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When a child has a stuffy nose, he can neither eat, nor sleep, nor play quietly. The baby’s irritation inevitably passes on to the parents, because they want to help the baby. The vasoconstrictor Nazivin will make breathing easier in a matter of minutes. The effect of using drops occurs within 20–25 seconds, which has been proven by clinical trials.

The drug is available without a doctor's prescription and can be found in any pharmacy. In order not to harm the child, when using vasoconstrictor nasal drops, you must strictly follow the instructions.

Choosing the release form

Paying attention to the pharmacy shelf with anti-runny nose remedies, any parent will be confused. There can be at least 2 types of drops with the same name. In the case of Nazivin, the pharmaceutical industry is surprising; the range includes 5 types of products:

• Nazivin drops 0.01%;
• Nazivin drops 0.025%;
• Nazivin drops 0.05%;
• Nazivin Sensitive 0.025% and 0.05%.

It’s very easy to navigate among the dosages, especially since the manufacturer provides explanations right on the packaging:

• drops with the lowest concentration are intended for children from birth to 1 year;
• 0.025% of the active substance contains the drug for children from 1 to 6 years;
• the highest dose (0.05%) is intended for children over 6 years of age and adults;
• Nazivin Sensitive is produced in the form of a spray, which facilitates the process of nasal instillation for children over one year old and adults.

The spray form of the drug differs from other drugs intended for spraying into the nasal passages, which in most cases are intended for persons over 6 years of age. Thanks to a special mechanism, a fine spray of the solution is achieved, and its quantity is accurately measured and released in the same volume each time the dispenser is pressed. Compared to other products, Nazivin Sensitive is considered safer.

Nazivin drops and sprays are packaged in dark glass jars and equipped with a pipette or dispenser spray. Each bottle is accompanied by an annotation and is protected from light by a cardboard box. It is better to store the product in its original packaging.

Composition and effect of the drug

Nazivin is a local sympathomimetic. That is, the drug is active only in the application area. The active substance is oxymetazoline hydrochloride. The connection provides the following effects:

• vasoconstrictor;
• decongestant;
• restores airway patency;
• facilitates breathing with nasal congestion;
• helps restore drainage and aeration of the paranasal sinuses;
• reduces the volume of liquid discharge from the nose;
• normalizes the air supply to the middle ear cavity;
• reduces the risk of bacterial complications of rhinitis.

Excipients are citric acid monohydrate, sodium citrate, purified water, 50% benzalkonium hydrochloride solution, glycerin (85%). The last component softens and moisturizes irritated mucous membranes, promotes their regeneration, and prevents discomfort during use of the drug.

Clinical trials have proven the complex effect of Nazivin in acute rhinitis. The product provides antiviral, immunomodulatory, anti-inflammatory effects, relieves nasal congestion, reduces rhinorrhea and sneezing, and helps to quickly improve the patient’s well-being. Nazivin does not irritate mucous membranes and quickly eliminates dryness.

The drug almost does not penetrate into the systemic circulation. Plasma concentrations are minimal and do not produce a systemic effect (provided the recommended doses are followed). The action of Nazivin develops over 20–25 seconds, reaching a maximum after 15 minutes. The effect lasts up to 12 hours, the average duration is 6-8 hours. The half-life of the drug is 35 hours. Approximately 2% of the drug that enters the blood is utilized by the kidneys, and 1.1% is excreted in the feces.

When can you use Nazivin

The medicine is prescribed as part of complex therapy for viral and bacterial diseases accompanied by acute rhinitis. The drug can be used for vasomotor and allergic forms. The drug is also used in the complex treatment of inflammation of the paranasal sinuses (sinusitis, sinusitis), to restore their drainage and aeration (air penetration).

Vasoconstrictor nasal drops are appropriate for eustachitis (tubo-otitis, inflammation of the middle ear), which occurs against the background of acute rhinitis. Nazivin is used before diagnostic procedures, to increase the lumen of the airways and eliminate swelling after medical interventions. For children, the drug is most often prescribed for influenza and ARVI, accompanied by a severe runny nose, congestion, difficulty breathing, and intense sneezing.

How to use the product

Nazivin solution is intended for instillation into the nasal passages. The drops are used with a pipette, and the spray is simply sprayed while holding the bottle vertically. The regimen of use is the same for all categories of patients - the drug is used 2-3 times a day, with a minimum interval of 6 hours. It is not advisable to administer the drug more often due to the increased risk of overdose. Doses depend on the age of the patient and the dosage form of the drug:

• for children under 4 weeks of age, instill 1 drop of a 0.01% solution into each nostril;
• infants older than 1 month can be administered 1-2 drops;
• for children over one year old, 1-2 drops of a 0.025% solution are instilled or a 0.025% spray is sprayed once;
• For patients over 6 years of age, 1-2 drops of a 0.05% solution or 1 spray of a spray of the same concentration are instilled.

Doses higher than recommended can only be used in a hospital setting under the supervision of medical personnel. Nazivin should be used for no more than 5–7 days in a row. If after this period rhinitis persists or new symptoms appear, you should consult a doctor.

Features of application

The drug cannot be used to treat patients who are taking drugs from the group of MAO inhibitors (used in exceptional cases in pediatric practice) or who were treated with such medications less than 2 weeks ago. Caution is required if the patient is taking tricyclic antidepressants, hypertensive drugs, or drugs that can increase blood pressure. Nazivin should be prescribed by a doctor after assessing the risk-benefit ratio for patients with:

• increased intraocular pressure;
• severe cardiovascular pathologies (coronary disease, hypertension);
• pheochromocytoma (hormone-producing tumor of the adrenal glands);
• porphyria (pigment metabolism disorders in the body);
• diabetes mellitus;
• prostatic hyperplasia.

Long-term use of vasoconstrictor drops (including Nazivin) can lead to addiction and a decrease in the effectiveness of the drug. The auxiliary substance benzalkonium hydrochloride in sensitized people can provoke reactive swelling of the mucous membranes with aggravation of breathing problems. With prolonged use, it is possible to develop drug-induced rhinitis (when it is almost impossible to breathe without drops), atrophy of the mucous membranes (thinning), and reactive hyperemia (the opposite effect).

The drug can be used to treat rhinitis in premature babies or those born with low body weight only under the supervision of a doctor.

Contraindications

Nazivin in any doses is contraindicated in case of hypersensitivity of the body to the active substance or any of the excipients. If a child has previously had allergic reactions to the drug, it should not be used again, even after some time.

Contraindications also include atrophy of the nasal mucosa and dry rhinitis (a chronic form that accompanies atrophic processes). The drug should not be used after transsphenoidal hypophyseectomy and other surgical interventions accompanied by exposure of the meninges.

What side effects may there be?

During clinical trials, it was found that Nazivin was well tolerated by all categories of patients. The most common side effects (more than 1, but less than 10 out of 100 people) are dry nose, sneezing, and burning. More often than 1 person out of 1000, swelling, bleeding, and hypersensitivity of the membranes occur.

Rare side effects include heart rhythm disturbances. Isolated cases of anxiety, convulsions, insomnia, headaches, and hallucinations were recorded. There have been isolated cases of sudden respiratory arrest among premature and newborn babies.

Question: The child has a severe runny nose, and it is not clear whether it is due to a cold or an allergy? The doctor prescribed Rinostop, but the drug turned out to be a syrup for internal use. Is it possible to combine it with Nazivin?

Answer: Rinostop is a combination drug that contains paracetamol, pseudoephedrine, and chlorphenamine. It has antipyretic, anti-inflammatory, analgesic, vasoconstrictor, antihistamine, sedative, bronchodilator properties and relieves symptoms of ARVI and flu well, and can be used for allergic reactions. There is no point in combining syrup and Nazivin, since among the indications for Rinostop is allergic rhinitis (the drug affects the nasal mucosa and fights their swelling). It would be advisable to resort to drops if the allergic nature of the runny nose is confirmed. Then giving the child a complex remedy is pointless, since you can get by with drops and an antihistamine (after consultation with the doctor).

conclusions

• Nazivin is a line of drugs for the common cold in the form of drops and sprays based on oxymetazoline hydrochloride.
• Nazivin products do not contain aromatic components and can be used if the patient is allergic to essential oils and plant extracts.
• The effect of using drops develops after half a minute and lasts up to 12 hours.
• The products are absolutely safe for health if you use the right concentration and follow the dosage exactly.
• If the child’s condition worsens while using the drops, you should stop taking the drug and consult a doctor.

Most medications are divided into children's and adults'. In preparations for children, the amount of active substance is reduced. The manufacturer also tries to select only proven and clinically tested components for the production of such drugs. Nazivin nasal drops were no exception. Today's article will provide an overview of this drug and its instructions.

Characteristics: composition of the drug and its types

The drug "Nazivin" for children (drops) is available in several variations. At pharmacies you can purchase the product placed in a glass container. The pipette of such a medicine will be unscrewed and graduated. The manufacturer also produces Nazivin Sensitive drops. It is assumed that this medication is suitable for sensitive and allergy-prone patients.

The main active ingredient of the drug is oxymetazoline hydrochloride. Depending on the type of drug, its amount may vary. Thus, the following drops are presented to the consumer for purchase:

• "Nazivin" for children under one year of age 0.01% (can be used from the first days of life);
• "Nazivin" 0.025% (suitable for children from 1 to 6 years old);
• "Nazivin" 0.05% (used for children over 6 years of age and adults).

As you already know, the drug has a separate “Sensitive” line. For newborns, this medicine contains the same amount of oxymetazoline as in regular drops. For children over one year old, the product is available in the form of a dosed spray. One spray contains 11.25 mcg of active ingredient. After 6 years, the manufacturer suggests using the spray in double dosage: one spray - 22.5 mcg. Nazivin drops are available in volumes of 5 and 10 milliliters.

Action of the medicine

How does Nazivin (drops) work? The instructions say that the medication has a vasoconstrictor effect. After application, a rapid anti-edematous effect is noted. The consumer's breathing is restored, general well-being is normalized and the amount of nasal discharge is reduced. In addition, the medication improves ventilation between the sinuses and the ear. This fact does not allow complications to arise: otitis, eustachitis and sinusitis.

Indications for prescribing the drug to children

"Nazivin" for children (drops up to one year and after) is used only on the recommendation of a doctor. It is unacceptable to take such medications on your own. The doctor prescribes the medicine in the following situations:

• vasomotor and acute rhinitis;
• sinusitis and sinusitis;
• otitis and eustachitis (in complex therapy);
• respiratory viral and bacterial diseases, accompanied by nasal congestion and swelling.

The drug is used for preventive purposes in cases where there is a risk of swelling: during research, rhinoscopy, tendency to otitis media, and so on.

Read the contraindications before use

When should you not use Nazivin drops? The drug is not prescribed at a dose of 0.05% and 0.025% for up to a year. Children under 6 years of age are not prescribed drops containing a 0.05% oxymetazoline solution. It is prohibited to use the spray in any dose for newborns.

The drug is not prescribed to patients who have a high sensitivity to its components. Also contraindicated for use are hypertension, angle-closure glaucoma, atrophic and medicinal rhinitis. During pregnancy, the use of children's drops and adult spray is prohibited.

"Nazivin" (drops). Children: instructions for use. Dosage and application regimen

The drug is administered exclusively into the nasal passages. Before doing this, you should clear your sinuses of mucus as much as possible. During the administration of the drug, the child should be in a horizontal position. Tilt your baby's head back strongly. After this, enter the amount of the drug indicated in the annotation according to age. As you already know, Nazivin drops have a pipette with marked portions. If you use the “Sensitive” line, then one press will be equal to squeezing out a single dose. Sprays are administered exclusively in a vertical position.

• Nazivin drops 0.01% are prescribed to children in the first month of life, 1 drop. From the fifth week it is permissible to use 1-2 drops in each nasal passage.
• The drug "Nazivin" 0.025% is recommended for 1-2 drops for children from one to 6 years of age. If this type is used after 6 years, then it is advisable to double the portion and administer 2-4 drops.
• "Nazivin" 0.05% is used in children over 6 years of age and adults, 1-2 drops.
• The spray is used according to the age of the child and one spray is administered into each nasal passage.

The frequency of use of the drug is up to three times a day. However, the duration of its use should not exceed 5 days. The instructions indicate that treatment is carried out for 3-5 days. But according to certain indications, the doctor may extend this period.

Alternative uses of pediatric vasoconstrictor drops

How else can you use Nazivin drops for up to a year? The instructions say that it is permissible to apply the medication to cotton swabs, which are then inserted into the nasal passages. Moreover, the effect of such use will be noticeable.

Take sterile cotton wool and a bandage. Twist them into a small turunda, onto which you apply the preparation. This can be done using the same pipette. Insert the tampons into the nasal passages for 10-15 minutes. Use this method no more than three times a day.

Adverse reactions that require discontinuation of the medication

The drug usually has a positive effect on the patient's condition and does not cause negative reactions. But it also happens that the drug provokes severe swelling and hyperemia occurs. The medication may also cause dry nose, sneezing, and itching. All these signs can be attributed to side effects. If they appear, you should stop using the drug and consult a doctor. An antidote is not required in the situations described. Negative effects go away on their own after discontinuation of Nazivin vasoconstrictor drops.

With repeated use and an increase in the norms specified in the instructions, the medicine helps to increase blood pressure. The patient's pulse quickens and tachycardia develops.

Development of drug-induced rhinitis: special instructions

You already know how and in what quantity you need to use Nazivin for children (drops up to a year). The instructions say that if you use the medicine in prohibited concentrations for children, an overdose may occur. It is manifested by nausea and vomiting, insomnia, increased nervous excitability, and fever. Respiratory depression and pulmonary edema may also develop. All these situations are quite dangerous, especially for young children. Therefore, if they occur, you should immediately call an ambulance.

Long-term use of the drug - even in acceptable doses - leads to atrophy of the nasal mucosa and the development of drug-induced rhinitis. The clinical picture of this disease is manifested by the following symptoms: it is impossible to breathe without drops, constant nasal congestion for no reason, relief after using the drug, and so on. Rhinitis medicamentosa must be treated with more serious medications (often requiring corticosteroids) and only as directed by a doctor.

Nazivin Children's 0.025% is a nasal drop with a vasoconstrictor and anti-edematous effect, used to eliminate various types of rhinitis in children from 1 to 6 years old. Active ingredient: Oxymetazoline.

Drops reduce swelling of inflamed nasal mucous membranes, restore nasal breathing, reduce the amount of discharge and prevent the development of bacterial complications, including sinusitis, sinusitis and otitis media.

When used in therapeutic doses, they do not irritate the mucous membranes and do not have a systemic effect.

Dosage selection:

• Drops of 0.025% are used for instillation in children from 1 to 6 years old;
• Drops of 0.01% are prescribed to children under 1 year of age.

The drug begins to act 7-15 minutes after topical application. Duration of action – up to 12 hours.

Indications for use

What does children's Nazivin help with? According to the instructions, the drug is prescribed in the following cases:

• Treatment of acute respiratory diseases accompanied by rhinitis;
• Allergic rhinitis;
• Vasomotor rhinitis;
• Restoration of drainage in case of inflammation of the paranasal sinuses, eustachitis, otitis media;
• Elimination of edema before diagnostic manipulations in the nasal passages.

Instructions for use of Nazivin for children, dosage

Nazivin Children's drops 0.025% are intended for use in children from 1 to 6 years old.

It is also effective to apply children's Nazivin to cotton wool and cleanse the nasal passages.

The course of application is up to 5 days.

Nazivina 0.01%

Intended for use in children under 1 year of age.

Standard dosages (2-3 times a day):

• For newborns up to one month old, 1 drop is administered into each nostril;
• From a month to a year - 1-2 drops.

To ensure dosage accuracy, the bottle of 0.01% drops has a graduated pipette with markings on the number of drops. If 1 drop is prescribed, then the pipette should be filled with the solution to the 1 mark.

It is permissible not to drip the drug, but to apply it on a cotton swab and wipe the nasal passages.

The course of application is up to 3-5 days.

Do not exceed the dosage and frequency of use!

special instructions

If it is necessary to continue treatment with Nazivin for more than 3-5 days, consultation with a doctor is necessary.

Long-term use and overdose of the drug should be avoided, especially in children. Long-term use may cause drug-induced rhinitis.

Co-administration of other vasoconstrictor drugs increases the risk of side effects.

Side effects

The instructions warn about the possibility of developing the following side effects when prescribing Nazivin for Children:

• Transient dryness and burning of the nasal mucosa, dry mouth and throat, sneezing;
• Increased blood pressure, increased anxiety, nausea, dizziness, headache, insomnia, palpitations, sleep disturbances.
• With long-term use - tachyphylaxis, reactive hyperemia of the mucous membrane and atrophy of the nasal mucosa.

Contraindications

It is contraindicated to prescribe Nazivin for Children in the following cases:

• Atrophic rhinitis;
• Angle-closure glaucoma;
• Severe diseases of the circulatory system;
• Pheochromocytoma;
• Metabolic diseases;
• Prostate hyperplasia;
• Hypersensitivity to the components of the drug.

Carefully:

• Pregnancy and breastfeeding period;
• Thyrotoxicosis;
• Diabetes;
• High blood pressure;
• Angina pectoris.

Overdose

Symptoms of overdose are tachycardia, increased blood pressure, and central nervous system depression.

Treatment is symptomatic and hospitalization may be required.

Analogs of Nazivin for Children, price in pharmacies

If necessary, you can replace Nazivin for Children with an analogue in terms of therapeutic effect - these are the following drugs:

1. Knoxprey Baby;
2. Sialor Rhino;
3. Nazivin Sensitive;
4. Knoxprey.

When choosing analogues, it is important to understand that the instructions for use of Nazivin for children, price and reviews do not apply to drugs with similar effects. It is important to consult a doctor and not change the drug yourself.

Price in Russian pharmacies: Nazivin drops for children 1-6 years old 0.025% 10 ml - from 139 to 167 rubles, cost of drops 0.01% 5 ml for children under 1 year - from 155 to 173 rubles, according to 724 pharmacies.

Store out of the reach of children at a temperature not exceeding 25°C. Shelf life – 3 years.

Conditions for dispensing from pharmacies - without a prescription.

Doctor's review

Vasoconstrictor drops should be considered as an “ambulance” and used only for 3-5 days to relieve severe nasal congestion. With prolonged use, mucosal atrophy is possible.

It should be noted that Nazivin drops for children, when used in the recommended dosage regimen, do not cause significant damage to the mucous membrane, and their therapeutic effect (compared to other vasoconstrictor drops) is achieved at low concentrations of the active substance. Therefore, the 0.01% solution form is safe and effective for the treatment of rhinitis even in newborns and infants.

In 1 ml drops oxymetazoline hydrochloride 500 µg, 250 µg or 100 µg. Solution benzalkonium chloride, sodium dihydrogen phosphate dihydrate, EDTA, sodium hydroxide, water, sodium hydrogen phosphate dihydrate - as excipients.

Spray composition: 1 ml oxymetazoline hydrochloride 500 mcg. A solution of benzalkonium chloride, sodium dihydrogen phosphate dihydrate, EDTA, sodium hydroxide, water, sodium hydrogen phosphate dihydrate - as excipients.

Release form

Drops in bottles with a pipette cap 0.05% 0.025% and 0.01%.

Spray 0.05% in a 10 ml bottle with a sprayer.

pharmachologic effect

Vasoconstrictor.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Vasoconstrictor drug alpha2-adrenergic agonist. Reduces swelling of the mucous membrane when applied topically and the amount of discharge. By eliminating swelling of the mucous membranes, it restores breathing and aeration of the paranasal sinuses and middle ear. The use of the drug prevents the development sinusitis, sinusitis, otitis.

At therapeutic concentrations it does not cause hyperemia and does not irritate mucous membranes. It begins to act in 10 minutes and the effect lasts 12 hours.

Pharmacokinetics

When applied topically, it has no systemic effect. The half-life is about 35 hours. 2.1% is excreted in urine and 1.1% in feces.

Indications for use

• Respiratory diseases accompanied by rhinitis;
• eustachitis;
• sinusitis;
• allergic rhinitis;
• diagnostic procedures in the nasal passages;
• otitis media;
• vasomotor rhinitis.

Contraindications

• glaucoma;
• increased sensitivity;
• atrophic rhinitis;
• age up to 6 years (for the drug 0.05%).

Prescribed with caution when using MAO inhibitors, increased intraocular pressure, severe forms arterial hypertension And angina pectoris, during pregnancy, thyrotoxicosis.

Side effects

All side effects are rare:

• sneeze;
• dryness and burning of the nasal mucosa;
• reactive hyperemia after completion of treatment, manifested by nasal congestion (in case of overdose);
• insomnia;
• anxiety;
• headache;
• nausea;
• tachycardia And arterial hypertension(in case of overdose);
• atrophy of the mucous membranes (in case of overdose).

Instructions for use of Nazivin (Method and dosage)

Spray Nazivin, instructions for use

Spray 0.05% is prescribed for adults and children over 6 years of age. It is recommended to spray 1 spray into the nasal passages 2-3 times a day. The recommended dose can be used for up to 7 days. If symptoms worsen within 3 days, you should consult a doctor.

Nazivin drops, instructions for use

Adults and children over 6 years of age are prescribed 0.05% drops, 1-2 drops 2-3 times a day. Children from 1 year to 6 years - 0.025% drops, 1-2 drops 2-3 times. Children under 1 year of age are prescribed 0.01% of the drug: newborns 1 drop 2-3 times. The bottle of 0.01% of the drug has a graduated pipette on which the number of drops is marked (1, 2, etc.).

It is possible to administer the drug into the nose in another way: the required number of drops is applied to a cotton swab and the nasal cavity is wiped with it. The duration of use of the drug is 3-4 days.

Overdose

An overdose appears as constriction of the pupils, vomiting, nausea, fever, tachycardia, depression of cardiac activity, arterial hypertension, collapse. There may be mental disorders. Treatment consists of gastric lavage and taking sorbents.

Interaction

When used simultaneously with antidepressants and MAO blockers, an increase in blood pressure is observed. When prescribing other vasoconstrictor drugs simultaneously, the risk of adverse reactions increases.

Terms of sale

Storage conditions

Storage temperature up to 25°C.

Best before date

Nazivin during pregnancy

Nazivin at pregnancy it can be used only after assessing the benefits for the pregnant woman and the risk to the fetus. It is unacceptable to exceed the dose during this period.

Analogues Level 4 ATX code matches:

Preparations with the same active ingredient: Nazol, Nazol Advance, Sanorinchik, Knoxprey, Afrin, Nesopin, Fazin. Analogue drugs that have a similar effect: Galazolin, Xylometazoline, ForNose, Xymelin.

Reviews about Nazivin

Nazivin vasoconstrictor drops, like other drops, should be considered as an “ambulance” and used only for 3-5 days of severe nasal congestion. With long-term use, mucosal atrophy is possible. It should be noted that Nazivin, when used in the recommended dosage regimen, does not cause significant damage to the mucous membrane, is not addictive even with long-term use, and its therapeutic effectiveness, compared to other vasoconstrictor drops, is achieved at low concentrations. Therefore the form oxymetazoline in the form of a 0.01% solution is safe and effective for treatment rhinitis even in newborns and infants.

It is a known fact that this drug also has antiviral and anti-inflammatory effects. This explains its high efficiency in rhinitis viral etiology. This drug is the only one anticongestant, which is approved in Russia for use in newborns. Research has shown its high efficiency. This is evidenced by reviews of Nazivin:

• “... I use Nazivin 0.01% children's nasal drops for my 2-year-old child. They act for a long time, so I drop them 2 times a day, but not for long”;
• “... The child often has a runny nose and we can only save ourselves with these drops - 2 days of treatment are enough and the congestion goes away”;
• “...I like these drops most of all. We use it with the whole family, but we give it to children in less concentration”;
• “... It is enough to instill the drops for 1-1.5 days, and then we switch to medicinal drops (such as Pinosol), or simply instill herbal decoctions and treat the runny nose to the end.”

Nazivin spray is convenient for use in adults and some people find it more effective than drops. This is true: aerosol forms are distributed more evenly throughout the mucous membrane, which creates a pronounced therapeutic effect. In addition, the spray does not roll into the nasopharynx, as happens when using drops.

Nazivin price, where to buy

You can buy the drug at any pharmacy. The price of Nazivin spray 0.05% ranges from 221 rubles. up to 248 rubles, the cost of Nazivin Sensitive spray is 231-352 rubles.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

WER.RU

Nazivin drops 0.01% 5 ml for children Merck & Co

Nazivin Sensitive nasal spray 22.5 mcg/dose 10 ml 220 doses

Nazivin Sensitive nasal spray 11.25 mcg/dose 10 ml 220 doses

Nazivin spray 0.05% 10 mlMerck & Co

Nazivin drops 0.05% 10 mlMerck & Co

ZdravZone

Nazivin nasal drops for children under 1 year 0.01% 5mlMerck KGaA

Nazivin nasal drops for children 1-6 years old 0.025% 10mlMerck KGaA

Nazivin nasal spray 0.05% 10mlMerck KGaA

Nazivin Sensitive nasal spray for children 1-6 years old 11.25 µg/dose 10 mlMerck KGaA

Nazivin Sensitive nasal spray 22.5 µg/dose 10 mlMerck KGaA

Pharmacy IFC

Naziwin Merck, Germany

Naziwin Merck, Germany

Naziwin Merck, Germany

Nazivin SensitiveMerck, Germany

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Pharmacy24

Nazivin nasal aerosol 0.05% 10mlNycomed (Austria)

NazivinMerck KGaA (Germany)

NazivinMerck KGaA (Germany)

NazivinMerck KGaA (Germany)

PaniPharmacy

Nazivin nasal drops 0.01% 5mlNycomed

Nazivin sensitive nasal drops 0.01% 5mlMerck KgaA

Nazivin spray 0.05% 10mlNycomed

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BIOSPHERE

Nazivin Sensitive 11.25 mcg/dose 10 ml nasal dose spray Ursapharm Arzneimittel (Germany)

Nazivin Sensitive 22.5 mcg/dose 10 ml nasal dose spray Ursapharm Arzneimittel (Germany)

Nazivin Sensitive 0.01% 5 ml drops called Ursapharm Arzneimittel (Germany)

Nazivin 0.025% 10 ml drops called Merck KGaA (Germany)

Nazivin 0.05% 10 ml spray called Merck KGaA (Germany)

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NOTE! Information about medications on the site is for reference and general information, collected from publicly available sources and cannot serve as a basis for making a decision on the use of medications in the course of treatment. Before using the drug Nazivin, be sure to consult with your doctor.

Registration number:

Name of the drug: NAZIVIN®

International nonproprietary name:

Oxymetazoline

Dosage form:

Nasal drops

Compound
1 ml of the drug contains:
Active substance:
Nazivin 0.01% - Oxymetazoline hydrochloride 0.1 mg
Nazivin 0.025% - Oxymetazoline hydrochloride 0.25 mg
Nazivin 0.05% - Oxymetazoline hydrochloride 0.5 mg
Excipients: benzalkonium chloride 50% solution, disodium edetate dihydrate, sodium dihydrogen phosphate dihydrate, sodium hydrogen phosphate dihydrate, sodium hydroxide 1 M solution, purified water.

Description: Almost transparent, colorless to slightly yellowish solution.

Pharmacotherapeutic group:

Alpha

Adrenomimetic agent.

ATX Code: .

Pharmacological properties

Pharmacodynamics. Nazivin® (oxymetazoline) has a vasoconstrictor effect. When applied topically to the inflamed nasal mucosa, it reduces swelling and nasal discharge. Restores nasal breathing.
Elimination of mucosal edema helps restore aeration of the paranasal sinuses and middle ear cavity, which prevents the development of bacterial complications (sinusitis, sinusitis, otitis media).
When used locally intranasally in therapeutic concentrations, it does not irritate the mucous membrane and does not cause hyperemia.
When administered locally intranasally, the drug does not have a systemic effect. The drug begins to act quickly (within a few minutes). The duration of action of Nazivin is up to 12 hours.

Indications

treatment of acute respiratory diseases accompanied by a runny nose; allergic rhinitis; vasomotor rhinitis; to restore drainage in case of inflammation of the paranasal sinuses, eustachitis, otitis media; to eliminate swelling before diagnostic manipulations in the nasal passages. Contraindications
Atrophic rhinitis; angle-closure glaucoma; hypersensitivity to the components of the drug.
You should adhere to the recommended concentrations of the drug intended for different age categories (see methods of use). Carefully
In patients taking monoamine oxidase inhibitors and other drugs that increase blood pressure for up to 10 days after their use; with increased intraocular pressure, during pregnancy and lactation, with severe forms of cardiovascular diseases (hypertension, angina); with thyrotoxicosis and diabetes mellitus. Pregnancy and lactation
Directions for use and doses
Nazivin® 0.01%, 0.025% and 0.05% drops are intended for use in the nose.
Adults and children over 6 years of age: use Nazivin® 0.05% drops, 1 to 2 drops in each nasal passage 2-3 times a day.
Children from 1 year to 6 years: use Nazivin® 0.025% drops, 1 - 2 drops in each nasal passage 2-3 times a day.
Children under 1 year: Children under 4 weeks of age are prescribed 1 drop of Nazivin® 0.01% in each nasal passage 2-3 times a day. From the 5th week of life to 1 year - 1 - 2 drops in each nasal passage 2-3 times a day.
To ensure dosage accuracy, the bottle of Nazivin® 0.01% drops has a graduated pipette with marks on the number of drops. For example, if 1 drop is prescribed, then the pipette should be filled with the solution to the 1 mark.
The following procedure has also been proven effective: depending on age, 1-2 drops of a 0.01% solution are applied to cotton wool and wiped over the nasal passages. Nazivin® 0.01%, 0.025% and 0.05% drops should be used for 3 to 5 days. Doses higher than recommended can only be used under medical supervision. special instructions
Interaction with other drugs
When MAO blockers and tricyclic antidepressants are prescribed simultaneously, blood pressure increases.
Side effect
Sometimes: burning or dryness of the nasal membranes, sneezing. In rare cases: after the effect of using Nazivin® wears off, a strong feeling of “stuffiness” in the nose (reactive hyperemia). Repeated overdose with local nasal use sometimes leads to systemic sympathomimetic effects such as increased heart rate (tachycardia) and increased blood pressure. In very rare cases, anxiety, insomnia, fatigue, headaches and nausea have been observed. Long-term continuous use of vasoconstrictor drugs can lead to tachyphylaxis, atrophy of the nasal mucosa and recurrent swelling of the nasal mucosa (rhinitis medicamentosa). Overdose
After a significant overdose or accidental ingestion, the following symptoms may appear: constriction of the pupils, nausea, vomiting, cyanosis, fever, tachycardia, arrhythmia, collapse, cardiac depression, arterial hypertension, pulmonary edema, respiratory disorders. In addition, mental disorders may appear, as well as depression of the functions of the central nervous system, accompanied by drowsiness, decreased body temperature, bradycardia, arterial hypotension, respiratory arrest and possible development of coma. In case of overdose associated with oral administration of the drug, gastric lavage and activated charcoal are prescribed. Impact on the ability to drive vehicles and equipment:
After long-term use or administration of cold remedies containing oxymetazoline in dosages exceeding the recommended ones, a general effect on the cardiovascular system and central nervous system cannot be excluded. In these cases, the ability to operate a vehicle or equipment may be impaired. Release form.
Nasal drops 0.01%; 0.025% and 0.05%.
For Nazivin® 0.01%: 5 ml in a dark glass bottle with a pipette cap.
For Nazivin® 0.025% and 0.05%: 10 ml in a dark glass bottle with a pipette cap.
1 bottle with instructions for use is placed in a cardboard box. Storage
Store at a temperature not exceeding 25 °C.
Keep out of the reach of children. Best before date
3 years.
Do not use after expiration date.

Conditions for dispensing from pharmacies:

over the counter.

Manufacturer:

Merck KGaA, Germany
Frankfurter str. 250, 64293 Darmstadt
Frankfurter str., 250,64293 Darmstadt Address of the representative office of Nycomed in Russia/CIS:
119049 Moscow, st. Shabolovka, 10, building 2.

Nazivin is a well-known pharmaceutical drug widely used for medical purposes for ENT diseases and colds.

The main active ingredient of the drug is oxymetazoline. This substance stimulates the functioning of α2-adrenergic receptors, as a result of which more hormones norepinephrine and adrenaline are released at the site of exposure, which reduce swelling by constricting blood vessels, reducing the volume of blood in them. Thanks to this effect, nasal breathing is facilitated, air penetrates into the sinuses, and the amount of mucus released is reduced.

For these purposes, the medication is used not only for adults; Nazivin for children is also widely used, which has various release forms, such as Nazivin Baby, Nazivin Sensitive, etc.

Clinical and pharmacological group

Vasoconstrictor drug for local use in ENT practice.

Conditions for dispensing from pharmacies

Dispensed without a doctor's prescription.

Prices

How much does Nazivin cost? The average price in pharmacies is 140 rubles.

Release form and composition

The active substance of the drug is oxymetazoline.

Children's Nizivin is produced in a solution of 0.025% and 0.01%. The solution base is aqueous. It contains additional components: disodium edetate, benzalkonium chloride 50%, sodium hydrogen phosphate, sodium hydroxide 1 ml solution. Available in dark glass bottles of 5 ml or 10 ml with a pipette in the cap.

When used for children under one year of age, the drops are diluted with special water used for injections in a 1:1 ratio or distilled in the same proportion. Used for instillation into the nose.

Pharmacological effect

When Nazivin gets on the inflamed nasal mucosa, its swelling and the volume of mucus secreted decreases. This occurs due to the effect of the drug on adrenaline receptors, which are located in blood vessels (in muscle fibers). The receptors contract, and vascular permeability decreases due to their narrowing.

The use of Nazivin improves nasal breathing and eliminates swelling of the mucous membranes. The drug also reduces the risk of complications in the paranasal sinuses and middle ear (sinusitis, sinusitis and otitis media). After the drug enters the bloodstream due to absorption in the mucous membranes, a narrowing of blood vessels (arteries) occurs in organs and tissues, and the heart rate also increases. Due to this, blood pressure increases and heart rate changes.

When Nazivin is applied to the mucous membranes in recommended doses, it does not enter the circulatory system and does not cause a systemic effect on the body. Nazivin does not irritate the nasal mucosa and does not cause blood vessels to overflow (hyperemia).

The maximum effect of the drug is achieved 15 minutes after application. The effect lasts for 8 hours.

Indications for use

What does it help with? Nazivin is used for:

• acute respiratory infections, if there is a runny nose;
• sinusitis, eustachitis, otitis media and inflammation of the paranasal sinuses to facilitate the outflow of mucus;
• preparing the nasal passages for diagnostic procedures;
• allergic and vasomotor rhinitis.

Contraindications

When using the product, it is important to follow the rules given in the instructions; then the substance can be instilled even in children under 1 year of age. However, the drug also has a number of contraindications. In a number of cases, its use will have to be abandoned:

• children under 6 years of age (drops and nasal spray 0.05%);
• atrophic rhinitis;
• angle-closure glaucoma;
• hypersensitivity to the components of the drug.

Caution should be used during the simultaneous use of MAO inhibitors and other drugs that increase blood pressure, as well as for up to 10 days after discontinuation of these drugs; with increased intraocular pressure; during pregnancy and lactation; in severe forms of cardiovascular diseases (arterial hypertension, angina pectoris); with thyrotoxicosis and diabetes mellitus.

Use during pregnancy and lactation

When used during pregnancy or breastfeeding, do not exceed the recommended dosage. The drug should be used only after a careful assessment of the risk-benefit ratio for the mother and fetus.

Dosage and method of administration

The instructions for use indicate that Nazivin drops are intended for intranasal use.

Children under 1 year of age are prescribed 0.01% drops.

1. For newborns (children under 4 weeks of age), administer 1 drop into each nostril 2-3 times a day.
2. Children aged 1 month to 1 year are prescribed 1-2 drops in each nostril 2-3 times a day.
3. Children aged 1 to 6 years should be prescribed drops of 0.025%, 1-2 drops in each nostril 2-3 times a day.
4. Adults and children over 6 years of age should be prescribed 0.05% drops, 1-2 drops in each nostril 2-3 times a day.

To ensure dosage accuracy, the bottle of 0.01% drops has a graduated pipette with markings on the number of drops. If 1 drop is prescribed, then the pipette should be filled with the solution to the 1 mark.

The following procedure has also been proven effective: depending on age, 1-2 drops of a 0.01% solution are applied to cotton wool and wiped over the nasal passages.

Nazivin should be used for 3-5 days. Doses higher than recommended are prescribed at the discretion of the physician.

Side effects

Side effects when using Nazivin occur infrequently. Possible burning, dry nasal mucosa and sneezing. Rarely, reactive hyperemia occurs - severe nasal congestion when the effect of the drug weakens.

Overdose

An overdose of oxymetazoline occurs when a large amount of the substance enters the gastrointestinal tract and bloodstream. This can happen when a young child has access to the drops and accidentally drinks them. Parents are strongly advised to keep any medications out of the child's reach.

When applying drops topically according to the instructions, overdose is excluded. But there is a risk when using drugs with a high concentration of the active ingredient to treat young children.

Manifestations of severe overdose:

• temperature rise to subfebrile;
• breathing difficulties due to edema;
• mental and nervous disorders;
• increased blood pressure;
• arrhythmia, difficulty breathing;
• constriction of the pupils;
• drowsiness and decreased activity.

When a life-threatening amount of a substance enters the blood, a sharp decrease in body temperature, respiratory depression, and a decrease in heart rate are observed. This may result in respiratory arrest and the development of coma.

Treatment: taking activated carbon and washing the child’s stomach.

special instructions

Long-term use and overdose of the drug should be avoided, especially in children.

After long-term use of drugs containing oxymetazoline in doses exceeding the recommended ones, a general effect on the cardiovascular system and the central nervous system cannot be excluded; in these cases, the ability to operate a vehicle or equipment may be impaired.

Drug interactions

When Nazivin is used simultaneously with MAO blockers or tricyclic antidepressants, an increase in blood pressure is observed.

Co-administration of other vasoconstrictor drugs increases the risk of side effects.

Nazivin– a drug in the form of nasal drops or spray, which has a pronounced anti-edematous and vasoconstrictor effect. The drug contains an active component - oxymetazoline - which stimulates alpha-adrenergic receptors located in the smooth muscle layer of the vessels of the nasal mucosa. The drug eliminates rhinorrhea, swelling of the nasal mucosa and paranasal sinuses, and facilitates nasal breathing. When using the drug in therapeutic doses, no stimulation of alpha1-adrenergic receptors was observed, however, when using excessive doses, some effect of oxymetazoline on alpha1-adrenergic receptors is possible.

The drug is not absorbed into the systemic circulation and does not have a systemic effect.

Indications for use

The drug is used to treat patients with acute rhinitis of various etiologies, including allergic rhinitis.

The drug is prescribed to patients with vasomotor rhinitis, sinusitis, inflammation of the Eustachian tube and middle ear, as well as acute respiratory diseases that are accompanied by impaired nasal breathing.

In addition, the drug can be prescribed in preparation for various diagnostic procedures.

Mode of application

Nazivin 0.05% (nasal drops, spray):

Adults and children over 6 years of age are usually prescribed 1-2 drops (1-2 injections) of the drug 2-3 times a day.

Nazivin 0.025% (nasal drops):

Children aged 1 to 6 years are usually prescribed 1-2 drops of the drug 2-3 times a day.

Nazivin 0.01% (nasal drops):

Children aged from birth to 4 weeks are usually prescribed 1 drop of the drug 2-3 times a day.

Children aged 5 weeks to 1 year are usually prescribed 1-2 drops of the drug 2-3 times a day.

In addition to instilling the drug into the nasal passages, it is also possible to apply the required amount of the drug (1-2 drops) to a cotton swab and treat the nasal passages.

It should be borne in mind that with prolonged use of the drug, its therapeutic effect is somewhat reduced.

Side effects

The drug is usually well tolerated by patients; in isolated cases, a burning sensation and dryness of the nasal mucosa, reactive hyperemia, and sneezing were noted.

When using excessive doses of the drug for a long time, the development of tachycardia, arterial hypertension, disturbances in sleep and wakefulness, headache and nausea is possible.

Contraindications

Increased individual sensitivity to the components of the drug.

The drug is contraindicated in patients suffering from angle-closure glaucoma.

The drug is not used to treat patients suffering from atrophic rhinitis.

A drug Nazivin 0.05% is contraindicated in children under the age of 6 years, Nazivin 0.025% - in children under the age of 1 year.

Caution should be exercised when prescribing the drug to patients with arterial hypertension, tachycardia, atherosclerosis, diabetes mellitus, hyperthyroidism, as well as increased intraocular pressure and pheochromocytoma.

Pregnancy

The drug can be used during pregnancy as prescribed by the attending physician, who must carefully weigh the expected benefits for the mother and the potential risks for the fetus.

If it is necessary to use the drug during lactation, the minimum effective dose of oxymetazoline should be used.

Interaction with other drugs

When the drug is used in combination with monoamine oxidase inhibitors and tricyclic antidepressants, the development of arterial hypertension is possible.

Overdose

When using excessive doses of the drug, as well as when accidentally taking the drug orally, nausea, vomiting, increased body temperature, cardiac arrhythmias, arterial hypertension, respiratory problems, pulmonary edema and cardiac arrest may develop. In addition, some patients experienced depression of the functions of the central nervous system and the development of drowsiness, arterial hypotension, bradycardia, respiratory arrest and coma.

There is no specific antidote. In case of accidental oral administration of the drug, gastric lavage and enterosorbents are indicated. In case of overdose, symptomatic therapy is carried out.

Release form

Nasal drops, 10 ml in a bottle, 1 bottle in a cardboard box.