized anxiety disorders,
• neurasthenia,
• adaptation disorders,
• in patients with various somatic diseases (bronchial asthma,
• irritable bowel syndrome,
• systemic lupus erythematosus,
• coronary heart disease,
• hypertension,
• arrhythmias,
• dermatologically,
• oncological and other diseases.

In the treatment of sleep disorders associated with anxiety, neurocirculatory dystonia, premenstrual syndrome, alcohol withdrawal syndrome, to alleviate the “withdrawal” syndrome when quitting smoking.

Contraindications Afobazole

Individual intolerance to the drug.

Galactose intolerance, lactase deficiency or glucose-galactose malabsorption.

Pregnancy, lactation period.

Children under 18 years of age.

Directions for use and dosage

Used internally after meals.

Optimal single doses - 10 mg; daily - 30 mg, divided into 3 doses during the day.

The duration of the course of use of the drug is 2-4 weeks.

Overdose

With significant overdose and intoxication, the development of sedation and increased drowsiness without manifestations of muscle relaxation is possible.

As an emergency solution, caffeine 20% solution in 1.0 ml ampoules is used 2-3 times a day subcutaneously.

Interaction

The drug does not interact with ethanol and does not affect the hypnotic effect of thiopental.

Enhances the anticonvulsant effect of carbamazepine.

Causes an increase in the anxiolytic effect of diazepam.

special instructions

The drug does not have a negative effect on driving vehicles and performing potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Storage conditions

In a dry place, protected from light, out of the reach of children, at a temperature not exceeding 25 C.

The drug is classified as an anti-anxiety drug. Effectively eliminates excessive irritability, anxiety and improves cognitive functions. It is non-toxic and does not exhibit dangerous pharmacological effects, like other drugs in this group. Not prescribed for children.

Dosage form

Afobazole is available in tablet form. The tablets may be white or have a faint creamy tint. They are made in the form of a flat cylinder with a chamfer.

Description and composition

Afobazole or Fabomotizol is a domestic drug developed as a reasonable alternative to benzodiazepine tranquilizers. The drug is classified as an antagonist:

• melatonin receptor type 1;
• melatonin receptor type 3, although only in vitro.

In addition, the drug is a selective anti-anxiety agent aimed at σ1 receptors present in the nerve endings of the GM (brain). It is distinguished from benzodiazepine drugs by a number of advantages associated with qualities that the drug does not have. A drug:

• low toxicity;
• the risk of developing withdrawal syndrome after completion of therapy is minimal;
• can be used in conjunction with other agents, without adding toxicity to them;
• does not have qualities that reduce the quality of life of patients and limit their activity (taking is not accompanied by drowsiness, lethargy, coordination disorders, or muscle relaxation);
• does not affect the cognitive functions of the GM (memory, thinking, attention, etc.).

With these advantages, the effectiveness of the drug is only slightly inferior to more “serious” tranquilizers from the category of benzodiazepines.

GABA (γ-aminobutyric acid) is the main neurotransmitter. Afobazole prevents the development of negative membrane-dependent changes in the receptors of this mediator, and does not have a sedative effect unless the medicine is taken in doses an order of magnitude higher than recommended. Thanks to this quality, the drug restores the sensitivity of the above receptors to inhibitory mediators.

In addition to the above qualities, the active substance of the drug can serve as an MAO-A.

The ability to inhibit the production of monoamine oxidase is usually not indicated in the official annotation. But those taking the medicine need to know that MAO-A, including Fabomotizol, have a number of side effects (from dry mouth, tremors and allergies to increased symptoms of anxiety).

The main components of the pharmacological action of the drug are:

• anti-anxiety;
• unexpressed activating;
• neuroprotective.

The active substance of the drug (fabomotizol in the form of dihydrochloride) protects nerve cells and helps their recovery. Each tablet contains 5 or 10 mg of active substance.

Clinical trials confirm the therapeutic effectiveness of the drug when used to treat individuals:

• suspicious;
• asthenics;
• with low self-esteem;
• prone to demonstrating psychosomatic symptoms of an anxiety disorder: pain syndrome (encephalopathy, gastralgia, cardialgia, spinal pain).

Within a week of taking the drug, it can eliminate or significantly reduce anxiety, foreboding, phobic manifestations, tearfulness and irritability. The patient regains the ability to relax. During treatment with Afobazole, combined somatic symptoms (digestive disorders, respiratory failure, sensory and cardiovascular manifestations, muscle signs of illness) decrease.

The maximum effect of taking the drug occurs in the 4th week of treatment and remains high for another 14 days after stopping treatment.

Pharmacological group

The drug is classified in the pharmacogroup of anxiolytics. This means that it has a pronounced anti-anxiety effect.

Indications for use

for adults

Afobazole has found application in the treatment of neuropsychic disorders (adaptive, cases of neurasthenia and generalized anxiety).

It is prescribed to ease withdrawal from alcohol dependence and to reduce the “withdrawal syndrome” in patients struggling with tobacco addiction.

The medication is effective in the complex treatment of PMS, sleep disorders, dystonia, IBS (irritable bowel disease). It can be used as an adjuvant for some somatic ailments:

• BA (asthma);
• SLE (lupus);
• IHD (myocardial ischemia);
• hypertension (persistent hypertension);
• arrhythmias;
• oncopathologies;
• long-term dermatological diseases.

In some cases, other diseases may be the reason for prescribing this drug, if the doctor deems it appropriate.

for children

Not applicable

Not used during these periods.

Contraindications

The main contraindications include:

• childhood (until the patient turns 18 years old);
• pregnancy and;
• intolerance to any of the components of the drug (main or auxiliary);

In case of any reactions to the medicine not described in the instructions, you should consult a doctor.

Applications and dosages

for adults

The optimal dose is 30 mg of medication per day. The daily dose is divided into 3 doses. Afobazole is taken orally after meals. Therapeutic course - 1 month

According to the doctor's decision, the course can be extended to 3 months, and the daily dose increased to 60 mg.

for children

Does not apply to under 18s

for pregnant women and during lactation

Contraindicated during the gestational-lactation period.

Side effects

Afobazole is one of those few non-homeopathic medications for which the official instructions included allergies and practically nothing else in the section on side effects. In extremely rare cases, patients report mild cephalgia that goes away on its own. There is no need to stop treatment.

Interaction with other drugs

Does not affect the absorption and activity of ethanol. Strengthens the effect as an anticonvulsant and anti-anxiety properties. Does not affect the hypnotic effect of taking Thiopental.

special instructions

Afobazole does not affect motor skills and psyche in terms of reducing their reactions. Does not interfere with driving.

Overdose

Storage conditions

During storage, the drug should not be accessible to children. It is valid for up to 3 years from the date of issue. The storage area for this product should be dark and cool. the maximum temperature at which the drug retains its medicinal properties is +25 o C.

Analogs

You can replace Afobazol with similar drugs:

1. Neurofazol is a complete analogue of Afobazol, but the medicine is produced in the form of a concentrate for the preparation of an infusion solution. Contraindications to its use are age under 18 years, pregnancy and lactation.
2. - a tranquilizer, which is a substitute for Afobazole in the clinical and pharmacological group. The drug has a nootropic and calming effect and is available in tablets. They are not suitable for persons under 18 years of age or for pregnant or lactating patients.
Not allowed in the first trimester and for women who are breastfeeding.

Price

The cost of Afobazole is on average 355 rubles. Prices range from 329 to 600 rubles.