Influenza vaccines Grippol and Grippol Plus: instructions for use and price. Affordable flu vaccine for children and adults influenza Is it possible to take influenza after an illness

  • Side effects, complications after influenza vaccination
    • What side effects may occur after receiving the flu shot?
    • Redness and swelling at the injection site. Pain at the injection site
    • Does influenza affect the ability to drive a car?
  • Prices for influenza vaccine in Russian cities
  • Reviews about influenza

    • The site provides reference information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. Consultation with a specialist is required!

    What is influenza?

    Grippol- this is domestic vaccine against the flu. It was developed and patented by Russian immunologists back in 1995. Its peculiarity is that it contains a reduced amount of viral material ( antigens), due to the inclusion of the immunostimulant polyoxidonium in its composition. This drug has been used for many years as part of the state vaccination program in Russia. Scientists are constantly working to improve the composition of this vaccine. In July 2018, a new anti-influenza vaccine, influenza quadrivalent, was registered, which is the most advanced domestic vaccine. According to the creators, it has high preventive effectiveness and safety.


    There are the following types of influenza vaccine:

    • Flu. Graft protects against 3 strains of influenza viruses, namely two type A viruses ( H1N1 and H3N2) and one type B virus grown in chicken embryos. It also contains an adjuvant ( immunostimulant) polyoxidonium.
    • Grippol plus. This vaccine is an improved analogue of influenza. It is produced without preservatives and in an individual syringe dose.
    • Grippol neo. The vaccination is an analogue of influenza plus, but the viral material for it is grown without the use of chicken embryos, on a mammalian kidney cell culture.
    • Monogrippol. The vaccine protects against one strain of influenza A virus ( H1N1). It also contains polyoxidonium.
    • Monogrippol plus. This vaccine is an improved analogue of monogrippol. It is produced without preservatives and in an individual syringe dose.
    • Monogrippol neo. The vaccination is an analogue of monogrippol plus, but the viral material for it is grown without the use of chicken embryos, on a mammalian kidney cell culture.
    • Flu is quadrivalent. The vaccine protects against 4 strains of influenza viruses, two type A viruses ( H1N1 and H3N2) and two type B viruses. It also contains polyoxidonium. It is approved for use in adults over 18 years of age.
    Influenza vaccines are produced by several Russian pharmaceutical companies. These include FSUE NPO Microgen, NPO Petrovax Pharm and others. NPO Petrovax Pharm is currently one of the most high-tech biopharmaceutical enterprises in Russia.

    What is the flu, and what danger does it pose?

    Flu is a very dangerous infection. It can spread very quickly and cause epidemics. The name of the disease comes from the French verb “to grab”, “to grasp”, which characterizes this disease as quickly transmitted and rapidly developing. The flu can occur in a lightning-fast, very severe form and cause serious complications. It begins with fever, cough, and harmless catarrhal symptoms. However, it is not the flu that is dangerous, but its complications. Millions of people die every year from complications caused by influenza. Complications of influenza affect the cardiovascular, nervous systems, lungs, kidneys, and liver. Influenza is very dangerous for elderly patients suffering from various chronic diseases, young children and pregnant women.

    Complications of influenza are the following diseases:

    • difficult to treat viral pneumonia;
    • myocarditis - inflammation of the heart muscle, pericarditis - inflammation of the tissues surrounding the heart;
    • meningitis - inflammation of the meninges, encephalitis - inflammation of the brain;
    • abortion ;
    • fetal infections in pregnant women and some others.

    What types of influenza viruses are there?

    The influenza virus was isolated in the middle of the last century. Since then, scientists around the world have been concerned about creating effective influenza vaccines. Currently, three types of influenza virus are known - A, B and C. Each of them, in turn, is divided into strains and serotypes, depending on what proteins the influenza virus contains. New strains of influenza viruses emerge every year as they constantly mutate.

    Type A viruses cause the most severe influenza epidemics. These viruses are transmitted not only from person to person, but also from animals to humans. Type B viruses are less likely to cause epidemics. However, some of them can also cause severe forms of this disease. Influenza virus type C does not cause epidemics. It is relatively safe for humans and affects only the most weakened categories of the population.
    If a person has had the flu and acquired immunity to one strain, this does not mean that the next year he will not be able to get the flu caused by another strain of influenza. Therefore, it is very important to undergo preventive vaccination against influenza with a current vaccine every year before the onset of the autumn-winter season.

    What types of flu vaccines are there?

    There are currently two types of influenza vaccines - live and inactivated. Live vaccines contain weakened influenza viruses. This type of vaccine helps to develop the most stable and long-lasting immunity to influenza. However, there are many contraindications for their use. They often cause complications and are characterized by a high likelihood of side effects. Inactivated vaccines do not contain live viruses. They contain protein material from influenza viruses. The influenza virus itself consists of an RNA molecule containing genetic information, as well as protein molecules that can be located inside the body of the virus or on its surface.

    Inactivated influenza vaccines include the following types of vaccines:

    • whole virion, containing the entire protein shell of the virus;
    • split ( split vaccines), containing envelope proteins and proteins from the internal part of the virus;
    • subunit, containing only proteins from the surface of the virus shell - hemagglutinin and neuraminidase, they lack internal proteins.

    What type of vaccine is influenza?

    Influenza is an inactivated subunit adjuvant influenza vaccine. This means that it is a highly purified vaccine with the inclusion of immunostimulants ( adjuvants). It can be monovalent, trivalent or tetravalent. The valency of the vaccine depends on the number of influenza virus antigens included in its composition. In other words, the valence of a vaccine shows how many strains of influenza viruses it protects against. An adjuvant is also added to influenza ( immunostimulant) polyoxidonium.

    Mechanism of action of the influenza vaccine. How long does the effect of this vaccine last?

    When administering the influenza vaccine, which contains influenza virus antigens - hemagglutinin and neuraminidase proteins, the human immune system begins to produce antibodies in response - proteins that destroy the infection. After influenza vaccination, antibodies appear after 8 - 12 days in 75 - 95% of vaccinated people. As a result, the person becomes immune to influenza caused by the viruses contained in the vaccine.

    In the future, if a person is attacked by such viruses, he does not get sick, since the immune system recognizes them. The antibodies produced destroy viruses, preventing them from multiplying. If a person does catch the flu, he will experience it in a mild form, without developing complications. The immunity acquired as a result of vaccination lasts for a period of 6 to 12 months. The inclusion of the immunomodulator polyoxidonium in this vaccine can significantly reduce the vaccination dose of antigens, increase immunological memory, and increase the body's resistance to other infections by strengthening general immunity.

    Efficacy of the influenza vaccine

    The composition of influenza vaccines, including influenza vaccines, is adjusted annually in accordance with the recommendations of the World Health Organization ( WHO). These recommendations are based on data from immunological laboratories from more than 90 countries. In 90% of cases, scientists’ predictions are correct, and the influenza vaccine created in this way reliably protects against strains circulating in the year in question. Typically, the composition of vaccines includes components of 3 types of viruses that are most common in the world in a given season. Influenza forms high specific immunity against influenza. However, the effectiveness of the vaccine is guaranteed in the year in which it is released. Its use in subsequent years is not recommended.

    The effectiveness of influenza vaccination is also influenced by the following factors:

    • the correct choice of the type of influenza vaccine, taking into account the characteristics of the human body - compliance of the vaccine with age, health status, the presence of chronic diseases, allergies and others;
    • qualitative examination of the patient before vaccination;
    • the patient has hidden diseases ( during the incubation period);
    • correct vaccination technique;
    • proper storage, transportation, compliance with vaccine expiration dates;
    • epidemiological situation in a particular year.

    Composition, types, release form, conditions and shelf life of the influenza vaccine

    The main component of the influenza vaccine is biomaterial ( antigens) 1 or 2 influenza viruses, which is produced in Holland. This vaccine also contains the immunostimulant polyoxidonium. This vaccine may contain preservatives. Vaccine viruses are often grown in chicken embryos. Therefore, traces of chicken protein may be present in the vaccine. The remainder of the drug consists of excipients. The content of antigens in influenza is 3 times less compared to the values ​​recommended by WHO. The antigenic composition of influenza is adjusted annually in accordance with WHO recommendations for the current epidemic season.


    Composition of the influenza vaccine

    Grippol is a suspension for intramuscular and subcutaneous administration. It is a colorless or slightly yellowish transparent liquid. This drug is packaged in 0.5 ml ampoules or syringes ( 1 dose). There can be 1, 5 or 10 pieces in a cardboard box. Packs of 5 or 10 doses are intended for use in healthcare settings.

    1 dose ( 0.5 mlH1N1 strainstrain H3N2) - 5 mcg, influenza virus type B hemagglutinin - 11 mcg and polyoxidonium 500 mcg. This vaccine contains the preservative thiomersal ( merthiolate) and traces of chicken protein.

    Composition of the vaccine influenpol plus

    Grippol Plus is a suspension for intramuscular and subcutaneous administration. It is a colorless or yellowish slightly opalescent liquid. This drug is packaged in disposable syringes or in ampoules or bottles of 0.5 ml ( 1 dose). There may be 1, 5 or 10 pieces in a package. Packs of 5 or 10 doses are intended for use in healthcare settings.

    1 dose ( 0.5 ml) the drug contains 3 antigens of influenza viruses. Namely, hemagglutinin of the influenza A virus ( H1N1 strain) - 5 mcg, hemagglutinin of influenza virus type A ( strain H3N2) - 5 µg, influenza virus type B hemagglutinin - 5 µg and polyoxidonium 500 µg in phosphate-buffered saline. This preparation contains traces of chicken protein, but does not contain preservatives.

    Composition of the vaccine influenpol neo

    Grippol neo is a suspension for intramuscular and subcutaneous administration. It is a colorless or yellowish slightly opalescent liquid. This drug is packaged in ampoules of 0.5 ml ( 1 dose), which are placed in blister packaging and in a cardboard box with instructions for use.

    1 dose ( 0.5 ml) the drug contains 3 antigens of influenza viruses. It includes the hemagglutinin of the influenza A virus ( H1N1 strain) - 5 mcg, hemagglutinin of influenza virus type A ( strain H3N2) - 5 µg, influenza virus type B hemagglutinin - 5 µg and polyoxidonium 500 µg in phosphate-buffered saline. The vaccine does not contain preservatives or traces of egg white ( ovalbumin).

    Composition of the vaccine influenpol quadrivalent

    Grippol quadrivalent is a solution for intramuscular and subcutaneous administration. It is a colorless or yellowish slightly opalescent liquid. This medication is supplied in single-use glass syringes of 0.5 ml ( 1 dose) or in 5 ml bottles ( 10 doses). A cardboard box can contain 1, 5 or 10 syringes, pre-packaged in a strip packaging. The vaccine, packaged in vials, is packaged in cardboard packs of 1, 20 or 50 vials.

    1 dose ( 0.5 ml) the drug contains 4 influenza virus antigens. It contains hemagglutinin from the influenza A virus ( H1N1 strain) - 5 mcg, hemagglutinin of influenza virus type A ( strain H3N2) - 5 mcg, hemagglutinin of influenza virus type B ( Yamagata line) – 5 mcg, hemagglutinin of influenza virus type B ( Victoria line) – 5 µg and polyoxidonium 500 µg in phosphate-buffered saline. This preparation contains traces of chicken protein. The preservative thiomersal is contained only in the vaccine packaged in 5 ml bottles ( 10 doses).

    Storage rules and shelf life of the influenza vaccine

    This vaccine is available with a doctor's prescription. The drug should be stored out of the reach of children, protected from light, in the refrigerator at a temperature of 2 - 8 degrees, without freezing. If the drug has been frozen, it cannot be used. It should be transported in light-proof containers at the same temperature. The vaccine can be kept at temperatures up to 25 degrees for no more than 6 hours. The shelf life of the vaccine is 12 months.

    Is the presence of a preservative in the influenza vaccine dangerous?

    Thiomersal or merthiolate is a substance containing mercury that has antibacterial and antifungal effects. It is added to influenza as a preservative to preserve the quality of the drug during the shelf life. Unfortunately, mercury in large doses is highly toxic and can cause mutations and tumors. The vaccine contains it in a microdose and is therefore safe. However, to prevent negative effects on the child’s body when vaccinating children, it is better to use the influenza vaccine without the preservative thimerosal.

    What kind of substance is polyoxidonium, and why is it present in the influenza vaccine?

    Polyoxidonium or azoximer bromide is a medicine created by Russian immunologists. It has been approved for use since 1996. This medicine is an immunomodulator. It normalizes the immune response of the human body. Polyoxidonium is also an antioxidant, detoxicant, has an anti-inflammatory effect, and increases the body's resistance to infections. The presence of polyoxidonium in the vaccine makes it possible to reduce the amount of influenza virus antigens in influenza vaccines to 5 mcg, instead of the WHO recommended 15 mcg. In this drug, polyoxidonium plays the role of an adjuvant. It provides a more pronounced immune response to antigens, increases the rate of development and duration of immunity to influenza viruses, and increases the body's resistance to respiratory infections ( ARVI).

    What composition should the flu vaccine have in 2018–2019?

    In February 2018, a WHO meeting was held in Geneva, Switzerland on the composition of vaccines against influenza viruses for the 2018–2019 season in the Northern Hemisphere. Based on the decision of this meeting, influenza vaccines in 2018-2019 must contain antigens of 2 influenza A viruses ( H1N1 – Michigan, H3N2 – Singapore) and 2 type B viruses ( Victoria Line, Yamagata Line). The new vaccine, influenza quadrivalent, fully meets these requirements.

    Influenza vaccine analogues

    Vaccines from different manufacturers contain the same antigens of influenza viruses approved by WHO for the current season. However, they all may differ in the degree of purification, the content of preservatives, the frequency of side effects and allergies. All this affects a person’s well-being after vaccination and the durability of the developed immunity.


    The following vaccines are analogues of influenza:
    • Vaxigrip ( France);
    • begrivak ( Germany);
    • ultrix ( Russia);
    • influvac ( Netherlands);
    • Agrippal S1 ( Italy);
    • soviflu ( Russia) and some others.
    Prices for influenza vaccines are affordable. Imported vaccinations are somewhat more expensive, Russian ones are cheaper. Citizens of Russia who are at risk can receive free influenza vaccination at the place of registration or at work, with domestic vaccines specially provided for this purpose, which include influenza. If a person decides to purchase an influenza vaccine on his own, it is better to consult a doctor before purchasing it to avoid intolerance and side effects.

    Vaxigrip and influenza

    Vaxigrip is a split vaccine ( split vaccine). It is produced in France. The day vaccine is considered one of the safest drugs in the world. It does not contain preservatives. During the manufacturing process of the vaccine, its components undergo multi-stage purification and quality control. The drug is available in doses for children and adults.

    Begrivak and influenza

    Begrivac is a split vaccine. It is produced in Germany. This drug shows the highest efficiency among all existing split vaccines. Protective antibodies are produced in 100% of people who are vaccinated. It is well tolerated and practically does not cause adverse reactions or complications.

    Ultrix and Grippol

    Ultrix is ​​a split vaccine. It is produced by the domestic company Microgen. It is analogous to imported vaccines. Contains the amount of antigens recommended by WHO - 15 mcg of three strains of influenza viruses. The vaccine may contain a preservative, which limits its use in children and pregnant women. Despite this, the Ultrix vaccine is considered one of the best domestic vaccines.

    Influvac and influenza

    Influvac is a trivalent inactivated subunit influenza vaccine. Produced by a Dutch pharmaceutical company. It contains 15 μg of antigens of viral strains A( H1N1), A( H3N2) and V. Influvac does not contain preservatives, so it is approved for use from 6 months of age. The drug has been used for many years and has earned the trust of patients and doctors. The vaccine is considered one of the most popular in the CIS countries. It is recommended for flu vaccination in children and people with chronic diseases.

    Agrippal and grippol

    Agrippal is a trivalent inactivated purified subunit vaccine produced in Italy. Agrippal does not contain mercury preservatives, is highly purified, and is therefore recommended for use in more than 40 countries around the world for the prevention of influenza in children, pregnant women and adults from 6 months.

    Sovigripp and influenza

    Sovigripp is a trivalent inactivated subunit adjuvant influenza vaccine. It is produced by the Russian pharmaceutical company Microgen. Sovigripp is produced with and without a preservative. Like the influenza vaccine, it contains the adjuvant sovidone, which increases its immunological properties. The drug without a preservative is approved for use in children over 6 months and pregnant women. The vaccine with a preservative is used in people over 18 years of age.

    Ultravac, Gripvac and Grippol

    Ultravac is a live nasal vaccine produced by the domestic company Microgen. It is produced in children's and adult forms. It is injected into the nasal passages with a special dispenser and used in children from 3 years of age, in the absence of any contraindications and various types of allergies.

    Grippovac is a whole-virion vaccine, which is produced by a domestic enterprise for the production of bacterial preparations. It contains attenuated, whole, purified influenza virus. The drug may cause adverse reactions. It is prescribed to people only in the absence of any contraindications and allergies. Its main advantage is accessibility and low cost.

    Indications and contraindications for the use of the influenza vaccine

    For many years, influenza has been offered by government medical institutions as a free preventative against influenza. Anyone can get this vaccination. Flu vaccination is not mandatory for all Russian citizens. However, doctors ask everyone to get vaccinated to protect themselves and others from this infection. In particular, people for whom the flu can cause serious complications, including death, need to be vaccinated. Vaccination is also necessary for children, pregnant women and workers in certain professions, as they have an increased risk of contracting the flu.


    Doctors strongly recommend vaccinating adults and children from the following risk groups:
    • if a person has diseases, developmental defects, dysfunctions of the central nervous system;
    • in the presence of diseases, pathologies of the cardiovascular system;
    • in the presence of diseases of the blood and hematopoietic organs;
    • in the presence of kidney disease;
    • in the presence of respiratory diseases;
    • people prone to frequent colds;
    • patients in a state of immunodeficiency ( HIV, after chemotherapy and others);
    • for diabetes mellitus of any type;
    • people with metabolic diseases, autoimmune diseases, allergic diseases ( except for an allergy to chicken protein);
    • people living in hostels, nursing homes and others;
    • military personnel, police officers;
    • people working in public, crowded places, transport - sellers, waiters, flight attendants and others;
    • health workers;
    • people working closely with children;
    • children attending preschool, general education institutions, clubs and other public places;
    • agricultural workers, livestock farmers and others.

    Is flu vaccination included in the national vaccination schedule, and who should receive it? Is influenza used for this purpose?

    In Russia, influenza vaccination is included in the national vaccination calendar. It is carried out in public medical institutions ( clinics and others) in the fall or early winter, before the onset of a predicted influenza epidemic. For this purpose, Russian-made vaccines are used, which include influenza.

    According to the national vaccination calendar, mandatory influenza vaccination is provided for the following categories of the population:

    • children from 6 months;
    • students of grades 1–11;
    • students studying in the vocational education system, university students;
    • adults working in medical and educational organizations, in transport, in the public utilities sector;
    • pregnant women;
    • people over 60 years of age;
    • persons subject to conscription for military service;
    • people with chronic diseases ( pathology of the lungs, cardiovascular system, metabolic disorders and obesity).

    At what age can you get the flu vaccine?

    The influenza and influenza plus vaccines can be administered to children from 6 months of age, as well as to adolescents and adults without any age limit. Influenza neo vaccination can be performed on children from 3 years of age and older people. The new 2018 vaccine, influenza quadrivalent, can only be used in people over 18 years of age.

    Is it possible to refuse a flu shot? Is the influenza vaccine mandatory?

    WHO calls vaccination the only effective way to protect against influenza. Mass vaccination is an obstacle to influenza epidemics in cities and towns. The Russian state has made this procedure free for everyone. Regardless of whether a person is included in the group of people subject to mandatory flu vaccination or not, flu vaccination is carried out only on the basis of his voluntary, independent decision.

    No one can force either an adult or a child to be vaccinated. A person can also refuse a free vaccination, for example, influenza, and purchase the drug for vaccination that he considers the most effective. A person has the right to choose the vaccine, time, place and method of vaccination. The state gives the opportunity to Russian citizens announced in the vaccination calendar to protect themselves against the flu for free. Everyone makes their own decision about whether to take advantage of this opportunity or not. There will be no negative consequences if you refuse. Refusal to vaccinate means you risk getting sick yourself and infecting those around you.

    Can a child attend kindergarten if he has not received the flu shot?

    It is very important to vaccinate children against influenza before the onset of the epidemiological season, which comes to Russia in December and can persist throughout the spring months. Children suffer from this disease especially hard. They often experience serious complications - pneumonia, meningitis, the heart, kidneys, and other organs and systems are affected. Therefore, parents should not take flu vaccinations lightly or negatively.

    No one can prohibit a child from attending kindergarten if they refuse to get a free vaccination, for example, influenza. However, leaving a child unprotected from the flu is also wrong. In this case, parents can choose another, more effective and safe vaccine at their discretion. It is also necessary to choose the right time for vaccination when the child is healthy. He should not have a cold, suffer from an intestinal disorder or other ailment. To reduce the load on the immune system and prevent complications, it is advisable not to combine a child’s flu vaccination with vaccination against other diseases.

    Is it possible to vaccinate with influenza during pregnancy or breastfeeding?

    Influenza vaccination can be carried out during pregnancy. It is even recommended to do this, since during pregnancy women's immunity is often greatly reduced. Experimental studies have shown that the influenza vaccine does not have a negative effect on the embryo or fetus. The safest time for vaccination is considered to be the second and third trimester of pregnancy.

    For vaccination of pregnant women, you should choose the drug influpol without a preservative. If a woman has chicken protein intolerance, this factor should also be taken into account. The final decision to vaccinate a pregnant woman should be made by a doctor on an individual basis, taking into account the risks and contraindications.

    Breastfeeding is also not a contraindication for vaccination. After vaccination, antibodies against influenza pass into breast milk, and the baby also receives protection. Therefore, vaccination of infants begins at 6 months, when the share of mother's milk in the child's diet gradually decreases or stops altogether.
    For vaccination of pregnant women and nursing mothers, the most effective and safe vaccines are influenza plus and influenza neo.

    Contraindications to the use of the drug Grippol

    This drug has absolute ( vaccination should not be done under any circumstances), relative ( vaccination is given at the discretion of the doctor) and temporary ( vaccination is carried out after recovery or during remission) contraindications. To ensure that this vaccine does not cause complications and has a protective effect, you must be examined by a doctor before using it. It is recommended to get tested first. At your appointment, you should tell the doctor about chronic diseases, allergy episodes, and ailments at the time of the examination ( If there are any), as well as medications that a person takes.

    Absolute contraindications for vaccination with influenza are:

    • hypersensitivity to previous administration of influenza vaccine ( generalized allergic reactions, anaphylactic shock);
    • allergy to chicken protein and vaccine components;
    • age up to 6 months;
    • pregnancy in the 1st trimester;
    • age up to 3, 18 years in case of using Grippol Neo or Grippola Quadrivalent.
    Relative contraindications for flu vaccination are:
    • diseases of the endocrine system ( diabetes mellitus, hypothyroidism and others);
    • diseases of the nervous system ( multiple sclerosis, epilepsy, brain tumors and others);
    • chronic diseases of the respiratory system ( obstructive bronchitis, bronchial asthma);
    • recovery period after suffering an acute respiratory or other disease;
    • tendency to various allergic reactions ( vaccination is accompanied by the use of antihistamines or corticosteroids).
    Temporary contraindications for influenza vaccination are:
    • acute febrile conditions ( );
    • presence of acute diseases ( vaccination is carried out after recovery);
    • exacerbation of chronic diseases ( vaccination is carried out during remission);
    • mild ARVI, acute intestinal diseases ( vaccination is carried out after the temperature has normalized);
    • pregnancy and breastfeeding ( for some types of influenza vaccine).
    In case of poisoning, respiratory infections or other ailments, this vaccination should be postponed for a period of 5 to 7 days. If the disease is more serious, then this vaccination can be done at least a month after recovery. If a patient has a chronic disease, vaccination with this drug can only be done with the permission of a doctor during the period of remission.

    Instructions for use of the drug influenpol

    The effectiveness of influenza vaccination depends on many aspects. A very important factor is how correctly the vaccination procedure was carried out. In Russia in 2018 - 2019, the vaccination campaign is carried out from September 4 to December 29. The peak of an influenza epidemic usually occurs in January–February. Vaccination done within the specified time frame provides reliable protection against this infection throughout the winter. Protection against influenza extends even into the spring months. It is important that this vaccination is given in a certified medical facility, by qualified medical personnel, in strict compliance with the instructions for use of this drug.


    In order for vaccination to take place without complications, and to develop lasting immunity to the flu, before this vaccination you should take tests, undergo an examination, and consult with therapist ( sign up) or pediatrician ( sign up) . Flu vaccination is carried out upon the direction of a doctor in public and private medical institutions. Children under 15 years of age can receive this vaccination only with the consent of one of his parents or his legal representative. Children over 15 years of age and adults independently decide on routine preventive vaccination. Parents are allowed to be present when children are vaccinated. They calm and support young patients during the procedure and monitor their condition after vaccination. If complications occur, parents immediately inform the doctor.

    How to choose the right type of influenza vaccine?

    When choosing the type of influenza vaccine, you should be guided by the patient’s health status at the time of vaccination, taking into account his individual characteristics. His age, the presence or absence of chronic diseases, allergic reactions and other characteristics of his body. In Russia, in 2018 - 2019, in public clinics, children and adults are vaccinated against influenza free of charge with domestic drugs influnpol, sovigripp, and ultrix. In some clinics and private clinics you can purchase foreign vaccines that are of higher quality. In any case, before vaccination, it is necessary to check that the vaccine will be released this year. The instructions for the drug should state that the influenza virus strains have been updated in accordance with WHO recommendations.

    Is it possible to get the flu vaccine for free?

    This vaccination is provided free of charge, at the expense of budgetary funds, to people from risk groups announced in the 2018 national preventive vaccination calendar. Namely, children from 6 months, people over 60 years of age, students, military personnel, teachers, health workers, pregnant women, people with chronic diseases and in some other cases. The rest need to purchase this drug at the pharmacy and get vaccinated at the clinic at their own expense. An option is possible when the patient buys the vaccine at the clinic and pays for the procedure. Some enterprises enter into contracts with medical institutions to vaccinate their employees and pay them for this procedure.

    When is the best time to get a flu shot?

    The optimal time to start flu vaccination is September or October. It is better to get vaccinated before mid-November. In this case, the person develops the necessary immunity by the beginning of the epidemic season. When vaccinated at a later date or at the height of an epidemic, the risk of getting vaccinated during a hidden ( incubation) period of this disease.

    Who and where vaccinates with the drug influenza?

    This vaccination can be performed at any medical institution licensed to conduct vaccinations. It can be done in public clinics, commercial clinics, and immunological centers. Vaccinations are performed in a vaccination room by certified medical personnel. These rooms must be equipped with the necessary equipment and medications to carry out anti-shock measures and relieve an allergic anaphylactic reaction. After vaccination, the patient must be under medical supervision for 30 minutes.

    After vaccination, a certificate is issued, which records the name of the flu vaccine, series, number, date of vaccination, name of the medical institution, and the presence of adverse reactions. When vaccinations are carried out in medical centers, the quality of the vaccine is guaranteed. If the patient purchased the vaccine independently from a pharmacy, the doctor has the right to refuse to administer it, since he has no guarantee of its correct storage and transportation. If these conditions are not met, the vaccine may deteriorate. When this drug is administered to a person, complications may occur or the vaccine may not be effective.

    What actions are performed before administering the influenza vaccine?

    Before use, this vaccine is removed from the refrigerator, warmed to room temperature and shaken.

    It is prohibited to use the influenza vaccine in ampoules, vials or syringes in the following cases:

    • if the integrity or labeling of the drug is violated;
    • when the color or transparency of the drug changes;
    • when the expiration date has expired;
    • if the requirements for storage conditions of the drug are violated.
    The vaccination procedure must be carried out in strict compliance with the rules of asepsis and antiseptics. The drug cannot be stored in an opened ampoule or bottle. The vaccine remaining after administration must be destroyed.

    Before vaccination with influenza, perform the following steps:

    • before opening, the ampoule knife, ampoule neck or bottle stopper is wiped with cotton wool moistened with 70% ethyl alcohol;
    • open the ampoule or pierce the rubber stopper of the bottle with a needle;
    • draw the vaccine into a disposable syringe;
    • remove excess air from the syringe;
    • wipe the skin at the injection site with alcohol;
    • Before vaccinating small children, first remove half the contents of the syringe by pressing the plunger to the special mark marked on the body of the syringe.

    Where is the influenza vaccine administered?

    This influenza vaccine is administered to patients intramuscularly. For adults and children over 3 years of age, the vaccination is performed in the upper third of the outer surface of the shoulder, for children under 3 years old - in the anterior outer surface of the thigh. This drug should not be administered intravenously.

    What is the schedule for vaccination with the drug influenza?

    Influenza vaccination of children over 3 years of age and adults without age restrictions is carried out with a single vaccination with a dose of 0.5 ml in the autumn months. Children from 6 months to 3 years are vaccinated twice with a dose of 0.25 ml, with an interval of 4 weeks between vaccinations. If a child was vaccinated against influenza in the previous season, he is given one vaccination in a dose of 0.5 ml. For patients with immunodeficiency conditions, this vaccine is administered twice in a dose of 0.5 ml with an interval between vaccinations of 4 weeks.

    Is revaccination with influenza vaccine required?

    Immunity from this vaccine lasts for a year. Viruses are constantly mutating. At the same time, new strains are constantly being formed. As a result, the human body almost never encounters the same versions of viruses. Immunity from influenza is short-lived and unstable. Therefore, it is necessary to carry out annual revaccination against influenza virus strains common in a given season. To do this, the composition of this vaccine is updated before the start of each influenza season.

    How to prepare for vaccination with influenza drug?

    Immediately before vaccination with this drug, you must undergo a medical examination. The doctor will measure body temperature and assess the person’s general condition. If the temperature is above 37 degrees, vaccination will have to be postponed. Also, vaccination is not carried out if a person does not feel well. Namely, if he has a stomach ache or a sore throat, he coughs or there are rashes on his body, as well as other symptoms of malaise. Before vaccination, a person must feel well, which must be confirmed by a medical examination. Other preparatory measures in the form of taking vitamins and antiallergic drugs are not required for vaccination in a healthy person.

    When planning vaccination with the drug influenza, it is recommended to take the following measures:

    • take general laboratory tests and consult a doctor in advance;
    • a few days before vaccination, do not visit crowded places so as not to become infected with any viral infection and not get vaccinated during the incubation period;
    • a few days before vaccination, eliminate allergens from food and do not try new foods.

    What should you not do after receiving the flu shot?

    Vaccination is not a disease, therefore, in the absence of side effects from vaccination, a person can and should lead his normal lifestyle. He can go to work, do household chores, go for walks, and meet friends. However, in order for the immunization process to proceed without complications, you should be more careful and attentive during the 2 weeks while immunity from influenza is developing.
    • avoid hypothermia, including swimming in cool water, hardening;
    • do not take a hot bath;
    • avoid excessive emotional and physical stress;
    • do not drink alcoholic beverages;
    • do not consume new foods or those that may cause allergies;
    • Avoid or limit your stay in places with large crowds of people - cafes, shopping centers.

    Flu and strengthening the immune system

    Influenza forms specific immunity against influenza for a year. However, it is necessary to constantly maintain the body's defenses at a high level in order to resist a variety of infections. To do this, there are non-medicinal ways to strengthen the immune system.

    To maintain a high level of immunity you need to:

    • eat well, eat plenty of fruits and vegetables rich in vitamins and minerals;
    • lead an active lifestyle, play sports;
    • get regular and complete rest;
    • toughen up and often walk in the fresh air;
    • ventilate the premises and carry out wet cleaning of the premises;
    • during epidemics - avoid contact with infected people and others.

    Side effects, complications after influenza vaccination

    Influenza vaccination is well tolerated and does not cause complications or side effects when it is performed correctly, in accordance with the instructions for use. Before vaccination, a person must undergo a medical examination and feel well. The injection technique also affects how the patient will tolerate the vaccine. The success of vaccination also depends on the quality of the drug. Before use, it must be properly stored and transported and not expired.


    However, sometimes side effects and complications still occur, even if all necessary precautions are taken. The human body may react unpredictably to a vaccine, even if such reactions did not occur with previous vaccinations. Before vaccination, a person must be informed about the phenomena that may occur after vaccination. The patient should be under medical supervision for another 30 minutes after vaccination. Within 1–2 days after vaccination, you should be especially attentive to your well-being. And if a sharp deterioration of the condition occurs, you must immediately consult a doctor.

    What side effects may occur after receiving the flu shot?

    After vaccination, a person may experience local and systemic reactions. These reactions are temporary and usually go away on their own within 1 to 2 days.
    Local reactions are pain, swelling, thickening, redness at the injection site. Systemic reactions are allergies, headache, weakness, fever, muscle pain and joint pain, runny nose, sore throat, cough and some others. Allergies can manifest as minor rashes at the injection site, on the body, or severe forms - Quincke's edema, anaphylactic shock.

    Allergic reaction to influenza

    To prevent allergies from occurring after vaccination with this drug, it is very important to tell your doctor if you have had any food or drug allergies in the past. Patients suffering from bronchial asthma also have an increased chance of developing allergic reactions after vaccination.

    An allergy to this vaccine can develop quickly or slowly. Very rarely, it quickly manifests itself as Quincke's edema or anaphylactic shock. More often it appears as an itchy rash near the injection site. The rash may appear after some time in other places on the human body. If it occurs, you should take an anti-allergy drug ( for example, suprastin). For more severe forms of allergies, it is necessary to urgently call an ambulance.

    It should be noted that in the history of the drug influenpol there was an episode of a massive severe allergic reaction in 9 Russian regions. Patients experienced swelling of the larynx, rapid heartbeat, and difficulty breathing. In November 2006, approximately 1 million doses of the influenza vaccine were withdrawn from circulation due to 68 cases of severe allergic reactions to the drug.

    Increase in temperature after influenza vaccination

    A slight increase in temperature, headache, weakness, and muscle pain are short-term symptoms that occur in response to vaccination. This reaction is considered normal and should not cause concern to the patient receiving this vaccination. This reaction in most cases goes away within 1 - 2 days and does not require medication. However, to alleviate it, you can take ibuprofen or paracetamol. If your health after vaccination has not improved after 3 days or even worsened, you should consult a doctor, as this condition may no longer be related to vaccination.

    Runny nose, cough after flu shot

    Cough and runny nose are symptoms of flu, colds and other respiratory diseases. The appearance of these signs after vaccination with the drug influenza is a coincidence and can be caused either by a cold or by infection with acute respiratory infections or influenza from others. A person could have picked up these infections at the clinic where vaccination was performed. Unfortunately, in medical institutions there are constantly many people with various infections from which one can become infected through airborne droplets, including influenza.

    Redness and swelling at the injection site. Pain at the injection site

    The appearance of a local inflammatory reaction at the injection site is observed quite often after vaccination. This inflammation should not frighten a person, since it is normal and is caused by the reaction of the immune system to the introduction of foreign agents. Leukocytes, macrophages and other cells secrete various substances that cause inflammation. It is manifested by redness, pain at the injection site, swelling and thickening. After some time, these symptoms go away on their own.

    Flu and alcohol

    After receiving the flu shot, it is not recommended to drink alcohol, as alcohol weakens the immune system. As a result, the body's immune response to the vaccine may not be strong enough, and acquired immunity will be weak and short-lived. Therefore, doctors recommend avoiding drinking alcohol during the period of immunity formation after vaccination.

    Does influenza affect the ability to drive a car?

    When performing this vaccination, in accordance with the manufacturer's recommendations, a person should not experience serious ailments that would prevent him from driving a car or performing other activities. This drug does not reduce attention, does not reduce reaction speed, and does not affect a person’s ability to drive a car or use other machinery.

    Prices for influenza vaccine in Russian cities

    Flu vaccination with influenza is free of charge, since this drug is recommended as an official drug within the national vaccination calendar. After contacting your family doctor, if there are indications and no contraindications, he will give a referral for this vaccine. Unlike imported flu vaccines, you do not need to purchase this drug yourself. However, when visiting private clinics, the flu vaccination service may have a certain cost, depending on the pricing policy of the institution. Grippol can also be purchased in pharmacies, and it is affordable relative to foreign taxes.

    Prices for influenza in cities of the Russian Federation

    City

    Cost of drugs

    Grippol Plus,

    0.5 ml)

    Grippol Neo,

    suspension for intramuscular administration, 1 dose ( 0.5 ml)

    Moscow

    167 rubles

    250 rubles

    Saint Petersburg

    175 rubles

    Krasnodar

    138 rubles

    228 rubles

    Ekaterinburg

    149 rubles

    239 rubles

    Ufa

    259 rubles

    Voronezh

    148 rubles

    240 rubles

    Novosibirsk

    177 rubles

    Krasnoyarsk

    166 rubles

    275 rubles

    Rostov-on-Don

    235 rubles

    Chelyabinsk

    159 rubles

    249 rubles

    Do I need a prescription to buy the influenza vaccine?

    Grippol is sold in most pharmacies in the Russian Federation. To purchase it, you must have a prescription for the drug with a doctor’s stamp, issued on a special form. It should also be taken into account that vaccination can only be carried out by qualified medical personnel. Using the vaccine on your own can lead to serious complications and side effects.

    One immunizing dose (0.5 ml) contains

    active substances:

    influenza virus type A allantoic antigen:

    A/Michigan/45/2015 (H1N1)pdm09-like….……5 µg hemagglutinin

    A/Hong Kong/4801/2014 (H3N2)-like…………….. 5 µg hemagglutinin

    influenza virus type B allantoic antigen

    B/Brisbane/60/2008-like...……………………….5 mcg hemagglutinin

    polyoxidonium® lyophilisate for preparation

    dosage forms and vaccines………………………...500 mcg.

    excipient – ​​phosphate-buffered saline solution up to 0.5 ml.

    Description

    Colorless or yellowish, slightly opalescent liquid.

    Pharmacotherapeutic group

    Vaccines. Antiviral vaccines. Influenza vaccines. Influenza virus - inactivated, split vaccine (split) or surface antigens.

    ATX code J07BB02

    Pharmacological properties

    Pharmacokinetics

    Pharmacokinetic evaluation is not required for vaccines

    Pharmacodynamics

    Grippol® plus belongs to the class of subunit vaccines for the prevention of influenza, containing inactivated surface antigens (hemagglutinin (HA), neuraminidase (NA)) of influenza viruses type A and B grown in chicken embryos.

    Seroprotection is usually achieved within 2-3 weeks. The duration of post-vaccination immunity to homologous strains or strains close to vaccine strains may vary, but is usually 6-12 months.

    Immunobiological properties

    The vaccine causes the formation of a high level of specific immunity against influenza. The protective effect after vaccination, as a rule, occurs after 8-12 days and lasts up to 12 months, including in elderly people. Protective titers of antibodies to influenza viruses after vaccination of people of different ages are determined in 76-95% of vaccinated people.

    The inclusion of the immunomodulator Polyoxidonium, which has a wide range of immunopharmacological effects, in the vaccine preparation ensures an increase in the stability and immunogenicity of antigens, increases immunological memory, significantly reduces the vaccination dose of antigens (by 3 times), and increases the body's resistance to other infections due to the correction of the immune status.

    Indications for use

    Specific prevention of influenza in children starting from 6 months of age, adolescents and adults without age restrictions.

    Contingents subject to vaccination. The vaccine is especially indicated:

    1. For people at high risk of complications from influenza:

    Over 60 years old; preschool children, schoolchildren;

    Adults and children who often suffer from acute respiratory infections, suffering from chronic somatic diseases, including: diseases and malformations of the central nervous, cardiovascular and bronchopulmonary systems, bronchial asthma, chronic kidney diseases, diabetes mellitus, metabolic diseases, autoimmune diseases, allergic diseases (except allergy to chicken proteins); chronic anemia, congenital or acquired immunodeficiency, HIV-infected;

    2. Persons whose occupation has a high risk of contracting influenza or infecting others with it:

    Health workers, employees of educational institutions, social services, transport, trade, police, military personnel, etc.

    Directions for use and doses

    The vaccine is administered intramuscularly or deep subcutaneously!

    Do not administer intravenously!

    Vaccination is carried out annually in the autumn-winter period. Vaccination is possible at the beginning of an epidemic rise in the incidence of influenza.

    For children over 3 years of age, adolescents and adults, the vaccine is administered intramuscularly or deeply subcutaneously into the upper third of the outer surface of the shoulder (deltoid muscle), and for younger children - intramuscularly into the anterolateral surface of the thigh.

    Children from 6 to 35 months inclusive, 0.25 ml twice with an interval of 3-4 weeks.

    For children over 36 months and adults, the vaccine is administered once in a dose of 0.5 ml.

    For children who have not previously had influenza and have not been vaccinated, the vaccine can be administered twice with an interval of 3-4 weeks.

    For patients with immunodeficiency and receiving immunosuppressive therapy, the vaccine can be administered twice, 0.5 ml, with an interval of 3-4 weeks.

    To immunize children for whom the administration of 0.25 ml (1/2 dose) of the vaccine is indicated, it is necessary to remove half the contents of the syringe by pressing the plunger to the special mark marked on the syringe body, or to the red mark on the edge of the label, and inject remaining 0.25 ml.

    Instructions for handling the disposable single-dose syringe (syringe-dose)

    Before use, keep the vaccine at room temperature and shake the syringe immediately before injection. Remove the protective cap from the needle and remove air from the syringe by holding it in a vertical position with the needle up and slowly pressing the plunger.

    Side effects

    The vaccine is a highly purified drug and is well tolerated by children and adults. The frequency of side effects is determined according to the following criteria: very often (≥ 1/10), often (≥ 1/100 to< 1/10), нечасто (≥ от 1/1000 до < 1/100), редко (≥ 1/10000 до < 1/1000), очень редко (< 1/10000).

    Rarely, reactions such as pain, swelling and redness of the skin may develop at the injection site.

    Very rarely, individuals may experience general reactions in the form of malaise, headache, fever, slight runny nose, sore throat. These reactions usually disappear on their own after 1-3 days.

    Extremely rarely, as with any other vaccination, allergic reactions, myalgia, neuralgia, paresthesia, and neurological disorders, including Guillain-Baré syndrome, can be observed.

    If any of the side effects indicated in the instructions get worse or you notice any other side effects not listed in the instructions, tell your doctor.

    Contraindications

    Allergic reactions to chicken protein and vaccine components.

    Acute febrile conditions or exacerbation of a chronic disease (vaccination is carried out after recovery or during remission).

    Persons who have previously had allergic reactions to influenza vaccines

    For mild ARVI and acute intestinal diseases, vaccination is carried out after the temperature has normalized.

    Children's age up to 6 months.

    First trimester of pregnancy.

    Drug interactions

    The Grippol® plus vaccine can be used simultaneously with inactivated and live vaccines of the National Preventive Vaccination Calendar (except for BCG and BCG-M) and inactivated vaccines of the preventive vaccination calendar for epidemic indications (except for rabies). In this case, contraindications to each of the vaccines used must be taken into account; drugs should be injected into different parts of the body with different syringes.

    The vaccine can be administered against the background of basic therapy for the underlying disease. Vaccination in patients receiving immunosuppressive therapy (corticosteroids, cytotoxic drugs, radiotherapy) may be less effective.

    special instructions

    On the day of vaccination, those vaccinated must be examined by a doctor (paramedic) with mandatory thermometry. At temperatures above 37.0 °C, vaccination is not carried out.

    The physician should be informed of the presence of immunodeficiency, allergy or unusual reaction to previous vaccination, as well as of any treatment coinciding with or preceding vaccination.

    The drug is not suitable for use in syringe doses with damaged integrity or labeling, if the physical properties (color, transparency) have changed, if the expiration date has expired, or if the requirements for storage conditions are violated.

    Precautionary measures.

    Do not administer intravenously! In the rooms where vaccination is carried out, it is necessary to have anti-shock therapy. The vaccinated person should be under the supervision of a health care worker for 30 minutes after immunization.

    Anyone is susceptible to the flu during epidemics of this infectious disease. In addition to unpleasant symptoms, the disease is dangerous due to consequences and complications. To prevent this from happening, routine vaccination with Grippol should be carried out. This drug forms stable immune protection against the disease and is equally easily tolerated by adult patients and children.

    More information about the Grippol vaccine

    The medicine is produced by NPO Microgen and developed by the Institute of Immunology of the Ministry of Health. The composition of the influenza plus vaccine includes influenza virus antigens and polyoxidonium. It improves the formation of the patient's immune response. This substance relieves the toxicity of the drug, accelerates the process of synthesizing antibodies, phagocytes and T-killers.

    It is a colorless liquid, sometimes has a yellowish tint. Container for the drug: ampoule or glass bottle with a volume of 0.5 mg. The medicine is packaged in cardboard packs of 5 or 10 pieces. The product can be packaged in an individual syringe.

    The medicine is well tolerated by all groups of the population and can be used by children from the age of six months. It is effective in developing immunity in people over 60 years of age. The drug produces lasting immunity against influenza a week after vaccination and is effective for 12 months. At the same time, it has a small number of side effects for the body. After injection, antibodies are produced in 75–95% of patients.

    Effect on the body

    Grippol contains antigens that are isolated from viruses type A and B. They are grown on chicken embryos. The components of the drug change annually, in accordance with WHO epidemiological forecasts. The flu shot helps develop immune protection against the disease.

    It becomes active within 7–14 days after the injection. Immunity lasts up to 12 months, even in people with poor health and the elderly. The production of antigens to the influenza virus is formed in 75–95% of cases. The patient becomes more resistant due to improved immunity to other viruses.

    Indications of the drug

    The medicine is recommended for use by people working in healthcare and services, where they often come into contact with people, including those sick with the flu. In addition, doctors recommend using Grippol for those patients who have weak immunity and often suffer from acute respiratory infections and colds.

    Vaccination is necessary for those who suffer from diseases of the heart, blood vessels, and respiratory system. The use of Grippol is recommended for patients with diagnosed diabetes, metabolic problems, various types of anemia and kidney pathologies.

    The influenza plus vaccine is used to prevent influenza in patients over 6 years of age and teachers of educational institutions. The drug should be used by people over 60 years of age.

    Vaccination scheme

    Injections with the medicine are given once a year (in autumn or winter), you can give an injection when the flu epidemic is just beginning.

    Intramuscular injections are given under the skin or into the muscle of the shoulder. This method is recommended for vaccination in children over 3 years of age, in adolescence, and in adult patients. For children under 3 years of age, the vaccine is given in the thigh. Influenza vaccination for children aged from six months to 35 months is given at a dosage of 0.25 ml 2 times. In this case, the interval between injections is 21–28 days.

    For adults and children over 3 years of age, a single dose of 0.5 ml is used. If the child has not had the flu before and has not been vaccinated before, then the vaccine is administered 2 times, with a break of 3 weeks between injections. In case of immunodeficiency or after therapy aimed at reducing immune defense, the medicine is administered into the body 2 times with a dosage of 0.5 ml. In this case, the interval between injections is 4 weeks.

    Injecting the vaccine intravenously is prohibited. The vaccination must be done under antiseptic conditions. The influenza vaccine is not stored unopened, but is disposed of.

    Who should not be given an injection?

    Contraindications for the use of Grippol are absolute and relative. It is not recommended to use the drug for acute forms of chronic pathologies if the patient has a fever. Patients under six years of age are prohibited from using the medicine without a preservative.

    An absolute contraindication is an allergy to the ingredients of the drug, chicken protein, or vaccinations with a similar composition.

    A relative contraindication is the presence of a viral disease or intestinal infection. Vaccinations should be carried out with caution during pregnancy. In this case, the decision on the need for vaccination is made by the doctor, based on the course of pregnancy, the risk of contracting the virus and possible complications.

    Vaccination rules

    Before administration, the medicine is warmed to room temperature. After this, the doctor shakes it, removes the cap from the syringe and removes excess air bubbles from it. In this case, the medical worker holds the syringe vertically, raising the needle up and gently pressing the syringe plunger.

    To vaccinate a child with a dosage of 0.25 ml, half of the medicine is removed from the syringe, bringing its level to the appropriate level. The remainder of the drug is administered to the patient. During the autopsy and the vaccination itself, it is necessary to follow the rules of antiseptics. Therefore, the neck of the ampoule and the tool for opening the container are pre-treated with alcohol (70%).

    After this, the glass container is opened. If the medicine is packaged in a bottle, then the rubber cap is pierced with a needle and the liquid is drawn into a disposable sterile syringe. Before administering the injection, excess air is also removed from the syringe.

    The injection site is pre-treated with cotton wool moistened with alcohol. Do not store an opened container with remaining medication. The office should have tools for quick assistance to the patient in case of anaphylactic shock. The patient is observed for half an hour after the injection to reduce the risk of an allergic reaction.

    Interaction with other drugs

    The medicine combines well with other medications, except BZhTs, and can be administered simultaneously with medications. In some cases, doctors introduce Grippol into the basic treatment of influenza. If the patient has previously received immunosuppressive treatment, the effectiveness of the vaccine may be lower. In cases where the drug is administered simultaneously with other medications, vaccinations must be placed in different parts of the body and not mixed with each other.

    Side effects

    Sometimes an injection with Grippol can cause local reactions, for example, weakness, a slight increase in temperature, lethargy.

    1. At the puncture site, the patient feels pain, slight swelling, and a thickening in the form of a lump.
    2. The patient may experience a slight sore throat, migraine, and rhinitis, like a cold.
    3. With allergies, the patient may experience neuralgia, myalgia and other neurological syndromes.
    4. For any symptoms, you should consult a doctor, but in general the drug is a highly purified medicine and is well tolerated by patients.
    5. During the use of the vaccine, no cases of overdose were recorded.

    Nuances of use during pregnancy and lactation

    The medicine is non-toxic and easily tolerated by patients. The doctor decides whether or not to give a flu vaccine to a pregnant woman after assessing the following factors:

    • Risk of contracting a virus
    • Patient's health condition
    • Possible complications when contracting the disease.

    It is best to vaccinate in the second or third trimester of pregnancy. Vaccination to prevent influenza can also be carried out during lactation. Feeding is not a contraindication for Grippol injection.

    Storage and release from pharmacies

    • The medicine is placed in a dark, cool place with a temperature of 2–8 degrees, inaccessible to children.
    • The drug should not be frozen.
    • The vaccine can be stored for 12 months from the date of release.
    • Transportation of the drug is carried out in light-proof containers.
    • It is dispensed only with a prescription from the attending physician.

    What not to do after vaccination

    The first days after the Grippol injection, you do not need to follow any special restrictions or recommendations. After administration of this vaccine, you can wash, visit the sauna and bathhouse, and swim. The only thing is that this should not be done if the patient has a fever and is unwell. In these situations, water procedures are postponed until the patient's condition returns to normal.

    You should be careful during this time of drafts and hypothermia. It is better if a person does not catch a cold or suffer from ARVI or influenza for 14 days after vaccination. During this time, stable immunity is formed. Local reactions, for example, pain at the puncture site, seals disappear on their own within 3 days. But it is better not to rub the grafting site, apply pressure or wet it with water. This will protect you from unwanted consequences.

    Adult patients should avoid drinking alcoholic beverages for several days so as not to increase the load on the liver. Alcohol negatively affects the formation of immune defense and increases the risk of allergies.

    Doctors' opinion

    Many doctors note the price of Grippol (about 120–130 rubles) and note the general availability for the population. You can get an injection at any hospital. It is also possible to purchase it independently in pharmacies with a prescription from your attending physician.

    The Grippol vaccine is no worse than modern imported analogues. It is cheap and well tolerated by patients, which is confirmed by a number of medical studies. But if a person has a tendency to allergies and rarely spends time in crowded places, then it is better not to get vaccinated.

    Flu vaccination: pros and cons

    This procedure has many defenders and opponents. What do both sides say about vaccination? Proponents say that after the injection, people get sick less, suffer from illnesses more easily and have virtually no complications after illness. In their opinion, even if a vaccinated patient gets sick, he will survive the disease more easily, and immunity will quickly normalize his health. Opponents of vaccines note that all anti-flu medications have a number of side effects that are similar to the clinical symptoms of influenza, which causes human discomfort.

    What to do against the flu virus? With the onset of the season, when the body's defenses are seriously tested, we have to look for remedies that will reduce the risk of disease. Vaccination has become a specific prevention; its effectiveness depends on the correctly chosen drug and timely immunization.

    Among the vaccines produced by pharmaceutical manufacturers, the latest generation of medications are considered relevant and contribute to the formation of immunity in children, women during pregnancy, and adults. The Russian-made Grippol Plus vaccine, which is a colorless, sometimes yellowish, liquid for intramuscular or subcutaneous administration, is well tolerated. The improved analogue of the drug Grippol surpassed its predecessor according to the following criteria:

    • no preservatives;
    • convenient release form (individual syringe dose);
    • compliance with international quality standards.

    Vaccine composition

    To protect against infection, the body needs time to develop immunity. Not only timely vaccination helps children and adults achieve this result. The composition of the vaccine has no less influence on the process designed to protect the body from infections. The flu vaccine is an immunostimulating drug that does not contain live viruses, while antigens help resist type A and B strains, another active component - polyoxidonium - supports immunological memory and increases the body's resistance to other types of infections.

    Grippol Plus - action

    The inactivated vaccine has certain advantages, but even it cannot cope with all existing varieties of influenza. The composition of the drug is adjusted annually taking into account the epidemic situation, but the flu vaccine does not serve as a full guarantee of protection against infection. After vaccination, specific immunity will be developed within 12 days, and the beneficial effect will be felt for another year and is determined by the presence of protective antibodies to viruses.

    Grippol Plus - instructions

    Adhering to the general rules of vaccination, before starting it, you should inspect the packaging for integrity, expiration date, and physical properties. If stored improperly, the suspension may change color or transparency, making the vaccine unsuitable for use. An examination by a doctor or paramedic is also a prerequisite before getting vaccinated. If there are no contraindications, for example, fever, intestinal disorders, then permission to administer the vaccine is given.

    Brief instructions for using the vaccine look like this:

    1. Before use, warm the drug to room temperature and shake.
    2. Remove the protective layer, squeeze out the air by pressing the syringe plunger, which must be held in a vertical position with the needle up.
    3. Half the volume of the syringe is the dose for children. Before administering the drug to a child, excess liquid must be squeezed out by moving the piston to the level of the red mark, after which the vaccination is allowed.
    4. Treat the injection site with alcohol and administer the vaccine.
    5. After immunization, it is recommended to remain under the supervision of a healthcare professional for 30 minutes.

    Reviews from doctors

    Discussions about the effectiveness of vaccination are controversial, but in the medical community the advisability of vaccination is not questioned - only the quality of the vaccine produced. Reviews from doctors about Grippol Plus boil down to safety, affordability, convenience, and versatility of the drug, which is used for immunization of different age groups or during pregnancy. Should I get vaccinated to increase my immunity to infections? The answer will be positive, but how the vaccine will work depends on the individual characteristics of the body.

    Contraindications

    Restrictions on vaccination may be temporary, for example, a cold or exacerbation of a chronic disease, or vaccination may not be permitted for certain reasons. A reliable description of Grippol Plus as an effective remedy in the fight against the influenza virus is given by contraindications. To prevent the vaccine from causing serious complications during immunization, you should refrain from using it in the following cases:

    • allergic reactions that have previously been noted with the administration of other influenza vaccines or to chicken protein;
    • colds accompanied by fever;
    • exacerbation of chronic diseases;
    • intestinal disorders.

    Can the drug be used during pregnancy? There are no strict restrictions, but at the initial stage a woman should pay special attention to her health. The decision to vaccinate should be made after consultation with a doctor, as there is a risk of complications. The second and third trimesters are considered relatively safe, and the period of breastfeeding is not at all considered a reason to refuse vaccination.

    Reaction to Grippol Plus

    A positive aspect of using the vaccine is the development of immunity against influenza infection. Achieving such a result may be accompanied by a response from the body to the use of an immunostimulating and anti-influenza drug. Reactions after administration of the drug can be general or local, depending on the degree of manifestation - weak or completely absent. Typical body responses to this vaccine include:

    • general malaise, weakness;
    • runny nose;
    • a sore throat;
    • swelling, redness of the skin;
    • low temperature is possible, but goes away on its own after a couple of days;
    • neurological disorders;

    Grippol Plus - side effects

    The advantage of the vaccine, which is a highly purified drug, is that it is well tolerated by adults and children. It would be wrong to exclude the occurrence of side effects, because each organism is individual. If Grippol Plus is introduced, side effects will manifest themselves either immediately or will be noticeable for a few more days, after which they will go away on their own. A healthcare professional can familiarize the patient with common reactions to the vaccine, and a complete list can be found in the instructions for the drug.

    Grippol Plus - complications

    An affordable price, which helps the domestic drug to win when compared with identical foreign-made anti-influenza drugs, does not justify itself in all cases. The common vaccine is considered safe, but do not lose sight of the fact that it is a medical drug that is injected into the body. The danger of its use is consequences that can manifest themselves as allergic reactions or influenza infection.

    Price

    The cost of the vaccine relates to its benefits, but the final price will be influenced by a number of factors: time of year, region, delivery conditions. Maintaining temperature conditions during storage and transportation is a must, so you should consider the place of purchase. You can order from a catalog and buy inexpensively in an online store any other products, but it is better to purchase the vaccine at a pharmacy. The price for 1 dose of 0.5 ml varies from 170 to 270 rubles.

    Grippol plus: instructions for use and reviews

    Latin name: Grippol Plus

    ATX code: J07BB02

    Active substance: vaccine for the prevention of influenza, inactivated + azoximer bromide (vaccine influenza virus inactivated + azoximer bromide)

    Manufacturer: Nearmedic Plus LLC (Russia), Oxygen Plus LLC (Russia), Novofarma Plus JV LLC (Uzbekistan)

    Updating the description and photo: 04.07.2018

    Grippol plus is a trivalent inactivated polymer-subunit influenza vaccine.

    Release form and composition

    The dosage form of Grippol plus is a suspension for intramuscular (IM) and subcutaneous administration: colorless or yellowish, slightly opalescent liquid (0.5 ml in a disposable syringe or ampoule/vial; 1, 5 or 10 syringes, or 5 ampoules/ bottles in blister packs; in a cardboard box: 1 or 2 blister packs, 5 or 10 ampoules/bottles without blister packs).

    Composition per 0.5 ml suspension:

    • active substances: influenza virus type A antigen (H 1 N 1) containing hemagglutinin - 5 μg; influenza virus type A antigen (H 3 N 2) containing hemagglutinin – 5 μg; influenza virus type B antigen containing hemagglutinin – 5 μg; polyoxidonium – 500 mcg;
    • auxiliary components: phosphate-saline buffer solution.

    The drug contains strains of influenza virus antigens - in accordance with the recommendations of the World Health Organization (WHO) for the current epidemic season.

    Pharmacological properties

    Pharmacodynamics

    Grippol Plus is a flu vaccine containing an immunostimulant, due to which the dosage of antibodies in its composition is reduced.

    Under the influence of the drug, stable immunity to influenza types A and B develops within 7–12 days after injection, which subsequently persists throughout the year. In 75–95% of patients after vaccination, protective antibody titers were detected in the blood.

    Polyoxidonium has an immunomodulatory and detoxification effect. Its action is due to the activation of phagocytes and killer T-cells, which are an important component of cellular immunity. In addition, polyoxidonium increases the resistance of cell membranes to the effects of various medications, thereby reducing their toxicity.

    Grippol Plus does not contain preservatives.

    Indications for use

    Grippol plus is indicated as a specific prevention of influenza for children over 6 months of age and adults.

    Vaccination is especially recommended for the following groups:

    1. Patients at high risk of complications in case of influenza: children of preschool and school age; patients with anemia, a tendency to allergic reactions, bronchial asthma, chronic kidney disease, a tendency to frequent acute respiratory viral infections (ARVI) and colds, chronic diseases of the central nervous system (CNS), diseases of the bronchopulmonary or cardiovascular system, diabetes mellitus, metabolic pathologies; HIV-infected and patients with congenital/acquired immunodeficiency; elderly patients over 60 years of age.
    2. Persons who frequently communicate with people due to their professional activities: medical workers, social service workers, educational institutions, trade, transport, police, military personnel, etc.

    Contraindications

    • ARVI (including mild);
    • acute intestinal diseases;
    • acute febrile conditions;
    • exacerbation of a chronic disease;
    • history of allergic reactions to the influenza vaccine;
    • allergic reaction to chicken protein or vaccine components.

    In case of diseases and their exacerbation, vaccination is allowed after recovery or during remission.

    Instructions for use of Grippol plus: method and dosage

    The suspension is injected deeply subcutaneously or intramuscularly into the deltoid muscle (in the upper third of the outer surface of the shoulder). Grippol plus is recommended for children under 3 years of age to be injected intramuscularly into the anterolateral surface of the thigh.

    • children 6 months - 3 years old, as well as older ones, if they have not previously had the flu and have not been vaccinated: 0.25 ml, twice, with an interval of 3-4 weeks;
    • children over 3 years of age and adults: 0.5 ml once;
    • patients with immunodeficiency, as well as patients receiving immunosuppressive therapy: 0.5 ml, twice, with an interval of 3-4 weeks.

    The vaccine should be kept at room temperature before use. Shake the syringe thoroughly, then, removing the protective cap from the needle, remove air from the syringe, holding it with the needle up. If it is necessary to administer 0.25 ml of the drug, the excess vaccine is removed by pressing the piston to the mark on the syringe body or label.

    The vaccination procedure must be carried out in compliance with the rules of asepsis and antiseptics. After opening the vial or ampoule, the vaccine cannot be stored.

    It is prohibited to administer Grippol Plus intravenously. The office where vaccination is carried out must have anti-shock therapy equipment. The patient must be monitored for 30 minutes after vaccination.

    Side effects

    Grippol Plus is a highly purified vaccine and is well tolerated if vaccination rules are followed. However, the following reactions are possible, usually going away on their own within 1–2 days after vaccination:

    • soreness, induration, swelling and hyperemia at the injection site;
    • weakness, malaise, low-grade fever;
    • runny nose, sore throat, fever above subfebrile.

    In rare cases, the following are possible: neuralgia, paresthesia, neurological disorders, myalgia, allergic reactions, including immediate ones.

    Overdose

    There are no data on cases of overdose of the Grippol Plus vaccine.

    special instructions

    Immediately before vaccination, the patient must be examined by a medical specialist, with mandatory thermometry; if the temperature rises above 37 °C, vaccination is not carried out.

    If the labeling or integrity of the packaging is violated, as well as if the color or transparency of the suspension changes, the expiration date has expired, or storage conditions are violated, the use of the drug is not permissible.

    Impact on the ability to drive vehicles and complex mechanisms

    According to the instructions, Grippol plus does not affect the ability to drive vehicles and other complex mechanisms that require rapid psychomotor reactions.

    Use during pregnancy and lactation

    Preclinical studies did not reveal embryotoxic or teratogenic effects of the drug. Vaccination of pregnant women is carried out only according to the doctor’s decision, after a careful assessment of the benefit/risk ratio. Vaccination is safest in the second and third trimesters.

    During lactation, the Grippol plus vaccine is approved for use.

    Use in childhood

    Grippol plus is used for children from 6 months of age.

    Drug interactions

    The combined use of Grippol plus with the rabies vaccine, as well as with the BCG and BCG-M vaccines against tuberculosis is not allowed.

    When used together with other vaccines, the contraindications of each must be taken into account, and the drugs should be administered to different parts of the body with different syringes.

    It is allowed to use Grippol plus against the background of basic therapy for the underlying disease. In patients receiving immunosuppressive therapy, the effect of vaccination may be reduced.

    Analogs

    An analogue of Grippol Plus is MonoGrippol, etc.

    Terms and conditions of storage

    Store away from light, at temperatures between 2 and 8 °C. Keep away from children. Do not freeze.

    Transportation is permitted in light-proof containers at temperatures from 2 to 8 °C, as well as at temperatures not exceeding 25 °C, for no longer than 6 hours.

    Shelf life – 1 year.

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